TADB
TA Pair: Xre-GNAT
#OrganismToxinAntitoxinLocus IDReplicon
1Acidovorax citrulli AAC00-13309 Aave_2197Aave_2196NC_008752
2Acinetobacter baumannii ATCC 179783591 A1S_1516A1S_1515NC_009085
3Acinetobacter baumannii AYE5122 ABAYE2123ABAYE2124NC_010410
4Acinetobacter baumannii SDF5113 ABSDF2126ABSDF2127NC_010400
5Acinetobacter sp. ADP11353 ACIAD1637ACIAD1638NC_005966
6Agrobacterium tumefaciens str. C58333 Atu0246Atu0245NC_003062
7Azorhizobium caulinodans ORS 5714651 AZC_3533AZC_3532NC_009937
8Bacillus pumilus SAFR-0324541 BPUM_0585BPUM_0584NC_009848
9Bacillus subtilis subsp. subtilis str. 168136 BSU19060BSU19050NC_000964
10Bacteroides fragilis NCTC 93431765 BF3476BF3477NC_003228
11Bacteroides fragilis YCH461306 BF3685BF3686NC_006347
12Bradyrhizobium diazoefficiens USDA 110838 blr1116blr1115NC_004463
13Bradyrhizobium sp. ORS 2783851 BRADO4106BRADO4105NC_009445
14Burkholderia ambifaria AMMD2970 Bamb_1024Bamb_1025NC_008390
15Burkholderia ambifaria MC40-65352 BamMC406_1028BamMC406_1029NC_010551
16Burkholderia cenocepacia AU 10542731 Bcen_0667Bcen_0668NC_008060
17Burkholderia cenocepacia HI24243104 Bcen2424_1146Bcen2424_1147NC_008542
18Burkholderia cenocepacia MC0-35233 Bcenmc03_1122Bcenmc03_1123NC_010508
19Burkholderia lata2094 Bcep18194_A4258Bcep18194_A4259NC_007510
20Burkholderia mallei ATCC 233441838 BMA2020BMA2019NC_006348
21Burkholderia mallei SAVP13424 BMASAVP1_A0894BMASAVP1_A0895NC_008785
22Burkholderia multivorans ATCC 176164799 Bmul_2159Bmul_2158NC_010084
23Burkholderia phytofirmans PsJN5503 Bphyt_4546Bphyt_4547NC_010676
24Burkholderia phytofirmans PsJN5505 Bphyt_5268Bphyt_5267NC_010676
25Burkholderia pseudomallei 1106a3580 BURPS1106A_3175BURPS1106A_3174NC_009076
26Burkholderia pseudomallei 1710b2023 BURPS1710b_3192BURPS1710b_3191NC_007434
27Burkholderia pseudomallei 6683578 BURPS668_3138BURPS668_3137NC_009074
28Clostridium perfringens ATCC 131242825 CPF_0811CPF_0812NC_008261
29Clostridium perfringens str. 13541 CPE0814CPE0815NC_003366
30Cytophaga hutchinsonii ATCC 334062813 CHU_0641CHU_0642NC_008255
31Escherichia coli 5362802 ECP_1193ECP_1194NC_008253
32Flavobacterium johnsoniae UW1013837 Fjoh_4873Fjoh_4874NC_009441
33Flavobacterium johnsoniae UW1013832 Fjoh_0496Fjoh_0497NC_009441
34Methylobacillus flagellatus KT2571 Mfla_0436Mfla_0437NC_007947
35Methylobacterium sp. 4-465245 M446_4767M446_4768NC_010511
36Polaromonas sp. JS6662583 Bpro_2086Bpro_2085NC_007948
37Pseudomonas aeruginosa PA74275 PSPA7_1851PSPA7_1852NC_009656
38Pseudomonas aeruginosa PAO1183 PA3270PA3269NC_002516
39Pseudomonas aeruginosa UCBPP-PA143008 PA14_21710PA14_21720NC_008463
40Pseudomonas mendocina ymp3813 Pmen_3328Pmen_3327NC_009439
41Pseudomonas protegens Pf-51781 PFL_4044PFL_4043NC_004129
42Pseudomonas putida F14036 Pput_3670Pput_3671NC_009512
43Ralstonia solanacearum GMI1000508 RSc3133RSc3132NC_003295
44Rhizobium etli CFN 422352 RHE_CH00251RHE_CH00250NC_007761
45Rhizobium etli CIAT 6525735 RHECIAT_CH0000286RHECIAT_CH0000285NC_010994
46Saccharophagus degradans 2-402494 Sde_3816Sde_3817NC_007912
47Salinispora tropica CNB-4403738 Strop_0839Strop_0840NC_009380
48Serratia proteamaculans 5684524 Spro_1455Spro_1454NC_009832
49Sinorhizobium meliloti 1021863 SMc00352SMc00351NC_003047
50Streptomyces coelicolor A3(2)579 SCO6803SCO6802NC_003888
The closest characterized GNAT family acetyltrasferase is involved in antibiotic resistance

Antitoxin domain: Xre. Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.

Toxin domain: GNAT. Acetyltransferase (GNAT) family. S. enterica GNAT toxin protein TacT was reported to block the primary amine group of amino acids on charged tRNA molecules, and then inhibit translation.


Structure
Crystal structure of TacT (tRNA acetylating toxin) from Salmonella [PDB ID: 5FVJ] [PudMed:27264868]
Crystal structure of PH1933 from Pyrococcus horikoshii OT3 [PDB ID: 1WWZ]
(1) Makarova KS et al. (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct 4:19. [PudMed:19493340] in_silico