TADB
TA Pair: COG5606-RelE
#OrganismToxinAntitoxinLocus IDReplicon
1Acidiphilium cryptum JF-53914 Acry_3516Acry_3517NC_009469
2Bordetella petrii DSM 128044863 Bpet2167Bpet2168NC_010170
3Bradyrhizobium diazoefficiens USDA 110842 blr2113blr2114NC_004463
4Burkholderia xenovorans LB4002598 Bxe_A3974Bxe_A3975NC_007951
5Candidatus Koribacter versatilis Ellin3452671 Acid345_4451Acid345_4450NC_008009
6Candidatus Solibacter usitatus Ellin60763058 Acid_0940Acid_0941NC_008536
7Candidatus Solibacter usitatus Ellin60763079 Acid_4183Acid_4182NC_008536
8Cellvibrio japonicus Ueda1075755 CJA_1213CJA_1214NC_010995
9Escherichia coli O157:H7 str. EDL933194 experimental Z3230Z3231NC_002655
10Escherichia coli O157:H7 str. Sakai1010 ECs2869ECs2870NC_002695
11Escherichia coli SMS-3-55201 EcSMS35_0998EcSMS35_0997NC_010498
12Geobacter uraniireducens Rf43952 Gura_1359Gura_1358NC_009483
13Methylobacterium radiotolerans JCM 28315257 Mrad2831_6395Mrad2831_6394NC_010514
14Microcystis aeruginosa NIES-8434958 MAE_15460MAE_15450NC_010296
15Microcystis aeruginosa NIES-8434980 MAE_29280MAE_29270NC_010296
16Microcystis aeruginosa NIES-8435026 MAE_55780MAE_55770NC_010296
17Mycobacterium abscessus5104 MAB_1762MAB_1763NC_010397
18Nitrobacter winogradskyi Nb-2551998 Nwi_0732Nwi_0731NC_007406
19Nitrosomonas eutropha C912901 Neut_1480Neut_1481NC_008344
20Nitrosospira multiformis ATCC 251962209 Nmul_A0117Nmul_A0118NC_007614
21Nitrosospira multiformis ATCC 251962220 Nmul_D2815Nmul_D2814NC_007617
22Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133)5448 Npun_R0147Npun_R0146NC_010628
23Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)460 all1034all1033NC_003272
24Paracoccus aminophilus6038 pAMI2_p05pAMI2_p06NC_010847
25Photobacterium profundum SS91256 PBPRB0418PBPRB0419NC_006371
26Photorhabdus luminescens subsp. laumondii TTO11202 plu1224plu1223NC_005126
27Photorhabdus luminescens subsp. laumondii TTO11249 plu4781plu4782NC_005126
28Polaromonas naphthalenivorans CJ23398 Pnap_2998Pnap_2999NC_008781
29Pseudomonas aeruginosa PA74277 PSPA7_3746PSPA7_3745NC_009656
30Pseudomonas sp. LM136025 ORF3ORF4KJ920396
31Pseudomonas syringae pv. tomato str. DC30001795 PSPTO_B0025PSPTO_B0026NC_004632
32Rhodopseudomonas palustris BisB182510 RPC_1582RPC_1581NC_007925
33Rhodopseudomonas palustris TIE-15798 Rpal_4351Rpal_4350NC_011004
34Salmonella enterica subsp. enterica serovar Agona str. SL4835965 SeAg_B4131SeAg_B4132NC_011149
35Salmonella enterica subsp. enterica serovar Dublin str. CT 020218535982 SeD_A4296SeD_A4297NC_011205
36Salmonella enterica subsp. enterica serovar Paratyphi A str.5954 SSPA3490SSPA3491NC_011147
37Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC1657 SPA3745SPA3746NC_006511
38Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB74807 SPAB_04851SPAB_04852NC_010102
39Salmonella enterica subsp. enterica serovar Typhimurium str. LT2445 STM3906STM3907NC_003197
40Salmonella enterica subsp. enterica serovar Typhi str. CT18826 STY3651STY3650NC_003198
41Salmonella enterica subsp. enterica serovar Typhi str. Ty2752 t3392t3391NC_004631
42Serratia proteamaculans 5684537 Spro_4386Spro_4385NC_009832
43Shigella dysenteriae Sd1972199 SDY_2200SDY_2199NC_007606
44Verminephrobacter eiseniae EF01-23457 Veis_4347Veis_4348NC_008786
45Verminephrobacter eiseniae EF01-23437 Veis_2859Veis_2858NC_008786
46Verminephrobacter eiseniae EF01-23431 Veis_1559Veis_1558NC_008786
47Xylella fastidiosa 9a5c1735 XFa0034XFa0035NC_002490
48Xylella fastidiosa 9a5c152 XF1678XF1677NC_002488
49Xylella fastidiosa 9a5c148 XF1573XF1572NC_002488
50Xylella fastidiosa M235390 XfasM23_1038XfasM23_1039NC_010577
51Xylella fastidiosa M235389 XfasM23_1023XfasM23_1024NC_010577
52Xylella fastidiosa Temecula1779 PD0967PD0968NC_004556
53Xylella fastidiosa Temecula1780 PD0982PD0983NC_004556

experimental Data derived from experimental literature


Antitoxin domain: COG5606. Uncharacterized conserved small protein [Function unknown]

Toxin domain: RelE. Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]


Structure
NMR Structure of Protein UPF0165 protein AF_2212 from Archaeoglobus Fulgidus; Northeast Structural Genomics Consortium Target GR83 [PDB ID: 2NWT]
(1) Shavit et al. (2015) The vapB-vapC Operon of Acidovorax citrulli Functions as a Bona-fide Toxin-Antitoxin Module Front Microbiol 6:1499. [PudMed:26779154] experimental
(2) Dziewit L et al. (2007) The SXT conjugative element and linear prophage N15 encode toxin-antitoxin-stabilizing systems homologous to the tad-ata module of the Paracoccus aminophilus plasmid pAMI2. J Bacteriol 189(5):1983-97. [PudMed:17158670] experimental
(3) Makarova KS et al. (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct 4:19. [PudMed:19493340] in_silico