TADB
TA Pair: AbrB-RelE
#OrganismToxinAntitoxinLocus IDReplicon
1Acidithiobacillus ferrooxidans ATCC 539935999 Lferr_1132Lferr_1133NC_011206
2Acidovorax sp. JS423406 Ajs_1247Ajs_1246NC_008782
3Archaeoglobus fulgidus DSM 430445 AF1075AF1074NC_000917
4Archaeoglobus fulgidus DSM 430448 AF1080AF1079NC_000917
5Bordetella petrii DSM 128044862 Bpet1507Bpet1508NC_010170
6Bordetella petrii DSM 128044867 Bpet4256Bpet4255NC_010170
7Bradyrhizobium diazoefficiens USDA 110840 bll1687bll1688NC_004463
8Bradyrhizobium sp. BTAi13917 BBta_p0281BBta_p0282NC_009475
9Burkholderia cenocepacia AU 10542738 Bcen_2915Bcen_2914NC_008060
10Burkholderia xenovorans LB4002603 Bxe_A1175Bxe_A1174NC_007951
11Candidatus Desulforudis audaxviator MP104C5141 Daud_1918Daud_1919NC_010424
12Candidatus Solibacter usitatus Ellin60763082 Acid_4367Acid_4366NC_008536
13Caulobacter sp. K315070 Caul_5360Caul_5361NC_010333
14Delftia acidovorans SPH-14766 Daci_4188Daci_4189NC_010002
15Dinoroseobacter shibae DFL 12 = DSM 164934728 Dshi_3729Dshi_3730NC_009955
16Dinoroseobacter shibae DFL 12 = DSM 164934730 Dshi_4011Dshi_4012NC_009957
17Escherichia coli 5362808 ECP_3220ECP_3219NC_008253
18Escherichia coli ATCC 87395154 EcolC_0570EcolC_0571NC_010468
19Escherichia coli CFT073677 c3885c3884NC_004431
20Escherichia coli HS4509 EcHS_A3320EcHS_A3319NC_009800
21Escherichia coli O157:H7 str. EDL933197 Z4482Z4481NC_002655
22Escherichia coli O157:H7 str. Sakai1013 ECs4008ECs4007NC_002695
23Escherichia coli SMS-3-55204 EcSMS35_3427EcSMS35_3426NC_010498
24Escherichia coli str. K-12 substr. DH10B5174 ECDH10B_3303ECDH10B_3302NC_010473
25Escherichia coli str. K-12 substr. MG16551047 experimental b3130b3129NC_000913
26Geobacillus kaustophilus HTA4261184 GK2354GK2355NC_006510
27Herminiimonas arsenicoxydans3604 HEAR2029HEAR2030NC_009138
28Lactobacillus gasseri ATCC 333233046 LGAS_0928LGAS_0929NC_008530
29Methanoregula boonei 6A84376 Mboo_0403Mboo_0404NC_009712
30Methylobacterium populi BJ0015550 Mpop_0844Mpop_0845NC_010725
31Moorella thermoacetica ATCC 390732290 Moth_1940Moth_1941NC_007644
32Neisseria gonorrhoeae NCCP119455818 NGK_1059NGK_1058NC_011035
33Nitrobacter hamburgensis X142635 Nham_4639Nham_4640NC_007961
34Nitrosomonas europaea ATCC 19718934 NE1999NE1998NC_004757
35Parvibaculum lavamentivorans DS-14416 Plav_3433Plav_3434NC_009719
36Pelotomaculum thermopropionicum SI3860 PTH_0033PTH_0034NC_009454
37Pelotomaculum thermopropionicum SI3863 PTH_0397PTH_0396NC_009454
38Photorhabdus luminescens subsp. laumondii TTO11237 plu3944plu3943NC_005126
39Pseudomonas putida KT2440304 PP_1267PP_1268NC_002947
40Pseudomonas stutzeri A15013773 PST_3459PST_3460NC_009434
41Synechocystis sp. PCC 6803959 slr0725slr0724NC_000911
42Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112907 Swol_0119Swol_0118NC_008346
43Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112913 Swol_0286Swol_0287NC_008346
44Verminephrobacter eiseniae EF01-23429 Veis_1416Veis_1415NC_008786
45Xanthobacter autotrophicus Py24391 Xaut_4954Xaut_4955NC_009717

experimental Data derived from experimental literature


Antitoxin domain: AbrB. Regulators of stationary/sporulation gene expression [Transcription]

Toxin domain: RelE. Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]


Structure
Crystal Structure of RelB-RelE antitoxin-toxin complex from Methanococcus jannaschii [PDB ID: 3BPQ] [PudMed:19712680]
Crystal structure of archaeal RelE-RelB complex from Pyrococcus horikoshii OT3 [PDB ID: 1WMI] [PudMed:15768033]
Solution Structure of the Bacterial Toxin Rele from Thermus Thermophilus HB8 [PDB ID: 2KHE]
The crystal structure of the isolated E. coli RelE toxin [PDB ID: 3KHA] [PudMed:20005802]
The crystal structure of the toxin-antitoxin complex RelBE2 (Rv2865-2866) from Mycobacterium tuberculosis [PDB ID: 3G5O]
NMR Structure of Protein UPF0165 protein AF_2212 from Archaeoglobus Fulgidus; Northeast Structural Genomics Consortium Target GR83 [PDB ID: 2NWT]
(1) Norton JP; Mulvey MA (2012) Toxin-antitoxin systems are important for niche-specific colonization and stress resistance of uropathogenic Escherichia coli PLoS Pathog 8(10):e1002954. [PudMed:23055930] experimental
(2) Makarova KS et al. (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct 4:19. [PudMed:19493340] in_silico