TADB
TA Pair: PHD-RelE
#OrganismToxinAntitoxinLocus IDReplicon
1Acaryochloris marina MBIC110174629 AM1_2740AM1_2741NC_009925
2Acaryochloris marina MBIC110174627 AM1_2604AM1_2603NC_009925
3Acaryochloris marina MBIC110174623 AM1_0880AM1_0879NC_009925
4Acaryochloris marina MBIC110174647 AM1_E0216AM1_E0215NC_009930
5Acaryochloris marina MBIC110174630 AM1_2751AM1_2750NC_009925
6Acidithiobacillus ferrooxidans ATCC 539935998 Lferr_1012Lferr_1011NC_011206
7Acidithiobacillus ferrooxidans ATCC 539935997 Lferr_0995Lferr_0994NC_011206
8Acidovorax citrulli AAC00-13312 Aave_4464Aave_4465NC_008752
9Acinetobacter baumannii ACICU5439 ACICU_p0010ACICU_p0009NC_010605
10Acinetobacter baumannii AYE5115 p1ABAYE0005p1ABAYE0004NC_010401
11Actinobacillus pleuropneumoniae serovar 3 str. JL034918 APJL_1288APJL_1287NC_010278
12Agrobacterium tumefaciens str. C58345 Atu2017Atu2018NC_003062
13Agrobacterium vitis S46178 Avi_3785Avi_3784NC_011989
14Aliivibrio salmonicida LFI12386177 VSAL_I1469VSAL_I1470NC_011312
15Alkalilimnicola ehrlichii MLHE-12883 Mlg_1786Mlg_1787NC_008340
16Alkalilimnicola ehrlichii MLHE-12888 Mlg_2563Mlg_2562NC_008340
17Alkaliphilus metalliredigens QYMF4231 Amet_0747Amet_0746NC_009633
18Alkaliphilus metalliredigens QYMF4228 Amet_0378Amet_0377NC_009633
19Alkaliphilus metalliredigens QYMF4229 Amet_0596Amet_0595NC_009633
20Arthrobacter aurescens TC13274 AAur_0707AAur_0708NC_008711
21Azoarcus sp. BH723254 azo2024azo2023NC_008702
22Azorhizobium caulinodans ORS 5714648 AZC_0539AZC_0538NC_009937
23Beijerinckia indica subsp. indica ATCC 90395398 Bind_3688Bind_3687NC_010580
24Burkholderia ambifaria MC40-66175 BamMC406_5382BamMC406_5383NC_010552
25Caldicellulosiruptor saccharolyticus DSM 89033801 Csac_2646Csac_2645NC_009437
26Campylobacter curvus 525.924386 CCV52592_0926CCV52592_2220NC_009715
27Candidatus Desulforudis audaxviator MP104C5132 Daud_0750Daud_0751NC_010424
28Candidatus Solibacter usitatus Ellin60763077 Acid_3909Acid_3908NC_008536
29Cellvibrio japonicus Ueda1075758 CJA_2979CJA_2977NC_010995
30Cellvibrio japonicus Ueda1075764 CJA_3725CJA_3726NC_010995
31Cellvibrio japonicus Ueda1075751 CJA_1013CJA_1012NC_010995
32Chlorobium chlorochromatii CaD32139 Cag_0957Cag_0956NC_007514
33Chlorobium chlorochromatii CaD32155 Cag_1752Cag_1751NC_007514
34Chlorobium chlorochromatii CaD32137 Cag_0909Cag_0908NC_007514
35Chlorobium limicola DSM 2455604 Clim_0726Clim_0727NC_010803
36Chlorobium phaeobacteroides BS15676 Cphamn1_1668Cphamn1_1669NC_010831
37Chlorobium phaeobacteroides BS15657 Cphamn1_0570Cphamn1_0571NC_010831
38Chlorobium phaeobacteroides DSM 2663198 Cpha266_2186Cpha266_2187NC_008639
39Chloroherpeton thalassium ATCC 351105803 Ctha_0636Ctha_0637NC_011026
40Citrobacter koseri ATCC BAA-8954490 CKO_00282CKO_00281NC_009792
41Clostridium kluyveri DSM 5554365 CKL_2072CKL_2073NC_009706
42Coxiella burnetii RSA 3314817 COXBURSA331_A0757COXBURSA331_A0759NC_010117
43Coxiella burnetii RSA 493321 CBU_1992CBU_1991NC_002971
44Coxiella burnetii RSA 493317 CBU_0644CBU_0645NC_002971
45Cupriavidus taiwanensis LMG 194245300 pRALTA_0043pRALTA_0044NC_010529
46Cyanothece sp. ATCC 511425346 cce_4261cce_4262NC_010546
47Cyanothece sp. ATCC 511425340 cce_3133cce_3132NC_010546
48Cyanothece sp. ATCC 511425324 cce_2036cce_2037NC_010546
49Cyanothece sp. ATCC 511425312 cce_0050cce_0049NC_010546
50Cyanothece sp. ATCC 511425345 cce_4066cce_4067NC_010546
51Deinococcus geothermalis DSM 113004660 Dgeo_2905Dgeo_2906NC_009939
52Desulfococcus oleovorans Hxd34681 Dole_2607Dole_2606NC_009943
53Desulfococcus oleovorans Hxd34678 Dole_2119Dole_2120NC_009943
54Desulfotomaculum reducens MI-13655 Dred_2467Dred_2468NC_009253
55Enterobacter sp. 6383764 Ent638_4314Ent638_4315NC_009425
56Escherichia coli6132 D616_p107005D616_p107004NC_022992
57Escherichia coli6131 D616_p108005D616_p108004NC_022996
58Escherichia coli 5362805 ECP_2060ECP_2061NC_008253
59Escherichia coli APEC O13124 APECO1_1114APECO1_1115NC_008563
60Escherichia coli B1716151 pB171_043pB171_044NC_002142
61Escherichia coli CFT073674 c2544c2545NC_004431
62Escherichia coli HS4505 EcHS_A2155EcHS_A2156NC_009800
63Escherichia coli str. K-12 substr. DH10B5170 ECDH10B_2164ECDH10B_2165NC_010473
64Escherichia coli str. K-12 substr. MG16551043 experimental b4539b2017NC_000913
65Frankia alni ACN14a2851 FRAAL2443FRAAL2444NC_008278
66Frankia sp. CcI32387 Francci3_2556Francci3_2555NC_007777
67Frankia sp. CcI32379 Francci3_1442Francci3_1443NC_007777
68Frankia sp. CcI32389 Francci3_2679Francci3_2678NC_007777
69Geobacter bemidjiensis Bem5946 Gbem_1926Gbem_1927NC_011146
70Geobacter metallireducens GS-152160 Gmet_0221Gmet_0220NC_007517
71Geobacter metallireducens GS-152164 Gmet_0677Gmet_0678NC_007517
72Geobacter sulfurreducens PCA1535 GSU2439GSU2438NC_002939
73Geobacter sulfurreducens PCA1532 GSU1354GSU1353NC_002939
74Geobacter uraniireducens Rf43958 Gura_1444Gura_1443NC_009483
75Geobacter uraniireducens Rf43956 Gura_1424Gura_1423NC_009483
76Geobacter uraniireducens Rf43951 Gura_1318Gura_1319NC_009483
77Geobacter uraniireducens Rf43961 Gura_1487Gura_1488NC_009483
78Geobacter uraniireducens Rf43970 Gura_2099Gura_2098NC_009483
79Geobacter uraniireducens Rf43984 Gura_3267Gura_3268NC_009483
80Geobacter uraniireducens Rf43986 Gura_3420Gura_3421NC_009483
81Geobacter uraniireducens Rf43926 Gura_0312Gura_0311NC_009483
82Geobacter uraniireducens Rf43949 Gura_1263Gura_1262NC_009483
83Gloeobacter violaceus PCC 74211456 gsr3132glr3131NC_005125
84Haemophilus influenzae PittEE4192 CGSHiEE_07380CGSHiEE_07375NC_009566
85Haemophilus influenzae PittGG4198 CGSHiGG_03985CGSHiGG_03990NC_009567
86Haemophilus somnus 23365263 HSM_1143HSM_1142NC_010519
87Halorhodospira halophila SL13465 Hhal_0408Hhal_0407NC_008789
88Halorhodospira halophila SL13472 Hhal_0793Hhal_0794NC_008789
89Hydrogenobaculum sp. Y04AAS15908 HY04AAS1_1546HY04AAS1_1545NC_011126
90Idiomarina loihiensis L2TR1313 IL1161IL1162NC_006512
91Idiomarina loihiensis L2TR1309 IL0286IL0285NC_006512
92Kocuria rhizophila DC22015443 KRH_01380KRH_01370NC_010617
93Lactobacillus acidophilus NCFM1670 LBA1402LBA1403NC_006814
94Lactobacillus brevis ATCC 3673014 LVIS_B21LVIS_B20NC_008499
95Lactobacillus helveticus DPC 45714794 lhv_2502lhv_1127NC_010080
96Lactobacillus salivarius UCC1181853 LSL_1995LSL_1994NC_006530
97Legionella pneumophila str. Lens1506 lpl1588lpl1587NC_006369
98Legionella pneumophila str. Paris1839 plpp0089plpp0090NC_006365
99Leifsonia xyli subsp. xyli str. CTCB071346 Lxx22677Lxx22678NC_006087
100Leptothrix cholodnii SP-65279 Lcho_2963Lcho_2964NC_010524
101Maricaulis maris MCS102949 Mmar10_1753Mmar10_1752NC_008347
102Marinomonas sp. MWYL14258 Mmwyl1_1401Mmwyl1_1400NC_009654
103Marinomonas sp. MWYL14259 Mmwyl1_1748Mmwyl1_1747NC_009654
104Marinomonas sp. MWYL14260 Mmwyl1_1783Mmwyl1_1782NC_009654
105Marinomonas sp. MWYL14263 Mmwyl1_2695Mmwyl1_2696NC_009654
106Marinomonas sp. MWYL14265 Mmwyl1_3849Mmwyl1_3850NC_009654
107Methylobacterium sp. 4-465244 M446_4070M446_4071NC_010511
108Microcystis aeruginosa NIES-8434931 MAE_04180MAE_04170NC_010296
109Microcystis aeruginosa NIES-8434942 MAE_07940MAE_07930NC_010296
110Microcystis aeruginosa NIES-8435033 MAE_61710MAE_61720NC_010296
111Microcystis aeruginosa NIES-8434952 MAE_10540MAE_10530NC_010296
112Microcystis aeruginosa NIES-8434954 MAE_12280MAE_12290NC_010296
113Microcystis aeruginosa NIES-8434969 MAE_18960MAE_18970NC_010296
114Microcystis aeruginosa NIES-8435004 MAE_40090MAE_40100NC_010296
115Microcystis aeruginosa NIES-8434946 MAE_09090MAE_09100NC_010296
116Moorella thermoacetica ATCC 390732281 Moth_0655Moth_0654NC_007644
117Mycobacterium bovis AF2122/971174 Mb3393Mb3392NC_002945
118Mycobacterium bovis AF2122/971168 Mb2891Mb2890NC_002945
119Mycobacterium bovis AF2122/971140 Mb1278cMb1279cNC_002945
120Mycobacterium bovis BCG str. Pasteur 1173P23348 BCG_1306cBCG_1307cNC_008769
121Mycobacterium bovis BCG str. Pasteur 1173P23381 BCG_3430BCG_3429NC_008769
122Mycobacterium bovis BCG str. Pasteur 1173P23375 BCG_2888BCG_2887NC_008769
123Mycobacterium sp. KMS3261 Mkms_5886Mkms_5885NC_008704
124Mycobacterium sp. MCS2753 Mmcs_5486Mmcs_5485NC_008147
125Mycobacterium tuberculosis CDC1551289 MT3466MT3465NC_002755
126Mycobacterium tuberculosis F114183 TBFG_13394TBFG_13393NC_009565
127Mycobacterium tuberculosis F114156 TBFG_11272TBFG_11273NC_009565
128Mycobacterium tuberculosis F114178 TBFG_12882TBFG_12881NC_009565
129Mycobacterium tuberculosis H37Ra4135 MRA_3398MRA_3397NC_009525
130Mycobacterium tuberculosis H37Ra4129 MRA_2891MRA_2890NC_009525
131Mycobacterium tuberculosis H37Ra4100 MRA_1255MRA_1255ANC_009525
132Mycobacterium tuberculosis H37Rv93 experimental Rv1246cRv1247cNC_000962
133Mycobacterium tuberculosis H37Rv130 experimental Rv3358Rv3357NC_000962
134Mycobacterium tuberculosis H37Rv124 experimental Rv2866Rv2865NC_000962
135Nitratiruptor sp. SB155-24293 NIS_1330NIS_1331NC_009662
136Nitrosococcus oceani ATCC 197072043 Noc_1100Noc_1101NC_007484
137Nitrosococcus oceani ATCC 197072035 Noc_0433Noc_0434NC_007484
138Nitrosomonas europaea ATCC 19718900 NE0702NE0703NC_004757
139Nitrosomonas europaea ATCC 19718901 NE0713NE0712NC_004757
140Nitrosomonas europaea ATCC 19718916 NE1345NE1346NC_004757
141Nitrosomonas europaea ATCC 19718925 NE1563NE1562NC_004757
142Nitrosomonas europaea ATCC 19718926 NE1577NE1578NC_004757
143Nitrosomonas europaea ATCC 19718929 NE1584NE1583NC_004757
144Nitrosomonas europaea ATCC 19718933 NE1599NE1598NC_004757
145Nitrosomonas europaea ATCC 19718938 NE2114NE2115NC_004757
146Nitrosospira multiformis ATCC 251962217 Nmul_B2801Nmul_B2802NC_007615
147Nocardioides sp. JS6143240 Noca_2680Noca_2681NC_008699
148Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133)5458 Npun_R2912Npun_R2913NC_010628
149Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133)5453 Npun_R1755Npun_R1756NC_010628
150Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133)5451 Npun_R0938Npun_R0939NC_010628
151Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)452 asl0171all0172NC_003272
152Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)491 asr4471asr4470NC_003272
153Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)467 asl2100asl2101NC_003272
154Ochrobactrum anthropi ATCC 491884332 Oant_4546Oant_4547NC_009669
155Pectobacterium atrosepticum SCRI10431103 ECA0443ECA0444NC_004547
156Pectobacterium atrosepticum SCRI10431100 ECA0326ECA0325NC_004547
157Pectobacterium atrosepticum SCRI10431097 ECA0063ECA0064NC_004547
158Pectobacterium atrosepticum SCRI10431109 ECA2241ECA2242NC_004547
159Pelobacter carbinolicus DSM 23802078 Pcar_1790Pcar_1789NC_007498
160Pelodictyon phaeoclathratiforme BU-15854 Ppha_1443Ppha_1444NC_011060
161Pelodictyon phaeoclathratiforme BU-15839 Ppha_0681Ppha_0682NC_011060
162Pelodictyon phaeoclathratiforme BU-15837 Ppha_0279Ppha_0280NC_011060
163Pelodictyon phaeoclathratiforme BU-15888 Ppha_2586Ppha_2587NC_011060
164Pelodictyon phaeoclathratiforme BU-15879 Ppha_2193Ppha_2194NC_011060
165Pelodictyon phaeoclathratiforme BU-15845 Ppha_1043Ppha_1042NC_011060
166Photobacterium profundum SS91259 PBPRB1201PBPRB1200NC_006371
167Photobacterium profundum SS91258 PBPRB0956PBPRB0955NC_006371
168Photobacterium profundum SS91834 PBPRC0063PBPRC0062NC_005871
169Photorhabdus luminescens subsp. laumondii TTO11234 plu3316plu3315NC_005126
170Photorhabdus luminescens subsp. laumondii TTO11188 plu0251plu0252NC_005126
171Photorhabdus luminescens subsp. laumondii TTO11210 plu2105plu2104NC_005126
172Photorhabdus luminescens subsp. laumondii TTO11217 plu2264plu2265NC_005126
173Photorhabdus luminescens subsp. laumondii TTO11246 plu4594plu4593NC_005126
174Polaromonas naphthalenivorans CJ23402 Pnap_3904Pnap_3905NC_008781
175Proteus mirabilis HI43205367 PMI3358PMI3359NC_010554
176Proteus mirabilis HI43205368 PMIP32PMIP33NC_010555
177Pseudoalteromonas haloplanktis TAC1252025 PSHAa1041PSHAa1040NC_007481
178Pseudomonas fluorescens Pf0-12069 Pfl01_4635Pfl01_4634NC_007492
179Pseudomonas putida KT2440310 PP_2939PP_2940NC_002947
180Pseudomonas syringae pv. phaseolicola 1448A1938 PSPPH_A0095PSPPH_A0094NC_007274
181Pseudomonas syringae pv. phaseolicola 1448A1942 PSPPH_B0016PSPPH_B0015NC_007275
182Pseudomonas syringae pv. syringae B728a1874 Psyr_3833Psyr_3832NC_007005
183Pseudomonas syringae pv. syringae B728a1875 Psyr_4644Psyr_4645NC_007005
184Pseudomonas syringae pv. tomato str. DC30001052 PSPTO_0336PSPTO_0337NC_004578
185Pseudomonas syringae pv. tomato str. DC30001051 PSPTO_0241PSPTO_0240NC_004578
186Psychrobacter arcticus 273-46174 Psyc_1266Psyc_1265NC_007204
187Psychrobacter cryohalolentis K52645 Pcryo_1307Pcryo_1308NC_007969
188Ralstonia solanacearum GMI1000502 RSc0263RSc0264NC_003295
189Rhizobium etli CIAT 6525768 RHECIAT_PA0000048RHECIAT_PA0000047NC_010998
190Rhodopseudomonas palustris BisB182496 RPC_0027RPC_0028NC_007925
191Rickettsia akari str. Hartford4551 A1C_04425A1C_04420NC_009881
192Rickettsia akari str. Hartford4549 A1C_02885A1C_02880NC_009881
193Rickettsia bellii OSU 85-3894573 A1I_01325A1I_01320NC_009883
194Rickettsia bellii OSU 85-3894580 A1I_03005A1I_03010NC_009883
195Rickettsia bellii RML369-C2551 RBE_0524RBE_0525NC_007940
196Rickettsia bellii RML369-C2564 RBE_1191RBE_1192NC_007940
197Rickettsia conorii str. Malish 7351 RC0291RC0290NC_003103
198Rickettsia felis URRWXCal21909 RF_1368RF_1369NC_007109
199Rickettsia felis URRWXCal21899 RF_0787RF_0788NC_007109
200Rickettsia felis URRWXCal21895 RF_0602RF_0601NC_007109
201Rickettsia felis URRWXCal21894 RF_0490RF_0489NC_007109
202Rickettsia felis URRWXCal21901 RF_0911RF_0910NC_007109
203Rickettsia felis URRWXCal21885 RF_0016RF_0015NC_007109
204Rickettsia massiliae MTU54591 RMA_0128RMA_0129NC_009900
205Rickettsia massiliae MTU54593 RMA_0299RMA_0298NC_009900
206Rickettsia rickettsii str. Iowa4901 RrIowa_0352RrIowa_0351NC_010263
207Rickettsia rickettsii str. Sheila Smith4557 A1G_01665A1G_01660NC_009882
208Roseiflexus sp. RS-14061 RoseRS_2038RoseRS_2039NC_009523
209Saccharophagus degradans 2-402492 Sde_2750Sde_2751NC_007912
210Saccharophagus degradans 2-402490 Sde_1844Sde_1845NC_007912
211Salinispora arenicola CNS-2054713 Sare_3025Sare_3026NC_009953
212Salinispora tropica CNB-4403739 Strop_0988Strop_0989NC_009380
213Salmonella enterica arizonae serovar 62 z4 z23 RSK29804779 SARI_00373SARI_00372NC_010067
214Salmonella enterica subsp. enterica serovar Agona str. SL4835961 SeAg_B1619SeAg_B1618NC_011149
215Salmonella enterica subsp. enterica serovar Dublin str. CT 020218535975 SeD_B0115SeD_B0116NC_011204
216Salmonella enterica subsp. enterica serovar Enteritidis6155 pSE34_02pSE34_01NC_010860
217Salmonella enterica subsp. enterica serovar Schwarzengrund str.6176 SeSA_A1655SeSA_A1656NC_011094
218Salmonella enterica subsp. enterica serovar Typhimurium str. LT2436 STM1550STM1551NC_003197
219Serratia proteamaculans 5684528 Spro_2342Spro_2343NC_009832
220Shewanella baltica OS1553535 Sbal_4433Sbal_4434NC_009036
221Shewanella baltica OS1954750 Sbal195_4670Sbal195_4669NC_010000
222Shewanella frigidimarina NCIMB 4002905 Sfri_3471Sfri_3472NC_008345
223Shewanella oneidensis MR-11792 SO_A0088SO_A0087NC_004349
224Shewanella oneidensis MR-1662 SO_4641SO_4642NC_004347
225Shewanella putrefaciens CN-323808 Sputcn32_1990Sputcn32_1991NC_009438
226Shewanella putrefaciens CN-323806 Sputcn32_0428Sputcn32_0429NC_009438
227Shewanella putrefaciens CN-323803 Sputcn32_0176Sputcn32_0177NC_009438
228Shewanella putrefaciens CN-323805 Sputcn32_0191Sputcn32_0190NC_009438
229Shewanella sediminis HAW-EB34518 Ssed_3815Ssed_3814NC_009831
230Shewanella sp. MR-42876 Shewmr4_0332Shewmr4_0333NC_008321
231Shewanella sp. MR-72880 Shewmr7_3694Shewmr7_3693NC_008322
232Shewanella sp. W3-18-13296 Sputw3181_0282Sputw3181_0283NC_008750
233Shewanella sp. W3-18-13299 Sputw3181_2902Sputw3181_2903NC_008750
234Shigella boydii CDC 3083-945494 SbBS512_E1215SbBS512_E1214NC_010658
235Shigella sonnei Ss0461986 SSON_2087SSON_2088NC_007384
236Sorangium cellulosum So ce564834 sce0382sce0383NC_010162
237Sphingomonas wittichii RW14025 Swit_2739Swit_2740NC_009511
238Staphylococcus aureus RF1222227 SAB2287cSAB2288cNC_007622
239Staphylococcus aureus RF1222228 SAB2339cSAB2340cNC_007622
240Staphylococcus aureus subsp. aureus COL1278 SACOL2404SACOL2405NC_002951
241Staphylococcus aureus subsp. aureus COL1279 SACOL2464SACOL2465NC_002951
242Staphylococcus aureus subsp. aureus MRSA2521539 SAR2497SAR2498NC_002952
243Staphylococcus aureus subsp. aureus MSSA4761384 SAS2348SAS2349NC_002953
244Staphylococcus aureus subsp. aureus MSSA4761383 SAS2298SAS2299NC_002953
245Staphylococcus aureus subsp. aureus Mu34484 SAHV_2440SAHV_2441NC_009782
246Staphylococcus aureus subsp. aureus Mu34483 SAHV_2391SAHV_2392NC_009782
247Staphylococcus aureus subsp. aureus Mu50297 SAV2456SAV2457NC_002758
248Staphylococcus aureus subsp. aureus Mu50296 SAV2407SAV2408NC_002758
249Staphylococcus aureus subsp. aureus MW2613 MW2329MW2330NC_003923
250Staphylococcus aureus subsp. aureus MW2614 MW2380MW2381NC_003923
251Staphylococcus aureus subsp. aureus N3151074 experimental SA2195SA2196NC_002745
252Staphylococcus aureus subsp. aureus N3151075 experimental SA2245SA2246NC_002745
253Staphylococcus aureus subsp. aureus NCTC 83252427 SAOUHSC_02691SAOUHSC_02692NC_007795
254Staphylococcus aureus subsp. aureus NCTC 83252428 SAOUHSC_02756SAOUHSC_02757NC_007795
255Staphylococcus aureus subsp. aureus USA300 TCH15164791 USA300HOU_2387USA300HOU_2388NC_010079
256Staphylococcus aureus subsp. aureus USA300 TCH15164792 USA300HOU_2446USA300HOU_2447NC_010079
257Staphylococcus saprophyticus subsp. saprophyticus ATCC 153051975 SSPP129SSPP130NC_007351
258Streptococcus agalactiae 2603V/R636 SAG2008SAG2009NC_004116
259Streptococcus pneumoniae CGSP145417 SPCG_1714SPCG_1715NC_010582
260Streptococcus pneumoniae D393052 SPD_1550SPD_1551NC_008533
261Streptococcus pneumoniae Hungary19A-65098 SPH_1849SPH_1850NC_010380
262Streptococcus pneumoniae R6728 spr1585spr1586NC_003098
263Streptococcus pneumoniae TIGR4327 SP_1740SP_1741NC_003028
264Streptomyces avermitilis MA-4680 = NBRC 14893416 SAV_3205SAV_3206NC_003155
265Streptomyces coelicolor A3(2)6122 experimental SCO2236SCO2235NC_003888
266Sulfurovum sp. NBC37-14302 SUN_1017SUN_1018NC_009663
267Sulfurovum sp. NBC37-14303 SUN_1367SUN_1366NC_009663
268Synechococcus elongatus PCC 6301 (Synechococcus leopoliensis SAG)1628 syc0343_dsyc0342_dNC_006576
269Synechococcus elongatus PCC 79422194 Synpcc7942_1207Synpcc7942_1208NC_007604
270Synechococcus sp. WH 81021272 SYNW0575SYNW0576NC_005070
271Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112920 Swol_0577Swol_0576NC_008346
272Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112929 Swol_1411Swol_1410NC_008346
273Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112936 Swol_1971Swol_1972NC_008346
274Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112915 Swol_0432Swol_0433NC_008346
275Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112916 Swol_0496Swol_0495NC_008346
276Thermoanaerobacter pseudethanolicus ATCC 332235053 Teth39_1480Teth39_1481NC_010321
277Thermoanaerobacter pseudethanolicus ATCC 332235057 Teth39_1581Teth39_1582NC_010321
278Thermoanaerobacter sp. X5145047 Teth514_2262Teth514_2263NC_010320
279Thermoanaerobacter sp. X5145043 Teth514_2162Teth514_2163NC_010320
280Thermoanaerobacter tengcongensis MB4 (Caldanaerobacter subterraneus)765 TTE0859TTE0858NC_003869
281Thiobacillus denitrificans ATCC 252591996 Tbd_2277Tbd_2278NC_007404
282Vibrio campbellii ATCC BAA-11164468 VIBHAR_p08231VIBHAR_p08232NC_009777
283Vibrio campbellii ATCC BAA-11164469 VIBHAR_p08247VIBHAR_p08246NC_009777
284Vibrio campbellii ATCC BAA-11164485 VIBHAR_02594VIBHAR_02595NC_009783
285Vibrio campbellii ATCC BAA-11164486 VIBHAR_02600VIBHAR_02601NC_009783
286Vibrio cholerae O1 biovar El Tor str. N16961175 experimental VCA0478VCA0477NC_002506
287Vibrio cholerae O1 biovar El Tor str. N16961178 experimental VCA0489VCA0488NC_002506
288Vibrio cholerae O1 biovar El Tor str. N16961173 experimental VCA0444VCA0445NC_002506
289Vibrio cholerae O1 biovar El Tor str. N16961172 experimental VCA0423VCA0422NC_002506
290Vibrio cholerae O1 biovar El Tor str. N16961170 experimental VCA0385VCA0386NC_002506
291Vibrio cholerae O1 biovar El Tor str. N16961164 experimental VCA0311VCA0312NC_002506
292Vibrio cholerae O3953891 VC0395_0849VC0395_0850NC_009456
293Vibrio cholerae O3953892 VC0395_0861VC0395_0862NC_009456
294Vibrio cholerae O3953895 VC0395_0937VC0395_0936NC_009456
295Vibrio cholerae O3953890 VC0395_0823VC0395_0822NC_009456
296Vibrio cholerae O3953888 VC0395_0794VC0395_0795NC_009456
297Vibrio parahaemolyticus RIMD 2210633703 VP1820VP1821NC_004603
298Vibrio parahaemolyticus RIMD 2210633707 VP1885VP1886NC_004603
299Vibrio vulnificus CMCP6692 VV1_2547VV1_2546NC_004459
300Vibrio vulnificus CMCP6688 VV1_2410VV1_2409NC_004459
301Vibrio vulnificus CMCP6689 VV1_2433VV1_2432NC_004459
302Xanthomonas axonopodis pv. citri str. 306731 XAC0081XAC0080NC_003919
303Xanthomonas oryzae KACC103311620 XOO0163XOO0164NC_006834
304Xanthomonas oryzae pv. oryzae MAFF 3110182324 XOO_0142XOO_0143NC_007705
305Xanthomonas oryzae pv. oryzae PXO99A5520 PXO_03336PXO_03335NC_010717
306Yersinia enterocolitica subsp. enterocolitica 80813477 YE1160YE1159NC_008800
307Yersinia pestis Angola4832 YpAngola_0124YpAngola_0125NC_010158
308Yersinia pestis CO921761 YPMT1.69YPMT1.68ANC_003134
309Yersinia pestis KIM10+1801 Y1074Y1075NC_004838

experimental Data derived from experimental literature


Antitoxin domain: PHD. PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains. Several PHD fingers have been identified as binding modules of methylated histone H3.

Toxin domain: RelE. Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]


Structure
NMR Structure of Protein UPF0165 protein AF_2212 from Archaeoglobus Fulgidus; Northeast Structural Genomics Consortium Target GR83 [PDB ID: 2NWT]
(1) Zhang Y et al. (2009) The inhibitory mechanism of protein synthesis by YoeB, an Escherichia colitoxin. J Biol Chem 284(11):6627-38. [PudMed:19124462] experimental
(2) Norton JP; Mulvey MA (2012) Toxin-antitoxin systems are important for niche-specific colonization and stress resistance of uropathogenic Escherichia coli PLoS Pathog 8(10):e1002954. [PudMed:23055930] experimental
(3) Korch SB et al. (2009) Three Mycobacterium tuberculosis Rel toxin-antitoxin modules inhibitmycobacterial growth and are expressed in infected human macrophages. J Bacteriol 191(5):1618-30. [PudMed:19114484] experimental
(4) Yang M et al. (2010) Characterization of the interaction and cross-regulation of three Mycobacteriumtuberculosis RelBE modules. PLoS One 5(5):e10672. [PudMed:20498855] experimental
(5) Donegan NP et al. (2010) Proteolytic regulation of toxin-antitoxin systems by ClpPC in Staphylococcusaureus. J Bacteriol 192(5):1416-22. [PudMed:20038589] experimental
(6) Makarova KS et al. (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct 4:19. [PudMed:19493340] in_silico
(7) Sevillano L; Diaz M; Yamaguchi Y; Inouye M; Santamaria RI (2012) Identification of the first functional toxin-antitoxin system in Streptomyces PLoS One 7(3):e32977. [PudMed:22431991] experimental
(8) Iqbal et al. (2015) Comprehensive Functional Analysis of the 18 Vibrio cholerae N16961 Toxin-Antitoxin Systems Substantiates Their Role in Stabilizing the Superintegron Journal of bacteriology 13:2150-9. [PudMed:25897030] experimental