TADB
TA Pair: RHH-COG2929
#OrganismToxinAntitoxinLocus IDReplicon
1Acidithiobacillus ferrooxidans ATCC 539936008 Lferr_2283Lferr_2284NC_011206
2Acidithiobacillus ferrooxidans ATCC 539936007 Lferr_2045Lferr_2046NC_011206
3Acidithiobacillus ferrooxidans ATCC 539936002 Lferr_1315Lferr_1314NC_011206
4Acidithiobacillus ferrooxidans ATCC 539935991 Lferr_0132Lferr_0133NC_011206
5Acidovorax citrulli AAC00-13308 Aave_1720Aave_1719NC_008752
6Acidovorax sp. JS423417 Ajs_3339Ajs_3338NC_008782
7Acinetobacter baumannii AYE5116 p2ABAYE0006p2ABAYE0007NC_010402
8Actinobacillus pleuropneumoniae serovar 3 str. JL034913 APJL_0499APJL_0498NC_010278
9Actinobacillus pleuropneumoniae serovar 3 str. JL034915 APJL_0757APJL_0758NC_010278
10Actinobacillus pleuropneumoniae serovar 5b str. L203561 APL_0472APL_0471NC_009053
11Actinobacillus pleuropneumoniae serovar 7 str. AP765717 APP7_0549APP7_0548NC_010939
12Actinobacillus pleuropneumoniae serovar 7 str. AP765719 APP7_0799APP7_0800NC_010939
13Azorhizobium caulinodans ORS 5714652 AZC_3641AZC_3640NC_009937
14Azorhizobium caulinodans ORS 5714655 AZC_4142AZC_4143NC_009937
15Beijerinckia indica subsp. indica ATCC 90395411 Bind_3176Bind_3175NC_010581
16Bifidobacterium longum DJO10A5647 BLD_1132BLD_1133NC_010816
17Bordetella avium 197N5489 BAV1456BAV1455NC_010645
18Bordetella avium 197N5487 BAV0944BAV0943NC_010645
19Bordetella bronchiseptica RB501333 BB2141BB2140NC_002927
20Bordetella bronchiseptica RB501332 BB1689BB1688NC_002927
21Bordetella parapertussis 128221292 BPP1954BPP1953NC_002928
22Bordetella petrii DSM 128044868 Bpet4546Bpet4547NC_010170
23Brucella abortus bv. 1 str. 9-9411868 BruAb1_0981BruAb1_0980NC_006932
24Brucella canis ATCC 233654815 BCAN_A0992BCAN_A0991NC_010103
25Brucella melitensis biovar Abortus 23082224 experimental BAB1_0994BAB1_0993NC_007618
26Brucella melitensis biovar Abortus 23086121 experimental BAB1_0994BAB1_0993NC_007618
27Brucella suis 1330645 BR0975BR0974NC_004310
28Burkholderia cenocepacia MC0-35234 Bcenmc03_1152Bcenmc03_1151NC_010508
29Burkholderia pseudomallei K962431547 BPSS0395BPSS0394NC_006351
30Burkholderia thailandensis E2642308 BTH_II1354BTH_II1355NC_007650
31Burkholderia thailandensis E2642307 BTH_II1040BTH_II1041NC_007650
32Burkholderia vietnamiensis G43638 Bcep1808_7750Bcep1808_7751NC_009226
33Burkholderia xenovorans LB4002604 Bxe_A0188Bxe_A0189NC_007951
34Candidatus Desulforudis audaxviator MP104C5136 Daud_1518Daud_1517NC_010424
35Candidatus Solibacter usitatus Ellin60763092 Acid_6543Acid_6542NC_008536
36Candidatus Solibacter usitatus Ellin60763084 Acid_5482Acid_5481NC_008536
37Caulobacter crescentus CB15225 CC_0489CC_0488NC_002696
38Chlorobaculum parvum NCIB 83275813 Cpar_0863Cpar_0862NC_011027
39Chlorobium chlorochromatii CaD32149 Cag_1360Cag_1361NC_007514
40Chlorobium chlorochromatii CaD32141 Cag_1103Cag_1104NC_007514
41Chlorobium chlorochromatii CaD32127 Cag_0520Cag_0521NC_007514
42Chlorobium phaeobacteroides BS15668 Cphamn1_1052Cphamn1_1051NC_010831
43Chlorobium phaeobacteroides BS15673 Cphamn1_1262Cphamn1_1261NC_010831
44Chlorobium phaeobacteroides DSM 2663180 Cpha266_0286Cpha266_0287NC_008639
45Chlorobium phaeobacteroides DSM 2663181 Cpha266_0289Cpha266_0290NC_008639
46Chlorobium tepidum TLS300 CT0821CT0820NC_002932
47Chlorobium tepidum TLS299 CT0460CT0461NC_002932
48Corynebacterium efficiens YS-314669 CE1256CE1255NC_004369
49Coxiella burnetii RSA 3314823 COXBURSA331_A2200COXBURSA331_A2199NC_010117
50Coxiella burnetii RSA 3314822 COXBURSA331_A2195COXBURSA331_A2196NC_010117
51Coxiella burnetii RSA 493322 CBU_2084CBU_2085NC_002971
52Cupriavidus taiwanensis LMG 194245299 RALTA_A3068RALTA_A3067NC_010528
53Cyanothece sp. ATCC 511425344 cce_3912cce_3913NC_010546
54Cyanothece sp. ATCC 511425334 cce_2865cce_2864NC_010546
55Cyanothece sp. ATCC 511425338 cce_3108cce_3109NC_010546
56Cyanothece sp. ATCC 511425350 cce_4754cce_4753NC_010546
57Deinococcus geothermalis DSM 113002700 Dgeo_1357Dgeo_1356NC_008025
58Desulfococcus oleovorans Hxd34665 Dole_0658Dole_0659NC_009943
59Desulfococcus oleovorans Hxd34685 Dole_2753Dole_2752NC_009943
60Desulfococcus oleovorans Hxd34683 Dole_2639Dole_2640NC_009943
61Desulfovibrio vulgaris DP43303 Dvul_1490Dvul_1491NC_008751
62Desulfovibrio vulgaris DP43304 Dvul_1494Dvul_1495NC_008751
63Desulfovibrio vulgaris str. Hildenborough1666 DVU1735DVU1736NC_002937
64Francisella philomiragia subsp. philomiragia ATCC 250175075 Fphi_0831Fphi_1915NC_010336
65Geobacter lovleyi SZ5633 Glov_2221Glov_2220NC_010814
66Geobacter uraniireducens Rf43972 Gura_2272Gura_2273NC_009483
67Geobacter uraniireducens Rf43938 Gura_0788Gura_0787NC_009483
68Geobacter uraniireducens Rf43931 Gura_0562Gura_0563NC_009483
69Geobacter uraniireducens Rf43942 Gura_1009Gura_1008NC_009483
70Geobacter uraniireducens Rf43953 Gura_1396Gura_1395NC_009483
71Geobacter uraniireducens Rf43932 Gura_0581Gura_0580NC_009483
72Gloeobacter violaceus PCC 74211420 gll1112gsl1111NC_005125
73Leptospira biflexa serovar Patoc strain Patoc 1 (Paris)5435 LEPBI_I3058LEPBI_I3057NC_010602
74Leptospira borgpetersenii serovar Hardjo-bovis str. JB1973027 LBJ_2609LBJ_2610NC_008510
75Leptospira borgpetersenii serovar Hardjo-bovis str. L5503016 LBL_0503LBL_0502NC_008508
76Maricaulis maris MCS102942 Mmar10_0092Mmar10_0091NC_008347
77Methylobacterium extorquens PA14871 Mext_0338Mext_0337NC_010172
78Methylobacterium extorquens PA14876 Mext_1757Mext_1758NC_010172
79Methylobacterium populi BJ0015545 Mpop_0417Mpop_0416NC_010725
80Methylobacterium populi BJ0015556 Mpop_1537Mpop_1536NC_010725
81Methylobacterium populi BJ0015552 Mpop_1184Mpop_1185NC_010725
82Methylobacterium radiotolerans JCM 28315216 Mrad2831_1006Mrad2831_1007NC_010505
83Microcystis aeruginosa NIES-8434971 MAE_19500MAE_19510NC_010296
84Microcystis aeruginosa NIES-8434932 MAE_04190MAE_04200NC_010296
85Microcystis aeruginosa NIES-8434991 MAE_33320MAE_33310NC_010296
86Neisseria meningitidis 0534424826 NMCC_1037NMCC_1036NC_010120
87Neisseria meningitidis MC58404 NMB1118NMB1117NC_003112
88Nitrobacter winogradskyi Nb-2552004 Nwi_2483Nwi_2484NC_007406
89Nitrosococcus oceani ATCC 197072029 Noc_0085Noc_0086NC_007484
90Nitrosococcus oceani ATCC 197072028 Noc_0083Noc_0084NC_007484
91Nitrosococcus oceani ATCC 197072032 Noc_0410Noc_0411NC_007484
92Nitrosococcus oceani ATCC 197072042 Noc_1098Noc_1099NC_007484
93Nitrosomonas europaea ATCC 19718935 NE2104NE2103NC_004757
94Nitrosomonas eutropha C912904 Neut_1999Neut_2000NC_008344
95Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133)5452 Npun_F0976Npun_F0977NC_010628
96Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)488 asl4138asl4137NC_003272
97Ochrobactrum anthropi ATCC 491884329 Oant_1533Oant_1532NC_009667
98Ochrobactrum anthropi ATCC 491884325 Oant_0616Oant_0615NC_009667
99Pelodictyon phaeoclathratiforme BU-15843 Ppha_0914Ppha_0915NC_011060
100Pelodictyon phaeoclathratiforme BU-15887 Ppha_2521Ppha_2520NC_011060
101Pelodictyon phaeoclathratiforme BU-15885 Ppha_2409Ppha_2410NC_011060
102Pelodictyon phaeoclathratiforme BU-15884 Ppha_2272Ppha_2271NC_011060
103Pelodictyon phaeoclathratiforme BU-15872 Ppha_1926Ppha_1925NC_011060
104Pelodictyon phaeoclathratiforme BU-15862 Ppha_1715Ppha_1716NC_011060
105Polaromonas naphthalenivorans CJ23399 Pnap_3100Pnap_3099NC_008781
106Polaromonas sp. JS6662575 Bpro_0452Bpro_0451NC_007948
107Pseudomonas entomophila L482710 PSEEN3950PSEEN3949NC_008027
108Pseudomonas protegens Pf-51774 PFL_0169PFL_0170NC_004129
109Pseudomonas putida F14033 Pput_1380Pput_1381NC_009512
110Pseudomonas putida KT2440315 PP_4530PP_4529NC_002947
111Pseudomonas putida W6195211 PputW619_3823PputW619_3822NC_010501
112Psychrobacter cryohalolentis K52644 Pcryo_2490Pcryo_2489NC_007968
113Rhodopseudomonas palustris BisA532995 RPE_3359RPE_3360NC_008435
114Rhodopseudomonas palustris BisA532982 RPE_1776RPE_1775NC_008435
115Rhodopseudomonas palustris BisA532992 RPE_2599RPE_2598NC_008435
116Rhodopseudomonas palustris BisA532986 RPE_2043RPE_2042NC_008435
117Rhodopseudomonas palustris BisB182518 RPC_2263RPC_2262NC_007925
118Rhodopseudomonas palustris BisB182515 RPC_2135RPC_2134NC_007925
119Rhodopseudomonas palustris BisB182517 RPC_2249RPC_2250NC_007925
120Rhodopseudomonas palustris BisB52624 RPD_3974RPD_3975NC_007958
121Rhodopseudomonas palustris CGA0091485 RPA3108RPA3109NC_005296
122Rhodopseudomonas palustris HaA22410 RPB_2437RPB_2436NC_007778
123Rhodopseudomonas palustris HaA22415 RPB_3765RPB_3764NC_007778
124Rhodopseudomonas palustris HaA22412 RPB_3499RPB_3498NC_007778
125Rhodopseudomonas palustris TIE-15802 Rpal_4929Rpal_4930NC_011004
126Rhodopseudomonas palustris TIE-15791 Rpal_3226Rpal_3227NC_011004
127Rhodopseudomonas palustris TIE-15797 Rpal_4127Rpal_4128NC_011004
128Rickettsia bellii OSU 85-3894585 A1I_04160A1I_04155NC_009883
129Rickettsia bellii RML369-C2554 RBE_0668RBE_0669NC_007940
130Rickettsia conorii str. Malish 7357 RC0824RC0825NC_003103
131Rickettsia conorii str. Malish 7353 RC0476RC0477NC_003103
132Rickettsia felis URRWXCal21887 RF_0168RF_0169NC_007109
133Rickettsia felis URRWXCal21890 RF_0312RF_0311NC_007109
134Rickettsia massiliae MTU54596 RMA_0861RMA_0862NC_009900
135Rickettsia rickettsii str. Iowa4905 RrIowa_0976RrIowa_0977NC_010263
136Rickettsia rickettsii str. Sheila Smith4561 A1G_04635A1G_04640NC_009882
137Roseiflexus sp. RS-14048 RoseRS_0173RoseRS_0172NC_009523
138Salmonella enterica subsp. enterica serovar Dublin str. CT 020218535988 SeD_A4941SeD_A4942NC_011205
139Salmonella enterica subsp. enterica serovar Paratyphi A str.5959 SSPA4038SSPA4039NC_011147
140Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC1662 SPA4349SPA4350NC_006511
141Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB74812 SPAB_05698SPAB_05699NC_010102
142Salmonella enterica subsp. enterica serovar Typhimurium str. LT2450 STM4528STM4529NC_003197
143Salmonella enterica subsp. enterica serovar Typhimurium str. LT26086 STM4528STM4529NC_003197
144Salmonella enterica subsp. enterica serovar Typhi str. CT18834 STY4886STY4887NC_003198
145Salmonella enterica subsp. enterica serovar Typhi str. Ty2760 t4578t4579NC_004631
146Serratia proteamaculans 5684533 Spro_3908Spro_3907NC_009832
147Sinorhizobium meliloti 1021865 SMc04431SMc04432NC_003047
148Sphingomonas wittichii RW14017 Swit_1213Swit_1214NC_009511
149Sulfurimonas denitrificans DSM 12512179 Suden_1479Suden_1478NC_007575
150Sulfurimonas denitrificans DSM 12512180 Suden_1717Suden_1718NC_007575
151Sulfurovum sp. NBC37-14300 SUN_0723SUN_0724NC_009663
152Sulfurovum sp. NBC37-14304 SUN_1528SUN_1527NC_009663
153Synechococcus elongatus PCC 79422184 Synpcc7942_B2631Synpcc7942_B2652NC_007595
154Synechococcus elongatus PCC 79422185 Synpcc7942_B2638Synpcc7942_B2639NC_007595
155Synechococcus elongatus PCC 79422188 Synpcc7942_0410Synpcc7942_0409NC_007604
156Thermus thermophilus HB81843 TTHB007TTHB006NC_006462
157Treponema denticola ATCC 354051706 TDE1841TDE1840NC_002967
158Treponema denticola ATCC 354051709 TDE2106TDE2105NC_002967
159Treponema denticola ATCC 354051704 TDE1807TDE1806NC_002967
160Treponema denticola ATCC 354051703 TDE1801TDE1800NC_002967
161Treponema denticola ATCC 354051702 TDE1788TDE1787NC_002967
162Treponema denticola ATCC 354051700 TDE1635TDE1634NC_002967
163Verminephrobacter eiseniae EF01-23432 Veis_1887Veis_1886NC_008786
164Verminephrobacter eiseniae EF01-23440 Veis_2869Veis_2868NC_008786
165Verminephrobacter eiseniae EF01-23441 Veis_2884Veis_2885NC_008786
166Verminephrobacter eiseniae EF01-23387 Veis_5046Veis_5047NC_008771
167Verminephrobacter eiseniae EF01-23386 Veis_5033Veis_5032NC_008771
168Vibrio cholerae O1 biovar El Tor str. N16961167 experimental VCA0332VCA0333NC_002506
169Xylella fastidiosa 9a5c145 XF0533XF0532NC_002488
170Xylella fastidiosa 9a5c147 XF1562XF1563NC_002488
171Xylella fastidiosa M125250 Xfasm12_0665Xfasm12_0664NC_010513
172Xylella fastidiosa M125254 Xfasm12_1331Xfasm12_1330NC_010513
173Xylella fastidiosa M235391 XfasM23_1055XfasM23_1054NC_010577
174Xylella fastidiosa Temecula1781 PD0998PD0997NC_004556
175Yersinia pestis Antiqua2772 YPA_1257YPA_1258NC_008150
176Yersinia pestis biovar Microtus str. 910011399 YP_1510YP_1509NC_005810
177Yersinia pestis KIM10+629 y2428y2427NC_004088
178Yersinia pestis Nepal5162763 YPN_2244YPN_2243NC_008149
179Yersinia pseudotuberculosis IP 329531525 YPTB1901YPTB1902NC_006155
180Yersinia pseudotuberculosis PB1/+5479 YPTS_1947YPTS_1948NC_010634
181Yersinia pseudotuberculosis YPIII5149 YPK_2295YPK_2294NC_010465

experimental Data derived from experimental literature


Antitoxin domain: RHH. RHH_2: Uncharacterized protein family (UPF0156). This family of proteins are about 80 amino acids in length and their function is unknown. The proteins contain a conserved GRY motif. This family appears to be related to ribbon-helix-helix DNA-binding proteins

Toxin domain: COG2929. Uncharacterized protein conserved in bacteria [Function unknown]


Structure
N/A
(1) Heaton BE; Herrou J; Blackwell AE; Wysocki VH; Crosson S (2012) Molecular structure and function of the novel BrnT/BrnA toxin-antitoxin system of Brucella abortus J Biol Chem 287(15):12098-110. [PudMed:22334680] experimental
(2) Makarova KS et al. (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct 4:19. [PudMed:19493340] in_silico