TADB
TA Pair: RHH-GNAT
#OrganismToxinAntitoxinLocus IDReplicon
1Acaryochloris marina MBIC110174634 AM1_4739AM1_4738NC_009925
2Acidiphilium cryptum JF-53909 Acry_3270Acry_3271NC_009467
3Acidithiobacillus ferrooxidans ATCC 539936000 Lferr_1136Lferr_1137NC_011206
4Acidovorax citrulli AAC00-13310 Aave_2748Aave_2749NC_008752
5Acinetobacter baumannii ATCC 179783594 A1S_2119A1S_2118NC_009085
6Acinetobacter baumannii AYE5121 ABAYE1443ABAYE1444NC_010410
7Acinetobacter baumannii SDF5112 ABSDF1619ABSDF1620NC_010400
8Acinetobacter sp. ADP11356 ACIAD2379ACIAD2378NC_005966
9Actinobacillus pleuropneumoniae serovar 3 str. JL034920 APJL_1565APJL_1566NC_010278
10Actinobacillus pleuropneumoniae serovar 5b str. L203566 APL_1538APL_1539NC_009053
11Actinobacillus pleuropneumoniae serovar 7 str. AP765721 APP7_1599APP7_1600NC_010939
12Agrobacterium tumefaciens str. C58341 Atu1311Atu1312NC_003062
13Aromatoleum aromaticum EbN11860 p1B136p1B137NC_006823
14Azoarcus sp. BH723255 azo2025azo2026NC_008702
15Bordetella parapertussis 128221287 BPP0380BPP0379NC_002928
16Bordetella petrii DSM 128044860 Bpet1307Bpet1308NC_010170
17Burkholderia vietnamiensis G43668 Bcep1808_6119Bcep1808_6120NC_009254
18Burkholderia vietnamiensis G43665 Bcep1808_6038Bcep1808_6037NC_009254
19Candidatus Solibacter usitatus Ellin60763056 Acid_0832Acid_0833NC_008536
20Candidatus Solibacter usitatus Ellin60763060 Acid_1299Acid_1300NC_008536
21Chelativorans sp. BNC12797 Meso_4577Meso_4578NC_008244
22Chlorobium chlorochromatii CaD32144 Cag_1273Cag_1272NC_007514
23Chlorobium limicola DSM 2455617 Clim_2101Clim_2100NC_010803
24Chlorobium phaeobacteroides BS15691 Cphamn1_2320Cphamn1_2321NC_010831
25Chlorobium phaeobacteroides DSM 2663186 Cpha266_1212Cpha266_1211NC_008639
26Cupriavidus taiwanensis LMG 194245298 RALTA_A3039RALTA_A3040NC_010528
27Deinococcus geothermalis DSM 113004661 Dgeo_2940Dgeo_2941NC_009939
28Enterobacter sp. 6383762 Ent638_4242Ent638_4243NC_009425
29Escherichia coli HS4502 EcHS_A0501EcHS_A0502NC_009800
30Escherichia coli O157:H7 str. EDL933199 Z4777Z4776NC_002655
31Escherichia coli O157:H7 str. EDL933200 experimental Z4832Z4833NC_002655
32Escherichia coli O157:H7 str. Sakai1016 ECs4307ECs4308NC_002695
33Escherichia coli O157:H7 str. Sakai1015 ECs4262ECs4261NC_002695
34Escherichia coli SMS-3-55197 EcSMS35_0466EcSMS35_0467NC_010498
35Escherichia coli SMS-3-55202 EcSMS35_2044EcSMS35_2043NC_010498
36Frankia alni ACN14a2850 FRAAL1873FRAAL1874NC_008278
37Frankia sp. CcI32378 Francci3_1170Francci3_1171NC_007777
38Frankia sp. EAN1pec4609 Franean1_2170Franean1_2169NC_009921
39Gloeobacter violaceus PCC 74211423 gll1199gsl1200NC_005125
40Gloeobacter violaceus PCC 74211459 glr3475gsr3474NC_005125
41Haemophilus influenzae PittGG4199 CGSHiGG_05310CGSHiGG_05305NC_009567
42Haemophilus somnus 129PT2864 HS_1783HS_1784NC_008309
43Haemophilus somnus 129PT2865 HS_1785HS_1786NC_008309
44Haemophilus somnus 23365267 HSM_1450HSM_1449NC_010519
45Hahella chejuensis KCTC 23962301 HCH_05627HCH_05628NC_007645
46Lactobacillus casei BL235778 LCABL_14510LCABL_14520NC_010999
47Marinobacter aquaeolei VT83294 Maqu_4287Maqu_4288NC_008738
48Marinomonas sp. MWYL14262 Mmwyl1_2493Mmwyl1_2494NC_009654
49Methanosarcina acetivorans C2A816 MA2815MA2814NC_003552
50Methanosarcina barkeri str. Fusaro1979 Mbar_A2251Mbar_A2250NC_007355
51Methanosarcina mazei Go1602 MM_2658MM_2657NC_003901
52Methylobacterium populi BJ0015553 Mpop_1352Mpop_1351NC_010725
53Mycobacterium bovis AF2122/971136 Mb0943Mb0942NC_002945
54Mycobacterium bovis BCG str. Pasteur 1173P23345 BCG_0971BCG_0970NC_008769
55Mycobacterium gilvum PYR-GCK3683 Mflv_0787Mflv_0786NC_009338
56Mycobacterium tuberculosis CDC1551250 MT0945MT0944NC_002755
57Mycobacterium tuberculosis F114153 TBFG_10937TBFG_10936NC_009565
58Mycobacterium tuberculosis F114176 TBFG_12818TBFG_12817NC_009565
59Mycobacterium tuberculosis H37Ra4097 MRA_0927MRA_0926NC_009525
60Mycobacterium tuberculosis H37Rv89 Rv0919Rv0918NC_000962
61Neisseria gonorrhoeae NCCP119455817 NGK_1047NGK_1046NC_011035
62Nitrobacter hamburgensis X142634 Nham_4587Nham_4586NC_007961
63Nitrobacter winogradskyi Nb-2552005 Nwi_2856Nwi_2855NC_007406
64Nitrobacter winogradskyi Nb-2552000 Nwi_0836Nwi_0837NC_007406
65Nitrosomonas europaea ATCC 19718909 NE1103NE1104NC_004757
66Nocardioides sp. JS6143242 Noca_3662Noca_3661NC_008699
67Pectobacterium atrosepticum SCRI10431106 ECA0959ECA0958NC_004547
68Pelobacter propionicus DSM 23793172 Ppro_3838Ppro_3839NC_008608
69Pelodictyon phaeoclathratiforme BU-15868 Ppha_1842Ppha_1843NC_011060
70Photobacterium profundum SS91257 PBPRB0879PBPRB0880NC_006371
71Photorhabdus luminescens subsp. laumondii TTO11229 plu2650plu2651NC_005126
72Photorhabdus luminescens subsp. laumondii TTO11186 plu0179plu0180NC_005126
73Photorhabdus luminescens subsp. laumondii TTO11195 plu0862plu0861NC_005126
74Photorhabdus luminescens subsp. laumondii TTO11199 plu0958plu0959NC_005126
75Photorhabdus luminescens subsp. laumondii TTO11204 plu1618plu1617NC_005126
76Photorhabdus luminescens subsp. laumondii TTO11236 plu3890plu3889NC_005126
77Polaromonas naphthalenivorans CJ23394 Pnap_1571Pnap_1572NC_008781
78Prosthecochloris aestuarii DSM 2715824 Paes_1729Paes_1730NC_011059
79Rhizobium etli CIAT 6525770 RHECIAT_PA0000114RHECIAT_PA0000113NC_010998
80Rhodopseudomonas palustris BisA532980 RPE_1488RPE_1489NC_008435
81Rhodopseudomonas palustris BisA532978 RPE_1402RPE_1403NC_008435
82Rhodopseudomonas palustris BisA532976 RPE_1145RPE_1144NC_008435
83Rhodopseudomonas palustris BisA532981 RPE_1638RPE_1639NC_008435
84Rhodopseudomonas palustris BisB182511 RPC_1608RPC_1609NC_007925
85Rhodopseudomonas palustris BisB182528 RPC_3551RPC_3552NC_007925
86Rhodopseudomonas palustris CGA0091488 RPA3582RPA3583NC_005296
87Rhodopseudomonas palustris TIE-15796 Rpal_4101Rpal_4102NC_011004
88Rhodospirillum rubrum ATCC 111702250 Rru_A1649Rru_A1648NC_007643
89Salmonella enterica arizonae serovar 62 z4 z23 RSK29804784 SARI_03988SARI_03987NC_010067
90Salmonella enterica subsp. enterica serovar Agona str. SL4835962 SeAg_B3025SeAg_B3024NC_011149
91Salmonella enterica subsp. enterica serovar Dublin str. CT 020218535985 SeD_A4713SeD_A4712NC_011205
92Salmonella enterica subsp. enterica serovar Dublin str. CT 020218535976 SeD_A3212SeD_A3211NC_011205
93Salmonella enterica subsp. enterica serovar Paratyphi A str.5957 SSPA3840SSPA3839NC_011147
94Salmonella enterica subsp. enterica serovar Paratyphi A str.5953 SSPA3269SSPA3270NC_011147
95Salmonella enterica subsp. enterica serovar Paratyphi A str.5950 SSPA2575SSPA2574NC_011147
96Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC1656 SPA3503SPA3504NC_006511
97Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC1660 SPA4135SPA4134NC_006511
98Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC1653 SPA2761SPA2760NC_006511
99Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB74802 SPAB_03613SPAB_03612NC_010102
100Salmonella enterica subsp. enterica serovar Typhimurium str. LT2448 STM4318STM4317NC_003197
101Salmonella enterica subsp. enterica serovar Typhimurium str. LT2437 STM2905STM2904NC_003197
102Salmonella enterica subsp. enterica serovar Typhimurium str. LT2443 experimental STM3651STM3652NC_003197
103Salmonella enterica subsp. enterica serovar Typhi str. CT18824 STY3027STY3026NC_003198
104Salmonella enterica subsp. enterica serovar Typhi str. CT18829 STY4151STY4150NC_003198
105Salmonella enterica subsp. enterica serovar Typhi str. CT18831 STY4518STY4517NC_003198
106Salmonella enterica subsp. enterica serovar Typhi str. CT18832 STY4668STY4667NC_003198
107Salmonella enterica subsp. enterica serovar Typhi str. Ty2757 t4224t4223NC_004631
108Salmonella enterica subsp. enterica serovar Typhi str. Ty2750 t2805t2804NC_004631
109Salmonella enterica subsp. enterica serovar Typhi str. Ty2755 t3868t3867NC_004631
110Salmonella enterica subsp. enterica serovar Typhi str. Ty2758 t4359t4358NC_004631
111Shewanella baltica OS1854318 Shew185_0724Shew185_0723NC_009665
112Shewanella baltica OS1854286 Shew185_4424Shew185_4423NC_009661
113Shewanella baltica OS1954748 Sbal195_4607Sbal195_4606NC_009999
114Shewanella baltica OS1954743 Sbal195_0753Sbal195_0752NC_009997
115Shewanella frigidimarina NCIMB 4002906 Sfri_3959Sfri_3958NC_008345
116Shewanella oneidensis MR-1657 SO_0636SO_0637NC_004347
117Shewanella oneidensis MR-11788 SO_A0060SO_A0059NC_004349
118Shewanella putrefaciens CN-323807 Sputcn32_1986Sputcn32_1985NC_009438
119Shewanella sp. W3-18-13298 Sputw3181_2024Sputw3181_2025NC_008750
120Shewanella sp. W3-18-13301 Sputw3181_3932Sputw3181_3933NC_008750
121Shewanella woodyi ATCC 519085228 Swoo_4633Swoo_4632NC_010506
122Shigella boydii Sb2272206 SBO_P049SBO_P048NC_007608
123Shigella boydii Sb2272208 SBO_P141SBO_P140NC_007608
124Shigella dysenteriae Sd1972203 SDY_3656SDY_3657NC_007606
125Shigella flexneri 2a str. 2457T722 S4812S0373NC_004741
126Shigella flexneri 2a str. 301646 SF0367SF0368NC_004337
127Shigella flexneri 5 str. 84012821 SFV_0397SFV_0398NC_008258
128Shigella sonnei Ss0461985 SSON_0409SSON_0410NC_007384
129Sinorhizobium meliloti 1021872 SMc04221SMc04222NC_003047
130Sinorhizobium meliloti 1021879 SMc00739SMc00740NC_003047
131Synechocystis sp. PCC 6803 (Synechocystis PCC6803)1812 sll7030sll7031NC_005230
132Syntrophus aciditrophicus SB2344 SYN_02693SYN_02692NC_007759
133Vibrio cholerae O1 biovar El Tor str. N16961177 experimental VCA0487VCA0486NC_002506
134Vibrio cholerae O1 biovar El Tor str. N16961176 experimental VCA0481VCA0482NC_002506
135Vibrio cholerae O1 biovar El Tor str. N16961165 experimental VCA0318VCA0319NC_002506
136Vibrio cholerae O3953893 VC0395_0916VC0395_0915NC_009456
137Vibrio cholerae O3953887 VC0395_0765VC0395_0764NC_009456
138Vibrio cholerae O3953886 VC0395_0759VC0395_0760NC_009456
139Vibrio vulnificus CMCP6691 VV1_2537VV1_2538NC_004459
140Xanthobacter autotrophicus Py24424 Xaut_0818Xaut_0819NC_009720
141Xanthobacter autotrophicus Py24429 Xaut_2852Xaut_2853NC_009720
142Xanthomonas campestris pv. campestris str. 80041877 XC_1051XC_1052NC_007086
143Xanthomonas campestris pv. campestris str. ATCC 33913610 XCC3105XCC3104NC_003902
144Xanthomonas campestris pv. campestris str. B1005514 xccb100_1083xccb100_1084NC_010688
145Xylella fastidiosa 9a5c1734 XFa0025XFa0024NC_002490
146Xylella fastidiosa M125251 Xfasm12_0945Xfasm12_0946NC_010513

experimental Data derived from experimental literature
T : is GNAT family acetyltrasferase

Antitoxin domain: RHH. RHH_2: Uncharacterized protein family (UPF0156). This family of proteins are about 80 amino acids in length and their function is unknown. The proteins contain a conserved GRY motif. This family appears to be related to ribbon-helix-helix DNA-binding proteins

Toxin domain: GNAT. Acetyltransferase (GNAT) family. S. enterica GNAT toxin protein TacT was reported to block the primary amine group of amino acids on charged tRNA molecules, and then inhibit translation.


Structure
Crystal structure of TacT (tRNA acetylating toxin) from Salmonella [PDB ID: 5FVJ] [PudMed:27264868]
Crystal structure of PH1933 from Pyrococcus horikoshii OT3 [PDB ID: 1WWZ]
(1) Jurenas et al. (2017) AtaT blocks translation initiation by N-acetylation of the initiator tRNAfMet Nat Chem Biol 13(6):640-646. [PudMed:28369041] experimental
(2) Cheverton et al. (2016) A Salmonella Toxin Promotes Persister Formation through Acetylation of tRNA Mol Cell 63(1):86-96. [PudMed:27264868] experimental
(3) Iqbal et al. (2015) Comprehensive Functional Analysis of the 18 Vibrio cholerae N16961 Toxin-Antitoxin Systems Substantiates Their Role in Stabilizing the Superintegron Journal of bacteriology 13:2150-9. [PudMed:25897030] experimental
(4) Makarova KS et al. (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct 4:19. [PudMed:19493340] in_silico