TADB
TA Pair: RHH-MazF
#OrganismToxinAntitoxinLocus IDReplicon
1Albidiferax ferrireducens T118 (Rhodoferax ferrireducens T118)2486 Rfer_2987Rfer_2988NC_007908
2Alkaliphilus metalliredigens QYMF4238 Amet_4143Amet_4144NC_009633
3Alkaliphilus oremlandii OhILAs4620 Clos_2273Clos_2274NC_009922
4Bacillus anthracis str. Ames615 BA_0254BA_0253NC_003997
5Bacillus anthracis str. Sterne1499 BAS0240BAS0239NC_005945
6Bacillus cereus ATCC 109871348 BCE_0274BCE_0273NC_003909
7Bacillus cereus ATCC 14579719 BC0266BC0265NC_004722
8Bacillus cereus E33L1357 BCZK0228BCZK0227NC_006274
9Bacillus clausii KSM-K161116 ABC0809ABC0808NC_006582
10Bacillus cytotoxicus NVH 391-984338 Bcer98_0240Bcer98_0239NC_009674
11Bacillus halodurans C-125184 BH0522BH0521NC_002570
12Bacillus licheniformis DSM 13 = ATCC 145801284 BL05041BL02805NC_006270
13Bacillus pumilus SAFR-0324540 BPUM_0439BPUM_0438NC_009848
14Bacillus subtilis subsp. subtilis str. 168134 BSU04660BSU04650NC_000964
15Bacillus thuringiensis serovar konkukian str. 97-271603 BT9727_0226BT9727_0225NC_005957
16Bacillus weihenstephanensis KBAB44896 BcerKBAB4_0232BcerKBAB4_0231NC_010184
17Caldicellulosiruptor saccharolyticus DSM 89033799 Csac_2617Csac_2618NC_009437
18Candidatus Desulforudis audaxviator MP104C5140 Daud_1831Daud_1832NC_010424
19Carboxydothermus hydrogenoformans Z-29012081 CHY_0716CHY_0715NC_007503
20Chelativorans sp. BNC12791 Meso_4226Meso_4227NC_008242
21Chlorobium limicola DSM 2455607 Clim_1327Clim_1326NC_010803
22Chlorobium limicola DSM 2455612 Clim_1348Clim_1347NC_010803
23Chlorobium phaeobacteroides DSM 2663190 Cpha266_1380Cpha266_1379NC_008639
24Clostridium acetobutylicum ATCC 824330 CA_C0494CA_C0493NC_003030
25Clostridium beijerinckii NCIMB 80524219 Cbei_4872Cbei_4873NC_009617
26Clostridium botulinum A str. ATCC 193974352 CLB_3452CLB_3453NC_009697
27Clostridium botulinum A str. ATCC 35024006 CBO3395ACBO3396NC_009495
28Clostridium botulinum A str. Hall4354 CLC_3339CLC_3340NC_009698
29Clostridium botulinum B str. Eklund 17B5501 CLL_A3362CLL_A3363NC_010674
30Clostridium botulinum E3 str. Alaska E435543 CLH_3108CLH_3109NC_010723
31Clostridium botulinum F str. Langeland4357 CLI_3580CLI_3581NC_009699
32Clostridium difficile 6303598 CD630_34610CD630_34620NC_009089
33Clostridium kluyveri DSM 5554370 CKL_3579CKL_3580NC_009706
34Clostridium novyi NT3160 NT01CX_1266NT01CX_1265NC_008593
35Clostridium thermocellum ATCC 274053524 Cthe_2699Cthe_2698NC_009012
36Cyanothece sp. ATCC 511425333 cce_2860cce_2859NC_010546
37Cytophaga hutchinsonii ATCC 334062814 CHU_0745CHU_0746NC_008255
38Desulfitobacterium hafniense Y512480 DSY4016DSY4017NC_007907
39Desulfotomaculum reducens MI-13657 Dred_2894Dred_2895NC_009253
40Escherichia coli 5362800 ECP_0050ECP_0049NC_008253
41Escherichia coli CFT073671 c0060c0059NC_004431
42Escherichia coli E24377A4489 EcE24377A_F0050EcE24377A_F0049NC_009786
43Escherichia coli K-126145 experimental D616_p97105D616_p97106NC_002483
44Escherichia coli O157:H7 str. EDL933190 Z0057Z0056NC_002655
45Escherichia coli O157:H7 str. Sakai1002 ECs0053ECs0052NC_002695
46Escherichia coli O157:H7 str. Sakai1732 pO157p29pO157p28NC_002128
47Escherichia coli UTI892570 UTI89_P057UTI89_P056NC_007941
48Exiguobacterium sibiricum 255-155370 Exig_2807Exig_2808NC_010556
49Frankia alni ACN14a2844 FRAAL0159FRAAL0160NC_008278
50Frankia alni ACN14a2856 FRAAL5929FRAAL5928NC_008278
51Frankia sp. CcI32394 Francci3_2958Francci3_2959NC_007777
52Frankia sp. EAN1pec4608 Franean1_1539Franean1_1538NC_009921
53Geobacillus kaustophilus HTA4261180 GK0233GK0232NC_006510
54Geobacillus thermodenitrificans NG80-23670 GTNG_0207GTNG_0206NC_009328
55Geobacter bemidjiensis Bem5947 Gbem_2488Gbem_2487NC_011146
56Geobacter uraniireducens Rf43967 Gura_2003Gura_2002NC_009483
57Geobacter uraniireducens Rf43939 Gura_0832Gura_0833NC_009483
58Geobacter uraniireducens Rf43948 Gura_1251Gura_1252NC_009483
59Geobacter uraniireducens Rf43966 Gura_1971Gura_1970NC_009483
60Geobacter uraniireducens Rf43977 Gura_2716Gura_2715NC_009483
61Gloeobacter violaceus PCC 74211415 glr0631gsr0630NC_005125
62Gramella forsetii KT08033136 GFO_2564GFO_2563NC_008571
63Heliobacterium modesticaldum Ice15078 HM1_1709HM1_1708NC_010337
64Lactobacillus casei ATCC 334 (Lactobacillus paracasei ATCC 334)3033 LSEI_2558LSEI_2559NC_008526
65Lactobacillus casei BL235779 LCABL_27260LCABL_27270NC_010999
66Lactobacillus rhamnosus ATCC 85306141 LRHK_2558LRHK_2559NC_017491
67Lactobacillus rhamnosus GG6135 LGG_02534LGG_02535NC_013198
68Lactobacillus rhamnosus GG6140 LRHM_2431LRHM_2432NC_017482
69Lactobacillus rhamnosus Lc 7056136 LC705_02539LC705_02540NC_013199
70Lactobacillus sakei subsp. sakei 23K2183 LSA1611LSA1612NC_007576
71Lactobacillus salivarius UCC1182545 LSL_0360LSL_0359NC_007929
72Leptospira biflexa serovar Patoc strain Patoc 1 (Ames)5712 LBF_2958LBF_2959NC_010842
73Leptospira biflexa serovar Patoc strain Patoc 1 (Paris)5436 LEPBI_I3066LEPBI_I3067NC_010602
74Leptospira interrogans serovar Copenhageni str. Fiocruz L1-1301516 LIC11193LIC11192NC_005823
75Leptospira interrogans serovar Lai str. 56601655 LA_2843LA_2844NC_004342
76Listeria innocua Clip11262789 lin0887lin0886NC_003212
77Listeria monocytogenes EGD-e744 lmo0888lmo0887NC_003210
78Listeria welshimeri serovar 6b str. SLCC53343120 lwe0870lwe0869NC_008555
79Magnetococcus marinus MC-13144 Mmc1_1255Mmc1_1256NC_008576
80Maricaulis maris MCS102952 Mmar10_2583Mmar10_2582NC_008347
81Microcystis aeruginosa NIES-8435034 MAE_62380MAE_62390NC_010296
82Moorella thermoacetica ATCC 390732294 Moth_2165Moth_2166NC_007644
83Mycobacterium bovis AF2122/971132 Mb0678cMb0679cNC_002945
84Mycobacterium bovis AF2122/971122 Mb0307Mb0306NC_002945
85Mycobacterium bovis BCG str. Pasteur 1173P23331 BCG_0339BCG_0338NC_008769
86Mycobacterium bovis BCG str. Pasteur 1173P23342 BCG_0708cBCG_0709cNC_008769
87Mycobacterium sp. KMS3263 Mkms_5927Mkms_5926NC_008704
88Mycobacterium sp. MCS2755 Mmcs_5525Mmcs_5524NC_008147
89Mycobacterium tuberculosis CDC1551246 MT0688MT0689NC_002755
90Mycobacterium tuberculosis CDC1551272 MT2123MT2122NC_002755
91Mycobacterium tuberculosis CDC1551267 MT2046MT2047NC_002755
92Mycobacterium tuberculosis F114175 TBFG_12814TBFG_12815NC_009565
93Mycobacterium tuberculosis F114142 TBFG_10306TBFG_10305NC_009565
94Mycobacterium tuberculosis F114150 TBFG_10672TBFG_10673NC_009565
95Mycobacterium tuberculosis H37Ra4094 MRA_0669MRA_0670NC_009525
96Mycobacterium tuberculosis H37Ra4085 MRA_0308MRA_0307NC_009525
97Mycobacterium tuberculosis H37Ra4117 MRA_2077MRA_2076NC_009525
98Mycobacterium tuberculosis H37Ra4112 MRA_2006MRA_2007NC_009525
99Mycobacterium tuberculosis H37Rv6248 Rv2063ARv2063NC_000962
100Mycobacterium tuberculosis H37Rv6252 experimental Rv2801cRv2801ANC_000962
101Mycobacterium tuberculosis H37Rv73 experimental Rv0299Rv0298NC_000962
102Mycobacterium tuberculosis H37Rv84 experimental Rv0659cRv0660cNC_000962
103Mycobacterium tuberculosis H37Rv6247 experimental Rv1991cRv1991aNC_000962
104Mycobacterium vanbaalenii PYR-13281 Mvan_1144Mvan_1145NC_008726
105Natranaerobius thermophilus JW/NM-WN-LF5527 Nther_0309Nther_0308NC_010718
106Nitratiruptor sp. SB155-24297 NIS_1763NIS_1762NC_009662
107Nitrosococcus oceani ATCC 197072048 Noc_1568Noc_1567NC_007484
108Nitrosomonas europaea ATCC 19718907 NE1076NE1077NC_004757
109Nitrosomonas europaea ATCC 19718927 NE1579NE1580NC_004757
110Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133)5454 Npun_R2292Npun_R2293NC_010628
111Oceanobacillus iheyensis HTE831640 OB0623OB0622NC_004193
112Parvibaculum lavamentivorans DS-14398 Plav_0216Plav_0217NC_009719
113Pediococcus pentosaceus ATCC 257453031 PEPE_1557PEPE_1558NC_008525
114Pelobacter carbinolicus DSM 23802074 Pcar_0962Pcar_0963NC_007498
115Pelotomaculum thermopropionicum SI3870 PTH_0738PTH_0737NC_009454
116Photorhabdus luminescens subsp. laumondii TTO11242 plu4296plu4295NC_005126
117Photorhabdus luminescens subsp. laumondii TTO11219 plu2279plu2278NC_005126
118Photorhabdus luminescens subsp. laumondii TTO11213 plu2155plu2154NC_005126
119Rhizobium etli CIAT 6525734 RHECIAT_CH0000281RHECIAT_CH0000282NC_010994
120Rhodospirillum rubrum ATCC 111702244 Rru_A0976Rru_A0977NC_007643
121Rhodospirillum rubrum ATCC 111702268 Rru_A3552Rru_A3553NC_007643
122Rickettsia akari str. Hartford4556 A1C_06565A1C_06560NC_009881
123Rickettsia bellii OSU 85-3894588 A1I_04895A1I_04900NC_009883
124Rickettsia bellii OSU 85-3894576 A1I_01920A1I_01925NC_009883
125Rickettsia bellii RML369-C2561 RBE_1083RBE_1082NC_007940
126Rickettsia bellii RML369-C2556 RBE_0757RBE_0758NC_007940
127Rickettsia conorii str. Malish 7350 RC0006RC0007NC_003103
128Rickettsia felis URRWXCal21908 RF_1343RF_1342NC_007109
129Saccharophagus degradans 2-402495 Sde_3989Sde_3990NC_007912
130Saccharopolyspora erythraea NRRL 23383612 SACE_1313SACE_1314NC_009142
131Salinispora arenicola CNS-2054716 Sare_4256Sare_4257NC_009953
132Salmonella enterica arizonae serovar 62 z4 z23 RSK29804780 SARI_00709SARI_00708NC_010067
133Salmonella enterica subsp. enterica serovar Agona str. SL4835969 SeAg_B4794SeAg_B4793NC_011149
134Salmonella enterica subsp. enterica serovar Choleraesuis str.1863 SCV17SCV18NC_006855
135Salmonella enterica subsp. enterica serovar Dublin str. CT 020218535974 SeD_B0036SeD_B0037NC_011204
136Salmonella enterica subsp. enterica serovar Dublin str. CT 020218535987 SeD_A4876SeD_A4875NC_011205
137Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB74811 SPAB_05650SPAB_05649NC_010102
138Serratia proteamaculans 5684525 Spro_1555Spro_1554NC_009832
139Shigella dysenteriae Sd1972197 SDY_0073SDY_0072NC_007606
140Sphingopyxis alaskensis RB22562727 Sala_3183Sala_3184NC_008048
141Staphylococcus aureus RF1222226 SAB1953cSAB1954cNC_007622
142Staphylococcus aureus subsp. aureus COL1277 SACOL2058SACOL2059NC_002951
143Staphylococcus aureus subsp. aureus MRSA2521538 SAR2156SAR2157NC_002952
144Staphylococcus aureus subsp. aureus MSSA4761382 SAS1973SAS1974NC_002953
145Staphylococcus aureus subsp. aureus Mu34482 SAHV_2053SAHV_2054NC_009782
146Staphylococcus aureus subsp. aureus Mu50295 SAV2068SAV2069NC_002758
147Staphylococcus aureus subsp. aureus MW2612 MW1992MW1993NC_003923
148Staphylococcus aureus subsp. aureus N3151073 experimental SA1873SAS067NC_002745
149Staphylococcus aureus subsp. aureus NCTC 83252426 SAOUHSC_02303SAOUHSC_02304NC_007795
150Staphylococcus aureus subsp. aureus USA300 TCH15164790 USA300HOU_2063USA300HOU_2064NC_010079
151Staphylococcus epidermidis ATCC 12228993 SE1672SE1673NC_004461
152Staphylococcus epidermidis RP62A1342 SERP1681SERP1682NC_002976
153Staphylococcus haemolyticus JCSC14351918 SH0963SH0962NC_007168
154Streptococcus agalactiae 2603V/R632 SAG0436SAG0435NC_004116
155Streptococcus agalactiae NEM316888 gbs0472gbs0471NC_004368
156Streptococcus pyogenes MGAS102702688 MGAS10270_Spy1407MGAS10270_Spy1408NC_008022
157Streptococcus pyogenes MGAS61801948 M28_Spy1333M28_Spy1334NC_007296
158Symbiobacterium thermophilum IAM 148631344 STH2934STH2935NC_006177
159Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112935 Swol_1879Swol_1880NC_008346
160Thermoanaerobacter pseudethanolicus ATCC 332235050 Teth39_0489Teth39_0488NC_010321
161Thermoanaerobacter sp. X5145040 Teth514_0966Teth514_0965NC_010320
162Thermoanaerobacter tengcongensis MB4 (Caldanaerobacter subterraneus)772 TTE2166TTE2167NC_003869
163Thermococcus kodakarensis KOD11596 TK1816TK1815NC_006624
164Trichodesmium erythraeum IMS1012866 Tery_0630Tery_0629NC_008312
165Xanthomonas axonopodis pv. citri str. 306734 XAC0768XAC0769NC_003919
166Xanthomonas campestris pv. campestris str. 80041883 XC_3521XC_3520NC_007086
167Xanthomonas campestris pv. campestris str. ATCC 33913605 XCC0714XCC0715NC_003902
168Xanthomonas campestris pv. campestris str. B1005519 xccb100_3642xccb100_3641NC_010688
169Yersinia enterocolitica subsp. enterocolitica 80813485 YE3480YE3481NC_008800

experimental Data derived from experimental literature


Antitoxin domain: RHH. RHH_2: Uncharacterized protein family (UPF0156). This family of proteins are about 80 amino acids in length and their function is unknown. The proteins contain a conserved GRY motif. This family appears to be related to ribbon-helix-helix DNA-binding proteins

Toxin domain: MazF. Growth inhibitor [Signal transduction mechanisms]


Structure
A Conserved Mode Of Protein Recognition And Binding In A ParD-ParE Toxin-Antitoxin Complex. [PDB ID: 3KXE] [PudMed:20143871]
(1) Kamada K et al. (2003) Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxinrecognition. Mol Cell 11(4):875-84. [PudMed:12718874] 3D_structure
(2) Ramage HR et al. (2009) Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxinsystems: implications for pathogenesis, stress responses, and evolution. PLoS Genet 5(12):e1000767. [PudMed:20011113] experimental
(3) Gupta A. (2009) Killing activity and rescue function of genome-wide toxin-antitoxin loci of Mycobacterium tuberculosis. FEMS Microbiol Lett. 290(1):45-53.. [PudMed:19016878] experimental
(4) Ramirez MV; Dawson CC; Crew R; England K; Slayden RA (2013) MazF6 toxin of Mycobacterium tuberculosis demonstrates antitoxin specificity and is coupled to regulation of cell growth by a Soj-like protein BMC Microbiol 13:240. [PudMed:24172039] experimental
(5) Makarova KS et al. (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct 4:19. [PudMed:19493340] in_silico
(6) Zhu L et al. (2009) Staphylococcus aureus MazF specifically cleaves a pentad sequence, UACAU, whichis unusually abundant in the mRNA for pathogenic adhesive factor SraP. J Bacteriol 191(10):3248-55. [PudMed:19251861] experimental
(7) Donegan NP et al. (2010) Proteolytic regulation of toxin-antitoxin systems by ClpPC in Staphylococcusaureus. J Bacteriol 192(5):1416-22. [PudMed:20038589] experimental