TADB
TA Pair: AbrB-MazF
#OrganismToxinAntitoxinLocus IDReplicon
1Acidiphilium cryptum JF-53915 Acry_3598Acry_3599NC_009471
2Acidithiobacillus ferrooxidans ATCC 539936010 Lferr_2505Lferr_2506NC_011206
3Agrobacterium tumefaciens str. C58338 Atu0940Atu0939NC_003062
4Bacillus halodurans C-125189 BH3721BH3720NC_002570
5Bartonella henselae str. Houston-11650 BH07060BH07050NC_005956
6Burkholderia ambifaria MC40-65355 BamMC406_6740BamMC406_6741NC_010553
7Burkholderia vietnamiensis G43643 Bcep1808_7444Bcep1808_7445NC_009229
8Burkholderia vietnamiensis G43669 Bcep1808_6217Bcep1808_6216NC_009254
9Burkholderia vietnamiensis G43639 Bcep1808_7150Bcep1808_7151NC_009227
10Burkholderia vietnamiensis G43662 Bcep1808_5564Bcep1808_5563NC_009254
11Candidatus Koribacter versatilis Ellin3452674 Acid345_4624Acid345_4623NC_008009
12Candidatus Solibacter usitatus Ellin60763072 Acid_2532Acid_2533NC_008536
13Chlorobium chlorochromatii CaD32126 Cag_0429Cag_0428NC_007514
14Chlorobium phaeobacteroides DSM 2663195 Cpha266_1647Cpha266_1648NC_008639
15Cupriavidus taiwanensis LMG 194245295 RALTA_A1745RALTA_A1744NC_010528
16Deinococcus geothermalis DSM 113002701 Dgeo_1937Dgeo_1936NC_008025
17Deinococcus radiodurans R1137 experimental DR_0417DR_0416NC_001263
18Enterobacter sp. 6383780 Ent638_2067Ent638_2066NC_009436
19Enterococcus faecalis V5831032 EF3262EF3261NC_004668
20Enterococcus faecalis V5831799 EFA0071EFA0072NC_004669
21Escherichia coli 5362806 ECP_2763ECP_2764NC_008253
22Escherichia coli ATCC 87395157 EcolC_0930EcolC_0929NC_010468
23Escherichia coli HS4510 EcHS_A4478EcHS_A4477NC_009800
24Escherichia coli HS4506 EcHS_A2926EcHS_A2927NC_009800
25Escherichia coli O157:H7 str. EDL933195 Z4097Z4098NC_002655
26Escherichia coli O157:H7 str. EDL933203 Z5836Z5835NC_002655
27Escherichia coli O157:H7 str. Sakai1019 ECs5203ECs5202NC_002695
28Escherichia coli O157:H7 str. Sakai1011 ECs3642ECs3643NC_002695
29Escherichia coli SMS-3-55207 EcSMS35_4703EcSMS35_4702NC_010498
30Escherichia coli SMS-3-55195 EcSMS35_A0164EcSMS35_A0165NC_010488
31Escherichia coli SMS-3-55203 EcSMS35_2920EcSMS35_2921NC_010498
32Escherichia coli str. K-12 substr. DH10B5176 ECDH10B_4420ECDH10B_4419NC_010473
33Escherichia coli str. K-12 substr. DH10B5171 ECDH10B_2949ECDH10B_2950NC_010473
34Escherichia coli str. K-12 substr. MG16551049 b4225b4224NC_000913
35Escherichia coli str. K-12 substr. MG16551044 experimental b2782b2783NC_000913
36Geobacillus kaustophilus HTA4261181 GK1648GK1647NC_006510
37Geobacter bemidjiensis Bem5939 Gbem_0024Gbem_0025NC_011146
38Geobacter lovleyi SZ5634 Glov_2470Glov_2471NC_010814
39Geobacter metallireducens GS-152170 Gmet_2503Gmet_2502NC_007517
40Geobacter uraniireducens Rf43985 Gura_3378Gura_3379NC_009483
41Geobacter uraniireducens Rf43960 Gura_1479Gura_1478NC_009483
42Gloeobacter violaceus PCC 74211408 glr0096gsr0095NC_005125
43Gluconobacter oxydans 621H1857 GOX2564GOX2565NC_006672
44Klebsiella pneumoniae subsp. pneumoniae MGH 785784253 KPN_pKPN7p10264KPN_pKPN7p10263NC_009653
45Lactobacillus casei BL235772 LCABL_00900LCABL_00910NC_010999
46Lactobacillus fermentum IFO 39565442 LAF_0113LAF_0112NC_010610
47Lactobacillus gasseri ATCC 333233048 LGAS_1707LGAS_1708NC_008530
48Lactobacillus helveticus DPC 45714796 lhv_1684lhv_1685NC_010080
49Lactobacillus johnsonii NCC 5331728 LJ0589LJ0588NC_005362
50Lactobacillus plantarum WCFS1699 lp_2882lp_2883NC_004567
51Lactobacillus rhamnosus ATCC 85306142 LRHK_2454LRHK_2455NC_017491
52Lactobacillus rhamnosus Lc 7056137 LC705_02444LC705_02445NC_013199
53Lactobacillus salivarius UCC1181852 pSF118-20_26pSF118-20_25NC_006529
54Leptospira biflexa serovar Patoc strain Patoc 1 (Ames)5697 LBF_0718LBF_0717NC_010842
55Leptospira biflexa serovar Patoc strain Patoc 1 (Paris)5422 LEPBI_I0741LEPBI_I0740NC_010602
56Leptospira borgpetersenii serovar Hardjo-bovis str. JB1973022 LBJ_0402LBJ_0401NC_008510
57Leptospira borgpetersenii serovar Hardjo-bovis str. L5503021 LBL_2675LBL_2676NC_008508
58Leptospira interrogans serovar Lai str. 56601653 LA_1781LA_1780NC_004342
59Marinobacter aquaeolei VT83293 Maqu_4224Maqu_4225NC_008738
60Methanospirillum hungatei JF-12450 Mhun_2566Mhun_2567NC_007796
61Methylobacterium populi BJ0015549 Mpop_0785Mpop_0786NC_010725
62Methylobacterium populi BJ0015586 Mpop_5408Mpop_5407NC_010725
63Methylococcus capsulatus str. Bath1722 MCA3007MCA3006NC_002977
64Moorella thermoacetica ATCC 390732286 Moth_1021Moth_1020NC_007644
65Neisseria gonorrhoeae FA 10901754 NGO0516NGO0517NC_002946
66Neisseria gonorrhoeae NCCP119455820 NGK_1418NGK_1417NC_011035
67Neisseria meningitidis 0534424827 NMCC_1042NMCC_1041NC_010120
68Neisseria meningitidis 0534424824 NMCC_0159NMCC_0160NC_010120
69Neisseria meningitidis FAM183327 NMC2019NMC2018NC_008767
70Neisseria meningitidis FAM183325 NMC0879NMC0880NC_008767
71Neisseria meningitidis MC58408 NMB2038NMB2037NC_003112
72Neisseria meningitidis MC58403 NMB0913NMB0914NC_003112
73Nitratiruptor sp. SB155-24289 NIS_0353NIS_0352NC_009662
74Nitrosomonas europaea ATCC 19718903 NE0974NE0975NC_004757
75Nitrosomonas eutropha C912900 Neut_1399Neut_1400NC_008344
76Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)480 all3211asl3212NC_003272
77Pectobacterium atrosepticum SCRI10431104 ECA0582ECA0583NC_004547
78Pectobacterium atrosepticum SCRI10431108 ECA1676ECA1677NC_004547
79Pedobacter sp. BG56126 pMWHK01_p6pMWHK01_p5NC_012033
80Pelodictyon phaeoclathratiforme BU-15835 Ppha_0265Ppha_0264NC_011060
81Photorhabdus luminescens subsp. laumondii TTO11223 plu2365plu2366NC_005126
82Polynucleobacter necessarius subsp. asymbioticus QLW-P1DMWA-13732 Pnuc_1107Pnuc_1108NC_009379
83Providencia rettgeri6095 09AY2001NDM_04409AY2001NDM_045KF295828
84Pseudomonas putida KT2440302 PP_0771PP_0770NC_002947
85Pseudomonas putida W6195213 PputW619_4418PputW619_4419NC_010501
86Pseudomonas syringae pv. syringae B728a1870 Psyr_0890Psyr_0889NC_007005
87Ralstonia eutropha H161824 PHG381PHG380NC_005241
88Rhodopseudomonas palustris BisA532988 RPE_2192RPE_2191NC_008435
89Rhodopseudomonas palustris BisB182526 RPC_3250RPC_3251NC_007925
90Roseiflexus sp. RS-14069 RoseRS_3307RoseRS_3308NC_009523
91Salmonella enterica arizonae serovar 62 z4 z23 RSK29804786 SARI_04525SARI_04523NC_010067
92Shigella boydii CDC 3083-945495 SbBS512_E3091SbBS512_E3090NC_010658
93Shigella dysenteriae Sd1972205 SDY_4461SDY_4460NC_007606
94Shigella dysenteriae Sd1972201 SDY_2999SDY_3000NC_007606
95Shigella flexneri 2a str. 301651 SF3434SF3433NC_004337
96Shigella sonnei Ss0461988 SSON_2939SSON_2940NC_007384
97Sphingomonas wittichii RW14030 Swit_4881Swit_4882NC_009511
98Staphylococcus aureus6091 experimental SACH_a18SACH_a19NC_020227
99Streptococcus mutans UA159663 experimental SMU_173SMU_172NC_004350
100Synechocystis sp. PCC 6803 (Synechocystis PCC6803)1815 slr7041ssr7040NC_005230
101Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112934 Swol_1876Swol_1877NC_008346
102Treponema denticola ATCC 354051712 TDE2247TDE2246NC_002967
103Verminephrobacter eiseniae EF01-23439 Veis_2866Veis_2865NC_008786
104Xylella fastidiosa6120 pXFRIV11_p03pXFRIV11_p02NC_014111

experimental Data derived from experimental literature


Antitoxin domain: AbrB. Regulators of stationary/sporulation gene expression [Transcription]

Toxin domain: MazF. Growth inhibitor [Signal transduction mechanisms]


Structure
Crystal Structure of RelB-RelE antitoxin-toxin complex from Methanococcus jannaschii [PDB ID: 3BPQ] [PudMed:19712680]
Crystal structure of archaeal RelE-RelB complex from Pyrococcus horikoshii OT3 [PDB ID: 1WMI] [PudMed:15768033]
Solution Structure of the Bacterial Toxin Rele from Thermus Thermophilus HB8 [PDB ID: 2KHE]
The crystal structure of the isolated E. coli RelE toxin [PDB ID: 3KHA] [PudMed:20005802]
The crystal structure of the toxin-antitoxin complex RelBE2 (Rv2865-2866) from Mycobacterium tuberculosis [PDB ID: 3G5O]
A Conserved Mode Of Protein Recognition And Binding In A ParD-ParE Toxin-Antitoxin Complex. [PDB ID: 3KXE] [PudMed:20143871]
(1) Kamada K et al. (2003) Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxinrecognition. Mol Cell 11(4):875-84. [PudMed:12718874] 3D_structure
(2) Kint CI; Verstraeten N; Wens I; Liebens VR; Hofkens J; Versees W; Fauvart M; Michiels J (2012) The Escherichia coli GTPase ObgE modulates hydroxyl radical levels in response to DNA replication fork arrest FEBS J 279(19):3692-704. [PudMed:22863262] experimental
(3) Bukowski M; Lyzen R; Helbin WM; Bonar E; Szalewska-Palasz A; Wegrzyn G; Dubin G; Dubin A; Wladyka B (2013) A regulatory role for Staphylococcus aureus toxin-antitoxin system PemIKSa Nat Commun 4:2012. [PudMed:23774061] experimental
(4) Syed MA et al. (2011) The Chromosomal mazEF Locus of Streptococcus mutans Encodes a Functional Type II Toxin-Antitoxin Addiction System. J Bacteriol. 193(5):1122-30. [PudMed:21183668] experimental
(5) Makarova KS et al. (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct 4:19. [PudMed:19493340] in_silico