TA Pair: AbrB-Fic
#OrganismToxinAntitoxinLocus IDReplicon
1Albidiferax ferrireducens T118 (Rhodoferax ferrireducens T118)2487 Rfer_3404Rfer_3405NC_007908
2Alkaliphilus metalliredigens QYMF4236 Amet_3365Amet_3364NC_009633
3Anaeromyxobacter dehalogenans 2CP-C2348 Adeh_2871Adeh_2870NC_007760
4Anaeromyxobacter sp. Fw109-54347 Anae109_2801Anae109_2800NC_009675
5Bacillus clausii KSM-K161118 ABC1017ABC1016NC_006582
6Bradyrhizobium sp. ORS 2783846 BRADO1194BRADO1193NC_009445
7Brucella abortus bv. 1 str. 9-9411867 BruAb1_0579BruAb1_0580NC_006932
8Brucella canis ATCC 233654814 BCAN_A0569BCAN_A0570NC_010103
9Brucella melitensis biovar Abortus 23082223 BAB1_0581BAB1_0582NC_007618
10Brucella melitensis bv. 1 str. 16M511 BMEI1376BMEI1375NC_003317
11Brucella suis 1330644 BR0557BR0558NC_004310
12Candidatus Koribacter versatilis Ellin3452668 Acid345_4108Acid345_4109NC_008009
13Candidatus Protochlamydia amoebophila UWE251391 pc1456pc1457NC_005861
14Candidatus Protochlamydia amoebophila UWE251389 pc1021pc1022NC_005861
15Candidatus Solibacter usitatus Ellin60763089 Acid_5842Acid_5843NC_008536
16Carboxydothermus hydrogenoformans Z-29012080 CHY_0266CHY_0265NC_007503
17Chlorobaculum parvum NCIB 83275814 Cpar_1702Cpar_1703NC_011027
18Chlorobium limicola DSM 2455618 Clim_2109Clim_2110NC_010803
19Chlorobium phaeobacteroides BS15667 Cphamn1_0890Cphamn1_0891NC_010831
20Chlorobium phaeobacteroides BS15674 Cphamn1_1313Cphamn1_1314NC_010831
21Chlorobium phaeobacteroides DSM 2663197 Cpha266_2176Cpha266_2175NC_008639
22Chlorobium tepidum TLS298 CT0333CT0332NC_002932
23Cyanothece sp. ATCC 511425306 cce_5263cce_5264NC_010541
24Enterococcus faecalis V5831023 EF0379EF0380NC_004668
25Geobacillus kaustophilus HTA4261182 GK1846GK1845NC_006510
26Gloeobacter violaceus PCC 74211451 glr2735gsr2734NC_005125
27Hyphomonas neptunium ATCC 154442955 HNE_0348HNE_0347NC_008358
28Jannaschia sp. CCS12471 Jann_3453Jann_3452NC_007802
29Lactobacillus gasseri ATCC 333233040 LGAS_0236LGAS_0235NC_008530
30Leptospira biflexa serovar Patoc strain Patoc 1 (Ames)5703 LBF_2179LBF_2178NC_010842
31Leptospira biflexa serovar Patoc strain Patoc 1 (Paris)5428 LEPBI_I2244LEPBI_I2243NC_010602
32Leptothrix cholodnii SP-65275 Lcho_1579Lcho_1578NC_010524
33Microcystis aeruginosa NIES-8435025 MAE_55090MAE_55100NC_010296
34Nitrosomonas eutropha C912889 Neut_2560Neut_2559NC_008341
35Ochrobactrum anthropi ATCC 491884331 Oant_2706Oant_2705NC_009667
36Pelodictyon phaeoclathratiforme BU-15850 Ppha_1370Ppha_1371NC_011060
37Polaromonas naphthalenivorans CJ23396 Pnap_2223Pnap_2222NC_008781
38Prosthecochloris aestuarii DSM 2715822 Paes_0780Paes_0781NC_011059
39Rhizobium etli CIAT 6525740 RHECIAT_CH0001569RHECIAT_CH0001570NC_010994
40Rhodobacter sphaeroides ATCC 170253769 Rsph17025_4297Rsph17025_4296NC_009431
41Rhodopseudomonas palustris BisA533000 RPE_4100RPE_4101NC_008435
42Rhodopseudomonas palustris BisB182532 RPC_3971RPC_3972NC_007925
43Rhodopseudomonas palustris BisB52613 RPD_1413RPD_1412NC_007958
44Rhodopseudomonas palustris HaA22404 RPB_1433RPB_1432NC_007778
45Rhodospirillum rubrum ATCC 111702235 Rru_B0035Rru_B0034NC_007641
46Salinibacter ruber DSM 138552322 SRU_2816SRU_2815NC_007677
47Streptococcus pneumoniae CGSP145415 SPCG_0839SPCG_0838NC_010582
48Streptococcus pneumoniae G545899 SPG_0815SPG_0814NC_011072
49Streptococcus pneumoniae Hungary19A-65096 SPH_0995SPH_0994NC_010380
50Streptococcus pneumoniae TIGR4324 SP_0889SP_0888NC_003028
51Streptococcus sanguinis SK363518 SSA_2383SSA_1456NC_009009
52Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112939 Swol_2275Swol_2276NC_008346
53Verminephrobacter eiseniae EF01-23435 Veis_2466Veis_2467NC_008786
54Xanthobacter autotrophicus Py24420 Xaut_0219Xaut_0218NC_009720
55Xanthomonas axonopodis pv. citri str. 306736 XAC1194XAC1195NC_003919
56Xanthomonas oryzae KACC103311622 XOO3444XOO3443NC_006834
57Xanthomonas oryzae pv. oryzae MAFF 3110182327 XOO_3244XOO_3243NC_007705
58Xanthomonas oryzae pv. oryzae PXO99A5524 PXO_02086PXO_02087NC_010717

Antitoxin domain: AbrB. Regulators of stationary/sporulation gene expression [Transcription]

Toxin domain: Fic. Fic/Doc family. This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing). The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism. This family contains a central conserved motif HPFXXGNG in most members. The exact molecular function of these proteins is uncertain. P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation. A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1. In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family. Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc.

Crystal Structure of RelB-RelE antitoxin-toxin complex from Methanococcus jannaschii [PDB ID: 3BPQ] [PudMed:19712680]
Crystal structure of archaeal RelE-RelB complex from Pyrococcus horikoshii OT3 [PDB ID: 1WMI] [PudMed:15768033]
Solution Structure of the Bacterial Toxin Rele from Thermus Thermophilus HB8 [PDB ID: 2KHE]
The crystal structure of the isolated E. coli RelE toxin [PDB ID: 3KHA] [PudMed:20005802]
The crystal structure of the toxin-antitoxin complex RelBE2 (Rv2865-2866) from Mycobacterium tuberculosis [PDB ID: 3G5O]
(1) Makarova KS et al. (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct 4:19. [PudMed:19493340] in_silico