TADB
TA Pair: AbrB-PIN
#OrganismToxinAntitoxinLocus IDReplicon
1Acaryochloris marina MBIC110174624 AM1_1044AM1_1043NC_009925
2Acidithiobacillus ferrooxidans ATCC 539936011 Lferr_2508Lferr_2509NC_011206
3Acidithiobacillus ferrooxidans ATCC 539936006 Lferr_1788Lferr_1789NC_011206
4Acidithiobacillus ferrooxidans ATCC 539935996 Lferr_0638Lferr_0637NC_011206
5Acidithiobacillus ferrooxidans ATCC 539936009 Lferr_2391Lferr_2392NC_011206
6Acidovorax citrulli AAC00-13306 Aave_0580Aave_0579NC_008752
7Actinobacillus pleuropneumoniae serovar 3 str. JL034914 APJL_0659APJL_0660NC_010278
8Actinobacillus pleuropneumoniae serovar 3 str. JL034922 APJL_1767APJL_1766NC_010278
9Actinobacillus pleuropneumoniae serovar 5b str. L203562 APL_0665APL_0666NC_009053
10Actinobacillus pleuropneumoniae serovar 5b str. L203569 APL_1731APL_1730NC_009053
11Actinobacillus pleuropneumoniae serovar 7 str. AP765723 APP7_1792APP7_1791NC_010939
12Actinobacillus pleuropneumoniae serovar 7 str. AP765718 APP7_0705APP7_0706NC_010939
13Aeropyrum pernix K110 APE_2617.1APE_2617aNC_000854
14Aeropyrum pernix K11 APE_0273APE_0273aNC_000854
15Aeropyrum pernix K17 APE_1209bAPE_1209c.1NC_000854
16Aeropyrum pernix K13 APE_0279.1APE_0279a.1NC_000854
17Aeropyrum pernix K19 APE_2616APE_2616aNC_000854
18Aeropyrum pernix K111 APE_2617bAPE_2617cNC_000854
19Archaeoglobus fulgidus DSM 430461 AF2012AF2011NC_000917
20Archaeoglobus fulgidus DSM 430432 AF0065AF0066NC_000917
21Archaeoglobus fulgidus DSM 430437 AF0313AF0314NC_000917
22Archaeoglobus fulgidus DSM 430438 AF0315AF0314NC_000917
23Archaeoglobus fulgidus DSM 430439 AF0315AF0316NC_000917
24Archaeoglobus fulgidus DSM 430440 AF0320AF0319NC_000917
25Archaeoglobus fulgidus DSM 430449 AF1086mAF1084NC_000917
26Archaeoglobus fulgidus DSM 430450 AF1089AF1090NC_000917
27Archaeoglobus fulgidus DSM 430451 AF1091AF1092NC_000917
28Archaeoglobus fulgidus DSM 430459 AF1711AF1712NC_000917
29Archaeoglobus fulgidus DSM 430463 AF2190AF2189NC_000917
30Archaeoglobus fulgidus DSM 430464 AF2213AF2212NC_000917
31Archaeoglobus fulgidus DSM 430467 AF2360AF2359NC_000917
32Bartonella bacilliformis KC5833421 BARBAKC583_0275BARBAKC583_0274NC_008783
33Beijerinckia indica subsp. indica ATCC 90395413 Bind_3611Bind_3610NC_010581
34Burkholderia ambifaria AMMD2972 Bamb_1545Bamb_1544NC_008390
35Burkholderia ambifaria MC40-65353 BamMC406_1566BamMC406_1565NC_010551
36Burkholderia cenocepacia HI24243110 Bcen2424_6878Bcen2424_6877NC_008545
37Burkholderia cenocepacia MC0-35230 Bcenmc03_0154Bcenmc03_0153NC_010508
38Burkholderia lata2091 Bcep18194_A3320Bcep18194_A3319NC_007510
39Burkholderia lata2096 Bcep18194_A4794Bcep18194_A4793NC_007510
40Burkholderia multivorans ATCC 176164787 Bmul_6255Bmul_6254NC_010070
41Burkholderia multivorans ATCC 176164797 Bmul_0138Bmul_0137NC_010084
42Burkholderia multivorans ATCC 176165593 BMULJ_06307BMULJ_06308NC_010802
43Caldicellulosiruptor saccharolyticus DSM 89033798 Csac_2495Csac_2496NC_009437
44Candidatus Amoebophilus asiaticus 5a25650 Aasi_1214Aasi_1215NC_010830
45Candidatus Desulforudis audaxviator MP104C5142 Daud_2106Daud_2107NC_010424
46Candidatus Desulforudis audaxviator MP104C5143 Daud_2114Daud_2113NC_010424
47Candidatus Desulforudis audaxviator MP104C5144 Daud_2128Daud_2127NC_010424
48Candidatus Desulforudis audaxviator MP104C5128 Daud_0375Daud_0376NC_010424
49Candidatus Desulforudis audaxviator MP104C5130 Daud_0406Daud_0407NC_010424
50Candidatus Desulforudis audaxviator MP104C5139 Daud_1709Daud_1708NC_010424
51Candidatus Korarchaeum cryptofilum OPF85190 Kcr_0752Kcr_0751NC_010482
52Candidatus Korarchaeum cryptofilum OPF85191 Kcr_0854Kcr_0855NC_010482
53Candidatus Korarchaeum cryptofilum OPF85187 Kcr_0716Kcr_0717NC_010482
54Candidatus Korarchaeum cryptofilum OPF85186 Kcr_0687Kcr_0686NC_010482
55Candidatus Korarchaeum cryptofilum OPF85185 Kcr_0676Kcr_0675NC_010482
56Candidatus Koribacter versatilis Ellin3452675 Acid345_4672Acid345_4673NC_008009
57Carboxydothermus hydrogenoformans Z-29012084 CHY_1914CHY_1915NC_007503
58Caulobacter crescentus CB15227 CC_0841CC_0842NC_002696
59Caulobacter crescentus CB15224 CC_0031CC_0032NC_002696
60Cellvibrio japonicus Ueda1075760 CJA_3607CJA_3608NC_010995
61Chlorobaculum parvum NCIB 83275810 Cpar_0377Cpar_0376NC_011027
62Chlorobium chlorochromatii CaD32131 Cag_0679Cag_0678NC_007514
63Chlorobium chlorochromatii CaD32151 Cag_1433Cag_1432NC_007514
64Chlorobium chlorochromatii CaD32148 Cag_1325Cag_1324NC_007514
65Chlorobium chlorochromatii CaD32140 Cag_1077Cag_1078NC_007514
66Chlorobium limicola DSM 2455594 Clim_0066Clim_0067NC_010803
67Chlorobium limicola DSM 2455613 Clim_1457Clim_1458NC_010803
68Chlorobium limicola DSM 2455603 Clim_0658Clim_0659NC_010803
69Chlorobium phaeobacteroides BS15670 Cphamn1_1153Cphamn1_1154NC_010831
70Chlorobium phaeobacteroides BS15660 Cphamn1_0728Cphamn1_0729NC_010831
71Chlorobium phaeobacteroides BS15675 Cphamn1_1401Cphamn1_1402NC_010831
72Chlorobium phaeobacteroides DSM 2663203 Cpha266_2655Cpha266_2656NC_008639
73Chlorobium phaeobacteroides DSM 2663177 Cpha266_0091Cpha266_0092NC_008639
74Chloroherpeton thalassium ATCC 351105805 Ctha_1026Ctha_1025NC_011026
75Clostridium thermocellum ATCC 274053520 Cthe_1620Cthe_1619NC_009012
76Cyanothece sp. ATCC 511425314 cce_0581cce_0580NC_010546
77Cyanothece sp. ATCC 511425316 cce_0612cce_0613NC_010546
78Delftia acidovorans SPH-14764 Daci_3757Daci_3758NC_010002
79Delftia acidovorans SPH-14767 Daci_4252Daci_4253NC_010002
80Desulfococcus oleovorans Hxd34669 Dole_1698Dole_1697NC_009943
81Desulfococcus oleovorans Hxd34688 Dole_3167Dole_3166NC_009943
82Desulfotomaculum reducens MI-13653 Dred_2426Dred_2425NC_009253
83Dichelobacter nodosus VCS1703A3856 DNO_0277DNO_0276NC_009446
84Dichelobacter nodosus VCS1703A3858 DNO_1042DNO_1041NC_009446
85Dinoroseobacter shibae DFL 12 = DSM 164934731 Dshi_4025Dshi_4024NC_009957
86Escherichia coli SMS-3-55194 EcSMS35_A0141EcSMS35_A0140NC_010488
87Frankia alni ACN14a2845 FRAAL0206FRAAL0207NC_008278
88Frankia sp. CcI32381 Francci3_1681Francci3_1682NC_007777
89Frankia sp. CcI32388 Francci3_2564Francci3_2565NC_007777
90Frankia sp. CcI32395 Francci3_3292Francci3_3291NC_007777
91Frankia sp. EAN1pec4610 Franean1_2348Franean1_2347NC_009921
92Geobacter bemidjiensis Bem5945 Gbem_1917Gbem_1918NC_011146
93Geobacter lovleyi SZ5630 Glov_2071Glov_2070NC_010814
94Geobacter lovleyi SZ5631 Glov_2132Glov_2131NC_010814
95Geobacter metallireducens GS-152168 Gmet_1340Gmet_1339NC_007517
96Geobacter sulfurreducens PCA1536 GSU2472GSU2473NC_002939
97Geobacter uraniireducens Rf43987 Gura_3493Gura_3494NC_009483
98Geobacter uraniireducens Rf43925 Gura_0308Gura_0309NC_009483
99Geobacter uraniireducens Rf43954 Gura_1404Gura_1405NC_009483
100Geobacter uraniireducens Rf43965 Gura_1868Gura_1867NC_009483
101Geobacter uraniireducens Rf43980 Gura_3013Gura_3012NC_009483
102Geobacter uraniireducens Rf43922 Gura_0169Gura_0170NC_009483
103Gloeobacter violaceus PCC 74211471 glr4343gsr4342NC_005125
104Gloeobacter violaceus PCC 74211465 glr3875gsr3874NC_005125
105Gloeobacter violaceus PCC 74211434 gll1708gsl1709NC_005125
106Gloeobacter violaceus PCC 74211411 glr0248gsr0247NC_005125
107Gluconobacter oxydans 621H1858 GOX2682GOX2681NC_006673
108Haemophilus influenzae 86-028NP1911 NTHI0440NTHI0439NC_007146
109Haemophilus influenzae 86-028NP1915 NTHI1120NTHI1121NC_007146
110Haemophilus influenzae PittEE4191 CGSHiEE_07225CGSHiEE_07220NC_009566
111Haemophilus influenzae PittEE4186 CGSHiEE_01420CGSHiEE_01425NC_009566
112Haemophilus influenzae PittGG4201 CGSHiGG_08305CGSHiGG_08310NC_009567
113Haemophilus influenzae Rd KW201070 HI0947HI0948NC_000907
114Haemophilus influenzae Rd KW201066 experimental HI0322HI0321NC_000907
115Haemophilus somnus 129PT2862 HS_1769HS_1770NC_008309
116Haemophilus somnus 129PT2863 HS_1771HS_1772NC_008309
117Haloarcula marismortui ATCC 430491541 rrnAC1048rrnAC1049NC_006396
118Halobacterium salinarum R15082 OE5042ROE5043RNC_010368
119Halobacterium salinarum R15085 OE6047A1ROE6049RNC_010369
120Halobacterium salinarum R15086 OE6069ROE6070RNC_010369
121Haloquadratum walsbyi DSM 167902787 HQ3587AHQ3588ANC_008212
122Haloquadratum walsbyi DSM 167902783 HQ3497AHQ3496ANC_008212
123Halorhodospira halophila SL13468 Hhal_0749Hhal_0748NC_008789
124Halorhodospira halophila SL13473 Hhal_0795Hhal_0796NC_008789
125Hyperthermus butylicus DSM 54563492 Hbut_0672Hbut_0671NC_008818
126Hyperthermus butylicus DSM 54563493 Hbut_0674Hbut_0673NC_008818
127Hyperthermus butylicus DSM 54563501 Hbut_1442Hbut_1443NC_008818
128Hyperthermus butylicus DSM 54563495 Hbut_0734Hbut_0735NC_008818
129Hyperthermus butylicus DSM 54563496 Hbut_0745Hbut_0746NC_008818
130Hyperthermus butylicus DSM 54563497 Hbut_0760Hbut_0761NC_008818
131Hyperthermus butylicus DSM 54563500 Hbut_1359Hbut_1360NC_008818
132Hyperthermus butylicus DSM 54563498 Hbut_1343Hbut_1344NC_008818
133Hyperthermus butylicus DSM 54563490 Hbut_0331Hbut_0332NC_008818
134Idiomarina loihiensis L2TR1317 IL2517IL2516NC_006512
135Jannaschia sp. CCS12469 Jann_3010Jann_3009NC_007802
136Leptospira biflexa serovar Patoc strain Patoc 1 (Ames)5705 LBF_2185LBF_2184NC_010842
137Leptospira biflexa serovar Patoc strain Patoc 1 (Ames)5714 LBF_3285LBF_3286NC_010842
138Leptospira biflexa serovar Patoc strain Patoc 1 (Paris)5430 LEPBI_I2250LEPBI_I2249NC_010602
139Leptospira biflexa serovar Patoc strain Patoc 1 (Paris)5438 LEPBI_I3399LEPBI_I3400NC_010602
140Leptospira interrogans serovar Copenhageni str. Fiocruz L1-1301518 LIC12660LIC12659NC_005823
141Leptospira interrogans serovar Lai str. 56601652 LA_1001LA_1002NC_004342
142Leptothrix cholodnii SP-65278 Lcho_2951Lcho_2952NC_010524
143Magnetococcus marinus MC-13157 Mmc1_3147Mmc1_3146NC_008576
144Mesorhizobium loti MAFF303099207 mll1670mll1671NC_002678
145Mesorhizobium loti MAFF303099217 mll3899msl3900NC_002678
146Metallosphaera sedula DSM 53483825 Msed_1184Msed_1183NC_009440
147Metallosphaera sedula DSM 53483831 Msed_1534Msed_1535NC_009440
148Metallosphaera sedula DSM 53483820 Msed_0864Msed_0865NC_009440
149Metallosphaera sedula DSM 53483828 Msed_1307Msed_1308NC_009440
150Methanocaldococcus jannaschii DSM 266119 MJ_0974MJ_0975NC_000909
151Methanocaldococcus jannaschii DSM 26611730 MJECL30MJECL31NC_001732
152Methanocella arvoryzae MRE503899 RCIX2346RCIX2347NC_009464
153Methanosphaera stadtmanae DSM 30912323 Msp_0729Msp_0730NC_007681
154Methanospirillum hungatei JF-12440 Mhun_1387Mhun_1388NC_007796
155Methanospirillum hungatei JF-12448 Mhun_2149Mhun_2150NC_007796
156Methanospirillum hungatei JF-12446 Mhun_1911Mhun_1910NC_007796
157Methanospirillum hungatei JF-12447 Mhun_1916Mhun_1917NC_007796
158Methanospirillum hungatei JF-12455 Mhun_2712Mhun_2713NC_007796
159Methylibium petroleiphilum PM13503 Mpe_A1364Mpe_A1365NC_008825
160Methylococcus capsulatus str. Bath1719 MCA1623MCA1622NC_002977
161Microcystis aeruginosa NIES-8434984 MAE_31220MAE_31210NC_010296
162Microcystis aeruginosa NIES-8435024 MAE_54730MAE_54740NC_010296
163Moorella thermoacetica ATCC 390732276 Moth_0252Moth_0253NC_007644
164Moorella thermoacetica ATCC 390732274 Moth_0195Moth_0196NC_007644
165Moorella thermoacetica ATCC 390732282 Moth_0679Moth_0678NC_007644
166Moorella thermoacetica ATCC 390732283 Moth_0685Moth_0686NC_007644
167Moorella thermoacetica ATCC 390732284 Moth_0688Moth_0687NC_007644
168Moorella thermoacetica ATCC 390732292 Moth_2069Moth_2070NC_007644
169Mycobacterium bovis AF2122/971127 Mb0614cMb0615cNC_002945
170Mycobacterium bovis AF2122/971163 Mb2627Mb2626NC_002945
171Mycobacterium bovis BCG str. Pasteur 1173P23370 BCG_2619BCG_2618NC_008769
172Mycobacterium bovis BCG str. Pasteur 1173P23336 BCG_0644cBCG_0645cNC_008769
173Mycobacterium sp. JLS3582 Mjls_0846Mjls_0845NC_009077
174Mycobacterium sp. KMS3266 Mkms_0841Mkms_0840NC_008705
175Mycobacterium tuberculosis CDC1551241 MT0628MT0629NC_002755
176Mycobacterium tuberculosis F114145 TBFG_10610TBFG_10611NC_009565
177Mycobacterium tuberculosis H37Ra4125 MRA_2624MRA_2623ANC_009525
178Mycobacterium tuberculosis H37Ra4089 MRA_0606MRA_0607NC_009525
179Mycobacterium tuberculosis H37Rv118 Rv2596Rv2595NC_000962
180Mycobacterium tuberculosis H37Rv78 experimental Rv0598cRv0599cNC_000962
181Natronomonas pharaonis DSM 21602010 NP2786ANP2784ANC_007426
182Nitrobacter winogradskyi Nb-2552007 Nwi_3084Nwi_3083NC_007406
183Nitrosococcus oceani ATCC 197072037 Noc_0440Noc_0441NC_007484
184Nitrosococcus oceani ATCC 197072053 Noc_2539Noc_2538NC_007484
185Nitrosococcus oceani ATCC 197072050 Noc_2205Noc_2206NC_007484
186Nitrosomonas europaea ATCC 19718921 NE1373NE1374NC_004757
187Nitrosomonas europaea ATCC 19718895 NE0479NE0478NC_004757
188Nitrosomonas europaea ATCC 19718898 NE0498NE0497NC_004757
189Nitrosomonas europaea ATCC 19718912 NE1225NE1224NC_004757
190Nitrosomonas europaea ATCC 19718917 NE1349NE1350NC_004757
191Nitrosomonas europaea ATCC 19718922 NE1377NE1376NC_004757
192Nitrosomonas eutropha C912894 Neut_0071Neut_0070NC_008344
193Nitrosospira multiformis ATCC 251962213 Nmul_A0984Nmul_A0985NC_007614
194Paracoccus denitrificans PD12223208 Pden_0483Pden_0482NC_008686
195Parvibaculum lavamentivorans DS-14400 Plav_0661Plav_0660NC_009719
196Parvibaculum lavamentivorans DS-14412 Plav_2595Plav_2596NC_009719
197Pectobacterium atrosepticum SCRI10431114 ECA3686ECA3687NC_004547
198Pectobacterium atrosepticum SCRI10431113 ECA2850ECA2851NC_004547
199Pelodictyon phaeoclathratiforme BU-15890 Ppha_2777Ppha_2778NC_011060
200Pelodictyon phaeoclathratiforme BU-15849 Ppha_1277Ppha_1276NC_011060
201Pelodictyon phaeoclathratiforme BU-15829 Ppha_0151Ppha_0152NC_011060
202Pelodictyon phaeoclathratiforme BU-15866 Ppha_1746Ppha_1745NC_011060
203Pelotomaculum thermopropionicum SI3867 PTH_0499PTH_0500NC_009454
204Pelotomaculum thermopropionicum SI3882 PTH_2796PTH_2795NC_009454
205Pelotomaculum thermopropionicum SI3877 PTH_2560PTH_2561NC_009454
206Pelotomaculum thermopropionicum SI3869 PTH_0703PTH_0702NC_009454
207Pelotomaculum thermopropionicum SI3862 PTH_0364PTH_0363NC_009454
208Pelotomaculum thermopropionicum SI3865 PTH_0411PTH_0412NC_009454
209Photorhabdus luminescens subsp. laumondii TTO11198 plu0929plu0928NC_005126
210Photorhabdus luminescens subsp. laumondii TTO11208 plu2050plu2051NC_005126
211Polaromonas naphthalenivorans CJ23397 Pnap_2552Pnap_2551NC_008781
212Polaromonas naphthalenivorans CJ23400 Pnap_3682Pnap_3681NC_008781
213Polaromonas sp. JS6662586 Bpro_2719Bpro_2718NC_007948
214Polynucleobacter necessarius subsp. asymbioticus QLW-P1DMWA-13729 Pnuc_0688Pnuc_0687NC_009379
215Polynucleobacter necessarius subsp. asymbioticus QLW-P1DMWA-13730 Pnuc_0693Pnuc_0694NC_009379
216Proteus mirabilis HI43205364 PMI2879PMI2880NC_010554
217Pseudomonas aeruginosa6085 t/at2t/at1KC189475
218Pseudomonas aeruginosa UCBPP-PA143009 PA14_28790PA14_28780NC_008463
219Pseudomonas entomophila L482712 PSEEN4876PSEEN4875NC_008027
220Pseudomonas putida W6195214 PputW619_4624PputW619_4623NC_010501
221Pseudomonas syringae pv. syringae B728a1871 Psyr_0894Psyr_0895NC_007005
222Pseudomonas syringae pv. tomato str. DC30001058 PSPTO_1045PSPTO_1046NC_004578
223Pyrobaculum aerophilum str. IM2522 PAE0498PAE0497NC_003364
224Pyrobaculum aerophilum str. IM2538 PAE2829PAE2828NC_003364
225Pyrobaculum aerophilum str. IM2515 PAE0101PAE0100NC_003364
226Pyrobaculum arsenaticum DSM 135143723 Pars_1641Pars_1640NC_009376
227Pyrobaculum arsenaticum DSM 135143700 Pars_0371Pars_0370NC_009376
228Pyrobaculum arsenaticum DSM 135143701 Pars_0392Pars_0393NC_009376
229Pyrobaculum calidifontis JCM 115483576 Pcal_1366Pcal_1365NC_009073
230Pyrobaculum islandicum DSM 41843246 Pisl_0239Pisl_0238NC_008701
231Pyrobaculum neutrophilum V24Sta5287 Tneu_0441Tneu_0442NC_010525
232Pyrococcus abyssi GE5984 PAB7218PAB8218NC_000868
233Pyrococcus abyssi GE5992 PAB1216PAB1216.1nNC_000868
234Pyrococcus abyssi GE5989 PAB0859PAB1517.1nNC_000868
235Pyrococcus abyssi GE5986 PAB1672PAB1672.1nNC_000868
236Pyrococcus abyssi GE5983 PAB0520PAB3187NC_000868
237Pyrococcus abyssi GE5981 PAB2271PAB3032NC_000868
238Pyrococcus furiosus DSM 3638548 PF0812PF0813NC_003413
239Pyrococcus furiosus DSM 3638543 PF0574PF0573NC_003413
240Pyrococcus furiosus DSM 3638544 PF0575PF0576NC_003413
241Pyrococcus furiosus DSM 3638556 PF2057PF2058NC_003413
242Pyrococcus furiosus DSM 3638547 PF0778PF0779NC_003413
243Pyrococcus horikoshii OT3860 PHS027.1nPHS027NC_000961
244Ralstonia eutropha JMP1341969 Reut_C6178Reut_C6177NC_007336
245Ralstonia solanacearum GMI1000507 RSc3055RSc3056NC_003295
246Rhizobium etli CFN 422359 RHE_CH03480RHE_CH03479NC_007761
247Rhizobium etli CIAT 6525744 RHECIAT_CH0002962RHECIAT_CH0002963NC_010994
248Rhizobium etli CIAT 6525747 RHECIAT_CH0003719RHECIAT_CH0003718NC_010994
249Rhizobium leguminosarum bv. viciae 38412963 pRL120363pRL120364NC_008378
250Rhodobacter sphaeroides 2.4.12060 RSP_4076RSP_7374NC_007489
251Rhodopseudomonas palustris BisA532994 RPE_3234RPE_3233NC_008435
252Rhodopseudomonas palustris BisA532985 RPE_2040RPE_2041NC_008435
253Rhodopseudomonas palustris BisA532984 RPE_1994RPE_1995NC_008435
254Rhodopseudomonas palustris BisB182529 RPC_3693RPC_3694NC_007925
255Rhodopseudomonas palustris BisB182514 RPC_2132RPC_2133NC_007925
256Rhodopseudomonas palustris BisB52620 RPD_2669RPD_2670NC_007958
257Rhodopseudomonas palustris BisB52617 RPD_2061RPD_2062NC_007958
258Rhodopseudomonas palustris BisB52610 RPD_0447RPD_0446NC_007958
259Rhodopseudomonas palustris BisB52623 RPD_3501RPD_3502NC_007958
260Rhodopseudomonas palustris CGA0091489 RPA3608RPA3607NC_005296
261Rhodopseudomonas palustris CGA0091481 RPA1992RPA1993NC_005296
262Rhodopseudomonas palustris HaA22406 RPB_1920RPB_1921NC_007778
263Rhodopseudomonas palustris HaA22414 RPB_3729RPB_3730NC_007778
264Rhodopseudomonas palustris HaA22419 RPB_4437RPB_4438NC_007778
265Rhodopseudomonas palustris TIE-15795 Rpal_3973Rpal_3974NC_011004
266Rickettsia akari str. Hartford4548 A1C_02785A1C_02790NC_009881
267Rickettsia akari str. Hartford4554 A1C_05665A1C_05660NC_009881
268Rickettsia bellii OSU 85-3894579 A1I_02850A1I_02855NC_009883
269Rickettsia bellii OSU 85-3894581 A1I_03035A1I_03030NC_009883
270Rickettsia bellii OSU 85-3894582 A1I_03445A1I_03440NC_009883
271Rickettsia bellii OSU 85-3894584 A1I_04025A1I_04030NC_009883
272Rickettsia bellii OSU 85-3894589 A1I_07230A1I_07225NC_009883
273Rickettsia bellii OSU 85-3894571 A1I_01100A1I_01095NC_009883
274Rickettsia bellii OSU 85-3894572 A1I_01135A1I_01130NC_009883
275Rickettsia bellii RML369-C2549 RBE_0137RBE_0138NC_007940
276Rickettsia bellii RML369-C2550 RBE_0493RBE_0494NC_007940
277Rickettsia bellii RML369-C2552 RBE_0529RBE_0528NC_007940
278Rickettsia bellii RML369-C2557 RBE_0928RBE_0927NC_007940
279Rickettsia bellii RML369-C2565 RBE_1214RBE_1213NC_007940
280Rickettsia bellii RML369-C2566 RBE_1229RBE_1230NC_007940
281Rickettsia conorii str. Malish 7354 RC0510RC0511NC_003103
282Rickettsia conorii str. Malish 7355 RC0600RC0601NC_003103
283Rickettsia felis URRWXCal21886 RF_0095RF_0094NC_007109
284Rickettsia felis URRWXCal21903 RF_1206RF_1207NC_007109
285Rickettsia massiliae MTU54595 RMA_0530RMA_0531NC_009900
286Rickettsia rickettsii str. Iowa4903 RrIowa_0606RrIowa_0607NC_010263
287Rickettsia rickettsii str. Iowa4904 RrIowa_0715RrIowa_0716NC_010263
288Rickettsia rickettsii str. Sheila Smith4559 A1G_02890A1G_02895NC_009882
289Rickettsia rickettsii str. Sheila Smith4560 A1G_03375A1G_03380NC_009882
290Roseiflexus sp. RS-14075 RoseRS_3905RoseRS_3906NC_009523
291Salinibacter ruber DSM 138552315 SRU_0235SRU_0234NC_007677
292Salmonella enterica subsp. enterica serovar Agona str. SL4835968 SeAg_B4731SeAg_B4732NC_011149
293Salmonella enterica subsp. enterica serovar Dublin str. CT 020218535977 SeD_A3368SeD_A3369NC_011205
294Salmonella enterica subsp. enterica serovar Paratyphi A str.5951 SSPA2703SSPA2704NC_011147
295Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC1654 SPA2901SPA2902NC_006511
296Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB74803 SPAB_03778SPAB_03779NC_010102
297Salmonella enterica subsp. enterica serovar Typhimurium str. LT2439 experimental STM3033STM3034NC_003197
298Salmonella enterica subsp. enterica serovar Typhi str. CT18825 STY3182STY3183NC_003198
299Salmonella enterica subsp. enterica serovar Typhi str. Ty2751 t2943t2944NC_004631
300Serratia proteamaculans 5684531 Spro_3558Spro_3559NC_009832
301Shewanella halifaxensis HAW-EB45074 Shal_3046Shal_3045NC_010334
302Sinorhizobium meliloti 1021881 SMc00687SMc00686NC_003047
303Sinorhizobium meliloti 1021886 SMc04881SMc04408NC_003047
304Sinorhizobium meliloti 1021877 experimental SMc01521SMc03949NC_003047
305Sinorhizobium meliloti 1021871 SMc01177SMc01176NC_003047
306Sinorhizobium meliloti 1021869 SMc02657SMc02658NC_003047
307Sphingomonas wittichii RW14024 Swit_2661Swit_2660NC_009511
308Sphingopyxis alaskensis RB22562726 Sala_2721Sala_2722NC_008048
309Sphingopyxis alaskensis RB22562723 Sala_2593Sala_2594NC_008048
310Sphingopyxis alaskensis RB22562724 Sala_2597Sala_2596NC_008048
311Staphylothermus marinus F13526 Smar_0328Smar_0326NC_009033
312Staphylothermus marinus F13525 Smar_0068Smar_0067NC_009033
313Stenotrophomonas maltophilia K279a5731 Smlt2244Smlt2243NC_010943
314Stenotrophomonas maltophilia R551-35895 Smal_1838Smal_1837NC_011071
315Streptococcus mutans UA159666 SMU_1767cSMU_1768cNC_004350
316Sulfolobus acidocaldarius DSM 6391925 Saci_1954Saci_1955NC_007181
317Sulfolobus acidocaldarius DSM 6391928 Saci_1985Saci_1984NC_007181
318Sulfolobus acidocaldarius DSM 6391931 Saci_2192Saci_2193NC_007181
319Sulfolobus solfataricus P2951 SSO1968SSO9378NC_002754
320Sulfolobus solfataricus P2947 SSO1657SSO8620NC_002754
321Sulfolobus solfataricus P2956 SSO3078SSO11914NC_002754
322Sulfolobus solfataricus P2957 SSO3128SSO12018NC_002754
323Sulfolobus tokodaii str. 7382 ST0906STS102NC_003106
324Sulfolobus tokodaii str. 7374 ST0741STS089NC_003106
325Sulfolobus tokodaii str. 7366 ST0017STS008NC_003106
326Sulfolobus tokodaii str. 7367 ST0036STS011NC_003106
327Sulfolobus tokodaii str. 7401 ST2191STS233NC_003106
328Sulfolobus tokodaii str. 7389 ST1572STS183NC_003106
329Sulfolobus tokodaii str. 7380 ST0839STS097NC_003106
330Sulfolobus tokodaii str. 7385 ST1101STS126NC_003106
331Synechocystis sp. PCC 6803962 ssl2923ssl2922NC_000911
332Synechocystis sp. PCC 6803974 sll0690ssl1300NC_000911
333Synechocystis sp. PCC 6803 (Synechocystis PCC6803)1819 sll8027ssl8028NC_005231
334Syntrophobacter fumaroxidans MPOB3117 Sfum_2575Sfum_2576NC_008554
335Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112937 Swol_1975Swol_1976NC_008346
336Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112912 Swol_0226Swol_0225NC_008346
337Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112940 Swol_2474Swol_2475NC_008346
338Thermococcus kodakarensis KOD11573 TK0889TK0888NC_006624
339Thermococcus kodakarensis KOD11588 TK1290TK1291NC_006624
340Thermococcus kodakarensis KOD11584 TK1075TK1076NC_006624
341Thermococcus kodakarensis KOD11581 TK1027TK1028NC_006624
342Thermococcus kodakarensis KOD11580 TK1014TK1013NC_006624
343Thermococcus kodakarensis KOD11579 TK0998TK0997NC_006624
344Thermococcus kodakarensis KOD11602 TK2262TK2261NC_006624
345Thermococcus kodakarensis KOD11601 TK2228TK2229NC_006624
346Thermococcus kodakarensis KOD11574 TK0910TK0909NC_006624
347Thermococcus kodakarensis KOD11554 TK0016TK0017NC_006624
348Thermococcus kodakarensis KOD11560 TK0191TK0192NC_006624
349Thermococcus kodakarensis KOD11568 TK0456TK0457NC_006624
350Thermococcus kodakarensis KOD11563 TK0334TK0335NC_006624
351Thermococcus kodakarensis KOD11571 TK0734TK0733NC_006624
352Thermofilum pendens Hrk 53221 Tpen_1339Tpen_1340NC_008698
353Thermofilum pendens Hrk 53237 Tpen_1709Tpen_1708NC_008698
354Thermofilum pendens Hrk 53229 Tpen_1609Tpen_1610NC_008698
355Thermofilum pendens Hrk 53227 Tpen_1477Tpen_1478NC_008698
356Thermus thermophilus HB81361 TTHA0033TTHA0032NC_006461
357Thermus thermophilus HB81848 TTHB169TTHB168NC_006462
358Thermus thermophilus HB81849 TTHB203TTHB204NC_006462
359Treponema denticola ATCC 354051681 TDE0036TDE0037NC_002967
360Verminephrobacter eiseniae EF01-23454 Veis_4147Veis_4146NC_008786
361Verminephrobacter eiseniae EF01-23428 Veis_1127Veis_1128NC_008786
362Verminephrobacter eiseniae EF01-23430 Veis_1509Veis_1510NC_008786
363Verminephrobacter eiseniae EF01-23451 Veis_3960Veis_3961NC_008786
364Xanthobacter autotrophicus Py24427 Xaut_2562Xaut_2561NC_009720
365Xanthomonas axonopodis pv. citri str. 306740 XAC2187XAC2188NC_003919
366Xanthomonas axonopodis pv. citri str. 306739 XAC1884XAC1883NC_003919
367Xanthomonas campestris pv. campestris str. 80041879 XC_2327XC_2328NC_007086
368Xanthomonas campestris pv. campestris str. 80041880 XC_2599XC_2600NC_007086
369Xanthomonas campestris pv. campestris str. ATCC 33913608 XCC1632XCC1631NC_003902
370Xanthomonas campestris pv. campestris str. ATCC 33913609 XCC1862XCC1861NC_003902
371Xanthomonas campestris pv. campestris str. B1005516 xccb100_2150xccb100_2149NC_010688
372Xanthomonas oryzae KACC103311621 XOO2863XOO2864NC_006834
373Xanthomonas oryzae pv. oryzae MAFF 3110182326 XOO_2718XOO_2719NC_007705
374Xanthomonas oryzae pv. oryzae PXO99A5523 PXO_00062PXO_00063NC_010717
375Xylella fastidiosa 9a5c150 XF1589XF1588NC_002488
376Xylella fastidiosa M125247 Xfasm12_0256Xfasm12_0255NC_010513
377Xylella fastidiosa M235386 XfasM23_0226XfasM23_0225NC_010577
378Yersinia enterocolitica subsp. enterocolitica 80813488 YE4141YE4142NC_008800
379Yersinia enterocolitica subsp. enterocolitica 80813479 YE1658YE1659NC_008800

experimental Data derived from experimental literature


Antitoxin domain: AbrB. Regulators of stationary/sporulation gene expression [Transcription]

Toxin domain: PIN. This PIN (PilT N terminus) domain is a compact domain of about 100 amino acids. The domain has two nearly invariant aspartates. The function of the PIN domain is unknown but a role in signaling appears likely given the presence of this domain is StbB and DIS3. The majority of PIN-domain proteins found in prokaryotes are the toxic components of toxin-antitoxin operon, and toxin-antitoxin gene cassettes, though first found in plasmids, are found to be abundant in free-living prokaryotes, including many pathogenic bacteria. These loci provide a control mechanism that helps free-living prokaryotes cope with nutritional stress. In many genomes PIN domains are annotated as VapC and are part of the VapBC toxin-antitoxin operons. These operons are expanded in number in several unrelated micro-organisisms including Mycobacterium tuberculosis and Sulfolobus solfataricus.


Structure
Crystal Structure of RelB-RelE antitoxin-toxin complex from Methanococcus jannaschii [PDB ID: 3BPQ] [PudMed:19712680]
Crystal structure of archaeal RelE-RelB complex from Pyrococcus horikoshii OT3 [PDB ID: 1WMI] [PudMed:15768033]
Solution Structure of the Bacterial Toxin Rele from Thermus Thermophilus HB8 [PDB ID: 2KHE]
The crystal structure of the isolated E. coli RelE toxin [PDB ID: 3KHA] [PudMed:20005802]
The crystal structure of the toxin-antitoxin complex RelBE2 (Rv2865-2866) from Mycobacterium tuberculosis [PDB ID: 3G5O]
Crystal structure of (YP_321193.1) from Anabaena variabilis ATCC 29413 at 2.00 A resolution [PDB ID: 2GA1]
(1) Daines DA et al. (2007) VapC-1 of nontypeable Haemophilus influenzae is a ribonuclease. J Bacteriol 189(14):5041-8. [PudMed:17496075] experimental
(2) Ramage HR et al. (2009) Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxinsystems: implications for pathogenesis, stress responses, and evolution. PLoS Genet 5(12):e1000767. [PudMed:20011113] experimental
(3) Winther KS et al. (2009) Ectopic production of VapCs from Enterobacteria inhibits translation andtrans-activates YoeB mRNA interferase. Mol Microbiol 72(4):918-30. [PudMed:19400780] experimental
(4) Bodogai M et al. (2006) The ntrPR operon of Sinorhizobium meliloti is organized and functions as atoxin-antitoxin module. Mol Plant Microbe Interact 19(7):811-22. [PudMed:16838793] experimental
(5) Makarova KS et al. (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct 4:19. [PudMed:19493340] in_silico