TADB
TA Pair: COG2442-PIN
#OrganismToxinAntitoxinLocus IDReplicon
1Aeropyrum pernix K112 APE_2617dAPE_2617e.1NC_000854
2Candidatus Desulforudis audaxviator MP104C5138 Daud_1681Daud_1682NC_010424
3Candidatus Solibacter usitatus Ellin60763098 Acid_7149Acid_7148NC_008536
4Candidatus Solibacter usitatus Ellin60763099 Acid_7697Acid_7698NC_008536
5Candidatus Solibacter usitatus Ellin60763059 Acid_1001Acid_1000NC_008536
6Candidatus Solibacter usitatus Ellin60763088 Acid_5680Acid_5681NC_008536
7Candidatus Solibacter usitatus Ellin60763090 Acid_6199Acid_6200NC_008536
8Candidatus Solibacter usitatus Ellin60763094 Acid_6676Acid_6677NC_008536
9Chlorobium phaeobacteroides BS15651 Cphamn1_0056Cphamn1_0057NC_010831
10Chlorobium phaeobacteroides DSM 2663199 Cpha266_2196Cpha266_2195NC_008639
11Chlorobium phaeobacteroides DSM 2663202 Cpha266_2642Cpha266_2643NC_008639
12Corynebacterium efficiens YS-314668 CE0817CE0818NC_004369
13Cyanothece sp. ATCC 511425349 cce_4373cce_4372NC_010546
14Cyanothece sp. ATCC 511425305 cce_5252cce_5253NC_010539
15Cyanothece sp. ATCC 511425342 cce_3368cce_3367NC_010546
16Desulfococcus oleovorans Hxd34674 Dole_1815Dole_1814NC_009943
17Dinoroseobacter shibae DFL 12 = DSM 164934689 Dshi_0283Dshi_0282NC_009952
18Flavobacterium johnsoniae UW1013838 Fjoh_4962Fjoh_4961NC_009441
19Frankia sp. CcI32371 Francci3_0387Francci3_0386NC_007777
20Frankia sp. EAN1pec4602 Franean1_0440Franean1_0439NC_009921
21Frankia sp. EAN1pec4615 Franean1_6320Franean1_6321NC_009921
22Gloeobacter violaceus PCC 74211445 glr2396gsr2395NC_005125
23Gloeobacter violaceus PCC 74211440 gll2160gll2161NC_005125
24Gloeobacter violaceus PCC 74211449 gll2687gsl2688NC_005125
25Gloeobacter violaceus PCC 74211453 gll2931gll2932NC_005125
26Gloeobacter violaceus PCC 74211454 gll2955gll2956NC_005125
27Gloeobacter violaceus PCC 74211466 gll3981gll3982NC_005125
28Haloquadratum walsbyi DSM 167902779 HQ2102AHQ2101ANC_008212
29Haloquadratum walsbyi DSM 167902782 HQ2913AHQ2914ANC_008212
30Ignicoccus hospitalis KIN4/I4467 Igni_1069Igni_1068NC_009776
31Leptothrix cholodnii SP-65283 Lcho_4190Lcho_4191NC_010524
32Methanoregula boonei 6A84381 Mboo_1771Mboo_1772NC_009712
33Methylobacterium populi BJ0015581 Mpop_4944Mpop_4945NC_010725
34Methylobacterium populi BJ0015565 Mpop_3252Mpop_3251NC_010725
35Methylobacterium populi BJ0015569 Mpop_3850Mpop_3849NC_010725
36Methylobacterium populi BJ0015572 Mpop_4280Mpop_4279NC_010725
37Methylobacterium populi BJ0015560 Mpop_2091Mpop_2092NC_010725
38Microcystis aeruginosa NIES-8434977 MAE_24740MAE_24730NC_010296
39Microcystis aeruginosa NIES-8434993 MAE_34480MAE_34490NC_010296
40Microcystis aeruginosa NIES-8435023 MAE_49650MAE_49640NC_010296
41Microcystis aeruginosa NIES-8435017 MAE_47160MAE_47150NC_010296
42Microcystis aeruginosa NIES-8435014 MAE_45530MAE_45540NC_010296
43Microcystis aeruginosa NIES-8435006 MAE_42140MAE_42130NC_010296
44Microcystis aeruginosa NIES-8434998 MAE_35570MAE_35580NC_010296
45Microcystis aeruginosa NIES-8434996 MAE_34850MAE_34840NC_010296
46Microcystis aeruginosa NIES-8434995 MAE_34790MAE_34800NC_010296
47Microcystis aeruginosa NIES-8434936 MAE_05270MAE_05280NC_010296
48Microcystis aeruginosa NIES-8434951 MAE_10430MAE_10420NC_010296
49Microcystis aeruginosa NIES-8434967 MAE_18190MAE_18180NC_010296
50Microcystis aeruginosa NIES-8434973 MAE_21350MAE_21340NC_010296
51Microcystis aeruginosa NIES-8434981 MAE_30350MAE_30360NC_010296
52Moorella thermoacetica ATCC 390732270 Moth_0170Moth_0169NC_007644
53Mycobacterium bovis AF2122/971153 Mb2042Mb2041NC_002945
54Mycobacterium bovis BCG str. Pasteur 1173P23360 BCG_2036BCG_2035NC_008769
55Mycobacterium tuberculosis CDC1551269 MT2075MT2074NC_002755
56Mycobacterium tuberculosis F114166 TBFG_12054TBFG_12053NC_009565
57Mycobacterium tuberculosis H37Ra4114 MRA_2035MRA_2034NC_009525
58Mycobacterium tuberculosis H37Rv108 Rv2019Rv2018NC_000962
59Mycobacterium vanbaalenii PYR-13290 Mvan_5392Mvan_5393NC_008726
60Nocardioides sp. JS6143238 Noca_2024Noca_2025NC_008699
61Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133)5455 Npun_R2700Npun_R2701NC_010628
62Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133)5456 Npun_R2703Npun_R2704NC_010628
63Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133)5460 Npun_R3776Npun_R3777NC_010628
64Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133)5469 Npun_F5739Npun_F5738NC_010628
65Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133)5471 Npun_F6176Npun_F6175NC_010628
66Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)477 asr2959asr2958NC_003272
67Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)499 alr5181alr5180NC_003272
68Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)484 asr3961asr3960NC_003272
69Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)468 alr2173asr2172NC_003272
70Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)462 alr1560asr1559NC_003272
71Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)486 alr4134asr4133NC_003272
72Parvibaculum lavamentivorans DS-14417 Plav_3471Plav_3472NC_009719
73Pelodictyon phaeoclathratiforme BU-15861 Ppha_1709Ppha_1708NC_011060
74Pseudomonas syringae pv. tomato str. DC30001056 PSPTO_0931PSPTO_0930NC_004578
75Rhizobium etli CFN 422360 RHE_PA00163RHE_PA00164NC_007762
76Rhodopseudomonas palustris CGA0091484 RPA2819RPA2820NC_005296
77Rhodopseudomonas palustris CGA0091476 RPA0827RPA0826NC_005296
78Rhodopseudomonas palustris TIE-15781 Rpal_0895Rpal_0894NC_011004
79Roseiflexus castenholzii DSM 139414456 Rcas_2777Rcas_2776NC_009767
80Roseiflexus castenholzii DSM 139414435 Rcas_0537Rcas_0538NC_009767
81Roseiflexus castenholzii DSM 139414432 Rcas_0081Rcas_0082NC_009767
82Roseiflexus castenholzii DSM 139414449 Rcas_1637Rcas_1636NC_009767
83Roseiflexus sp. RS-14054 RoseRS_0696RoseRS_0695NC_009523
84Roseiflexus sp. RS-14068 RoseRS_3128RoseRS_3127NC_009523
85Roseiflexus sp. RS-14053 RoseRS_0674RoseRS_0673NC_009523
86Roseiflexus sp. RS-14052 RoseRS_0654RoseRS_0655NC_009523
87Rubrobacter xylanophilus DSM 99412758 Rxyl_1594Rxyl_1595NC_008148
88Salinibacter ruber DSM 138552319 SRU_0638SRU_0637NC_007677
89Synechococcus elongatus PCC 6301 (Synechococcus leopoliensis SAG)1633 syc0989_dsyc0988_dNC_006576
90Synechococcus elongatus PCC 79422190 Synpcc7942_0532Synpcc7942_0533NC_007604
91Synechocystis sp. PCC 68036118 SYNGTS_0490SYNGTS_0489NC_017277
92Synechocystis sp. PCC 6803973 slr0771slr0770NC_000911
93Synechocystis sp. PCC 6803966 slr1210slr1209NC_000911
94Synechocystis sp. PCC 6803964 experimental slr1767ssr2962NC_000911
95Synechocystis sp. PCC 6803958 sll1400ssl2733NC_000911
96Synechocystis sp. PCC 6803 (Synechocystis PCC6803)1816 sll8007ssl8008NC_005231
97Synechocystis sp. PCC 6803 (Synechocystis PCC6803)1805 sll5003sll5004NC_005229
98Synechocystis sp. PCC 6803 (Synechocystis PCC6803)1813 sll7033sll7034NC_005230
99Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112941 Swol_2504Swol_2505NC_008346
100Trichodesmium erythraeum IMS1012869 Tery_2356Tery_2357NC_008312
101Verminephrobacter eiseniae EF01-23436 Veis_2486Veis_2485NC_008786
102Verminephrobacter eiseniae EF01-23461 Veis_4898Veis_4899NC_008786
103Xylella fastidiosa 9a5c156 XF2029XF2030NC_002488

experimental Data derived from experimental literature
Structure of AT is solved (PDB:2ga1):DNA/RNA-binding 3-helical bundle

Antitoxin domain: COG2442. Uncharacterized conserved protein [Function unknown]

Toxin domain: PIN. This PIN (PilT N terminus) domain is a compact domain of about 100 amino acids. The domain has two nearly invariant aspartates. The function of the PIN domain is unknown but a role in signaling appears likely given the presence of this domain is StbB and DIS3. The majority of PIN-domain proteins found in prokaryotes are the toxic components of toxin-antitoxin operon, and toxin-antitoxin gene cassettes, though first found in plasmids, are found to be abundant in free-living prokaryotes, including many pathogenic bacteria. These loci provide a control mechanism that helps free-living prokaryotes cope with nutritional stress. In many genomes PIN domains are annotated as VapC and are part of the VapBC toxin-antitoxin operons. These operons are expanded in number in several unrelated micro-organisisms including Mycobacterium tuberculosis and Sulfolobus solfataricus.


Structure
Crystal structure of (YP_321193.1) from Anabaena variabilis ATCC 29413 at 2.00 A resolution [PDB ID: 2GA1]
(1) Ning D; Liu S; Xu W; Zhuang Q; Wen C; Tang X (2013) Transcriptional and proteolytic regulation of the toxin-antitoxin locus vapBC10 (ssr2962/slr1767) on the chromosome of Synechocystis sp. PCC 6803 PLoS One 8(11):e80716. [PudMed:24260461] experimental
(2) Makarova KS et al. (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct 4:19. [PudMed:19493340] in_silico