TADB
TA Pair: Xre-COG2856
#OrganismToxinAntitoxinLocus IDReplicon
1Actinobacillus pleuropneumoniae serovar 3 str. JL034916 APJL_0961APJL_0962NC_010278
2Actinobacillus pleuropneumoniae serovar 5b str. L203563 APL_0950APL_0951NC_009053
3Alkaliphilus metalliredigens QYMF4233 Amet_0837Amet_0838NC_009633
4Alkaliphilus metalliredigens QYMF4234 Amet_2386Amet_2387NC_009633
5Alkaliphilus oremlandii OhILAs4618 Clos_1047Clos_1048NC_009922
6Alkaliphilus oremlandii OhILAs4619 Clos_1285Clos_1286NC_009922
7Bacillus anthracis str. Ames617 BA_3830BA_3829NC_003997
8Bacillus anthracis str. Sterne1501 BAS3546BAS3545NC_005945
9Bacillus cereus ATCC 109871349 BCE_4623BCE_4622NC_003909
10Bacillus cereus E33L1359 BCZK3460BCZK3459NC_006274
11Bacillus clausii KSM-K161119 ABC1358ABC1359NC_006582
12Bacillus cytotoxicus NVH 391-984339 Bcer98_1853Bcer98_1852NC_009674
13Bacillus cytotoxicus NVH 391-984341 Bcer98_2970Bcer98_2969NC_009674
14Bacillus halodurans C-125188 BH3550BH3549NC_002570
15Bacillus halodurans C-125186 BH1287BH1288NC_002570
16Bacillus licheniformis DSM 13 = ATCC 145801285 BL03749BL03748NC_006270
17Bacillus subtilis subsp. subtilis str. 168135 BSU04810BSU04820NC_000964
18Bacillus weihenstephanensis KBAB44899 BcerKBAB4_3466BcerKBAB4_3465NC_010184
19Bacillus weihenstephanensis KBAB44894 BcerKBAB4_5810BcerKBAB4_5811NC_010183
20Bordetella petrii DSM 128044869 Bpet4638Bpet4639NC_010170
21Bradyrhizobium diazoefficiens USDA 110839 bll1668bll1669NC_004463
22Bradyrhizobium diazoefficiens USDA 110835 bll0069bll0070NC_004463
23Bradyrhizobium sp. BTAi13916 BBta_p0024BBta_p0023NC_009475
24Brucella abortus bv. 1 str. 9-9411865 BruAb1_0264BruAb1_0263NC_006932
25Burkholderia ambifaria MC40-65356 BamMC406_6746BamMC406_6747NC_010553
26Burkholderia pseudomallei 1106a3579 BURPS1106A_0096BURPS1106A_0095NC_009076
27Burkholderia xenovorans LB4002599 Bxe_A2566Bxe_A2567NC_007951
28Caldicellulosiruptor saccharolyticus DSM 89033789 Csac_1409Csac_1408NC_009437
29Candidatus Koribacter versatilis Ellin3452656 Acid345_1121Acid345_1122NC_008009
30Candidatus Koribacter versatilis Ellin3452654 Acid345_0226Acid345_0227NC_008009
31Cellvibrio japonicus Ueda1075753 CJA_1207CJA_1208NC_010995
32Chelativorans sp. BNC12794 Meso_4400Meso_4401NC_008242
33Clostridium acetobutylicum ATCC 824331 CA_C0548CA_C0549NC_003030
34Clostridium beijerinckii NCIMB 80524218 Cbei_3960Cbei_3959NC_009617
35Clostridium botulinum A str. ATCC 193974351 CLB_0774CLB_0775NC_009697
36Clostridium botulinum A str. ATCC 35024003 CBO0732CBO0733NC_009495
37Clostridium botulinum A str. Hall4353 CLC_0789CLC_0790NC_009698
38Clostridium botulinum B str. Eklund 17B5496 CLL_A0919CLL_A0920NC_010674
39Clostridium botulinum B str. Eklund 17B5500 CLL_A2791CLL_A2790NC_010674
40Clostridium botulinum E3 str. Alaska E435541 CLH_2509CLH_2508NC_010723
41Clostridium botulinum E3 str. Alaska E435536 CLH_0885CLH_0886NC_010723
42Clostridium botulinum F str. Langeland4356 CLI_0822CLI_0823NC_009699
43Clostridium difficile 6303596 CD630_29510CD630_29500NC_009089
44Clostridium difficile 6303595 CD630_13590CD630_13600NC_009089
45Clostridium kluyveri DSM 5554359 CKL_1751CKL_1750NC_009706
46Clostridium novyi NT3162 NT01CX_2202NT01CX_2201NC_008593
47Clostridium perfringens ATCC 131242828 CPF_1020CPF_1021NC_008261
48Clostridium perfringens ATCC 131242826 CPF_0927CPF_0928NC_008261
49Clostridium phytofermentans ISDg4752 Cphy_0781Cphy_0782NC_010001
50Clostridium phytofermentans ISDg4753 Cphy_2995Cphy_2994NC_010001
51Clostridium tetani E88693 CTC01069CTC01070NC_004557
52Clostridium tetani E88695 CTC01859CTC01858NC_004557
53Clostridium thermocellum ATCC 274053521 Cthe_1746Cthe_1745NC_009012
54Clostridium thermocellum ATCC 274053522 Cthe_2459Cthe_2460NC_009012
55Corynebacterium urealyticum DSM 71095309 cur_0385cur_0384NC_010545
56Cupriavidus taiwanensis LMG 194245302 pRALTA_0124pRALTA_0123NC_010529
57Cupriavidus taiwanensis LMG 194245292 RALTA_A0936RALTA_A0937NC_010528
58Cyanothece sp. ATCC 511425317 cce_0909cce_0908NC_010546
59Dehalococcoides mccartyi BAV13884 DehaBAV1_0215DehaBAV1_0214NC_009455
60Delftia acidovorans SPH-14768 Daci_4663Daci_4662NC_010002
61Desulfotomaculum reducens MI-13645 Dred_0019Dred_0020NC_009253
62Desulfotomaculum reducens MI-13651 Dred_0915Dred_0916NC_009253
63Desulfotomaculum reducens MI-13647 Dred_0494Dred_0495NC_009253
64Dinoroseobacter shibae DFL 12 = DSM 164934690 Dshi_0408Dshi_0407NC_009952
65Enterococcus faecalis V5831030 EF2545EF2544NC_004668
66Enterococcus faecalis V5831020 EF0128EF0129NC_004668
67Enterococcus faecalis V5831022 EF0305EF0306NC_004668
68Enterococcus faecalis V5831025 EF1276EF1277NC_004668
69Enterococcus faecalis V5831026 EF1421EF1422NC_004668
70Enterococcus faecalis V5831027 EF2041EF2040NC_004668
71Enterococcus faecalis V5831028 EF2143EF2142NC_004668
72Enterococcus faecalis V5831031 EF2853EF2852NC_004668
73Finegoldia magna ATCC 293285089 FMG_0222FMG_0223NC_010376
74Frankia sp. CcI32396 Francci3_4018Francci3_4017NC_007777
75Frankia sp. CcI32376 Francci3_0909Francci3_0908NC_007777
76Frankia sp. CcI32367 Francci3_0128Francci3_0127NC_007777
77Frankia sp. CcI32375 Francci3_0882Francci3_0883NC_007777
78Fusobacterium nucleatum subsp. nucleatum ATCC 25586795 FN2066FN2065NC_003454
79Geobacillus thermodenitrificans NG80-23671 GTNG_2861GTNG_2860NC_009328
80Geobacter uraniireducens Rf43971 Gura_2215Gura_2216NC_009483
81Haemophilus somnus 23365260 HSM_0247HSM_0248NC_010519
82Hahella chejuensis KCTC 23962303 HCH_06282HCH_06281NC_007645
83Janthinobacterium sp. Marseille4284 mma_2741mma_2742NC_009659
84Lactobacillus casei ATCC 334 (Lactobacillus paracasei ATCC 334)3032 LSEI_0492LSEI_0493NC_008526
85Lactobacillus casei BL235774 LCABL_05540LCABL_05550NC_010999
86Lactobacillus casei BL235777 LCABL_12970LCABL_12980NC_010999
87Lactobacillus casei BL235776 LCABL_10830LCABL_10840NC_010999
88Lactobacillus casei BL235775 LCABL_09600LCABL_09610NC_010999
89Lactobacillus gasseri ATCC 333233044 LGAS_0636LGAS_0637NC_008530
90Lactobacillus gasseri ATCC 333233042 LGAS_0574LGAS_0575NC_008530
91Lactobacillus helveticus DPC 45714793 lhv_0083lhv_0084NC_010080
92Lactobacillus johnsonii NCC 5331723 LJ0293LJ0294NC_005362
93Lactobacillus johnsonii NCC 5331727 LJ1458LJ1457NC_005362
94Lactobacillus plantarum WCFS1697 lp_0630lp_0631NC_004567
95Lactobacillus plantarum WCFS1698 lp_2449lp_2448NC_004567
96Lactobacillus reuteri DSM 200164038 Lreu_0800Lreu_0801NC_009513
97Lactobacillus reuteri DSM 200164041 Lreu_1145Lreu_1144NC_009513
98Lactobacillus salivarius UCC1182546 LSL_0741LSL_0742NC_007929
99Lactobacillus salivarius UCC1182547 LSL_1190LSL_1191NC_007929
100Lactococcus lactis subsp. cremoris MG13633517 llmg_2140llmg_2139NC_009004
101Lactococcus lactis subsp. cremoris MG13633513 llmg_0792llmg_0793NC_009004
102Lactococcus lactis subsp. cremoris SK113036 LACR_2143LACR_2142NC_008527
103Lactococcus lactis subsp. lactis Il14031737 L38253L38687NC_002662
104Lactococcus lactis subsp. lactis Il14031740 L53979L53427NC_002662
105Leuconostoc citreum KM205163 LCK_p100020LCK_p100021NC_010470
106Leuconostoc citreum KM205165 LCK_01451LCK_01450NC_010471
107Leuconostoc mesenteroides subsp. mesenteroides ATCC 82933049 LEUM_1751LEUM_1750NC_008531
108Listeria innocua Clip11262790 lin1233lin1234NC_003212
109Listeria innocua Clip11262788 lin0160lin0161NC_003212
110Listeria innocua Clip11262792 lin2608lin2607NC_003212
111Listeria innocua Clip11262791 lin1763lin1762NC_003212
112Listeria monocytogenes EGD-e743 lmo0113lmo0114NC_003210
113Listeria monocytogenes serotype 4b str. F23651759 LMOf2365_0131LMOf2365_0132NC_002973
114Listeria welshimeri serovar 6b str. SLCC53343119 lwe0106lwe0107NC_008555
115Lysinibacillus sphaericus C3-415101 Bsph_p020Bsph_p019NC_010381
116Magnetococcus marinus MC-13154 Mmc1_2853Mmc1_2854NC_008576
117Magnetococcus marinus MC-13149 Mmc1_2613Mmc1_2614NC_008576
118Magnetococcus marinus MC-13150 Mmc1_2661Mmc1_2662NC_008576
119Magnetospirillum magneticum AMB-12229 amb0349amb0348NC_007626
120Mesorhizobium loti MAFF303099221 mll6134mll6136NC_002678
121Methanobrevibacter smithii ATCC 350614042 Msm_1529Msm_1528NC_009515
122Methylibium petroleiphilum PM13506 Mpe_A2374Mpe_A2373NC_008825
123Microcystis aeruginosa NIES-8434970 MAE_19380MAE_19390NC_010296
124Moorella thermoacetica ATCC 390732277 Moth_0277Moth_0278NC_007644
125Mycobacterium abscessus5103 MAB_1172cMAB_1173cNC_010397
126Mycobacterium abscessus5110 MAB_4886MAB_4885NC_010397
127Mycobacterium gilvum PYR-GCK3692 Mflv_5594Mflv_5593NC_009340
128Natranaerobius thermophilus JW/NM-WN-LF5531 Nther_2504Nther_2505NC_010718
129Natranaerobius thermophilus JW/NM-WN-LF5532 Nther_2541Nther_2542NC_010718
130Nitrobacter hamburgensis X142629 Nham_4489Nham_4490NC_007960
131Nitrobacter winogradskyi Nb-2551999 Nwi_0825Nwi_0826NC_007406
132Nitrobacter winogradskyi Nb-2552002 Nwi_1262Nwi_1263NC_007406
133Nitrosomonas europaea ATCC 19718941 NE2538NE2537NC_004757
134Nitrosospira multiformis ATCC 251962219 NmulC_2781NmulC_2782NC_007616
135Nitrosospira multiformis ATCC 251962221 Nmul_D2822Nmul_D2824NC_007617
136Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)466 alr1977alr1976NC_003272
137Nostoc sp. PCC 7120 (Anabaena sp. PCC7120)1766 all7686all7501NC_003240
138Novosphingobium aromaticivorans DSM 124442424 Saro_2203Saro_2204NC_007794
139Oceanobacillus iheyensis HTE831639 OB0206OB0207NC_004193
140Parvibaculum lavamentivorans DS-14405 Plav_1823Plav_1824NC_009719
141Pediococcus pentosaceus ATCC 257453030 PEPE_1035PEPE_1034NC_008525
142Pediococcus pentosaceus ATCC 257453029 PEPE_0747PEPE_0748NC_008525
143Polaromonas sp. JS6662591 Bpro_5156Bpro_5157NC_007949
144Polaromonas sp. JS6662580 Bpro_1546Bpro_1545NC_007948
145Psychrobacter arcticus 273-41932 Psyc_0986Psyc_0985NC_007204
146Rhodopirellula baltica SH 11037 RB11363RB11366NC_005027
147Rhodopseudomonas palustris BisA532990 RPE_2472RPE_2471NC_008435
148Rhodopseudomonas palustris BisB52619 RPD_2296RPD_2295NC_007958
149Rhodopseudomonas palustris CGA0091491 RPA4130RPA4129NC_005296
150Rhodospirillum rubrum ATCC 111702239 Rru_A0537Rru_A0536NC_007643
151Roseiflexus castenholzii DSM 139414464 Rcas_4188Rcas_4189NC_009767
152Roseiflexus sp. RS-14044 RoseRS_0060RoseRS_0059NC_009523
153Saccharopolyspora erythraea NRRL 23383622 SACE_4816SACE_4815NC_009142
154Saccharopolyspora erythraea NRRL 23383617 SACE_3170SACE_3169NC_009142
155Salinispora arenicola CNS-2054718 Sare_4703Sare_4702NC_009953
156Salinispora arenicola CNS-2054714 Sare_3101Sare_3100NC_009953
157Salinispora tropica CNB-4403756 Strop_4198Strop_4197NC_009380
158Shewanella amazonensis SB2B3243 Sama_2718Sama_2717NC_008700
159Shewanella sp. ANA-33141 Shewana3_4357Shewana3_4356NC_008573
160Sorangium cellulosum So ce564846 sce6148sce6149NC_010162
161Sphingomonas wittichii RW14028 Swit_4066Swit_4067NC_009511
162Staphylococcus aureus subsp. aureus COL1276 SACOL0889SACOL0890NC_002951
163Staphylococcus aureus subsp. aureus MRSA2521537 SAR1557SAR1556NC_002952
164Staphylococcus aureus subsp. aureus MSSA4761381 SAS0896SAS0897NC_002953
165Staphylococcus aureus subsp. aureus Mu34481 SAHV_0846SAHV_0847NC_009782
166Staphylococcus aureus subsp. aureus Mu50294 SAV0850SAV0851NC_002758
167Staphylococcus aureus subsp. aureus MW2611 MW1437MW1436NC_003923
168Staphylococcus aureus subsp. aureus str. Newman4244 experimental NWMN_0265NWMN_0266NC_009641
169Staphylococcus aureus subsp. aureus USA300 TCH15164788 USA300HOU_0853USA300HOU_0854NC_010079
170Staphylococcus aureus subsp. aureus USA300 TCH15164789 USA300HOU_1487USA300HOU_1486NC_010079
171Staphylococcus haemolyticus JCSC14351920 SH1806SH1805NC_007168
172Stenotrophomonas maltophilia K279a5729 Smlt1897Smlt1898NC_010943
173Streptococcus agalactiae 2603V/R635 SAG1883SAG1882NC_004116
174Streptococcus agalactiae A9092019 SAK_0609SAK_0608NC_007432
175Streptococcus agalactiae NEM316889 gbs0474gbs0475NC_004368
176Streptococcus mutans UA159664 SMU_219SMU_218NC_004350
177Streptococcus pneumoniae CGSP145418 SPCG_1910SPCG_1965NC_010582
178Streptococcus pneumoniae G545902 SPG_1845SPG_1846NC_011072
179Streptococcus pneumoniae Hungary19A-65100 SPH_2084SPH_2086NC_010380
180Streptococcus pneumoniae Hungary19A-65093 SPH_0072SPH_0073NC_010380
181Streptococcus pneumoniae R6730 spr1752spr1753NC_003098
182Streptococcus pneumoniae TIGR4329 SP_1935SP_1936NC_003028
183Streptococcus pyogenes MGAS102702687 MGAS10270_Spy1405MGAS10270_Spy1404NC_008022
184Streptococcus pyogenes MGAS102702685 MGAS10270_Spy0800MGAS10270_Spy0801NC_008022
185Streptococcus pyogenes MGAS102702686 MGAS10270_Spy1359MGAS10270_Spy1358NC_008022
186Streptococcus pyogenes MGAS103941637 M6_Spy0022M6_Spy0023NC_006086
187Streptococcus pyogenes MGAS107502697 MGAS10750_Spy1713MGAS10750_Spy1714NC_008024
188Streptococcus pyogenes MGAS107502696 MGAS10750_Spy0835MGAS10750_Spy0836NC_008024
189Streptococcus pyogenes MGAS20962692 MGAS2096_Spy1490MGAS2096_Spy1489NC_008023
190Streptococcus pyogenes MGAS315620 SpyM3_0683SpyM3_0684NC_004070
191Streptococcus pyogenes MGAS315624 SpyM3_1456SpyM3_1455NC_004070
192Streptococcus pyogenes MGAS315623 SpyM3_1351SpyM3_1350NC_004070
193Streptococcus pyogenes MGAS315622 SpyM3_1264SpyM3_1263NC_004070
194Streptococcus pyogenes MGAS50051953 M5005_Spy_1465M5005_Spy_1464NC_007297
195Streptococcus pyogenes MGAS50051952 M5005_Spy_1220M5005_Spy_1219NC_007297
196Streptococcus pyogenes MGAS61801947 M28_Spy1331M28_Spy1330NC_007296
197Streptococcus pyogenes MGAS61801946 M28_Spy1283M28_Spy1282NC_007296
198Streptococcus pyogenes MGAS8232994 spyM18_0339spyM18_0340NC_003485
199Streptococcus pyogenes MGAS94292681 MGAS9429_Spy1467MGAS9429_Spy1466NC_008021
200Streptococcus pyogenes SSI-1709 SPs0513SPs0514NC_004606
201Streptococcus pyogenes SSI-1708 SPs0410SPs0411NC_004606
202Streptococcus pyogenes SSI-1710 SPs0599SPs0600NC_004606
203Streptococcus pyogenes SSI-1712 SPs1169SPs1168NC_004606
204Streptococcus pyogenes str. Manfredo3675 SpyM51068SpyM51067NC_009332
205Streptococcus pyogenes str. Manfredo3672 SpyM50473SpyM50474NC_009332
206Streptococcus pyogenes str. Manfredo3674 SpyM50633SpyM50634NC_009332
207Streptomyces avermitilis MA-4680 = NBRC 14893412 SAV_1743SAV_1742NC_003155
208Streptomyces avermitilis MA-4680 = NBRC 14893409 SAV_219SAV_218NC_003155
209Streptomyces griseus subsp. griseus NBRC 13350 (Streptomyces)5376 SGR_3515SGR_3514NC_010572
210Synechocystis sp. PCC 6803 (Synechocystis PCC 6803)1820 slr6057slr6056NC_005232
211Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112938 Swol_2003Swol_2004NC_008346
212Thermoanaerobacter tengcongensis MB4 (Caldanaerobacter subterraneus)771 TTE2126TTE2125NC_003869
213Trichodesmium erythraeum IMS1012870 Tery_2753Tery_2752NC_008312
214Verminephrobacter eiseniae EF01-23458 Veis_4660Veis_4661NC_008786
215Xanthobacter autotrophicus Py24422 Xaut_0551Xaut_0552NC_009720
216Xanthomonas axonopodis pv. citri str. 306737 XAC1494XAC1493NC_003919

experimental Data derived from experimental literature
T : predicted Zn-dependent protease. Often fused to AT domain. Frequent association with RelE and PIN toxins

Antitoxin domain: Xre. Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.

Toxin domain: COG2856. Predicted Zn peptidase [Amino acid transport and metabolism]


Structure
crystal structure of MazEF complex [PDB ID: 1UB4] [PudMed:12718874]
(1) Sayed N; Nonin-Lecomte S; Rety S; Felden B (2012) Functional and structural insights of a Staphylococcus aureus apoptotic-like membrane peptide from a toxin-antitoxin module J Biol Chem 287(52):43454-63. [PudMed:23129767] experimental
(2) Makarova KS et al. (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct 4:19. [PudMed:19493340] in_silico