TADB
TA Pair: HicB-HicA
#OrganismToxinAntitoxinLocus IDReplicon
1Acaryochloris marina MBIC110174644 AM1_C0133AM1_C0132NC_009928
2Acaryochloris marina MBIC110174633 AM1_4315AM1_4316NC_009925
3Acaryochloris marina MBIC110174639 AM1_6128AM1_6129NC_009925
4Acaryochloris marina MBIC110174642 AM1_A0132AM1_A0131NC_009926
5Acinetobacter baumannii ATCC 179783593 A1S_2020A1S_2019NC_009085
6Acinetobacter baumannii SDF5114 ABSDF2802ABSDF2803NC_010400
7Albidiferax ferrireducens T118 (Rhodoferax ferrireducens T118)2482 Rfer_0179Rfer_0180NC_007908
8Alkaliphilus metalliredigens QYMF4235 Amet_3356Amet_3355NC_009633
9Arcobacter butzleri RM40184544 Abu_1565Abu_1566NC_009850
10Azorhizobium caulinodans ORS 5714656 AZC_4230AZC_4231NC_009937
11Bacteroides fragilis YCH461303 BF2482BF2483NC_006347
12Bartonella henselae str. Houston-11643 BH03210BH03220NC_005956
13Bartonella henselae str. Houston-11646 BH03520BH03510NC_005956
14Bordetella parapertussis 128221293 BPP2078BPP2077NC_002928
15Bradyrhizobium sp. ORS 2783848 BRADO1669BRADO1670NC_009445
16Burkholderia pseudomallei K962431546 BPSS0390BPSS0391NC_006351
17Burkholderia pseudomallei K962436107 BPSS0390BPSS0391NC_006351
18Burkholderia thailandensis E2642309 BTH_II1999BTH_II1998NC_007650
19Burkholderia xenovorans LB4002605 Bxe_A0136Bxe_A0135NC_007951
20Caldicellulosiruptor saccharolyticus DSM 89033795 Csac_2107Csac_2108NC_009437
21Caldicellulosiruptor saccharolyticus DSM 89033785 Csac_0502Csac_0501NC_009437
22Caldicellulosiruptor saccharolyticus DSM 89033782 Csac_0200Csac_0201NC_009437
23Caldicellulosiruptor saccharolyticus DSM 89033781 Csac_0082Csac_0081NC_009437
24Campylobacter concisus 138264499 CCC13826_0618CCC13826_0619NC_009795
25Campylobacter curvus 525.924385 CCV52592_0383CCV52592_0384NC_009715
26Campylobacter hominis ATCC BAA-3814383 CHAB381_1471CHAB381_1472NC_009714
27Campylobacter jejuni subsp. doylei 269.974371 JJD26997_2035JJD26997_2034NC_009707
28Campylobacter jejuni subsp. jejuni 81-1763474 CJJ81176_pTet0022CJJ81176_pTet0021NC_008790
29Campylobacter jejuni subsp. jejuni 81-1763464 CJJ81176_0946CJJ81176_0947NC_008787
30Candidatus Desulforudis audaxviator MP104C5134 Daud_0769Daud_0768NC_010424
31Candidatus Solibacter usitatus Ellin60763067 Acid_1963Acid_1962NC_008536
32Candidatus Solibacter usitatus Ellin60763100 Acid_7792Acid_7793NC_008536
33Candidatus Solibacter usitatus Ellin60763096 Acid_7063Acid_7062NC_008536
34Candidatus Solibacter usitatus Ellin60763093 Acid_6545Acid_6544NC_008536
35Candidatus Solibacter usitatus Ellin60763075 Acid_3197Acid_3196NC_008536
36Carboxydothermus hydrogenoformans Z-29012087 CHY_2496CHY_2497NC_007503
37Chlorobium phaeobacteroides BS15679 Cphamn1_1946Cphamn1_1945NC_010831
38Chlorobium phaeobacteroides BS15678 Cphamn1_1936Cphamn1_1937NC_010831
39Chlorobium phaeobacteroides BS15681 Cphamn1_1951Cphamn1_1952NC_010831
40Chlorobium phaeobacteroides DSM 2663194 Cpha266_1441Cpha266_1440NC_008639
41Citrobacter koseri ATCC BAA-8954492 CKO_01475CKO_01476NC_009792
42Clavibacter michiganensis subsp. michiganensis NCPPB 3823919 pCM1_0001pCM1_0002NC_009478
43Clavibacter michiganensis subsp. sepedonicus5111 CMS_pCS0003CMS_pCS0004NC_010399
44Clostridium botulinum B str. Eklund 17B5498 CLL_A2288CLL_A2289NC_010674
45Clostridium kluyveri DSM 5553905 CKL_4037CKL_4036NC_009466
46Clostridium kluyveri DSM 5554363 CKL_1952CKL_1951NC_009706
47Clostridium kluyveri DSM 5554361 CKL_1854CKL_1853NC_009706
48Clostridium kluyveri DSM 5554368 CKL_3284CKL_3285NC_009706
49Cupriavidus metallidurans CH342647 Rmet_1077Rmet_1076NC_007973
50Cyanothece sp. ATCC 511425327 cce_2393cce_2394NC_010546
51Cyanothece sp. ATCC 511425323 cce_1958cce_1957NC_010546
52Cyanothece sp. ATCC 511425331 cce_2848cce_2847NC_010546
53Cyanothece sp. ATCC 511425320 cce_1504cce_1505NC_010546
54Cyanothece sp. ATCC 511425318 cce_1219cce_1218NC_010546
55Cyanothece sp. ATCC 511425326 cce_2178cce_2179NC_010546
56Cyanothece sp. ATCC 511425337 cce_3064cce_3063NC_010546
57Cyanothece sp. ATCC 511425328 cce_2581cce_2582NC_010546
58Cyanothece sp. PCC 74256163 Cyan7425_1350Cyan7425_1351NC_011884
59Desulfococcus oleovorans Hxd34664 Dole_0442Dole_0443NC_009943
60Desulfococcus oleovorans Hxd34684 Dole_2751Dole_2750NC_009943
61Desulfotalea psychrophila LSv541473 DP0410DP0409NC_006138
62Desulfotomaculum reducens MI-13654 Dred_2427Dred_2428NC_009253
63Desulfovibrio vulgaris str. Hildenborough1663 DVU0223DVU0224NC_002937
64Erythrobacter litoralis HTCC25942337 ELI_09115ELI_09120NC_007722
65Escherichia coli ATCC 87395160 EcolC_2222EcolC_2221NC_010468
66Escherichia coli HS4501 EcHS_A0257EcHS_A0256NC_009800
67Escherichia coli O157:H7 str. EDL933201 Z4883Z4882NC_002655
68Escherichia coli O157:H7 str. Sakai1017 ECs4357ECs4356NC_002695
69Escherichia coli str. K-12 substr. DH10B5167 ECDH10B_1567ECDH10B_1568NC_010473
70Escherichia coli str. K-12 substr. MG16551039 experimental b4532b1438NC_000913
71Finegoldia magna ATCC 293285090 FMG_1477FMG_1476NC_010376
72Finegoldia magna ATCC 293285088 FMG_0017FMG_0018NC_010376
73Frankia sp. CcI32374 Francci3_0669Francci3_0670NC_007777
74Frankia sp. EAN1pec4614 Franean1_5956Franean1_5957NC_009921
75Geobacter lovleyi SZ5620 Glov_0060Glov_0059NC_010814
76Geobacter lovleyi SZ5632 Glov_2138Glov_2139NC_010814
77Geobacter metallireducens GS-152167 Gmet_1322Gmet_1321NC_007517
78Geobacter metallireducens GS-152171 Gmet_2592Gmet_2591NC_007517
79Geobacter uraniireducens Rf43930 Gura_0555Gura_0554NC_009483
80Geobacter uraniireducens Rf43940 Gura_0843Gura_0842NC_009483
81Gluconobacter oxydans 621H1859 GOX2706GOX2707NC_006674
82Granulibacter bethesdensis CGDNIH12891 GbCGDNIH1_1516GbCGDNIH1_1517NC_008343
83Haemophilus ducreyi 35000HP1280 HD0911HD0910NC_002940
84Haemophilus influenzae 86-028NP1916 NTHI1426NTHI1427NC_007146
85Haemophilus influenzae PittEE4189 CGSHiEE_04600CGSHiEE_04595NC_009566
86Haemophilus influenzae PittEE4190 CGSHiEE_05735CGSHiEE_05730NC_009566
87Haemophilus somnus 129PT2861 HS_1395HS_1396NC_008309
88Haemophilus somnus 23365261 HSM_0890HSM_0889NC_010519
89Halobacterium salinarum R15079 OE1062FOE1060FNC_010364
90Helicobacter pylori HPAG12740 HPAG1_0203HPAG1_0204NC_008086
91Helicobacter pylori J9971 jhp0961jhp0960NC_000921
92Lactobacillus delbrueckii subsp. bulgaricus ATCC 118422728 Ldb0299Ldb0300NC_008054
93Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-3653037 LBUL_0253LBUL_0254NC_008529
94Legionella pneumophila str. Lens1841 plpl0035plpl0034NC_006366
95Maricaulis maris MCS102951 Mmar10_2094Mmar10_2095NC_008347
96Methanococcus maripaludis C64736 MmarC6_0020MmarC6_0021NC_009975
97Methanococcus maripaludis C74242 MmarC7_0034MmarC7_0033NC_009637
98Methanoculleus marisnigri JR13546 Memar_0546Memar_0547NC_009051
99Methanoculleus marisnigri JR13548 Memar_1098Memar_1097NC_009051
100Methanoculleus marisnigri JR13555 Memar_1246Memar_1245NC_009051
101Methanoregula boonei 6A84379 Mboo_1034Mboo_1035NC_009712
102Methanoregula boonei 6A84377 Mboo_0853Mboo_0852NC_009712
103Methanoregula boonei 6A84372 Mboo_0152Mboo_0153NC_009712
104Methanosarcina acetivorans C2A820 MA4126MA4125NC_003552
105Methanosarcina acetivorans C2A805 MA0765MA0764NC_003552
106Methanosarcina barkeri str. Fusaro1978 Mbar_A2121Mbar_A2122NC_007355
107Methanosarcina barkeri str. Fusaro1981 Mbar_A2364Mbar_A2363NC_007355
108Methanosarcina barkeri str. Fusaro1980 Mbar_A2354Mbar_A2353NC_007355
109Methanosarcina mazei Go1596 MM_1924MM_1923NC_003901
110Methanosarcina mazei Go1582 MM_0023MM_0022NC_003901
111Methanosarcina mazei Go1584 MM_0032MM_0031NC_003901
112Methanosarcina mazei Go1585 MM_0160MM_0161NC_003901
113Methanospirillum hungatei JF-12431 Mhun_0399Mhun_0398NC_007796
114Methanospirillum hungatei JF-12435 Mhun_0711Mhun_0712NC_007796
115Methanospirillum hungatei JF-12430 Mhun_0377Mhun_0378NC_007796
116Methanospirillum hungatei JF-12451 Mhun_2649Mhun_2648NC_007796
117Methanospirillum hungatei JF-12458 Mhun_2779Mhun_2778NC_007796
118Methanospirillum hungatei JF-12456 Mhun_2715Mhun_2716NC_007796
119Methanospirillum hungatei JF-12462 Mhun_3102Mhun_3101NC_007796
120Methylobacterium radiotolerans JCM 28315221 Mrad2831_5715Mrad2831_5716NC_010505
121Microcystis aeruginosa NIES-8435010 MAE_44030MAE_44020NC_010296
122Microcystis aeruginosa NIES-8434938 MAE_06560MAE_06570NC_010296
123Microcystis aeruginosa NIES-8434930 MAE_03760MAE_03750NC_010296
124Microcystis aeruginosa NIES-8434924 MAE_00130MAE_00140NC_010296
125Microcystis aeruginosa NIES-8434947 MAE_09140MAE_09130NC_010296
126Microcystis aeruginosa NIES-8434948 MAE_09180MAE_09170NC_010296
127Microcystis aeruginosa NIES-8434957 MAE_15420MAE_15410NC_010296
128Microcystis aeruginosa NIES-8434960 MAE_16310MAE_16320NC_010296
129Microcystis aeruginosa NIES-8434962 MAE_16370MAE_16380NC_010296
130Microcystis aeruginosa NIES-8434963 MAE_16430MAE_16440NC_010296
131Microcystis aeruginosa NIES-8434966 MAE_17900MAE_17890NC_010296
132Microcystis aeruginosa NIES-8434974 MAE_22690MAE_22700NC_010296
133Microcystis aeruginosa NIES-8434985 MAE_31920MAE_31910NC_010296
134Microcystis aeruginosa NIES-8434986 MAE_32390MAE_32400NC_010296
135Microcystis aeruginosa NIES-8435001 MAE_38200MAE_38210NC_010296
136Microcystis aeruginosa NIES-8435003 MAE_40080MAE_40070NC_010296
137Microcystis aeruginosa NIES-8435007 MAE_42890MAE_42900NC_010296
138Microcystis aeruginosa NIES-8435011 MAE_44090MAE_44100NC_010296
139Microcystis aeruginosa NIES-8435012 MAE_44160MAE_44150NC_010296
140Microcystis aeruginosa NIES-8435013 MAE_45360MAE_45370NC_010296
141Microcystis aeruginosa NIES-8435015 MAE_46130MAE_46140NC_010296
142Microcystis aeruginosa NIES-8435022 MAE_48640MAE_48630NC_010296
143Microcystis aeruginosa NIES-8435036 MAE_62820MAE_62810NC_010296
144Moorella thermoacetica ATCC 390732275 Moth_0250Moth_0249NC_007644
145Moorella thermoacetica ATCC 390732278 Moth_0298Moth_0299NC_007644
146Moorella thermoacetica ATCC 390732279 Moth_0484Moth_0483NC_007644
147Natronomonas pharaonis DSM 21602017 NP7004ANP7006ANC_007428
148Natronomonas pharaonis DSM 21602011 NP3280ANP3282ANC_007426
149Neisseria gonorrhoeae FA 10901756 NGO1628NGO1627NC_002946
150Neisseria gonorrhoeae NCCP119455821 NGK_1459NGK_1460NC_011035
151Nitrosococcus oceani ATCC 197072027 Noc_A0004Noc_A0003NC_007483
152Nitrosococcus oceani ATCC 197072055 Noc_2744Noc_2743NC_007484
153Nitrosococcus oceani ATCC 197072051 Noc_2241Noc_2242NC_007484
154Nitrosococcus oceani ATCC 197072044 Noc_1109Noc_1108NC_007484
155Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133)5464 Npun_R4600Npun_R4601NC_010628
156Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133)5450 Npun_F0827Npun_F0826NC_010628
157Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133)5459 Npun_F3501Npun_F3502NC_010628
158Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133)5468 Npun_R5487Npun_R5486NC_010628
159Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133)5467 Npun_F5369Npun_F5370NC_010628
160Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)464 asl1824asl1825NC_003272
161Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)489 asl4362asl4361NC_003272
162Ochrobactrum anthropi ATCC 491884327 Oant_0622Oant_0621NC_009667
163Pelobacter carbinolicus DSM 23802072 Pcar_0788Pcar_0789NC_007498
164Pelodictyon phaeoclathratiforme BU-15875 Ppha_2116Ppha_2115NC_011060
165Pelodictyon phaeoclathratiforme BU-15858 Ppha_1594Ppha_1593NC_011060
166Pelotomaculum thermopropionicum SI3871 PTH_0936PTH_0935NC_009454
167Pelotomaculum thermopropionicum SI3875 PTH_2501PTH_2500NC_009454
168Petrotoga mobilis SJ954777 Pmob_1240Pmob_1241NC_010003
169Photorhabdus luminescens subsp. laumondii TTO11235 plu3492plu3491NC_005126
170Photorhabdus luminescens subsp. laumondii TTO11194 plu0707plu0706NC_005126
171Propionibacterium acnes KPA1712021252 PPA0653PPA0655NC_006085
172Pseudomonas entomophila L482713 PSEEN5230PSEEN5229NC_008027
173Pseudomonas fluorescens Pf0-12064 Pfl01_0304Pfl01_0305NC_007492
174Pseudomonas putida W6195212 PputW619_3854PputW619_3853NC_010501
175Pseudomonas syringae pv. tomato str. DC30001060 PSPTO_1634PSPTO_1635NC_004578
176Pyrococcus furiosus DSM 3638554 PF1323PF1322NC_003413
177Rhodobacter sphaeroides ATCC 170293538 Rsph17029_3343Rsph17029_3342NC_009050
178Rhodopseudomonas palustris BisA532987 RPE_2136RPE_2135NC_008435
179Rhodopseudomonas palustris BisB182505 RPC_0973RPC_0972NC_007925
180Rhodopseudomonas palustris HaA22421 RPB_4579RPB_4580NC_007778
181Rhodopseudomonas palustris HaA22416 RPB_4129RPB_4130NC_007778
182Rhodopseudomonas palustris HaA22411 RPB_2527RPB_2528NC_007778
183Rhodopseudomonas palustris HaA22407 RPB_2021RPB_2020NC_007778
184Rhodospirillum rubrum ATCC 111702252 Rru_A1739Rru_A1738NC_007643
185Rickettsia akari str. Hartford4553 A1C_05470A1C_05465NC_009881
186Rickettsia conorii str. Malish 7360 RC1072RC1071NC_003103
187Rickettsia felis URRWXCal21888 RF_0215RF_0216NC_007109
188Rickettsia rickettsii str. Iowa4908 RrIowa_1276RrIowa_1275NC_010263
189Rickettsia rickettsii str. Sheila Smith4564 A1G_05945A1G_05940NC_009882
190Roseiflexus castenholzii DSM 139414442 Rcas_1007Rcas_1008NC_009767
191Roseiflexus sp. RS-14058 RoseRS_1788RoseRS_1787NC_009523
192Rubrobacter xylanophilus DSM 99412757 Rxyl_0587Rxyl_0586NC_008148
193Ruegeria sp. TM10402715 TM1040_1683TM1040_1684NC_008044
194Salinispora arenicola CNS-2054720 Sare_4922Sare_4921NC_009953
195Shewanella baltica OS1954751 Sbal195_4681Sbal195_4680NC_010000
196Sinorhizobium meliloti 1021875 SMc04441SMc04269NC_003047
197Sphingomonas wittichii RW14013 Swit_0047Swit_0046NC_009511
198Streptococcus agalactiae 2603V/R634 SAG1836SAG1835NC_004116
199Streptococcus pneumoniae G545901 SPG_1676SPG_1675NC_011072
200Streptococcus pneumoniae Hungary19A-65099 SPH_1904SPH_1903NC_010380
201Streptococcus pneumoniae R6729 spr1613spr1612NC_003098
202Streptococcus pneumoniae TIGR4328 SP_1787SP_1786NC_003028
203Streptococcus pyogenes MGAS102702684 MGAS10270_Spy0569MGAS10270_Spy0568NC_008022
204Streptococcus pyogenes MGAS107502695 MGAS10750_Spy0594MGAS10750_Spy0593NC_008024
205Streptococcus pyogenes MGAS8232998 spyM18_0747spyM18_0746NC_003485
206Streptococcus pyogenes MGAS94292679 MGAS9429_Spy0565MGAS9429_Spy0564NC_008021
207Streptococcus pyogenes str. Manfredo3676 SpyM51292SpyM51293NC_009332
208Synechococcus elongatus PCC 6301 (Synechococcus leopoliensis SAG)1631 syc0670_dsyc0669_dNC_006576
209Synechococcus elongatus PCC 79422192 Synpcc7942_0870Synpcc7942_0871NC_007604
210Synechocystis sp. PCC 6803961 ssr1766ssr1765NC_000911
211Syntrophobacter fumaroxidans MPOB3112 Sfum_0436Sfum_0435NC_008554
212Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112924 Swol_1010Swol_1009NC_008346
213Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112923 Swol_0794Swol_0795NC_008346
214Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112922 Swol_0621Swol_0620NC_008346
215Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112932 Swol_1661Swol_1660NC_008346
216Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112919 Swol_0573Swol_0572NC_008346
217Syntrophomonas wolfei subsp. wolfei str. Goettingen G3112910 Swol_0219Swol_0218NC_008346
218Thermococcus kodakarensis KOD11566 TK0371TK0372NC_006624
219Thermococcus kodakarensis KOD11590 TK1510TK1511NC_006624
220Thermotoga maritima MSB81324 experimental TM1312TM1311NC_000853
221Thermotoga petrophila RKU-13996 Tpet_1471Tpet_1470NC_009486
222Thermotoga sp. RQ25193 TRQ2_1512TRQ2_1511NC_010483
223Thermus thermophilus HB271615 TTC1549TTC1548NC_005835
224Thermus thermophilus HB271617 TTC1705TTC1704NC_005835
225Thermus thermophilus HB271613 TTC1395TTC1394NC_005835
226Thermus thermophilus HB81371 TTHA0932TTHA0933NC_006461
227Thermus thermophilus HB81380 TTHA1913TTHA1912NC_006461
228Thiobacillus denitrificans ATCC 252591995 Tbd_1974Tbd_1973NC_007404
229Treponema denticola ATCC 354051689 TDE0482TDE0481NC_002967
230Treponema denticola ATCC 354051713 TDE2252TDE2253NC_002967
231Treponema denticola ATCC 354051711 TDE2213TDE2214NC_002967
232Treponema denticola ATCC 354051698 TDE0989TDE0990NC_002967
233Treponema denticola ATCC 354051705 TDE1838TDE1837NC_002967
234Treponema denticola ATCC 354051687 TDE0452TDE0453NC_002967
235Vibrio vulnificus YJ0161804 VVP65VVP66NC_005128
236Xanthobacter autotrophicus Py24425 Xaut_2097Xaut_2098NC_009720
237Xylella fastidiosa M125249 Xfasm12_0422Xfasm12_0421NC_010513
238Xylella fastidiosa M235396 XfasM23_1427XfasM23_1426NC_010577
239Xylella fastidiosa Temecula1786 PD1343PD1342NC_004556
240Yersinia pestis Antiqua2774 YPA_2865YPA_2866NC_008150
241Yersinia pestis Antiqua2771 YPA_1193YPA_1192NC_008150
242Yersinia pestis biovar Microtus str. 910011395 YP_0318YP_0317NC_005810
243Yersinia pestis biovar Microtus str. 910011401 YP_1575YP_1576NC_005810
244Yersinia pestis KIM10+630 y2489y2490NC_004088
245Yersinia pestis Nepal5162761 YPN_0725YPN_0724NC_008149
246Yersinia pestis Nepal5162764 YPN_2306YPN_2307NC_008149
247Yersinia pseudotuberculosis IP 329531524 YPTB0763YPTB0762NC_006155
248Yersinia pseudotuberculosis PB1/+5478 YPTS_0796YPTS_0795NC_010634
249Yersinia pseudotuberculosis YPIII5150 YPK_3438YPK_3439NC_010465

experimental Data derived from experimental literature


Antitoxin domain: HicB. Predicted nuclease of the RNAse H fold, HicB family

Toxin domain: HicA. Predicted RNA binding protein (dsRBD-like fold), HicA family


Structure
N/A
(1) Jorgensen MG et al. (2009) HicA of Escherichia coli defines a novel family of translation-independent mRNAinterferases in bacteria and archaea. J Bacteriol 191(4):1191-9. [PudMed:19060138] experimental
(2) Frock AD; Montero CI; Blumer-Schuette SE; Kelly RM (2013) Stationary phase and nutrient levels trigger transcription of a genomic locus containing a novel peptide (TM1316) in the hyperthermophilic bacterium Thermotoga maritima Appl Environ Microbiol 79(21):6637-46. [PudMed:23974142] experimental
(3) Makarova KS et al. (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct 4:19. [PudMed:19493340] in_silico