TADB
TA Pair: ArsR-COG3832
#OrganismToxinAntitoxinLocus IDReplicon
1Acaryochloris marina MBIC110174628 AM1_2724AM1_2723NC_009925
2Agrobacterium tumefaciens str. C58347 Atu2033Atu2034NC_003062
3Agrobacterium tumefaciens str. C58346 Atu8169Atu2028NC_003062
4Agrobacterium tumefaciens str. C58343 Atu1628Atu1629NC_003062
5Anaeromyxobacter dehalogenans 2CP-C2345 Adeh_1211Adeh_1210NC_007760
6Anaeromyxobacter dehalogenans 2CP-C2351 Adeh_3813Adeh_3812NC_007760
7Anaeromyxobacter sp. Fw109-54348 Anae109_2806Anae109_2805NC_009675
8Anaeromyxobacter sp. Fw109-54343 Anae109_0483Anae109_0484NC_009675
9Anaeromyxobacter sp. Fw109-54344 Anae109_0511Anae109_0512NC_009675
10Anaeromyxobacter sp. Fw109-54346 Anae109_1064Anae109_1065NC_009675
11Anaeromyxobacter sp. Fw109-54345 Anae109_0603Anae109_0602NC_009675
12Anaeromyxobacter sp. K5938 AnaeK_3870AnaeK_3869NC_011145
13Anaeromyxobacter sp. K5936 AnaeK_2658AnaeK_2659NC_011145
14Arthrobacter aurescens TC13277 AAur_3427AAur_3428NC_008711
15Arthrobacter aurescens TC13278 AAur_3816AAur_3818NC_008711
16Arthrobacter aurescens TC13276 AAur_0771AAur_0770NC_008711
17Bacillus anthracis str. Ames618 BA_4963BA_4962NC_003997
18Bacillus anthracis str. Sterne1502 BAS4607BAS4606NC_005945
19Bacillus cereus ATCC 109871350 BCE_4853BCE_4852NC_003909
20Bacillus cereus ATCC 14579721 BC4709BC4708NC_004722
21Bacillus cereus E33L1360 BCZK4461BCZK4460NC_006274
22Bacillus clausii KSM-K161117 ABC0847ABC0848NC_006582
23Bacillus cytotoxicus NVH 391-984342 Bcer98_3374Bcer98_3373NC_009674
24Bacillus halodurans C-125187 BH2087BH2086NC_002570
25Bacillus halodurans C-125185 BH0695BH0694NC_002570
26Bacillus licheniformis DSM 13 = ATCC 145801286 BL00646BL00645NC_006270
27Bacillus thuringiensis serovar konkukian str. 97-271604 BT9727_4443BT9727_4442NC_005957
28Bacillus weihenstephanensis KBAB44900 BcerKBAB4_4542BcerKBAB4_4541NC_010184
29Bacillus weihenstephanensis KBAB44897 BcerKBAB4_2885BcerKBAB4_2886NC_010184
30Bdellovibrio bacteriovorus HD1001283 Bd3667Bd3666NC_005363
31Bordetella bronchiseptica RB501330 BB0935BB0936NC_002927
32Bordetella bronchiseptica RB501334 BB2401BB2400NC_002927
33Bordetella parapertussis 128221290 BPP1335BPP1334NC_002928
34Bordetella pertussis Tohama I1750 BP2144BP2145NC_002929
35Bordetella pertussis Tohama I1752 BP3465BP3466NC_002929
36Bordetella petrii DSM 128044866 Bpet3501Bpet3500NC_010170
37Bordetella petrii DSM 128044865 Bpet2983Bpet2982NC_010170
38Bradyrhizobium diazoefficiens USDA 110846 bll5290bll5291NC_004463
39Bradyrhizobium diazoefficiens USDA 110847 blr5653blr5652NC_004463
40Bradyrhizobium diazoefficiens USDA 110837 blr0847blr0846NC_004463
41Bradyrhizobium diazoefficiens USDA 110836 blr0610blr0609NC_004463
42Bradyrhizobium diazoefficiens USDA 110845 blr4003blr4004NC_004463
43Bradyrhizobium diazoefficiens USDA 110849 blr7360blr7359NC_004463
44Bradyrhizobium diazoefficiens USDA 110848 blr6751blr6750NC_004463
45Bradyrhizobium sp. ORS 2783845 BRADO0525BRADO0524NC_009445
46Bradyrhizobium sp. ORS 2783852 BRADO4708BRADO4707NC_009445
47Bradyrhizobium sp. ORS 2783849 BRADO2804BRADO2803NC_009445
48Bradyrhizobium sp. ORS 2783847 BRADO1342BRADO1343NC_009445
49Bradyrhizobium sp. ORS 2783850 BRADO2928BRADO2927NC_009445
50Burkholderia lata2097 Bcep18194_A4977Bcep18194_A4978NC_007510
51Burkholderia lata2092 Bcep18194_A3794Bcep18194_A3793NC_007510
52Burkholderia phytofirmans PsJN5506 Bphyt_5333Bphyt_5334NC_010676
53Burkholderia phytofirmans PsJN5508 Bphyt_5808Bphyt_5809NC_010676
54Burkholderia pseudomallei K962431551 BPSS1817BPSS1816NC_006351
55Burkholderia thailandensis E2642306 BTH_II0560BTH_II0561NC_007650
56Candidatus Amoebophilus asiaticus 5a25649 Aasi_0529Aasi_0528NC_010830
57Candidatus Koribacter versatilis Ellin3452673 Acid345_4594Acid345_4595NC_008009
58Candidatus Koribacter versatilis Ellin3452667 Acid345_3952Acid345_3951NC_008009
59Candidatus Solibacter usitatus Ellin60763076 Acid_3367Acid_3366NC_008536
60Candidatus Solibacter usitatus Ellin60763069 Acid_2291Acid_2292NC_008536
61Candidatus Solibacter usitatus Ellin60763078 Acid_4020Acid_4019NC_008536
62Candidatus Solibacter usitatus Ellin60763083 Acid_5224Acid_5223NC_008536
63Candidatus Solibacter usitatus Ellin60763065 Acid_1918Acid_1917NC_008536
64Candidatus Solibacter usitatus Ellin60763064 Acid_1897Acid_1896NC_008536
65Candidatus Solibacter usitatus Ellin60763063 Acid_1876Acid_1877NC_008536
66Candidatus Solibacter usitatus Ellin60763061 Acid_1573Acid_1574NC_008536
67Candidatus Solibacter usitatus Ellin60763074 Acid_3037Acid_3036NC_008536
68Cellvibrio japonicus Ueda1075766 CJA_3741CJA_3742NC_010995
69Cupriavidus metallidurans CH342649 Rmet_1798Rmet_1799NC_007973
70Cupriavidus metallidurans CH342652 Rmet_2501Rmet_2500NC_007973
71Cytophaga hutchinsonii ATCC 334062818 CHU_2913CHU_2912NC_008255
72Cytophaga hutchinsonii ATCC 334062815 CHU_1110CHU_1109NC_008255
73Cytophaga hutchinsonii ATCC 334062816 CHU_1424CHU_1423NC_008255
74Delftia acidovorans SPH-14759 Daci_2051Daci_2050NC_010002
75Flavobacterium johnsoniae UW1013833 Fjoh_2148Fjoh_2149NC_009441
76Flavobacterium johnsoniae UW1013834 Fjoh_2828Fjoh_2829NC_009441
77Frankia alni ACN14a2852 FRAAL3029FRAAL3030NC_008278
78Frankia sp. CcI32392 Francci3_2808Francci3_2809NC_007777
79Frankia sp. EAN1pec4611 Franean1_4113Franean1_4112NC_009921
80Frankia sp. EAN1pec4607 Franean1_1534Franean1_1535NC_009921
81Gloeobacter violaceus PCC 74211427 gll1436gll1437NC_005125
82Hahella chejuensis KCTC 23962299 HCH_03204HCH_03203NC_007645
83Herpetosiphon aurantiacus DSM 7854734 Haur_1072Haur_1071NC_009972
84Hyphomonas neptunium ATCC 154442954 HNE_0059HNE_0058NC_008358
85Jannaschia sp. CCS12465 Jann_0561Jann_0562NC_007802
86Jannaschia sp. CCS12466 Jann_0938Jann_0939NC_007802
87Jannaschia sp. CCS12470 Jann_3408Jann_3407NC_007802
88Jannaschia sp. CCS12468 Jann_2413Jann_2412NC_007802
89Janthinobacterium sp. Marseille4282 mma_1897mma_1896NC_009659
90Kineococcus radiotolerans SRS30216 = ATCC BAA-1494311 Krad_1975Krad_1974NC_009664
91Leptospira biflexa serovar Patoc strain Patoc 1 (Ames)5693 LBF_0206LBF_0207NC_010842
92Leptospira biflexa serovar Patoc strain Patoc 1 (Ames)5694 LBF_0412LBF_0411NC_010842
93Leptospira biflexa serovar Patoc strain Patoc 1 (Ames)5713 LBF_3230LBF_3231NC_010842
94Leptospira biflexa serovar Patoc strain Patoc 1 (Ames)5710 LBF_2785LBF_2786NC_010842
95Leptospira biflexa serovar Patoc strain Patoc 1 (Paris)5433 LEPBI_I2884LEPBI_I2885NC_010602
96Leptospira biflexa serovar Patoc strain Patoc 1 (Paris)5437 LEPBI_I3344LEPBI_I3345NC_010602
97Leptospira biflexa serovar Patoc strain Patoc 1 (Paris)5420 LEPBI_I0431LEPBI_I0430NC_010602
98Leptospira biflexa serovar Patoc strain Patoc 1 (Paris)5419 LEPBI_I0211LEPBI_I0212NC_010602
99Leptospira borgpetersenii serovar Hardjo-bovis str. JB1973028 LBJ_2728LBJ_2727NC_008510
100Leptospira borgpetersenii serovar Hardjo-bovis str. L5503015 LBL_0342LBL_0343NC_008508
101Leptospira interrogans serovar Copenhageni str. Fiocruz L1-1301520 LIC13407LIC13408NC_005823
102Maricaulis maris MCS102945 Mmar10_1144Mmar10_1143NC_008347
103Maricaulis maris MCS102947 Mmar10_1556Mmar10_1557NC_008347
104Maricaulis maris MCS102950 Mmar10_2052Mmar10_2053NC_008347
105Mesorhizobium loti MAFF303099223 mlr8183mlr8182NC_002678
106Mesorhizobium loti MAFF303099204 mlr0746mlr0745NC_002678
107Mesorhizobium loti MAFF303099211 mlr2174mlr2173NC_002678
108Mesorhizobium loti MAFF303099213 mll2253mll2255NC_002678
109Mesorhizobium loti MAFF303099215 mll3558mll3559NC_002678
110Mesorhizobium loti MAFF303099216 mll3774mll3772NC_002678
111Mesorhizobium loti MAFF303099219 mll5358mll5360NC_002678
112Methylobacterium sp. 4-465242 M446_2321M446_2320NC_010511
113Mycobacterium abscessus5105 MAB_2015cMAB_2014cNC_010397
114Mycobacterium abscessus5106 MAB_2387MAB_2386NC_010397
115Mycobacterium abscessus5107 MAB_3376MAB_3375NC_010397
116Mycobacterium abscessus5108 MAB_3863MAB_3862NC_010397
117Mycobacterium abscessus5109 MAB_4140MAB_4139NC_010397
118Mycobacterium avium 1043164 MAV_2784MAV_2783NC_008595
119Mycobacterium avium subsp. paratuberculosis K-101326 MAP1640cMAP1641cNC_002944
120Mycobacterium bovis AF2122/971155 Mb2061Mb2060NC_002945
121Mycobacterium bovis BCG str. Pasteur 1173P23362 BCG_2054BCG_2053NC_008769
122Mycobacterium gilvum PYR-GCK3688 Mflv_3316Mflv_3317NC_009338
123Mycobacterium gilvum PYR-GCK3687 Mflv_3233Mflv_3234NC_009338
124Mycobacterium smegmatis str. MC2 1553166 MSMEG_4176MSMEG_4175NC_008596
125Mycobacterium smegmatis str. MC2 1553168 MSMEG_6760MSMEG_6762NC_008596
126Mycobacterium sp. JLS3588 Mjls_5736Mjls_5737NC_009077
127Mycobacterium sp. JLS3585 Mjls_3529Mjls_3530NC_009077
128Mycobacterium sp. JLS3584 Mjls_2366Mjls_2365NC_009077
129Mycobacterium sp. JLS3583 Mjls_1167Mjls_1168NC_009077
130Mycobacterium sp. JLS3581 Mjls_0384Mjls_0383NC_009077
131Mycobacterium sp. KMS3267 Mkms_1157Mkms_1158NC_008705
132Mycobacterium sp. KMS3268 Mkms_2374Mkms_2373NC_008705
133Mycobacterium sp. KMS3269 Mkms_3597Mkms_3598NC_008705
134Mycobacterium sp. KMS3270 Mkms_5448Mkms_5449NC_008705
135Mycobacterium sp. KMS3265 Mkms_0405Mkms_0404NC_008705
136Mycobacterium sp. MCS2748 Mmcs_0396Mmcs_0395NC_008146
137Mycobacterium sp. MCS2752 Mmcs_5358Mmcs_5359NC_008146
138Mycobacterium sp. MCS2751 Mmcs_3524Mmcs_3525NC_008146
139Mycobacterium sp. MCS2750 Mmcs_2327Mmcs_2326NC_008146
140Mycobacterium sp. MCS2749 Mmcs_1140Mmcs_1141NC_008146
141Mycobacterium tuberculosis CDC1551271 MT2095MT2094NC_002755
142Mycobacterium tuberculosis F114168 TBFG_12072TBFG_12071NC_009565
143Mycobacterium tuberculosis H37Ra4116 MRA_2050MRA_2049NC_009525
144Mycobacterium tuberculosis H37Rv110 Rv2035Rv2034NC_000962
145Mycobacterium ulcerans Agy993175 MUL_2936MUL_2937NC_008611
146Mycobacterium vanbaalenii PYR-13279 Mvan_0694Mvan_0693NC_008726
147Mycobacterium vanbaalenii PYR-13292 Mvan_5890Mvan_5891NC_008726
148Mycobacterium vanbaalenii PYR-13285 Mvan_2637Mvan_2636NC_008726
149Mycobacterium vanbaalenii PYR-13291 Mvan_5507Mvan_5506NC_008726
150Mycobacterium vanbaalenii PYR-13288 Mvan_3038Mvan_3039NC_008726
151Myxococcus xanthus DK 16222743 MXAN_6276MXAN_6275NC_008095
152Myxococcus xanthus DK 16222742 MXAN_5618MXAN_5617NC_008095
153Myxococcus xanthus DK 16222744 MXAN_7502MXAN_7501NC_008095
154Myxococcus xanthus DK 16222741 MXAN_2836MXAN_2835NC_008095
155Nitrosomonas europaea ATCC 19718891 NE0264NE0263NC_004757
156Nocardia farcinica IFM 101521081 nfa4700nfa4690NC_006361
157Nocardia farcinica IFM 101521089 nfa30860nfa30870NC_006361
158Nocardia farcinica IFM 101521090 nfa35510nfa35500NC_006361
159Nocardia farcinica IFM 101521086 nfa22970nfa22980NC_006361
160Nocardia farcinica IFM 101521092 nfa50940nfa50950NC_006361
161Nocardia farcinica IFM 101521091 nfa37010nfa37000NC_006361
162Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133)5475 Npun_BR165Npun_BR166NC_010632
163Novosphingobium aromaticivorans DSM 124442425 Saro_2212Saro_2213NC_007794
164Ochrobactrum anthropi ATCC 491884324 Oant_0481Oant_0482NC_009667
165Ochrobactrum anthropi ATCC 491884330 Oant_2550Oant_2551NC_009667
166Opitutus terrae PB90-15371 Oter_1306Oter_1305NC_010571
167Paracoccus denitrificans PD12223210 Pden_1215Pden_1214NC_008686
168Parvibaculum lavamentivorans DS-14410 Plav_2390Plav_2391NC_009719
169Parvibaculum lavamentivorans DS-14414 Plav_2931Plav_2932NC_009719
170Parvibaculum lavamentivorans DS-14413 Plav_2670Plav_2671NC_009719
171Parvibaculum lavamentivorans DS-14411 Plav_2508Plav_2507NC_009719
172Parvibaculum lavamentivorans DS-14409 Plav_2388Plav_2387NC_009719
173Polaromonas sp. JS6662578 Bpro_1366Bpro_1365NC_007948
174Ralstonia pickettii 12J5512 Rpic_4711Rpic_4710NC_010678
175Ralstonia solanacearum GMI1000504 RSc0992RSc0993NC_003295
176Ralstonia solanacearum GMI1000506 RSc1959RSc1960NC_003295
177Renibacterium salmoninarum ATCC 332094851 RSal33209_0066RSal33209_0067NC_010168
178Renibacterium salmoninarum ATCC 332094853 RSal33209_0530RSal33209_0529NC_010168
179Renibacterium salmoninarum ATCC 332094854 RSal33209_1411RSal33209_1412NC_010168
180Renibacterium salmoninarum ATCC 332094855 RSal33209_1569RSal33209_1570NC_010168
181Rhizobium etli CFN 422364 RHE_PE00139RHE_PE00138NC_007765
182Rhizobium etli CFN 422356 RHE_CH02424RHE_CH02425NC_007761
183Rhizobium etli CFN 422355 RHE_CH01413RHE_CH01412NC_007761
184Rhizobium etli CFN 422354 RHE_CH01078RHE_CH01079NC_007761
185Rhizobium etli CFN 422353 RHE_CH01075RHE_CH01076NC_007761
186Rhizobium etli CFN 422357 RHE_CH02430RHE_CH02431NC_007761
187Rhizobium etli CIAT 6525741 RHECIAT_CH0002523RHECIAT_CH0002524NC_010994
188Rhizobium etli CIAT 6525771 RHECIAT_PA0000125RHECIAT_PA0000126NC_010998
189Rhizobium etli CIAT 6525743 RHECIAT_CH0002953RHECIAT_CH0002952NC_010994
190Rhizobium etli CIAT 6525742 RHECIAT_CH0002528RHECIAT_CH0002529NC_010994
191Rhodococcus jostii RHA12834 RHA1_ro03808RHA1_ro03807NC_008268
192Rhodococcus jostii RHA12841 RHA1_ro07126RHA1_ro07127NC_008268
193Rhodococcus jostii RHA12840 RHA1_ro06924RHA1_ro06925NC_008268
194Rhodococcus jostii RHA12837 RHA1_ro05224RHA1_ro05225NC_008268
195Rhodococcus jostii RHA12836 RHA1_ro04215RHA1_ro04214NC_008268
196Rhodococcus jostii RHA12835 RHA1_ro04123RHA1_ro04124NC_008268
197Rhodococcus jostii RHA12832 RHA1_ro03046RHA1_ro03047NC_008268
198Rhodococcus jostii RHA12831 RHA1_ro01531RHA1_ro01532NC_008268
199Rhodopseudomonas palustris BisB52625 RPD_3982RPD_3981NC_007958
200Rhodopseudomonas palustris CGA0091478 RPA1281RPA1282NC_005296
201Rhodopseudomonas palustris TIE-15783 Rpal_1474Rpal_1475NC_011004
202Ruegeria pomeroyi DSS-31770 SPO3351SPO3352NC_003911
203Saccharophagus degradans 2-402489 Sde_1839Sde_1838NC_007912
204Saccharopolyspora erythraea NRRL 23383627 SACE_5772SACE_5771NC_009142
205Saccharopolyspora erythraea NRRL 23383636 SACE_7307SACE_7306NC_009142
206Saccharopolyspora erythraea NRRL 23383637 SACE_7313SACE_7314NC_009142
207Saccharopolyspora erythraea NRRL 23383621 SACE_3780SACE_3779NC_009142
208Saccharopolyspora erythraea NRRL 23383630 SACE_6153SACE_6152NC_009142
209Salinispora arenicola CNS-2054699 Sare_1205Sare_1204NC_009953
210Salinispora arenicola CNS-2054694 Sare_0240Sare_0241NC_009953
211Salinispora arenicola CNS-2054703 Sare_1540Sare_1541NC_009953
212Salinispora arenicola CNS-2054707 Sare_2108Sare_2109NC_009953
213Salinispora arenicola CNS-2054717 Sare_4629Sare_4628NC_009953
214Salinispora tropica CNB-4403747 Strop_2048Strop_2047NC_009380
215Salinispora tropica CNB-4403751 Strop_2682Strop_2681NC_009380
216Salinispora tropica CNB-4403736 Strop_0606Strop_0607NC_009380
217Serratia proteamaculans 5684527 Spro_1977Spro_1976NC_009832
218Serratia proteamaculans 5684529 Spro_2557Spro_2556NC_009832
219Sinorhizobium medicae WSM4194221 Smed_4182Smed_4181NC_009620
220Sinorhizobium medicae WSM4194223 Smed_4503Smed_4502NC_009620
221Sinorhizobium meliloti 1021874 SMc04161SMc04162NC_003047
222Sinorhizobium meliloti 1021885 SMc03842SMc03843NC_003047
223Sorangium cellulosum So ce564845 sce6060sce6059NC_010162
224Sorangium cellulosum So ce564844 sce5717sce5716NC_010162
225Sorangium cellulosum So ce564842 sce4169sce4170NC_010162
226Sorangium cellulosum So ce564839 sce2341sce2340NC_010162
227Sorangium cellulosum So ce564838 sce1405sce1404NC_010162
228Sorangium cellulosum So ce564836 sce1128sce1129NC_010162
229Sorangium cellulosum So ce564835 sce1126sce1127NC_010162
230Sorangium cellulosum So ce564848 sce8845sce8846NC_010162
231Sorangium cellulosum So ce564847 sce6313sce6312NC_010162
232Sphingomonas wittichii RW14021 Swit_2245Swit_2244NC_009511
233Sphingomonas wittichii RW14016 Swit_1189Swit_1190NC_009511
234Sphingomonas wittichii RW14015 Swit_0626Swit_0625NC_009511
235Sphingopyxis alaskensis RB22562720 Sala_0968Sala_0967NC_008048
236Sphingopyxis alaskensis RB22562721 Sala_1801Sala_1802NC_008048
237Stenotrophomonas maltophilia K279a5728 Smlt1818Smlt1817NC_010943
238Stenotrophomonas maltophilia K279a5730 Smlt2089Smlt2090NC_010943
239Stenotrophomonas maltophilia R551-35894 Smal_1683Smal_1684NC_011071
240Stenotrophomonas maltophilia R551-35896 Smal_2791Smal_2792NC_011071
241Streptomyces coelicolor A3(2)574 SCO5759SCO5758NC_003888
242Streptomyces coelicolor A3(2)567 SCO4058SCO4059NC_003888
243Streptomyces griseus subsp. griseus NBRC 13350 (Streptomyces)5374 SGR_1242SGR_1243NC_010572
244Symbiobacterium thermophilum IAM 148631343 STH2148STH2149NC_006177
T : Cyclase/dehydratase family protein. (PDB: 1xuv) START domain superfamily

Antitoxin domain: ArsR. Predicted transcriptional regulators [Transcription]

Toxin domain: COG3832. Uncharacterized conserved protein [Function unknown]


Structure
Crystal structure of a member of the VapBC family of toxin-antitoxin systems, VapBC-5, from Mycobacterium tuberculosis [PDB ID: 3DBO] [PudMed:18952600]
Crystal Structure of Rv0301(Antitoxin)-Rv0300 (Toxin) Toxin-Antitoxin Complex ( vapBC family) from Mycobacterium tuberculosis [PDB ID: 3H87]
(1) Makarova KS et al. (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct 4:19. [PudMed:19493340] in_silico