TADB
TA Pair: Xre-Bro
#OrganismToxinAntitoxinLocus IDReplicon
1Bacillus anthracis str. Ames616 BA_3827BA_3828NC_003997
2Bacillus anthracis str. Sterne1500 BAS3543BAS3544NC_005945
3Bacillus cereus ATCC 14579720 BC3702BC3703NC_004722
4Bacillus cereus E33L1358 BCZK3457BCZK3458NC_006274
5Bacillus clausii KSM-K161120 ABC2855ABC2856NC_006582
6Bacillus cytotoxicus NVH 391-984340 Bcer98_2967Bcer98_2968NC_009674
7Bacillus thuringiensis str. Al Hakam3169 BALH_p0023BALH_p0024NC_008598
8Bacillus weihenstephanensis KBAB44898 BcerKBAB4_3463BcerKBAB4_3464NC_010184
9Bacillus weihenstephanensis KBAB44895 BcerKBAB4_5813BcerKBAB4_5812NC_010183
10Bartonella bacilliformis KC5833423 BARBAKC583_1070BARBAKC583_1068NC_008783
11Clostridium acetobutylicum ATCC 824332 CA_C1945CA_C1946NC_003030
12Clostridium botulinum A str. ATCC 35024005 CBO2389CBO2390NC_009495
13Clostridium botulinum A str. ATCC 35024004 CBO1683CBO1682NC_009495
14Clostridium botulinum B str. Eklund 17B5499 CLL_A2788CLL_A2789NC_010674
15Clostridium botulinum E3 str. Alaska E435540 CLH_2506CLH_2507NC_010723
16Clostridium kluyveri DSM 5554360 CKL_1847CKL_1848NC_009706
17Clostridium kluyveri DSM 5554369 CKL_3310CKL_3311NC_009706
18Clostridium kluyveri DSM 5554362 CKL_1910CKL_1911NC_009706
19Clostridium novyi NT3161 NT01CX_2199NT01CX_2200NC_008593
20Clostridium perfringens ATCC 131242827 CPF_0930CPF_0929NC_008261
21Clostridium thermocellum ATCC 274053523 Cthe_2462Cthe_2461NC_009012
22Desulfotomaculum reducens MI-13656 Dred_2622Dred_2623NC_009253
23Gluconobacter oxydans 621H1352 GOX2472GOX2471NC_006677
24Lactobacillus gasseri ATCC 333233043 LGAS_0585LGAS_0584NC_008530
25Lactobacillus gasseri ATCC 333233045 LGAS_0647LGAS_0646NC_008530
26Lactobacillus johnsonii NCC 5331726 LJ1455LJ1456NC_005362
27Lactobacillus johnsonii NCC 5331724 LJ0295LJ0294bNC_005362
28Lactobacillus reuteri DSM 200164039 Lreu_0803Lreu_0802NC_009513
29Lactobacillus reuteri DSM 200164040 Lreu_1142Lreu_1143NC_009513
30Lactobacillus reuteri JCM 11125440 LAR_0772LAR_0771NC_010609
31Lactobacillus reuteri JCM 11125441 LAR_1077LAR_1078NC_010609
32Lactobacillus salivarius UCC1182544 LSL_0251LSL_0250NC_007929
33Lactococcus lactis subsp. cremoris MG13633516 llmg_2134llmg_2135NC_009004
34Lactococcus lactis subsp. cremoris SK113035 LACR_2135LACR_2136NC_008527
35Lactococcus lactis subsp. lactis Il14031739 L52331L53055NC_002662
36Lactococcus lactis subsp. lactis Il14031738 L39625L39394NC_002662
37Pseudomonas putida KT2440311 PP_3032PP_3033NC_002947
38Staphylococcus aureus RF1222225 SAB1755cSAB1756cNC_007622
39Staphylococcus haemolyticus JCSC14351919 SH1803SH1804NC_007168
40Staphylococcus saprophyticus subsp. saprophyticus ATCC 153051974 SSP1944SSP1945NC_007350
41Streptococcus agalactiae 2603V/R633 SAG0555SAG0554NC_004116
42Streptococcus pneumoniae Hungary19A-65092 SPH_0034SPH_0035NC_010380
43Streptococcus pneumoniae Hungary19A-65094 SPH_0075SPH_0074NC_010380
44Streptococcus pyogenes M1 GAS748 SPy_2128SPy_2127NC_002737
45Streptococcus pyogenes MGAS103941640 M6_Spy1808M6_Spy1807NC_006086
46Streptococcus pyogenes MGAS107502699 MGAS10750_Spy1901MGAS10750_Spy1900NC_008024
47Streptococcus pyogenes MGAS315621 SpyM3_0687SpyM3_0688NC_004070
48Streptococcus pyogenes MGAS82321000 spyM18_1802spyM18_1804NC_003485
49Streptococcus pyogenes MGAS8232995 spyM18_0344spyM18_0345NC_003485
50Streptococcus pyogenes MGAS8232997 spyM18_0723spyM18_0722NC_003485
51Streptococcus pyogenes MGAS94292680 MGAS9429_Spy0799MGAS9429_Spy0798NC_008021
52Streptococcus pyogenes SSI-1711 SPs1163SPs1162NC_004606
53Streptococcus pyogenes str. Manfredo3677 SpyM51316SpyM51317NC_009332
54Streptococcus pyogenes str. Manfredo3673 SpyM50476SpyM50475NC_009332


Antitoxin domain: Xre. Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.

Toxin domain: Bro.


Structure
Structure of DocH66Y dimer. Doc of phage P1 adopts an incomplete Fic fold that is complemented by its antitoxin Phd. [PDB ID: 3DD9]
Structure of DocH66Y in complex with the C-terminal domain of Phd [PDB ID: 3DD7] [PudMed:18757857]
(1) Makarova KS et al. (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct 4:19. [PudMed:19493340] in_silico