TADB
TA Pair: Xre-DUF397
#OrganismToxinAntitoxinLocus IDReplicon
1Frankia alni ACN14a2857 FRAAL6351FRAAL6352NC_008278
2Frankia alni ACN14a2855 FRAAL5501FRAAL5502NC_008278
3Frankia alni ACN14a2847 FRAAL0517FRAAL0518NC_008278
4Frankia sp. CcI32390 Francci3_2703Francci3_2702NC_007777
5Frankia sp. CcI32386 Francci3_2266Francci3_2267NC_007777
6Frankia sp. CcI32382 Francci3_1781Francci3_1780NC_007777
7Frankia sp. CcI32373 Francci3_0397Francci3_0398NC_007777
8Frankia sp. CcI32370 Francci3_0228Francci3_0229NC_007777
9Frankia sp. EAN1pec4617 Franean1_6649Franean1_6648NC_009921
10Frankia sp. EAN1pec4601 Franean1_0037Franean1_0036NC_009921
11Frankia sp. EAN1pec4605 Franean1_0906Franean1_0907NC_009921
12Frankia sp. EAN1pec4606 Franean1_1329Franean1_1328NC_009921
13Nocardia farcinica IFM 101521079 nfa3330nfa3320NC_006361
14Nocardia farcinica IFM 101521095 nfa56410nfa56420NC_006361
15Nocardia farcinica IFM 101521094 nfa56100nfa56110NC_006361
16Nocardia farcinica IFM 101521088 nfa26010nfa26020NC_006361
17Nocardia farcinica IFM 101521082 nfa4930nfa4940NC_006361
18Saccharopolyspora erythraea NRRL 23383618 SACE_3347SACE_3348NC_009142
19Saccharopolyspora erythraea NRRL 23383631 SACE_6212SACE_6211NC_009142
20Saccharopolyspora erythraea NRRL 23383629 SACE_5846SACE_5847NC_009142
21Saccharopolyspora erythraea NRRL 23383626 SACE_5740SACE_5739NC_009142
22Saccharopolyspora erythraea NRRL 23383625 SACE_5625SACE_5626NC_009142
23Saccharopolyspora erythraea NRRL 23383624 SACE_5411SACE_5410NC_009142
24Saccharopolyspora erythraea NRRL 23383623 SACE_5304SACE_5305NC_009142
25Saccharopolyspora erythraea NRRL 23383620 SACE_3734SACE_3733NC_009142
26Saccharopolyspora erythraea NRRL 23383619 SACE_3664SACE_3663NC_009142
27Saccharopolyspora erythraea NRRL 23383616 SACE_2221SACE_2220NC_009142
28Saccharopolyspora erythraea NRRL 23383615 SACE_1896SACE_1895NC_009142
29Saccharopolyspora erythraea NRRL 23383614 SACE_1545SACE_1546NC_009142
30Saccharopolyspora erythraea NRRL 23383613 SACE_1379SACE_1378NC_009142
31Saccharopolyspora erythraea NRRL 23383611 SACE_1220SACE_1219NC_009142
32Saccharopolyspora erythraea NRRL 23383610 SACE_0865SACE_0864NC_009142
33Saccharopolyspora erythraea NRRL 23383609 SACE_0301SACE_0300NC_009142
34Saccharopolyspora erythraea NRRL 23383608 SACE_0267SACE_0268NC_009142
35Saccharopolyspora erythraea NRRL 23383607 SACE_0169SACE_0170NC_009142
36Saccharopolyspora erythraea NRRL 23383635 SACE_7129SACE_7130NC_009142
37Saccharopolyspora erythraea NRRL 23383634 SACE_6741SACE_6742NC_009142
38Saccharopolyspora erythraea NRRL 23383633 SACE_6608SACE_6607NC_009142
39Salinispora arenicola CNS-2054692 Sare_0042Sare_0041NC_009953
40Salinispora arenicola CNS-2054693 Sare_0099Sare_0098NC_009953
41Salinispora arenicola CNS-2054695 Sare_0599Sare_0600NC_009953
42Salinispora arenicola CNS-2054697 Sare_0927Sare_0926NC_009953
43Salinispora arenicola CNS-2054700 Sare_1301Sare_1300NC_009953
44Salinispora arenicola CNS-2054701 Sare_1379Sare_1378NC_009953
45Salinispora arenicola CNS-2054702 Sare_1432Sare_1433NC_009953
46Salinispora arenicola CNS-2054704 Sare_1548Sare_1547NC_009953
47Salinispora arenicola CNS-2054705 Sare_1728Sare_1729NC_009953
48Salinispora arenicola CNS-2054719 Sare_4869Sare_4868NC_009953
49Salinispora arenicola CNS-2054706 Sare_1786Sare_1787NC_009953
50Salinispora arenicola CNS-2054708 Sare_2128Sare_2127NC_009953
51Salinispora arenicola CNS-2054709 Sare_2231Sare_2232NC_009953
52Salinispora arenicola CNS-2054711 Sare_2601Sare_2602NC_009953
53Salinispora arenicola CNS-2054712 Sare_2969Sare_2968NC_009953
54Salinispora arenicola CNS-2054698 Sare_1159Sare_1160NC_009953
55Salinispora arenicola CNS-2054715 Sare_4124Sare_4123NC_009953
56Salinispora tropica CNB-4403760 Strop_4568Strop_4567NC_009380
57Salinispora tropica CNB-4403733 Strop_0037Strop_0036NC_009380
58Salinispora tropica CNB-4403734 Strop_0103Strop_0102NC_009380
59Salinispora tropica CNB-4403735 Strop_0513Strop_0512NC_009380
60Salinispora tropica CNB-4403737 Strop_0643Strop_0644NC_009380
61Salinispora tropica CNB-4403740 Strop_1132Strop_1133NC_009380
62Salinispora tropica CNB-4403741 Strop_1269Strop_1270NC_009380
63Salinispora tropica CNB-4403742 Strop_1416Strop_1415NC_009380
64Salinispora tropica CNB-4403743 Strop_1517Strop_1518NC_009380
65Salinispora tropica CNB-4403744 Strop_1588Strop_1587NC_009380
66Salinispora tropica CNB-4403745 Strop_1745Strop_1746NC_009380
67Salinispora tropica CNB-4403746 Strop_1897Strop_1898NC_009380
68Salinispora tropica CNB-4403748 Strop_2090Strop_2091NC_009380
69Salinispora tropica CNB-4403750 Strop_2448Strop_2449NC_009380
70Salinispora tropica CNB-4403752 Strop_3009Strop_3010NC_009380
71Salinispora tropica CNB-4403754 Strop_3657Strop_3658NC_009380
72Salinispora tropica CNB-4403755 Strop_3743Strop_3742NC_009380
73Salinispora tropica CNB-4403757 Strop_4235Strop_4236NC_009380
74Salinispora tropica CNB-4403758 Strop_4463Strop_4464NC_009380
75Salinispora tropica CNB-4403759 Strop_4504Strop_4505NC_009380
76Streptomyces avermitilis MA-4680 = NBRC 14893435 SAV_7095SAV_7096NC_003155
77Streptomyces avermitilis MA-4680 = NBRC 14893411 SAV_1047SAV_1048NC_003155
78Streptomyces avermitilis MA-4680 = NBRC 14893421 SAV_4088SAV_4087NC_003155
79Streptomyces avermitilis MA-4680 = NBRC 14893420 SAV_4049SAV_4050NC_003155
80Streptomyces avermitilis MA-4680 = NBRC 14893419 SAV_3784SAV_3783NC_003155
81Streptomyces avermitilis MA-4680 = NBRC 14893418 SAV_3615SAV_3617NC_003155
82Streptomyces avermitilis MA-4680 = NBRC 14893417 SAV_3426SAV_3425NC_003155
83Streptomyces avermitilis MA-4680 = NBRC 14893415 SAV_3142SAV_3141NC_003155
84Streptomyces avermitilis MA-4680 = NBRC 14893414 SAV_2799SAV_2798NC_003155
85Streptomyces avermitilis MA-4680 = NBRC 14893413 SAV_2176SAV_2175NC_003155
86Streptomyces avermitilis MA-4680 = NBRC 14893423 SAV_4472SAV_4471NC_003155
87Streptomyces avermitilis MA-4680 = NBRC 14893424 SAV_4977SAV_4976NC_003155
88Streptomyces avermitilis MA-4680 = NBRC 14893425 SAV_5012SAV_5013NC_003155
89Streptomyces avermitilis MA-4680 = NBRC 14893426 SAV_5199SAV_5200NC_003155
90Streptomyces avermitilis MA-4680 = NBRC 14893427 SAV_5294SAV_5295NC_003155
91Streptomyces avermitilis MA-4680 = NBRC 14893428 SAV_5407SAV_5408NC_003155
92Streptomyces avermitilis MA-4680 = NBRC 14893429 SAV_5625SAV_5626NC_003155
93Streptomyces avermitilis MA-4680 = NBRC 14893431 SAV_5753SAV_5754NC_003155
94Streptomyces avermitilis MA-4680 = NBRC 14893432 SAV_5966SAV_5968NC_003155
95Streptomyces avermitilis MA-4680 = NBRC 14893433 SAV_6254SAV_6253NC_003155
96Streptomyces coelicolor A3(2)566 SCO2514SCO2513NC_003888
97Streptomyces coelicolor A3(2)564 SCO2252SCO2253NC_003888
98Streptomyces coelicolor A3(2)563 SCO2245SCO2246NC_003888
99Streptomyces coelicolor A3(2)561 SCO1978SCO1979NC_003888
100Streptomyces coelicolor A3(2)580 SCO7616SCO7615NC_003888
101Streptomyces coelicolor A3(2)578 SCO6630SCO6629NC_003888
102Streptomyces coelicolor A3(2)577 SCO6235SCO6236NC_003888
103Streptomyces coelicolor A3(2)576 SCO6128SCO6129NC_003888
104Streptomyces coelicolor A3(2)573 SCO5124SCO5125NC_003888
105Streptomyces coelicolor A3(2)572 SCO4679SCO4678NC_003888
106Streptomyces coelicolor A3(2)571 SCO4542SCO4543NC_003888
107Streptomyces coelicolor A3(2)570 SCO4442SCO4441NC_003888
108Streptomyces coelicolor A3(2)569 SCO4300SCO4301NC_003888
109Streptomyces coelicolor A3(2)568 SCO4177SCO4176NC_003888
110Streptomyces coelicolor A3(2)565 SCO2382SCO2381NC_003888
111Streptomyces griseus subsp. griseus NBRC 13350 (Streptomyces)5372 SGR_94tSGR_93tNC_010572
112Streptomyces griseus subsp. griseus NBRC 13350 (Streptomyces)5382 SGR_5028SGR_5027NC_010572
113Streptomyces griseus subsp. griseus NBRC 13350 (Streptomyces)5381 SGR_4774SGR_4775NC_010572
114Streptomyces griseus subsp. griseus NBRC 13350 (Streptomyces)5380 SGR_4397SGR_4398NC_010572
115Streptomyces griseus subsp. griseus NBRC 13350 (Streptomyces)5379 SGR_4334SGR_4333NC_010572
116Streptomyces griseus subsp. griseus NBRC 13350 (Streptomyces)5378 SGR_4256SGR_4257NC_010572
117Streptomyces griseus subsp. griseus NBRC 13350 (Streptomyces)5377 SGR_3949SGR_3948NC_010572
118Streptomyces griseus subsp. griseus NBRC 13350 (Streptomyces)5375 SGR_2945SGR_2944NC_010572
119Streptomyces griseus subsp. griseus NBRC 13350 (Streptomyces)5373 SGR_1054SGR_1055NC_010572
120Streptomyces griseus subsp. griseus NBRC 13350 (Streptomyces)5385 SGR_7045tSGR_7046tNC_010572
121Streptomyces griseus subsp. griseus NBRC 13350 (Streptomyces)5384 SGR_6284SGR_6285NC_010572
122Thermobifida fusca YX1964 Tfu_1657Tfu_1656NC_007333
123Thermobifida fusca YX1963 Tfu_0973Tfu_0974NC_007333
124Thermobifida fusca YX1962 Tfu_0708Tfu_0707NC_007333
125Thermobifida fusca YX1961 Tfu_0393Tfu_0392NC_007333
126Thermobifida fusca YX1960 Tfu_0262Tfu_0263NC_007333
127Thermobifida fusca YX1959 Tfu_0215Tfu_0216NC_007333
128Thermobifida fusca YX1958 Tfu_0091Tfu_0090NC_007333
129Thermobifida fusca YX1965 Tfu_1802Tfu_1801NC_007333
T: no prediction; molecular mechanism unknown

Antitoxin domain: Xre. Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.

Toxin domain: DUF397. The function of this family is unknown. It has been suggested that some members of this family are regulators of transcription. In particular, it is thought that this may regulator of antibiotic production in Streptomyces coelicolor.


Structure
N/A
(1) Makarova KS et al. (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct 4:19. [PudMed:19493340] in_silico