TA family: omega-epsilon-zeta
#OrganismLocus idToxinAntitoxinRegulatorReplicon
1Streptococcus pyogenes6024 pSM19035_009pSM19035_008pSM19035_007NC_006979
2Streptococcus pyogenes6079 pSM19035_012pSM19035_013pSM19035_014NC_006979
The omega-epsilon-zeta locus is firstly identified in the of the low-copy-number pSM19035. This locus encodes three components : the omega repressor autoregulates transcription of the omega-epsilon-zeta operon, epsilon encodes an antitoxin and zeta encodes a toxin.
Conserved Domain

Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae. PezAT are homologous to epsilon-zeta toxin-antitoxin system. [ PDB ID: 2P5T] [PudMed:17488720]
Crystal structure of the plasmid maintenance system epsilon/zeta: functional mechanism of toxin zeta and inactivation by epsilon 2 zeta 2 complex formation. [ PDB ID: 1GVN] [PudMed:11320325]
(1) Mutschler H et al. (2010) Assembly dynamics and stability of the Pneumococcal epsilon zeta Antitoxin Toxin(PezAT) system from Streptococcus pneumoniae. J Biol Chem 285(28):21797-806. [PudMed:20442221] experimental
(2) Lioy VS et al. (2010) Plasmid pSM19035, a model to study stable maintenance in Firmicutes. Plasmid. 64(1):1-17. [PudMed:20403380]
(3) Rosvoll TC et al. (2010) PCR-based plasmid typing in Enterococcus faecium strains reveals widelydistributed pRE25-, pRUM-, pIP501- and pHTbeta-related replicons associated withglycopeptide resistance and stabilizing toxin-antitoxin systems. FEMS Immunol Med Microbiol 58(2):254-68. [PudMed:20015231]
(4) Sletvold H et al. (2008) Complete sequence of Enterococcus faecium pVEF3 and the detection of anomega-epsilon-zeta toxin-antitoxin module and an ABC transporter. Plasmid 60(1):75-85. [PudMed:18511120] experimental
(5) O'Connor EB et al. (2007) pEOC01: a plasmid from Pediococcus acidilactici which encodes an identicalstreptomycin resistance (aadE) gene to that found in Campylobacter jejuni. Plasmid 58(2):115-26. [PudMed:17395262]
(6) Zielenkiewicz U et al. (2005) The toxin-antitoxin system of the streptococcal plasmid pSM19035. J Bacteriol 187(17):6094-105. [PudMed:16109951] experimental
(7) Camacho AG et al. (2002) In vitro and in vivo stability of the epsilon2zeta2 protein complex of the broadhost-range Streptococcus pyogenes pSM19035 addiction system. Biol Chem 383(11):1701-13. [PudMed:12530535] experimental
(8) Meinhart A et al. (2001) Crystallization and preliminary X-ray diffraction studies of the epsilonzetaaddiction system encoded by Streptococcus pyogenes plasmid pSM19035. Acta Crystallogr D Biol Crystallogr 57(Pt 5):745-724. . [PudMed:11320325] 3D_structure
experimental experimental literature
3D_structure protein structure literature