TADB
TA family: vapBC
#OrganismLocus idToxinAntitoxinReplicon
1Archaeoglobus fulgidus DSM 430432 AF0065AF0066NC_000917
2Archaeoglobus fulgidus DSM 430434 AF0296AF0295NC_000917
3Archaeoglobus fulgidus DSM 430461 AF2012AF2011NC_000917
4Archaeoglobus fulgidus DSM 430463 AF2190AF2189NC_000917
5Archaeoglobus fulgidus DSM 430433 AF0099AF0100NC_000917
6Archaeoglobus fulgidus DSM 430460 AF1996AF1997NC_000917
7Archaeoglobus fulgidus DSM 430467 AF2360AF2359NC_000917
8Archaeoglobus fulgidus DSM 430459 AF1711AF1712NC_000917
9Archaeoglobus fulgidus DSM 430458 AF1690AF1689NC_000917
10Archaeoglobus fulgidus DSM 430457 AF1683AF1682NC_000917
11Archaeoglobus fulgidus DSM 430453 AF1479AF1478NC_000917
12Archaeoglobus fulgidus DSM 430451 AF1091AF1092NC_000917
13Archaeoglobus fulgidus DSM 430446 AF1077AF1078NC_000917
14Archaeoglobus fulgidus DSM 430442 AF0598AF0597NC_000917
15Archaeoglobus fulgidus DSM 430439 AF0315AF0316NC_000917
16Archaeoglobus fulgidus DSM 430438 AF0315AF0314NC_000917
17Bifidobacterium longum NCC2705641 BL1399BL1398NC_004307
18Bordetella bronchiseptica RB501335 BB2471BB2472NC_002927
19Bordetella parapertussis 128221291 BPP1402BPP1403NC_002928
20Bradyrhizobium diazoefficiens USDA 110843 experimental bll2434bsl2435NC_004463
21Caulobacter crescentus CB15224 CC_0031CC_0032NC_002696
22Coxiella burnetii RSA 493319 CBU_1294CBU_1295NC_002971
23Deinococcus radiodurans R1142 DR_1530DR_1531NC_001263
24Deinococcus radiodurans R1144 DR_2102DR_2103NC_001263
25Deinococcus radiodurans R1138 DR_0419DR_0418NC_001263
26Escherichia coli EC302/046293 C381_p00140C381_p00145CP011493
27Geobacter sulfurreducens PCA1536 GSU2472GSU2473NC_002939
28Geobacter uraniireducens Rf43974 Gura_2455Gura_2456NC_009483
29Geobacter uraniireducens Rf43921 Gura_0038Gura_0037NC_009483
30Gloeobacter violaceus PCC 74211444 glr2382gsr2381NC_005125
31Gloeobacter violaceus PCC 74211446 gll2429gsl2430NC_005125
32Gloeobacter violaceus PCC 74211447 glr2432gsr2431NC_005125
33Gloeobacter violaceus PCC 74211417 gll0721gsl0722NC_005125
34Gloeobacter violaceus PCC 74211416 gll0632gsl0633NC_005125
35Gloeobacter violaceus PCC 74211412 glr0279gsr0278NC_005125
36Gloeobacter violaceus PCC 74211411 glr0248gsr0247NC_005125
37Gloeobacter violaceus PCC 74211465 glr3875gsr3874NC_005125
38Gloeobacter violaceus PCC 74211448 glr2609glr2608NC_005125
39Gloeobacter violaceus PCC 74211452 gll2899gsl2900NC_005125
40Gloeobacter violaceus PCC 74211471 glr4343gsr4342NC_005125
41Gloeobacter violaceus PCC 74211464 gll3798gsl3799NC_005125
42Gloeobacter violaceus PCC 74211457 glr3225gsr3224NC_005125
43Gloeobacter violaceus PCC 74211463 gll3555gsl3556NC_005125
44Gloeobacter violaceus PCC 74211428 gll1573gsl1574NC_005125
45Gloeobacter violaceus PCC 74211430 glr1678gsr1677NC_005125
46Gloeobacter violaceus PCC 74211431 gll1679gsl1680NC_005125
47Gloeobacter violaceus PCC 74211433 gll1696gll1697NC_005125
48Gloeobacter violaceus PCC 74211434 gll1708gsl1709NC_005125
49Gloeobacter violaceus PCC 74211438 gll2024gsl2025NC_005125
50Gloeobacter violaceus PCC 74211443 gll2300gsl2301NC_005125
51Gloeobacter violaceus PCC 74211418 gll0844gsl0845NC_005125
52Gluconobacter oxydans 621H1351 GOX1501GOX1500NC_006677
53Haemophilus influenzae Rd KW201066 experimental HI0322HI0321NC_000907
54Haemophilus influenzae Rd KW201070 HI0947HI0948NC_000907
55Haloarcula marismortui ATCC 430491542 rrnAC1057rrnAC1056NC_006396
56Haloarcula marismortui ATCC 430491545 rrnAC3206rrnAC3205NC_006396
57Helicobacter hepaticus ATCC 514491347 HH0272HH0273NC_004917
58Idiomarina loihiensis L2TR1317 IL2517IL2516NC_006512
59Leptospira interrogans serovar Copenhageni str. Fiocruz L1-1301519 LIC12713LIC12712NC_005823
60Leptospira interrogans serovar Copenhageni str. Fiocruz L1-1301514 LIC10866LIC10867NC_005823
61Leptospira interrogans serovar Copenhageni str. Fiocruz L1-1301518 LIC12660LIC12659NC_005823
62Leptospira interrogans serovar Copenhageni str. Fiocruz L1-1301517 LIC12116LIC12117NC_005823
63Leptospira interrogans serovar Lai str. 56601652 LA_1001LA_1002NC_004342
64Leptospira interrogans serovar Lai str. 56601656 LA_3274LA_3275NC_004342
65Mesorhizobium loti MAFF303099218 mll5078msl5079NC_002678
66Mesorhizobium loti MAFF303099220 mlr5903msr5902NC_002678
67Mesorhizobium loti MAFF303099207 mll1670mll1671NC_002678
68Mesorhizobium loti MAFF303099217 mll3899msl3900NC_002678
69Methanocaldococcus jannaschii DSM 266120 MJ_1121MJ_1122NC_000909
70Methanocaldococcus jannaschii DSM 266119 MJ_0974MJ_0975NC_000909
71Methanocaldococcus jannaschii DSM 266126 MJ_1680MJ_1679NC_000909
72Methanosarcina acetivorans C2A808 MA1515MA1514NC_003552
73Methanosarcina acetivorans C2A817 MA3426MA3427NC_003552
74Methanosarcina mazei Go1588 MM_0207MM_0208NC_003901
75Methylococcus capsulatus str. Bath1719 MCA1623MCA1622NC_002977
76Mycobacterium avium subsp. paratuberculosis K-101327 MAP2027cMAP2028cNC_002944
77Mycobacterium bovis AF2122/971134 Mb0684Mb0683NC_002945
78Mycobacterium bovis AF2122/971135 Mb0770Mb0769NC_002945
79Mycobacterium bovis AF2122/971124 Mb0564cMb0565cNC_002945
80Mycobacterium bovis AF2122/971125 Mb0597Mb0596NC_002945
81Mycobacterium bovis AF2122/971126 Mb0611cMb0612cNC_002945
82Mycobacterium bovis AF2122/971133 Mb0680cMb0681cNC_002945
83Mycobacterium bovis AF2122/971131 Mb0675cMb0676cNC_002945
84Mycobacterium bovis AF2122/971138 Mb1144Mb1143NC_002945
85Mycobacterium bovis AF2122/971139 Mb1274Mb1273NC_002945
86Mycobacterium bovis AF2122/971141 Mb1432cMb1433cNC_002945
87Mycobacterium bovis AF2122/971143 Mb1587Mb1586NC_002945
88Mycobacterium bovis AF2122/971144 Mb1749cMb1750cNC_002945
89Mycobacterium bovis AF2122/971130 Mb0643Mb0642NC_002945
90Mycobacterium bovis AF2122/971145 Mb1770Mb1769NC_002945
91Mycobacterium bovis AF2122/971146 Mb1869cMb1870cNC_002945
92Mycobacterium bovis AF2122/971129 Mb0640Mb0639NC_002945
93Mycobacterium bovis AF2122/971128 Mb0625Mb0624NC_002945
94Mycobacterium bovis AF2122/971148 Mb1988Mb1987NC_002945
95Mycobacterium bovis AF2122/971152 Mb2033Mb2032NC_002945
96Mycobacterium bovis AF2122/971156 Mb2129cMb2130cNC_002945
97Mycobacterium bovis AF2122/971157 Mb2522Mb2521NC_002945
98Mycobacterium bovis AF2122/971158 Mb2556Mb2555NC_002945
99Mycobacterium bovis AF2122/971159 Mb2559cMb2559AcNC_002945
100Mycobacterium bovis AF2122/971160 Mb2576Mb2575NC_002945
101Mycobacterium bovis AF2122/971127 Mb0614cMb0615cNC_002945
102Mycobacterium bovis AF2122/971161 Mb2578Mb2577NC_002945
103Mycobacterium bovis AF2122/971176 Mb3442Mb3441NC_002945
104Mycobacterium bovis AF2122/971175 Mb3416cMb3417cNC_002945
105Mycobacterium bovis AF2122/971173 Mb3349cMb3350cNC_002945
106Mycobacterium bovis AF2122/971169 Mb2897Mb2896NC_002945
107Mycobacterium bovis AF2122/971167 Mb2853cMb2854cNC_002945
108Mycobacterium bovis AF2122/971166 Mb2780cMb2781cNC_002945
109Mycobacterium bovis AF2122/971165 Mb2778cMb2779cNC_002945
110Mycobacterium bovis AF2122/971164 Mb2634Mb2633NC_002945
111Mycobacterium bovis AF2122/971163 Mb2627Mb2626NC_002945
112Mycobacterium bovis AF2122/971123 Mb0309Mb0308NC_002945
113Mycobacterium bovis AF2122/971162 Mb2579cMb2580cNC_002945
114Mycobacterium bovis AF2122/971121 Mb0246Mb0245NC_002945
115Mycobacterium tuberculosis CDC1551291 MT3516MT3515NC_002755
116Mycobacterium tuberculosis CDC1551238 MT0289MT0290NC_002755
117Mycobacterium tuberculosis CDC1551239 MT0574MT0575NC_002755
118Mycobacterium tuberculosis CDC1551240 MT0625MT0626NC_002755
119Mycobacterium tuberculosis CDC1551241 MT0628MT0629NC_002755
120Mycobacterium tuberculosis CDC1551242 MT0638MT0637NC_002755
121Mycobacterium tuberculosis CDC1551243 MT0646MT0645.2NC_002755
122Mycobacterium tuberculosis CDC1551244 MT0652MT0651NC_002755
123Mycobacterium tuberculosis CDC1551245 MT0685MT0686NC_002755
124Mycobacterium tuberculosis CDC1551247 MT0690MT0691NC_002755
125Mycobacterium tuberculosis CDC1551248 MT0693MT0692.1NC_002755
126Mycobacterium tuberculosis CDC1551249 MT0773MT0772.6NC_002755
127Mycobacterium tuberculosis CDC1551251 MT0988MT0987NC_002755
128Mycobacterium tuberculosis CDC1551253 MT1144MT1143.1NC_002755
129Mycobacterium tuberculosis CDC1551254 MT1280MT1279NC_002755
130Mycobacterium tuberculosis CDC1551255 MT1441MT1442NC_002755
131Mycobacterium tuberculosis CDC1551257 MT1612MT1611NC_002755
132Mycobacterium tuberculosis CDC1551258 MT1761MT1762NC_002755
133Mycobacterium tuberculosis CDC1551259 MT1783MT1782NC_002755
134Mycobacterium tuberculosis CDC1551260 MT1886MT1887NC_002755
135Mycobacterium tuberculosis CDC1551261 MT2003MT2002NC_002755
136Mycobacterium tuberculosis CDC1551264 MT2012MT2013NC_002755
137Mycobacterium tuberculosis CDC1551265 MT2034MT2035NC_002755
138Mycobacterium tuberculosis CDC1551268 MT2065MT2064.1NC_002755
139Mycobacterium tuberculosis CDC1551273 MT2163MT2164NC_002755
140Mycobacterium tuberculosis CDC1551275 MT2569MT2568NC_002755
141Mycobacterium tuberculosis CDC1551276 MT2602MT2601.2NC_002755
142Mycobacterium tuberculosis CDC1551277 MT2605MT2606NC_002755
143Mycobacterium tuberculosis CDC1551278 MT2622MT2621NC_002755
144Mycobacterium tuberculosis CDC1551279 MT2624MT2623NC_002755
145Mycobacterium tuberculosis CDC1551280 MT2677MT2676NC_002755
146Mycobacterium tuberculosis CDC1551282 MT2827MT2828NC_002755
147Mycobacterium tuberculosis CDC1551283 MT2829MT2830NC_002755
148Mycobacterium tuberculosis CDC1551284 MT2932MT2931NC_002755
149Mycobacterium tuberculosis CDC1551288 MT3421MT3422NC_002755
150Mycobacterium tuberculosis CDC1551290 MT3492MT3493NC_002755
151Mycobacterium tuberculosis CDC1551292 MT3799MT3800NC_002755
152Mycobacterium tuberculosis H37Rv116 Rv2548Rv2547NC_000962
153Mycobacterium tuberculosis H37Rv91 Rv1114Rv1113NC_000962
154Mycobacterium tuberculosis H37Rv87 experimental Rv0749Rv0748NC_000962
155Mycobacterium tuberculosis H37Rv86 experimental Rv0665Rv0664NC_000962
156Mycobacterium tuberculosis H37Rv85 experimental Rv0661cRv0662cNC_000962
157Mycobacterium tuberculosis H37Rv83 experimental Rv0656cRv0657cNC_000962
158Mycobacterium tuberculosis H37Rv82 experimental Rv0627Rv0626NC_000962
159Mycobacterium tuberculosis H37Rv81 Rv0624Rv0623NC_000962
160Mycobacterium tuberculosis H37Rv80 Rv0617Rv0616cNC_000962
161Mycobacterium tuberculosis H37Rv79 experimental Rv0609Rv0608NC_000962
162Mycobacterium tuberculosis H37Rv78 experimental Rv0598cRv0599cNC_000962
163Mycobacterium tuberculosis H37Rv77 experimental Rv0595cRv0596cNC_000962
164Mycobacterium tuberculosis H37Rv75 Rv0549cRv0550cNC_000962
165Mycobacterium tuberculosis H37Rv74 experimental Rv0301Rv0300NC_000962
166Mycobacterium tuberculosis H37Rv132 Rv3408Rv3407NC_000962
167Mycobacterium tuberculosis H37Rv131 Rv3384cRv3385cNC_000962
168Mycobacterium tuberculosis H37Rv129 experimental Rv3320cRv3321cNC_000962
169Mycobacterium tuberculosis H37Rv125 experimental Rv2872Rv2871NC_000962
170Mycobacterium tuberculosis H37Rv123 Rv2829cRv2830cNC_000962
171Mycobacterium tuberculosis H37Rv122 Rv2759cRv2760cNC_000962
172Mycobacterium tuberculosis H37Rv121 Rv2757cRv2758cNC_000962
173Mycobacterium tuberculosis H37Rv119 Rv2602Rv2601ANC_000962
174Mycobacterium tuberculosis H37Rv118 Rv2596Rv2595NC_000962
175Mycobacterium tuberculosis H37Rv117 experimental Rv2549cRv2550cNC_000962
176Mycobacterium tuberculosis H37Rv115 Rv2546Rv2545NC_000962
177Mycobacterium tuberculosis H37Rv114 Rv2530cRv2530ANC_000962
178Mycobacterium tuberculosis H37Rv113 Rv2527Rv2526NC_000962
179Mycobacterium tuberculosis H37Rv112 experimental Rv2494Rv2493NC_000962
180Mycobacterium tuberculosis H37Rv111 experimental Rv2103cRv2104cNC_000962
181Mycobacterium tuberculosis H37Rv107 experimental Rv2010Rv2009NC_000962
182Mycobacterium tuberculosis H37Rv102 Rv1953Rv1952NC_000962
183Mycobacterium tuberculosis H37Rv100 Rv1838cRv1839cNC_000962
184Mycobacterium tuberculosis H37Rv99 Rv1741Rv1740NC_000962
185Mycobacterium tuberculosis H37Rv97 experimental Rv1561Rv1560NC_000962
186Mycobacterium tuberculosis H37Rv94 experimental Rv1397cRv1398cNC_000962
187Mycobacterium tuberculosis H37Rv92 Rv1242Rv1241NC_000962
188Neisseria meningitidis MC58406 NMB1665NMB1666NC_003112
189Nitrosomonas europaea ATCC 19718898 NE0498NE0497NC_004757
190Nitrosomonas europaea ATCC 19718904 NE1064NE1065NC_004757
191Nitrosomonas europaea ATCC 19718895 NE0479NE0478NC_004757
192Nitrosomonas europaea ATCC 19718917 NE1349NE1350NC_004757
193Nitrosomonas europaea ATCC 19718912 NE1225NE1224NC_004757
194Nitrosomonas europaea ATCC 19718939 NE2174NE2175NC_004757
195Nitrosomonas europaea ATCC 19718937 NE2112NE2111NC_004757
196Nitrosomonas europaea ATCC 19718931 NE1589NE1590NC_004757
197Nitrosomonas europaea ATCC 19718928 NE1581NE1582NC_004757
198Nitrosomonas europaea ATCC 19718921 NE1373NE1374NC_004757
199Nocardia farcinica IFM 101521087 nfa23730nfa23740NC_006361
200Nocardia farcinica IFM 101521085 nfa19600nfa19590NC_006361
201Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)497 all5132all5133NC_003272
202Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)451 alr0149asr0148NC_003272
203Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)455 alr0504asr0503NC_003272
204Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)457 alr0683asr0682NC_003272
205Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)458 all0753all0754NC_003272
206Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)461 all1495asl1496NC_003272
207Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)470 all2196asl2197NC_003272
208Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)472 all2421all2422NC_003272
209Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)473 all2685asl2686NC_003272
210Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)481 alr3469asr3468NC_003272
211Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)482 alr3479asr3478NC_003272
212Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)483 alr3622asr3621NC_003272
213Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)485 all3972asl3973NC_003272
214Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)487 all4135asl4136NC_003272
215Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)496 alr4952asr4951NC_003272
216Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)498 all5132all5131NC_003272
217Pectobacterium atrosepticum SCRI10431113 ECA2850ECA2851NC_004547
218Pectobacterium atrosepticum SCRI10431114 ECA3686ECA3687NC_004547
219Photorhabdus luminescens subsp. laumondii TTO11208 plu2050plu2051NC_005126
220Photorhabdus luminescens subsp. laumondii TTO11233 plu3057plu3058NC_005126
221Photorhabdus luminescens subsp. laumondii TTO11224 plu2368plu2369NC_005126
222Photorhabdus luminescens subsp. laumondii TTO11198 plu0929plu0928NC_005126
223Picrophilus torridus DSM 97901319 PTO0276PTO0277NC_005877
224Picrophilus torridus DSM 97901320 PTO1512PTO1513NC_005877
225Propionibacterium acnes KPA1712021254 PPA2073PPA2075NC_006085
226Pseudomonas syringae pv. tomato str. DC30001061 PSPTO_1999PSPTO_2000NC_004578
227Pseudomonas syringae pv. tomato str. DC30001058 PSPTO_1045PSPTO_1046NC_004578
228Pseudomonas syringae pv. tomato str. DC30001059 PSPTO_1057PSPTO_1058NC_004578
229Pyrobaculum aerophilum str. IM2519 PAE0337PAE0335NC_003364
230Pyrobaculum aerophilum str. IM2513 PAE0033PAE0030aNC_003364
231Pyrobaculum aerophilum str. IM2515 PAE0101PAE0100NC_003364
232Pyrobaculum aerophilum str. IM2516 experimental PAE0151PAE0152NC_003364
233Pyrobaculum aerophilum str. IM2538 PAE2829PAE2828NC_003364
234Pyrobaculum aerophilum str. IM2535 experimental PAE2754PAE2755NC_003364
235Pyrobaculum aerophilum str. IM2534 PAE2676PAE2678NC_003364
236Pyrococcus abyssi GE5981 PAB2271PAB3032NC_000868
237Pyrococcus abyssi GE5987 PAB0786PAB7298NC_000868
238Pyrococcus abyssi GE5983 PAB0520PAB3187NC_000868
239Pyrococcus abyssi GE5982 PAB2079PAB3103NC_000868
240Pyrococcus furiosus DSM 3638548 PF0812PF0813NC_003413
241Pyrococcus furiosus DSM 3638543 PF0574PF0573NC_003413
242Pyrococcus furiosus DSM 3638544 PF0575PF0576NC_003413
243Pyrococcus furiosus DSM 3638545 PF0773PF0774NC_003413
244Pyrococcus furiosus DSM 3638542 PF0355PF0355.1nNC_003413
245Pyrococcus furiosus DSM 3638549 PF0839PF0838NC_003413
246Pyrococcus furiosus DSM 3638551 PF1206PF1207NC_003413
247Pyrococcus furiosus DSM 3638555 PF1352PF1353NC_003413
248Pyrococcus horikoshii OT3860 PHS027.1nPHS027NC_000961
249Pyrococcus horikoshii OT3850 PH0098PH0097.2nNC_000961
250Ralstonia solanacearum GMI1000503 RSc0871RSc0872NC_003295
251Ralstonia solanacearum GMI1000507 RSc3055RSc3056NC_003295
252Rhodopseudomonas palustris CGA0091480 RPA1833RPA1834NC_005296
253Rhodopseudomonas palustris CGA0091489 RPA3608RPA3607NC_005296
254Rhodopseudomonas palustris CGA0091492 RPA4142RPA4141NC_005296
255Rhodopseudomonas palustris CGA0091481 RPA1992RPA1993NC_005296
256Rickettsia conorii str. Malish 7354 RC0510RC0511NC_003103
257Rickettsia conorii str. Malish 7359 RC1014RC1013NC_003103
258Rickettsia conorii str. Malish 7365 RC1318RC1319NC_003103
259Rickettsia conorii str. Malish 7352 RC0379RC0380NC_003103
260Rickettsia conorii str. Malish 7356 RC0677RC0676NC_003103
261Rickettsia conorii str. Malish 7355 RC0600RC0601NC_003103
262Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC1654 SPA2901SPA2902NC_006511
263Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC1659 SPA3875SPA3874NC_006511
264Salmonella enterica subsp. enterica serovar Typhimurium str. LT2439 experimental STM3033STM3034NC_003197
265Salmonella enterica subsp. enterica serovar Typhi str. CT18827 STY3844STY3845NC_003198
266Salmonella enterica subsp. enterica serovar Typhi str. CT18825 STY3182STY3183NC_003198
267Salmonella enterica subsp. enterica serovar Typhi str. Ty2751 t2943t2944NC_004631
268Salmonella enterica subsp. enterica serovar Typhi str. Ty2753 t3587t3588NC_004631
269Sinorhizobium meliloti 1021871 SMc01177SMc01176NC_003047
270Sinorhizobium meliloti 1021876 SMc02715SMc02716NC_003047
271Sinorhizobium meliloti 1021877 experimental SMc01521SMc03949NC_003047
272Sinorhizobium meliloti 1021881 SMc00687SMc00686NC_003047
273Sinorhizobium meliloti 1021882 SMc02987SMc02988NC_003047
274Sinorhizobium meliloti 1021883 SMc03137SMc03136NC_003047
275Sinorhizobium meliloti 1021886 SMc04881SMc04408NC_003047
276Sinorhizobium meliloti 1021864 SMc00393SMc00392NC_003047
277Sinorhizobium meliloti 1021869 SMc02657SMc02658NC_003047
278Sinorhizobium meliloti 1021870 SMc01932SMc01933NC_003047
279Sinorhizobium meliloti 1021867 SMc00900SMc00899NC_003047
280Streptomyces avermitilis MA-4680 = NBRC 14893430 SAV_5694SAV_5693NC_003155
281Sulfolobus solfataricus P2951 SSO1968SSO9378NC_002754
282Sulfolobus solfataricus P2950 SSO1868SSO1867NC_002754
283Sulfolobus solfataricus P2957 SSO3128SSO12018NC_002754
284Sulfolobus solfataricus P2956 SSO3078SSO11914NC_002754
285Sulfolobus solfataricus P2945 SSO1493SSO1494NC_002754
286Sulfolobus solfataricus P2955 SSO2783SSO11133NC_002754
287Sulfolobus solfataricus P2947 SSO1657SSO8620NC_002754
288Sulfolobus tokodaii str. 7367 ST0036STS011NC_003106
289Sulfolobus tokodaii str. 7401 ST2191STS233NC_003106
290Sulfolobus tokodaii str. 7400 ST2012STS214NC_003106
291Sulfolobus tokodaii str. 7399 ST1943STS208NC_003106
292Sulfolobus tokodaii str. 7398 ST1932ST1931NC_003106
293Sulfolobus tokodaii str. 7395 ST1687ST1688NC_003106
294Sulfolobus tokodaii str. 7394 ST1642ST1641NC_003106
295Sulfolobus tokodaii str. 7393 ST1639ST1640NC_003106
296Sulfolobus tokodaii str. 7392 ST1628STS188NC_003106
297Sulfolobus tokodaii str. 7391 ST1593ST1594NC_003106
298Sulfolobus tokodaii str. 7389 ST1572STS183NC_003106
299Sulfolobus tokodaii str. 7386 ST1125STS128NC_003106
300Sulfolobus tokodaii str. 7385 ST1101STS126NC_003106
301Sulfolobus tokodaii str. 7383 STS118STS119NC_003106
302Sulfolobus tokodaii str. 7382 ST0906STS102NC_003106
303Sulfolobus tokodaii str. 7381 ST0897STS101NC_003106
304Sulfolobus tokodaii str. 7380 ST0839STS097NC_003106
305Sulfolobus tokodaii str. 7374 ST0741STS089NC_003106
306Sulfolobus tokodaii str. 7366 ST0017STS008NC_003106
307Synechococcus elongatus PCC 6301 (Synechococcus leopoliensis SAG)1629 syc0347_dsyc0346_dNC_006576
308Synechococcus elongatus PCC 6301 (Synechococcus leopoliensis SAG)1627 syc0004_dsyc0003_dNC_006576
309Synechococcus sp. WH 81021270 SYNW0569SYNW0570NC_005070
310Synechococcus sp. WH 81021271 SYNW0573SYNW0572NC_005070
311Synechococcus sp. WH 81021263 SYNW0071SYNW0072NC_005070
312Synechococcus sp. WH 81021264 SYNW0214SYNW0215NC_005070
313Synechocystis sp. PCC 6803977 sll0525ssl1004NC_000911
314Synechocystis sp. PCC 6803967 sll1715sll1714NC_000911
315Synechocystis sp. PCC 6803971 sll1225ssl2420NC_000911
316Synechocystis sp. PCC 6803970 slr1327ssr2201NC_000911
317Synechocystis sp. PCC 68036119 SYNGTS_1762SYNGTS_1763NC_017277
318Synechocystis sp. PCC 6803965 sll1912ssl3615NC_000911
319Synechocystis sp. PCC 6803962 ssl2923ssl2922NC_000911
320Synechocystis sp. PCC 6803972 experimental sll1092ssl2138NC_000911
321Thermoanaerobacter tengcongensis MB4 (Caldanaerobacter subterraneus)774 TTE2607TTE2608NC_003869
322Thermoanaerobacter tengcongensis MB4 (Caldanaerobacter subterraneus)766 TTE1060TTE1059NC_003869
323Thermoanaerobacter tengcongensis MB4 (Caldanaerobacter subterraneus)770 TTE2037TTE2038NC_003869
324Thermoanaerobacter tengcongensis MB4 (Caldanaerobacter subterraneus)773 TTE2584TTE2583NC_003869
325Thermococcus kodakarensis KOD11599 TK2067TK2068NC_006624
326Thermococcus kodakarensis KOD11556 TK0066TK0065NC_006624
327Thermococcus kodakarensis KOD11557 TK0128TK0127NC_006624
328Thermococcus kodakarensis KOD11558 TK0137TK0138NC_006624
329Thermococcus kodakarensis KOD11559 TK0176TK0177NC_006624
330Thermococcus kodakarensis KOD11560 TK0191TK0192NC_006624
331Thermococcus kodakarensis KOD11563 TK0334TK0335NC_006624
332Thermococcus kodakarensis KOD11565 TK0343TK0344NC_006624
333Thermococcus kodakarensis KOD11567 TK0374TK0373NC_006624
334Thermococcus kodakarensis KOD11568 TK0456TK0457NC_006624
335Thermococcus kodakarensis KOD11569 TK0542TK0543NC_006624
336Thermococcus kodakarensis KOD11570 TK0696TK0695NC_006624
337Thermococcus kodakarensis KOD11571 TK0734TK0733NC_006624
338Thermococcus kodakarensis KOD11573 TK0889TK0888NC_006624
339Thermococcus kodakarensis KOD11574 TK0910TK0909NC_006624
340Thermococcus kodakarensis KOD11575 TK0918TK0917NC_006624
341Thermococcus kodakarensis KOD11578 TK0972TK0973NC_006624
342Thermococcus kodakarensis KOD11579 TK0998TK0997NC_006624
343Thermococcus kodakarensis KOD11580 TK1014TK1013NC_006624
344Thermococcus kodakarensis KOD11581 TK1027TK1028NC_006624
345Thermococcus kodakarensis KOD11586 TK1185TK1184NC_006624
346Thermococcus kodakarensis KOD11587 TK1256TK1255NC_006624
347Thermococcus kodakarensis KOD11588 TK1290TK1291NC_006624
348Thermococcus kodakarensis KOD11592 TK1644TK1645NC_006624
349Thermococcus kodakarensis KOD11594 TK1751TK1752NC_006624
350Thermococcus kodakarensis KOD11595 TK1763TK1762NC_006624
351Thermococcus kodakarensis KOD11597 TK1995TK1996NC_006624
352Thermococcus kodakarensis KOD11598 TK2005TK2006NC_006624
353Thermococcus kodakarensis KOD11600 TK2155TK2154NC_006624
354Thermococcus kodakarensis KOD11601 TK2228TK2229NC_006624
355Thermococcus kodakarensis KOD11602 TK2262TK2261NC_006624
356Thermococcus kodakarensis KOD11554 TK0016TK0017NC_006624
357Thermus thermophilus HB271610 TTC1207TTC1208NC_005835
358Thermus thermophilus HB271618 TTC1804TTC1805NC_005835
359Thermus thermophilus HB271605 TTC0113TTC0114NC_005835
360Thermus thermophilus HB271606 TTC0125TTC0126NC_005835
361Thermus thermophilus HB81373 TTHA1052TTHA1051NC_006461
362Thermus thermophilus HB81376 TTHA1572TTHA1573NC_006461
363Thermus thermophilus HB81363 TTHA0182TTHA0181NC_006461
364Thermus thermophilus HB81361 TTHA0033TTHA0032NC_006461
365Thermus thermophilus HB81367 TTHA0501TTHA0502NC_006461
366Thermus thermophilus HB81365 TTHA0487TTHA0488NC_006461
367Treponema denticola ATCC 354051692 TDE0599TDE0600NC_002967
368Treponema denticola ATCC 354051682 TDE0197TDE0196NC_002967
369Treponema denticola ATCC 354051688 TDE0465TDE0466NC_002967
370Treponema denticola ATCC 354051683 TDE0236TDE0235NC_002967
371Treponema denticola ATCC 354051684 TDE0277TDE0278NC_002967
372Treponema denticola ATCC 354051685 TDE0280TDE0281NC_002967
373Treponema denticola ATCC 354051716 TDE2577TDE2578NC_002967
374Treponema denticola ATCC 354051714 TDE2532TDE2531NC_002967
375Treponema denticola ATCC 354051710 TDE2127TDE2126NC_002967
376Treponema denticola ATCC 354051707 TDE1961TDE1962NC_002967
377Treponema denticola ATCC 354051697 TDE0887TDE0888NC_002967
378Treponema denticola ATCC 354051694 TDE0698TDE0699NC_002967
379Xanthomonas axonopodis pv. citri str. 306742 XAC4315XAC4314NC_003919
380Xanthomonas axonopodis pv. citri str. 306739 XAC1884XAC1883NC_003919
381Xanthomonas axonopodis pv. citri str. 306740 XAC2187XAC2188NC_003919
382Xanthomonas campestris pv. campestris str. ATCC 33913608 XCC1632XCC1631NC_003902
383Xanthomonas campestris pv. campestris str. ATCC 33913609 XCC1862XCC1861NC_003902
384Xanthomonas oryzae KACC103311621 XOO2863XOO2864NC_006834
385Xylella fastidiosa 9a5c149 XF1589XF1590NC_002488
386Xylella fastidiosa 9a5c150 XF1589XF1588NC_002488

experimental Data derived from experimental literature
The vapBC (virulence associated protein)locus was firstly identified on a Salmonella dublin virulence plasmid. VapC toxin has PIN domain .
Conserved Domain
Accession No.NameRelation/involvement in TA lociReference
cd00093HTH_XREXRE-like domain present in HigA and VapB antitoxinsPubMed:17678530
COG1487VapCQuality control of gene expressionPubMed:17678530
COG2002AbrBDomain present in of MazE and VapB antitoxinsPubMed:17678530
COG3093VapINamed from VapI region; corresponds to VapB antitoxins (Plasmid maintenance)PubMed:17678530
COG4456VagCAntitoxin of plasmid maintenance systemPubMed:17678530
pfam01850PINDNA binding PIN domain, present in VapC toxinsPubMed:17678530
pfam04014AbrBDomain present in MazE and VapB antitoxinsPubMed:17678530
smart00530XreXRE-like HTH domain present in HigA and VapBPubMed:17678530
COG1848COG1848PIN domain, present in VapC toxinsPubMed:17678530
COG3609COG3609CopG/Arc/MetJ DNA-binding domain, present in RelB, ParD, VapBC and CcdA antitoxinsPubMed:17678530
COG4113COG4113PIN domain, present in VapC toxinsPubMed:17678530
COG4423COG4423Predicted antitoxin of PIN domain toxins (VapC)PubMed:17678530
pfam01381HTH_3Present in antitoxins of HigBA and VapBC familiesPubMed:17678530


Structure
Crystal structure of a member of the VapBC family of toxin-antitoxin systems, VapBC-5, from Mycobacterium tuberculosis [ PDB ID: 3DBO] [PudMed:18952600]
Crystal Structure of Rv0301(Antitoxin)-Rv0300 (Toxin) Toxin-Antitoxin Complex ( vapBC family) from Mycobacterium tuberculosis [ PDB ID: 3H87]
(1) Bloomfield GA et al. (1997) Analysis of sequences flanking the vap regions of Dichelobacter nodosus:evidence for multiple integration events, a killer system, and a new geneticelement. Microbiology 143 ( Pt 2):553-62. [PudMed:9043132] experimental
(2) Arcus VL et al. (2011) The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array. Protein Eng Des Sel. 24(1-2):33-40. [PudMed:21036780]
(3) Miclea PS et al. (2010) Atypical transcriptional regulation and role of a new toxin-antitoxin-likemodule and its effect on the lipid composition of Bradyrhizobium japonicum. Mol Plant Microbe Interact 23(5):638-50. [PudMed:20367472] experimental
(4) Ramage HR et al. (2009) Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxinsystems: implications for pathogenesis, stress responses, and evolution. PLoS Genet 5(12):e1000767. [PudMed:20011113] experimental
(5) Robson J et al. (2009) The vapBC operon from Mycobacterium smegmatis is an autoregulatedtoxin-antitoxin module that controls growth via inhibition of translation. J Mol Biol 390(3):353-67. [PudMed:19445953] experimental
(6) Winther KS et al. (2009) Ectopic production of VapCs from Enterobacteria inhibits translation andtrans-activates YoeB mRNA interferase. Mol Microbiol 72(4):918-30. [PudMed:19400780] experimental
(7) Cooper CR et al. (2009) Role of vapBC toxin-antitoxin loci in the thermal stress response of Sulfolobussolfataricus. Biochem Soc Trans 37(Pt 1):123-6. [PudMed:19143615] experimental
(8) Miallau L et al. (2009) Structure and proposed activity of a member of the VapBC family oftoxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis. J Biol Chem 284(1):276-83. [PudMed:18952600] 3D_structure
(9) Daines DA et al. (2007) VapC-1 of nontypeable Haemophilus influenzae is a ribonuclease. J Bacteriol 189(14):5041-8. [PudMed:17496075] experimental
(10) Gvakharia BO et al. (2007) Global transcriptional response of Nitrosomonas europaea to chloroform and chloromethane. Appl Environ Microbiol. 73(10):3440-5. [PudMed:17369330] experimental
(11) Bodogai M et al. (2006) The ntrPR operon of Sinorhizobium meliloti is organized and functions as atoxin-antitoxin module. Mol Plant Microbe Interact 19(7):811-22. [PudMed:16838793] experimental
(12) Zhang YX et al. (2004) Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospirainterrogans chromosome. Cell Res 14(3):208-16. [PudMed:15225414] experimental
(13) Pullinger GD et al. (1992) A Salmonella dublin virulence plasmid locus that affects bacterial growth undernutrient-limited conditions. Mol Microbiol 6(12):1631-43. [PudMed:1495391] experimental
(14) Anantharaman V et al. (2003) New connections in the prokaryotic toxin-antitoxin network: relationship withthe eukaryotic nonsense-mediated RNA decay system. Genome Biol 4(12):R81. [PudMed:14659018] in_silico
(15) Katz ME et al. (1992) Molecular characterization of a genomic region associated with virulence inDichelobacter nodosus. Infect Immun 60(11):4586-92. [PudMed:1398971] experimental
(16) Zhang J et al. (2003) Characterization of the interactions within the mazEF addiction module ofEscherichia coli. J Biol Chem 278(34):32300-6. [PudMed:12810711] experimental
(17) Sat B et al. (2003) The Escherichia coli mazEF suicide module mediates thymineless death. J Bacteriol 185(6):1803-7. [PudMed:12618443] experimental
(18) Clissold PM et al. (2000) PIN domains in nonsense-mediated mRNA decay and RNAi. Curr Biol 10(24):R888-90. [PudMed:11137022]
 
experimental experimental literature
in_silico in silico analysis literature
3D_structure protein structure literature