TADB
TA family: hicBA
#OrganismLocus idToxinAntitoxinReplicon
1Bacteroides fragilis YCH461303 BF2482BF2483NC_006347
2Bartonella henselae str. Houston-11646 BH03520BH03510NC_005956
3Bartonella henselae str. Houston-11643 BH03210BH03220NC_005956
4Bordetella parapertussis 128221299 BPP3141BPP3142NC_002928
5Bordetella parapertussis 128221293 BPP2078BPP2077NC_002928
6Burkholderia pseudomallei K962431546 BPSS0390BPSS0391NC_006351
7Caulobacter crescentus CB15236 CC_3184CC_3185NC_002696
8Cyanothece sp. PCC 74256163 Cyan7425_1350Cyan7425_1351NC_011884
9Desulfotalea psychrophila LSv541472 DP0409DP0408NC_006138
10Escherichia coli O157:H7 str. EDL933201 Z4883Z4882NC_002655
11Escherichia coli O157:H7 str. Sakai1017 ECs4357ECs4356NC_002695
12Escherichia coli str. K-12 substr. MG16551039 experimental b4532b1438NC_000913
13Geobacter uraniireducens Rf46184 Gura_0601Gura_0600NC_009483
14Haemophilus ducreyi 35000HP1280 HD0911HD0910NC_002940
15Helicobacter pylori J9971 jhp0961jhp0960NC_000921
16Mesorhizobium loti MAFF303099210 msr2149mlr2150NC_002678
17Methanosarcina acetivorans C2A820 MA4126MA4125NC_003552
18Methanosarcina acetivorans C2A805 MA0765MA0764NC_003552
19Methanosarcina acetivorans C2A812 MA2135MA2136NC_003552
20Methanosarcina mazei Go1585 MM_0160MM_0161NC_003901
21Methanosarcina mazei Go1582 MM_0023MM_0022NC_003901
22Methanosarcina mazei Go1584 MM_0032MM_0031NC_003901
23Methanosarcina mazei Go1596 MM_1924MM_1923NC_003901
24Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)500 asl5277all5276NC_003272
25Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)489 asl4362asl4361NC_003272
26Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)474 asl2714asl2713NC_003272
27Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)464 asl1824asl1825NC_003272
28Pectobacterium atrosepticum SCRI10431110 ECA2514ECA2513NC_004547
29Photorhabdus luminescens subsp. laumondii TTO11194 plu0707plu0706NC_005126
30Photorhabdus luminescens subsp. laumondii TTO11235 plu3492plu3491NC_005126
31Photorhabdus luminescens subsp. laumondii TTO11243 plu4353plu4354NC_005126
32Propionibacterium acnes KPA1712021253 PPA1449PPA1450NC_006085
33Propionibacterium acnes KPA1712021252 PPA0653PPA0655NC_006085
34Pseudomonas putida KT2440312 PP_3900PP_3899NC_002947
35Pseudomonas putida KT2440305 PP_1480PP_1479NC_002947
36Pseudomonas syringae pv. tomato str. DC30001060 PSPTO_1634PSPTO_1635NC_004578
37Pyrococcus furiosus DSM 3638554 PF1323PF1322NC_003413
38Rhodopirellula baltica SH 11033 RB3257RB3259NC_005027
39Rhodopseudomonas palustris HaA26183 RPB_4319RPB_4320NC_007778
40Sinorhizobium meliloti 1021875 SMc04441SMc04269NC_003047
41Streptococcus agalactiae 2603V/R634 SAG1836SAG1835NC_004116
42Streptococcus pneumoniae R6729 spr1613spr1612NC_003098
43Streptococcus pneumoniae R66282 experimental spr0952spr0951NC_003098
44Streptococcus pneumoniae TIGR4328 SP_1787SP_1786NC_003028
45Streptococcus pyogenes MGAS8232998 spyM18_0747spyM18_0746NC_003485
46Synechococcus elongatus PCC 6301 (Synechococcus leopoliensis SAG)1631 syc0670_dsyc0669_dNC_006576
47Synechocystis sp. PCC 6803961 ssr1766ssr1765NC_000911
48Thermococcus kodakarensis KOD11590 TK1510TK1511NC_006624
49Thermotoga maritima MSB81324 experimental TM1312TM1311NC_000853
50Thermotoga maritima MSB81325 experimental TM1313TM1312NC_000853
51Thermus thermophilus HB271617 TTC1705TTC1704NC_005835
52Thermus thermophilus HB271615 TTC1549TTC1548NC_005835
53Thermus thermophilus HB271613 TTC1395TTC1394NC_005835
54Thermus thermophilus HB81380 TTHA1913TTHA1912NC_006461
55Thermus thermophilus HB81371 TTHA0932TTHA0933NC_006461
56Treponema denticola ATCC 354051689 TDE0482TDE0481NC_002967
57Treponema denticola ATCC 354051698 TDE0989TDE0990NC_002967
58Treponema denticola ATCC 354051705 TDE1838TDE1837NC_002967
59Treponema denticola ATCC 354051711 TDE2213TDE2214NC_002967
60Treponema denticola ATCC 354051713 TDE2252TDE2253NC_002967
61Xylella fastidiosa Temecula1786 PD1343PD1342NC_004556
62Yersinia pestis biovar Microtus str. 910011401 YP_1575YP_1576NC_005810
63Yersinia pestis KIM10+630 y2489y2490NC_004088

experimental Data derived from experimental literature
The hicAB loci are abundant in bacteria and archaea. The toxin HicA induces RNA and severely reduced the global rate of translation. HicB neutralizes HicA as an antitoxin.
Conserved Domain
Accession No.NameRelation/involvement in TA lociReference
COG4226HicBHicB of HicAB system (predicted)PubMed:17678530
pfam05534HicBMember of the HicAB systemPubMed:17678530
COG1598COG1598HicB of HicAB system (function undetermined)PubMed:17678530
COG1724COG1724HicA of HicAB system (function undetermined)PubMed:17678530


Structure
N/A
(1) Jorgensen MG et al. (2009) HicA of Escherichia coli defines a novel family of translation-independent mRNAinterferases in bacteria and archaea. J Bacteriol 191(4):1191-9. [PudMed:19060138] experimental
(2) Makarova KS et al. (2006) The HicAB cassette, a putative novel, RNA-targeting toxin-antitoxin system inarchaea and bacteria. Bioinformatics 22(21):2581-4. [PudMed:16895922] in_silico
 
experimental experimental literature
in_silico in silico analysis literature