TADB 2.0: an updated database of toxin-antitoxin loci in Bacteria and Archaea


Toxin-antitoxin (TA) loci play a role in bacterial stress physiology and the stabilisation of horizontally acquired elements. TA loci are found abundantly distributed among free-living Bacteria and Archaea. TA loci code for a stable toxin that is neutralized by a short-lived antitoxin. The antitoxin can be either an antisense RNA (Type 1 TA loci) or a protein (Type 2 TA loci). To date, six type TA systems have been reported (see the recent review of Rebecca Page & Wolfgang PetiNature in Chemical Biology 2016, 12, 208–214).

The aim of this PostgreSQL-based TADB database is to create and maintain a resource of all currently available TA loci-relevant data ranging from 'wet' experimental data to information garnered by bioinformatics analyses. The TADB version 1.0 archived the type II TA loci. Now we try to offer TADB 2.0 as a 'one-stop-shop' for ease of access to the all the reported six type TA resources (type II, I, III, IV, V and VI). Importantly, we aim to continue to further develop TADB substantially over the years ahead, both through our own initiatives and in response to user suggestions and work patterns, and are confident that TADB will facilitate efficient investigation of the many molecular, biological, cellular and evolutionary processes that relate to these mysterious but near-ubiquitous prokaryotic systems.

Reference for TADB 1.0: Y. Shao, E.M. Harrison, D. Bi, C. Tai, X. He, H.Y. Ou, K. Rajakumar and Z. Deng (2011) TADB: a web-based resource for Type 2 toxin-antitoxin loci in Bacteria and Archaea. Nucleic Acids Research, 39, D606-D611. [Abstract]

Current version: 2.0
Since Dec., 2010; Updated: Sept., 2017
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