TADB
Last Update: June, 2017

Categories
Reviews Bioinformatics Experimental data Protein Structure
Genome/Sequence data Applications of TA loci News Persister related All
Search
    

Number of references found for the 'All' category : 592

References
(1) Loris R et al. (1999) Crystal structure of CcdB, a topoisomerase poison from E. coli. J Mol Biol. 285(4):1667-77.. [PudMed:9917404]
(2) Gronlund H et al. (1999) Toxin-antitoxin systems homologous with relBE of Escherichia coli plasmid P307are ubiquitous in prokaryotes. J Mol Biol 285(4):1401-15. [PudMed:9917385]
(3) Gazit E et al. (1999) Stability and DNA binding of the phd protein of the phage P1 plasmid addictionsystem. J Biol Chem 274(5):2652-7. [PudMed:9915794]
(4) Engelberg-Kulka H et al. (1998) rexB of bacteriophage lambda is an anti-cell death gene. Proc Natl Acad Sci U S A 95(26):15481-6. [PudMed:9860994]
(5) Hayes F. (1998) A family of stability determinants in pathogenic bacteria. J Bacteriol 180(23):6415-8. [PudMed:9829958]
(6) Magnuson R et al. (1998) Corepression of the P1 addiction operon by Phd and Doc. J Bacteriol 180(23):6342-51. [PudMed:9829946]
(7) Gotfredsen M et al. (1998) The Escherichia coli relBE genes belong to a new toxin-antitoxin gene family. Mol Microbiol 29(4):1065-76. [PudMed:9767574]
(8) Smith AS et al. (1998) Autoregulation of the pTF-FC2 proteic poison-antidote plasmid addiction system(pas) is essential for plasmid stabilization. J Bacteriol 180(20):5463-5. [PudMed:9765582]
(9) Smith AS et al. (1997) The poison-antidote stability system of the broad-host-range Thiobacillusferrooxidans plasmid pTF-FC2. Mol Microbiol 26(5):961-70. [PudMed:9426133]
(10) Easter CL et al. (1997) Contribution of different segments of the par region to stable maintenance ofthe broad-host-range plasmid RK2. J Bacteriol 179(20):6472-9. [PudMed:9335298]
(11) Bloomfield GA et al. (1997) Analysis of sequences flanking the vap regions of Dichelobacter nodosus:evidence for multiple integration events, a killer system, and a new geneticelement. Microbiology 143 ( Pt 2):553-62. [PudMed:9043132]
(12) Magnuson R et al. (1996) Autoregulation of the plasmid addiction operon of bacteriophage P1. J Biol Chem 271(31):18705-10. [PudMed:8702525]
(13) Aizenman E et al. (1996) An Escherichia coli chromosomal "addiction module" regulated by guanosine[corrected] 3',5'-bispyrophosphate: a model for programmed bacterial cell death. Proc Natl Acad Sci U S A 93(12):6059-63. [PudMed:8650219]
(14) Tian QB et al. (1996) A new plasmid-encoded proteic killer gene system: cloning, sequencing, andanalyzing hig locus of plasmid Rts1. Biochem Biophys Res Commun 220(2):280-4. [PudMed:8645296]
(15) Johnson EP et al. (1996) Plasmid RK2 toxin protein ParE: purification and interaction with the ParD antitoxin protein. J Bacteriol 178(5):1420-9. [PudMed:8631720]
(16) Lehnherr H et al. (1993) Plasmid addiction genes of bacteriophage P1: doc, which causes cell death oncuring of prophage, and phd, which prevents host death when prophage isretained. J Mol Biol 233(3):414-28. [PudMed:8411153]
(17) Black DS et al. (1994) Autoregulation of hip, an operon that affects lethality due to inhibition ofpeptidoglycan or DNA synthesis. J Bacteriol 176(13):4081-91. [PudMed:8021189]
(18) Bernard P et al. (1994) Positive-selection vectors using the F plasmid ccdB killer gene. Gene. 148(1):71-4.. [PudMed:7926841]
(19) Lehnherr H et al. (1995) Addiction protein Phd of plasmid prophage P1 is a substrate of the ClpXP serineprotease of Escherichia coli. Proc Natl Acad Sci U S A 92(8):3274-7. [PudMed:7724551]
(20) Bernard P. (1995) New ccdB positive-selection cloning vectors with kanamycin or chloramphenicol selectable markers. Gene. 162(1):159-60.. [PudMed:7557407]
(21) Jensen RB et al. (1995) Comparison of ccd of F, parDE of RP4, and parD of R1 using a novel conditionalreplication control system of plasmid R1. Mol Microbiol 17(2):211-20. [PudMed:7494470]
(22) Jensen RB et al. (1995) Programmed cell death in bacteria: proteic plasmid stabilization systems. Mol Microbiol 17(2):205-10. [PudMed:7494469]
(23) Moyed HS et al. (1983) hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis J Bacteriol. 155(2):768-75.. [PudMed:6348026]
(24) Jaffé A et al. (1985) Effects of the ccd function of the F plasmid on bacterial growth. J Bacteriol. 163(3):841-9.. [PudMed:3897195]
(25) Bravo A et al. (1987) Identification of components of a new stability system of plasmid R1, ParD, that is close to the origin of replication of this plasmid. Mol Gen Genet. 210(1):101-10.. [PudMed:3323833]
(26) Jurenas et al. (2017) AtaT blocks translation initiation by N-acetylation of the initiator tRNAfMet Nat Chem Biol 13(6):640-646. [PudMed:28369041]
(27) Ruangprasert et al. (2017) Importance of the E. coli DinJ antitoxin carboxy terminus for toxin suppression and regulated proteolysis Mol Microbiol 104(1):65-77. [PudMed:28164393]
(28) Li et al. (2016) Genomic analyses of multi-drug resistant Pseudomonas aeruginosa PA1 re-sequenced by single-molecule real-time sequencing Biosci Rep 36(6). pii: e00418. [PudMed:27765811]
(29) Chan et al. (2016) The Streptococcus pneumoniae pezAT Toxin-Antitoxin System Reduces beta-Lactam Resistance and Genetic Competence Front Microbiol 7:1322. [PudMed:27610103]
(30) Zhao et al. (2016) Toxin YafQ Reduces Escherichia coli Growth at Low Temperatures PLoS One 11(8):e0161577. [PudMed:27557125]
(31) Li et al. (2016) Identification and characterization of chromosomal relBE toxin-antitoxin locus in Streptomyces cattleya DSM46488 Sci Rep 6:32047. [PudMed:27534445]
(32) Wei et al. (2016) Functional characterization of RelBE toxin-antitoxin system in probiotic Bifidobacterium longum JDM301 Acta Biochim Biophys Sin (Shanghai) 48(8):741-9. [PudMed:27451444]
(33) Triplett et al. (2016) AvrRxo1 Is a Bifunctional Type III Secreted Effector and Toxin-Antitoxin System Component with Homologs in Diverse Environmental Contexts PLoS One 11(7):e0158856. [PudMed:27391081]
(34) Gupta et al. (2016) The Chromosomal parDE2 Toxin-Antitoxin System of Mycobacterium tuberculosis H37Rv: Genetic and Functional Characterization Front Microbiol 7:886. [PudMed:27379032]
(35) Merfa et al. (2016) The MqsRA Toxin-Antitoxin System from Xylella fastidiosa Plays a Key Role in Bacterial Fitness, Pathogenicity, and Persister Cell Formation Front Microbiol 7:904. [PudMed:27375608]
(36) Shen et al. (2016) Identification and functional analysis of two toxin-antitoxin systems in Campylobacter jejuni Mol Microbiol 101(6):909-23. [PudMed:27291507]
(37) Miyamoto et al. (2016) AAU-Specific RNA Cleavage Mediated by MazF Toxin Endoribonuclease Conserved in Nitrosomonas europaea Toxins (Basel) 8(6). [PudMed:27271670]
(38) Cheverton et al. (2016) A Salmonella Toxin Promotes Persister Formation through Acetylation of tRNA Mol Cell 63(1):86-96. [PudMed:27264868]
(39) Li et al. (2016) Identification and Characterization of the HicAB Toxin-Antitoxin System in the Opportunistic Pathogen Pseudomonas aeruginosa Toxins (Basel) 8(4):113. [PudMed:27104566]
(40) Page R et al. (2016) Toxin-antitoxin systems in bacterial growth arrest and persistence. Nat Chem Biol. 12(4):208-14. [PudMed:26991085]
(41) Brielle R et al. (2016) Linking bacterial type I toxins with their actions. Curr Opin Microbiol. 30:114-121. [PudMed:26874964]
(42) Ho et al. (2015) The Complete Sequence and Comparative Analysis of a Multidrug-Resistance and Virulence Multireplicon IncFII Plasmid pEC302/04 from an Extraintestinal Pathogenic Escherichia coli EC302/04 Indicate Extensive Diversity of IncFII Plasmids Front Microbiol 6:1547. [PudMed:26793180]
(43) Shavit et al. (2015) The vapB-vapC Operon of Acidovorax citrulli Functions as a Bona-fide Toxin-Antitoxin Module Front Microbiol 6:1499. [PudMed:26779154]
(44) Yamaguchi et al. (2015) An endogenous protein inhibitor, YjhX (TopAI), for topoisomerase I from Escherichia coli Nucleic acids research 43(21):10387-96. [PudMed:26553797]
(45) Korch et al. (2015) The Mycobacterium tuberculosis relBE toxin:antitoxin genes are stress-responsive modules that regulate growth through translation inhibition J Microbiol 11:783-95. [PudMed:26502963]
(46) Wessner et al. (2015) Regulatory crosstalk between type I and type II toxin-antitoxin systems in the human pathogen Enterococcus faecalis RNA Biol 10:1099-108. [PudMed:26305399]
(47) Melnicakova et al. (2015) Analysis of the Bacillus cereus SpoIIS antitoxin-toxin system reveals its three-component nature Front Microbiol 808. [PudMed:26300872]
(48) Short FL et al. (2015) A Type III protein-RNA toxin-antitoxin system from Bacillus thuringiensis promotes plasmid retention during spore development. RNA Biol. 12(9):933-7. [PudMed:26274022]
(49) Zheng et al. (2015) Identification and characterization of the chromosomal yefM-yoeB toxin-antitoxin system of Streptococcus suis Sci Rep 5:13125. [PudMed:26272287]
(50) Averina et al. (2015) Functional analysis of the type II toxin-antitoxin systems of the MazEF and RelBE families in Bifidobacterium longum subsp. infantis ATCC 15697 Anaerobe Pt B:59-67. [PudMed:26210151]
(51) Lee et al. (2015) Structural and functional studies of the Mycobacterium tuberculosis VapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides Nucleic Acids Res 15:7624-37. [PudMed:26150422]
(52) Yao et al. (2015) The chromosomal SezAT toxin-antitoxin system promotes the maintenance of the SsPI-1 pathogenicity island in epidemic Streptococcus suis Mol Microbiol 98(2):243-57. [PudMed:26138696]
(53) Yao et al. (2015) Identification and characterization of a HEPN-MNT family type II toxin-antitoxin in Shewanella oneidensis Microb Biotechnol 8(6):961-73. [PudMed:26112399]
(54) Heiss et al. (2015) Characterization of the Lactobacillus plantarum plasmid pCD033 and generation of the plasmid free strain L. plantarum 3NSH Plasmid 81:9-20. [PudMed:26038184]
(55) Schuster et al. (2015) The MazEF Toxin-Antitoxin System Alters the beta-Lactam Susceptibility of Staphylococcus aureus PloS one 5:e0126118. [PudMed:25965381]
(56) Iqbal et al. (2015) Comprehensive Functional Analysis of the 18 Vibrio cholerae N16961 Toxin-Antitoxin Systems Substantiates Their Role in Stabilizing the Superintegron Journal of bacteriology 13:2150-9. [PudMed:25897030]
(57) (2013) [Bacterial toxin-antitoxin systems and perspectives for their application in medicine: a review] Prikl Biokhim Mikrobiol 49(6):539-46. [PudMed:25434177]
(58) Schuster CF; Bertram R (2014) Fluorescence Based Primer Extension Technique to Determine Transcriptional Starting Points and Cleavage Sites of RNases In Vivo J Vis Exp (92):e52134. [PudMed:25406941]
(59) Doroghazi JR; Buckley DH (2014) Intraspecies comparison of Streptomyces pratensis genomes reveals high levels of recombination and gene conservation between strains of disparate geographic origin BMC Genomics 15(1):970. [PudMed:25399205]
(60) Hamilton B; Manzella A; Schmidt K; DiMarco V; Butler JS (2014) Analysis of Non-Typeable Haemophilous influenzae VapC1 Mutations Reveals Structural Features Required for Toxicity and Flexibility in the Active Site PLoS One 9(11):e112921. [PudMed:25391136]
(61) Bustamante P; Tello M; Orellana O (2014) Toxin-Antitoxin Systems in the Mobile Genome of Acidithiobacillus ferrooxidans PLoS One 9(11):e112226. [PudMed:25384039]
(62) Fiedoruk K; Daniluk T; Swiecicka I; Sciepuk M; Leszczynska K (2014) Type II toxin-antitoxin systems are unevenly distributed among Escherichia coli phylogroups Microbiology 161(Pt 1):158-67. [PudMed:25378561]
(63) Prax M; Bertram R (2014) Metabolic aspects of bacterial persisters Front Cell Infect Microbiol 4:148. [PudMed:25374846]
(64) De Gieter S; Konijnenberg A; Talavera A; Butterer A; Haesaerts S; De Greve H; Sobott F; Loris R; Garcia-Pino A (2014) The Intrinsically Disordered Domain of the Antitoxin Phd Chaperones the Toxin Doc Against Irreversible Inactivation and Misfolding J Biol Chem 289(49):34013-23. [PudMed:25326388]
(65) Weaver KE (2014) The Type I toxin-antitoxin par locus from Enterococcus faecalis plasmid pAD1: RNA regulation by both cis- and trans-acting elements Plasmid 78:65-70. [PudMed:25312777]
(66) Lee HJ; Jin HM; Park MS; Park W; Madsen EL; Jeon CO (2014) Recovery from natural environments of plasmid pEMB1 whose toxin-antitoxin system stabilizes an ampicillin-resistance beta-lactamase gene in E. coli Appl Environ Microbiol 81(1):40-7. [PudMed:25304509]
(67) Kumar S; Engelberg-Kulka H (2014) Quorum sensing peptides mediating interspecies bacterial cell death as a novel class of antimicrobial agents Curr Opin Microbiol 21C:22-27. [PudMed:25244032]
(68) Luo P; Hu C (2014) [Bacterial SXT/R391 family from integrating conjugative elements--a review] Wei Sheng Wu Xue Bao 54(5):471-9. [PudMed:25199245]
(69) Shimazu T; Mirochnitchenko O; Phadtare S; Inouye M (2014) Regression of solid tumors by induction of MazF, a bacterial mRNA endoribonuclease J Mol Microbiol Biotechnol 24(4):228-33. [PudMed:25196606]
(70) Sterckx YG; Haesaerts S; Van Melderen L; Loris R (2014) Crystallization and preliminary X-ray analysis of two variants of the Escherichia coli O157 ParE2-PaaA2 toxin-antitoxin complex Acta Crystallogr F Struct Biol Commun 70(Pt 9):1284-91. [PudMed:25195911]
(71) Lipuma J; Cinege G; Bodogai M; Olah B; Kiers A; Endre G; Dupont L; Dusha I (2014) A vapBC-type toxin-antitoxin module of Sinorhizobium meliloti influences symbiotic efficiency and nodule senescence of Medicago sativa Environ Microbiol 16(12):3714-29. [PudMed:25156344]
(72) Starosta AL; Lassak J; Jung K; Wilson DN (2014) The bacterial translation stress response FEMS Microbiol Rev 38(6):1172-201. [PudMed:25135187]
(73) Szuplewska M; Ludwiczak M; Lyzwa K; Czarnecki J; Bartosik D (2014) Mobility and generation of mosaic non-autonomous transposons by Tn3-derived inverted-repeat miniature elements (TIMEs) PLoS One 9(8):e105010. [PudMed:25121765]
(74) Proctor RA; Kriegeskorte A; Kahl BC; Becker K; Loffler B; Peters G (2014) Staphylococcus aureus Small Colony Variants (SCVs): a road map for the metabolic pathways involved in persistent infections Front Cell Infect Microbiol 4:99. [PudMed:25120957]
(75) Bibi-Triki S; Li de la Sierra-Gallay I; Lazar N; Leroy A; Van Tilbeurgh H; Sebbane F; Pradel E (2014) Functional and structural analysis of HicA3-HicB3, a novel toxin-antitoxin system of Yersinia pestis J Bacteriol 196(21):3712-23. [PudMed:25112480]
(76) Matilla MA; Salmond GP (2014) Bacteriophage varphiMAM1, a viunalikevirus, is a broad-host-range, high-efficiency generalized transducer that infects environmental and clinical isolates of the enterobacterial genera Serratia and Kluyvera Appl Environ Microbiol 80(20):6446-57. [PudMed:25107968]
(77) Conlon BP (2014) Staphylococcus aureus chronic and relapsing infections: Evidence of a role for persister cells: An investigation of persister cells, their formation and their role in S. aureus disease Bioessays 36(10):991-6. [PudMed:25100240]
(78) Wen J; Fozo EM (2014) sRNA antitoxins: more than one way to repress a toxin Toxins (Basel) 6(8):2310-35. [PudMed:25093388]
(79) Mingoia M; Morici E; Morroni G; Giovanetti E; Del Grosso M; Pantosti A; Varaldo PE (2014) Tn5253 family integrative and conjugative elements carrying mef(I) and catQ determinants in Streptococcus pneumoniae and Streptococcus pyogenes Antimicrob Agents Chemother 58(10):5886-93. [PudMed:25070090]
(80) Wen Y; Behiels E; Felix J; Elegheert J; Vergauwen B; Devreese B; Savvides SN (2014) The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence Nucleic Acids Res 42(15):10134-47. [PudMed:25056321]
(81) Lopes AP; Lopes LM; Fraga TR; Chura-Chambi RM; Sanson AL; Cheng E; Nakajima E; Morganti L; Martins EA (2014) VapC from the leptospiral VapBC toxin-antitoxin module displays ribonuclease activity on the initiator tRNA PLoS One 9(7):e101678. [PudMed:25047537]
(82) Hu Y; Kwan BW; Osbourne DO; Benedik MJ; Wood TK (2014) Toxin YafQ increases persister cell formation by reducing indole signalling Environ Microbiol 17(4):1275-85. [PudMed:25041421]
(83) Makroczyova J; Resetarova S; Florek P; Barak I (2014) Topology of the Bacillus subtilis SpoIISA protein and its role in toxin-antitoxin function FEMS Microbiol Lett 358(2):180-7. [PudMed:25039482]
(84) Aravind L; Zhang D; de Souza RF; Anand S; Iyer LM (2015) The Natural History of ADP-Ribosyltransferases and the ADP-Ribosylation System Curr Top Microbiol Immunol 384:3-32. [PudMed:25027823]
(85) Ghafourian S; Good L; Sekawi Z; Hamat RA; Soheili S; Sadeghifard N; Neela V (2014) The mazEF toxin-antitoxin system as a novel antibacterial target in Acinetobacter baumannii Mem Inst Oswaldo Cruz 109(4):502-5. [PudMed:25004148]
(86) Wardal E; Markowska K; Zabicka D; Wroblewska M; Giemza M; Mik E; Polowniak-Pracka H; Wozniak A; Hryniewicz W; Sadowy E (2014) Molecular analysis of vanA outbreak of Enterococcus faecium in two Warsaw hospitals: the importance of mobile genetic elements Biomed Res Int 2014:575367. [PudMed:25003118]
(87) Cottell JL; Saw HT; Webber MA; Piddock LJ (2014) Functional genomics to identify the factors contributing to successful persistence and global spread of an antibiotic resistance plasmid BMC Microbiol 14:168. [PudMed:24961279]
(88) Zhang D; Iyer LM; Burroughs AM; Aravind L (2014) Resilience of biochemical activity in protein domains in the face of structural divergence Curr Opin Struct Biol 26:92-103. [PudMed:24952217]
(89) Hammerle H; Amman F; Vecerek B; Stulke J; Hofacker I; Blasi U (2014) Impact of Hfq on the Bacillus subtilis transcriptome PLoS One 9(6):e98661. [PudMed:24932523]
(90) Liang Y; Gao Z; Wang F; Zhang Y; Dong Y; Liu Q (2014) Structural and functional characterization of Escherichia coli toxin-antitoxin complex DinJ-YafQ J Biol Chem 289(30):21191-202. [PudMed:24923448]
(91) Michaux C; Hartke A; Martini C; Reiss S; Albrecht D; Budin-Verneuil A; Sanguinetti M; Engelmann S; Hain T; Verneuil N; Giard JC (2014) Involvement of Enterococcus faecalis small RNAs in stress response and virulence Infect Immun 82(9):3599-611. [PudMed:24914223]
(92) Ogier JC; Pages S; Bisch G; Chiapello H; Medigue C; Rouy Z; Teyssier C; Vincent S; Tailliez P; Givaudan A; Gaudriault S (2014) Attenuated virulence and genomic reductive evolution in the entomopathogenic bacterial symbiont species, Xenorhabdus poinarii Genome Biol Evol 6(6):1495-513. [PudMed:24904010]
(93) Ruangprasert A; Maehigashi T; Miles SJ; Giridharan N; Liu JX; Dunham CM (2014) Mechanisms of toxin inhibition and transcriptional repression by Escherichia coli DinJ-YafQ J Biol Chem 289(30):20559-69. [PudMed:24898247]
(94) Mosqueda N; Gato E; Roca I; Lopez M; de Alegria CR; Fernandez Cuenca F; Martinez-Martinez L; Pachon J; Cisneros JM; Rodriguez-Bano J; Pascual A; Vila J; Bou G; Tomas M (2014) Characterization of plasmids carrying the blaOXA-24/40 carbapenemase gene and the genes encoding the AbkA/AbkB proteins of a toxin/antitoxin system J Antimicrob Chemother 69(10):2629-33. [PudMed:24879663]
(95) Wright O; Delmans M; Stan GB; Ellis T (2014) GeneGuard: A Modular Plasmid System Designed for Biosafety ACS Synth Biol 4(3):307-16. [PudMed:24847673]
(96) Loris R; Garcia-Pino A (2014) Disorder- and dynamics-based regulatory mechanisms in toxin-antitoxin modules Chem Rev 114(13):6933-47. [PudMed:24806488]
(97) Soo VW; Cheng HY; Kwan BW; Wood TK (2014) de novo synthesis of a bacterial toxin/antitoxin system Sci Rep 3.504861111. [PudMed:24797297]
(98) Helaine S; Kugelberg E (2014) Bacterial persisters: formation, eradication, and experimental systems Trends Microbiol 22(7):417-24. [PudMed:24768561]
(99) Sterckx YG; Volkov AN; Vranken WF; Kragelj J; Jensen MR; Buts L; Garcia-Pino A; Jove T; Van Melderen L; Blackledge M; van Nuland NA; Loris R (2014) Small-angle X-ray scattering- and nuclear magnetic resonance-derived conformational ensemble of the highly flexible antitoxin PaaA2 Structure 22(6):854-65. [PudMed:24768114]
(100) Maisonneuve E; Gerdes K (2014) Molecular mechanisms underlying bacterial persisters Cell 157(3):539-48. [PudMed:24766804]
(101) Clark CG; Chong PM; McCorrister SJ; Mabon P; Walker M; Westmacott GR (2014) DNA sequence heterogeneity of Campylobacter jejuni CJIE4 prophages and expression of prophage genes PLoS One 9(4):e95349. [PudMed:24756024]
(102) Zorzini V; Buts L; Sleutel M; Garcia-Pino A; Talavera A; Haesaerts S; De Greve H; Cheung A; van Nuland NA; Loris R (2014) Structural and biophysical characterization of Staphylococcus aureus SaMazF shows conservation of functional dynamics Nucleic Acids Res 42(10):6709-25. [PudMed:24748664]
(103) Guo Y; Quiroga C; Chen Q; McAnulty MJ; Benedik MJ; Wood TK; Wang X (2014) RalR (a DNase) and RalA (a small RNA) form a type I toxin-antitoxin system in Escherichia coli Nucleic Acids Res 42(10):6448-62. [PudMed:24748661]
(104) Yang M; Gao CH; Hu J; Dong C; He ZG (2014) Characterization of the interaction between a SirR family transcriptional factor of Mycobacterium tuberculosis, encoded by Rv2788, and a pair of toxin-antitoxin proteins RelJ/K, encoded by Rv3357 and Rv3358 FEBS J 281(12):2726-37. [PudMed:24725376]
(105) Martinez LC; Vadyvaloo V (2014) Mechanisms of post-transcriptional gene regulation in bacterial biofilms Front Cell Infect Microbiol 4:38. [PudMed:24724055]
(106) Van Acker H; Sass A; Dhondt I; Nelis HJ; Coenye T (2014) Involvement of toxin-antitoxin modules in Burkholderia cenocepacia biofilm persistence Pathog Dis 71(3):326-35. [PudMed:24719230]
(107) Schifano JM; Vvedenskaya IO; Knoblauch JG; Ouyang M; Nickels BE; Woychik NA (2014) An RNA-seq method for defining endoribonuclease cleavage specificity identifies dual rRNA substrates for toxin MazF-mt3 Nat Commun 2.665277778. [PudMed:24709835]
(108) Pinel-Marie ML; Brielle R; Felden B (2014) Dual toxic-peptide-coding Staphylococcus aureus RNA under antisense regulation targets host cells and bacterial rivals unequally Cell Rep 7(2):424-35. [PudMed:24703849]
(109) Hino M; Zhang J; Takagi H; Miyoshi T; Uchiumi T; Nakashima T; Kakuta Y; Kimura M (2014) Characterization of putative toxin/antitoxin systems in Vibrio parahaemolyticus J Appl Microbiol 117(1):185-95. [PudMed:24698443]
(110) Im H; Jang SB; Pathak C; Yang YJ; Yoon HJ; Yu TK; Suh JY; Lee BJ (2014) Crystal structure of toxin HP0892 from Helicobacter pylori with two Zn(II) at 1.8 A resolution Protein Sci 23(6):819-32. [PudMed:24677509]
(111) Sala A; Bordes P; Genevaux P (2014) Multiple toxin-antitoxin systems in Mycobacterium tuberculosis Toxins (Basel) 6(3):1002-20. [PudMed:24662523]
(112) Merhej V; Angelakis E; Socolovschi C; Raoult D (2014) Genotyping, evolution and epidemiological findings of Rickettsia species Infect Genet Evol 25:122-37. [PudMed:24662440]
(113) Sadeghifard N; Soheili S; Sekawi Z; Ghafourian S (2014) Is the mazEF toxin-antitoxin system responsible for vancomycin resistance in clinical isolates of Enterococcus faecalis GMS Hyg Infect Control 9(1):Doc05. [PudMed:24653969]
(114) Verma S; Kumar S; Gupta VP; Gourinath S; Bhatnagar S; Bhatnagar R (2014) Structural basis of Bacillus anthracis MoxXT disruption and the modulation of MoxT ribonuclease activity by rationally designed peptides J Biomol Struct Dyn 33(3):606-24. [PudMed:24650157]
(115) Ren D; Kordis AA; Sonenshine DE; Daines DA (2014) The ToxAvapA toxin-antitoxin locus contributes to the survival of nontypeable Haemophilus influenzae during infection PLoS One 9(3):e91523. [PudMed:24621787]
(116) Ciric L; Brouwer MS; Mullany P; Roberts AP (2014) Minocycline resistance in an oral Streptococcus infantis isolate is encoded by tet(S) on a novel small, low copy number plasmid FEMS Microbiol Lett 353(2):106-15. [PudMed:24605990]
(117) Schifano JM; Woychik NA (2014) 23S rRNA as an a-Maz-ing new bacterial toxin target RNA Biol 11(2):101-5. [PudMed:24525465]
(118) Bertram R; Schuster CF (2014) Post-transcriptional regulation of gene expression in bacterial pathogens by toxin-antitoxin systems Front Cell Infect Microbiol 4:06. [PudMed:24524029]
(119) Yamaguchi Y; Tokunaga N; Inouye M; Phadtare S (2014) Characterization of LdrA (long direct repeat A) protein of Escherichia coli J Mol Microbiol Biotechnol 24(2):91-7. [PudMed:24513967]
(120) Butt A; Higman VA; Williams C; Crump MP; Hemsley CM; Harmer N; Titball RW (2014) The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation Biochem J 459(2):333-44. [PudMed:24502667]
(121) Brzozowska I; Zielenkiewicz U (2014) The ClpXP protease is responsible for the degradation of the Epsilon antidote to the Zeta toxin of the streptococcal pSM19035 plasmid J Biol Chem 289(11):7514-23. [PudMed:24492616]
(122) Wen Y; Behiels E; Devreese B (2014) Toxin-Antitoxin systems: their role in persistence, biofilm formation, and pathogenicity Pathog Dis 70(3):240-9. [PudMed:24478112]
(123) Dy RL; Przybilski R; Semeijn K; Salmond GP; Fineran PC (2014) A widespread bacteriophage abortive infection system functions through a Type IV toxin-antitoxin mechanism Nucleic Acids Res 42(7):4590-605. [PudMed:24465005]
(124) Pimentel B; Nair R; Bermejo-Rodriguez C; Preston MA; Agu CA; Wang X; Bernal JA; Sherratt DJ; de la Cueva-Mendez G (2014) Toxin Kid uncouples DNA replication and cell division to enforce retention of plasmid R1 in Escherichia coli cells Proc Natl Acad Sci U S A 111(7):2734-9. [PudMed:24449860]
(125) Cruz JW; Rothenbacher FP; Maehigashi T; Lane WS; Dunham CM; Woychik NA (2014) Doc toxin is a kinase that inactivates elongation factor Tu J Biol Chem 289(11):7788-98. [PudMed:24448800]
(126) Hayes F; Kedzierska B (2014) Regulating toxin-antitoxin expression: controlled detonation of intracellular molecular timebombs Toxins (Basel) 6(1):337-58. [PudMed:24434949]
(127) Goeders N; Van Melderen L (2014) Toxin-antitoxin systems as multilevel interaction systems Toxins (Basel) 6(1):304-24. [PudMed:24434905]
(128) Xu Y; Zhang Z; Sun Z (2014) Drug resistance to Mycobacterium tuberculosis: From the traditional Chinese view to modern systems biology Crit Rev Microbiol 41(3):399-410. [PudMed:24433008]
(129) Demidenok OI; Kaprelyants AS; Goncharenko AV (2014) Toxin-antitoxin vapBC locus participates in formation of the dormant state in Mycobacterium smegmatis FEMS Microbiol Lett 352(1):69-77. [PudMed:24417293]
(130) Ning D; Zhao W; Qian Y (2013) [A hypothetical gene pair, ssl2138 and sll11092, constitutes a functional TA system on the chromosome of Synechocystis PCC 6803] Wei Sheng Wu Xue Bao 53(10):1043-9. [PudMed:24409759]
(131) Helaine S; Cheverton AM; Watson KG; Faure LM; Matthews SA; Holden DW (2014) Internalization of Salmonella by macrophages induces formation of nonreplicating persisters Science 343(6167):204-8. [PudMed:24408438]
(132) De la Cruz MA; Zhao W; Farenc C; Gimenez G; Raoult D; Cambillau C; Gorvel JP; Meresse S (2013) A toxin-antitoxin module of Salmonella promotes virulence in mice PLoS Pathog 9(12):e1003827. [PudMed:24385907]
(133) Tripathi A; Dewan PC; Siddique SA; Varadarajan R (2014) MazF-induced growth inhibition and persister generation in Escherichia coli J Biol Chem 289(7):4191-205. [PudMed:24375411]
(134) Cheng HY; Soo VW; Islam S; McAnulty MJ; Benedik MJ; Wood TK (2014) Toxin GhoT of the GhoT/GhoS toxin/antitoxin system damages the cell membrane to reduce adenosine triphosphate and to reduce growth under stress Environ Microbiol 16(6):1741-54. [PudMed:24373067]
(135) Feng J; Kessler DA; Ben-Jacob E; Levine H (2014) Growth feedback as a basis for persister bistability Proc Natl Acad Sci U S A 111(1):544-9. [PudMed:24344277]
(136) Kaspy I; Rotem E; Weiss N; Ronin I; Balaban NQ; Glaser G (2013) HipA-mediated antibiotic persistence via phosphorylation of the glutamyl-tRNA-synthetase Nat Commun 2.250694444. [PudMed:24343429]
(137) Agnoli K; Frauenknecht C; Freitag R; Schwager S; Jenul C; Vergunst A; Carlier A; Eberl L (2014) The third replicon of members of the Burkholderia cepacia Complex, plasmid pC3, plays a role in stress tolerance Appl Environ Microbiol 80(4):1340-8. [PudMed:24334662]
(138) Markovski M; Wickner S (2013) Preventing bacterial suicide: a novel toxin-antitoxin strategy Mol Cell 52(5):611-2. [PudMed:24332174]
(139) Loh JM; Proft T (2014) Comparison of firefly luciferase and NanoLuc luciferase for biophotonic labeling of group A Streptococcus Biotechnol Lett 36(4):829-34. [PudMed:24322775]
(140) Milunovic B; diCenzo GC; Morton RA; Finan TM (2014) Cell growth inhibition upon deletion of four toxin-antitoxin loci from the megaplasmids of Sinorhizobium meliloti J Bacteriol 196(4):811-24. [PudMed:24317400]
(141) Wu Z; Wang W; Tang M; Shao J; Dai C; Zhang W; Fan H; Yao H; Zong J; Chen D; Wang J; Lu C (2014) Comparative genomic analysis shows that Streptococcus suis meningitis isolate SC070731 contains a unique 105K genomic island Gene 535(2):156-64. [PudMed:24316490]
(142) Naka K; Koga M; Yonesaki T; Otsuka Y (2014) RNase HI stimulates the activity of RnlA toxin in Escherichia coli Mol Microbiol 91(3):596-605. [PudMed:24308852]
(143) Larson AS; Hergenrother PJ (2014) Light activation of Staphylococcus aureus toxin YoeBSa1 reveals guanosine-specific endoribonuclease activity Biochemistry 53(1):188-201. [PudMed:24279911]
(144) Mataseje LF; Boyd DA; Lefebvre B; Bryce E; Embree J; Gravel D; Katz K; Kibsey P; Kuhn M; Langley J; Mitchell R; Roscoe D; Simor A; Taylor G; Thomas E; Turgeon N; Mulvey MR (2014) Complete sequences of a novel blaNDM-1-harbouring plasmid from Providencia rettgeri and an FII-type plasmid from Klebsiella pneumoniae identified in Canada J Antimicrob Chemother 69(3):637-42. [PudMed:24275114]
(145) Chopra N; Saumitra; Pathak A; Bhatnagar R; Bhatnagar S (2013) Linkage, mobility, and selfishness in the MazF family of bacterial toxins: a snapshot of bacterial evolution Genome Biol Evol 5(12):2268-84. [PudMed:24265503]
(146) Ning D; Liu S; Xu W; Zhuang Q; Wen C; Tang X (2013) Transcriptional and proteolytic regulation of the toxin-antitoxin locus vapBC10 (ssr2962/slr1767) on the chromosome of Synechocystis sp. PCC 6803 PLoS One 8(11):e80716. [PudMed:24260461]
(147) Maj A; Dziewit L; Czarnecki J; Wlodarczyk M; Baj J; Skrzypczyk G; Giersz D; Bartosik D (2013) Plasmids of carotenoid-producing Paracoccus spp. (Alphaproteobacteria) - structure, diversity and evolution PLoS One 8(11):e80258. [PudMed:24260361]
(148) Schureck MA; Maehigashi T; Miles SJ; Marquez J; Cho SE; Erdman R; Dunham CM (2014) Structure of the Proteus vulgaris HigB-(HigA)2-HigB toxin-antitoxin complex J Biol Chem 289(2):1060-70. [PudMed:24257752]
(149) Unterholzner SJ; Poppenberger B; Rozhon W (2013) Toxin-antitoxin systems: Biology, identification, and application Mob Genet Elements 3(5):e26219. [PudMed:24251069]
(150) Schaufler K; Wieler LH; Semmler T; Ewers C; Guenther S (2013) ESBL-plasmids carrying toxin-antitoxin systems can be "cured" of wild-type Escherichia coli using a heat technique Gut Pathog 5(1):34. [PudMed:24245987]
(151) Aakre CD; Phung TN; Huang D; Laub MT (2013) A bacterial toxin inhibits DNA replication elongation through a direct interaction with the beta sliding clamp Mol Cell 52(5):617-28. [PudMed:24239291]
(152) Koksharova OA (2013) Bacteria and phenoptosis Biochemistry (Mosc) 78(9):963-70. [PudMed:24228917]
(153) Winther KS; Brodersen DE; Brown AK; Gerdes K (2013) VapC20 of Mycobacterium tuberculosis cleaves the sarcin-ricin loop of 23S rRNA Nat Commun 4:2796. [PudMed:24225902]
(154) Venturini C; Hassan KA; Roy Chowdhury P; Paulsen IT; Walker MJ; Djordjevic SP (2013) Sequences of two related multiple antibiotic resistance virulence plasmids sharing a unique IS26-related molecular signature isolated from different Escherichia coli pathotypes from different hosts PLoS One 8(11):e78862. [PudMed:24223859]
(155) Soo VW; Wood TK (2013) Antitoxin MqsA represses curli formation through the master biofilm regulator CsgD Sci Rep 2.3375. [PudMed:24212724]
(156) Wen J; Won D; Fozo EM (2014) The ZorO-OrzO type I toxin-antitoxin locus: repression by the OrzO antitoxin Nucleic Acids Res 42(3):1930-46. [PudMed:24203704]
(157) Sijbrandij T; Kaman WE; Ligtenberg AJ; Nazmi K; Veerman EC; Bikker FJ (2014) Bacillus globigii cell size is influenced by variants of the quorum sensing peptide extracellular death factor Antonie Van Leeuwenhoek 105(1):221-8. [PudMed:24198119]
(158) Das U; Kumar N; Gourinath S; Srinivasan A (2013) Preliminary crystallographic analysis of recombinant VapBC-15 toxin-antitoxin complex from Mycobacterium tuberculosis Acta Crystallogr Sect F Struct Biol Cryst Commun 69(Pt 11):1242-5. [PudMed:24192359]
(159) Ramirez MV; Dawson CC; Crew R; England K; Slayden RA (2013) MazF6 toxin of Mycobacterium tuberculosis demonstrates antitoxin specificity and is coupled to regulation of cell growth by a Soj-like protein BMC Microbiol 13:240. [PudMed:24172039]
(160) Tamman H; Ainelo A; Ainsaar K; Horak R (2014) A moderate toxin, GraT, modulates growth rate and stress tolerance of Pseudomonas putida J Bacteriol 196(1):157-69. [PudMed:24163334]
(161) Castro-Roa D; Garcia-Pino A; De Gieter S; van Nuland NA; Loris R; Zenkin N (2013) The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu Nat Chem Biol 9(12):811-7. [PudMed:24141193]
(162) Rose G; Cortes T; Comas I; Coscolla M; Gagneux S; Young DB (2013) Mapping of genotype-phenotype diversity among clinical isolates of mycobacterium tuberculosis by sequence-based transcriptional profiling Genome Biol Evol 5(10):1849-62. [PudMed:24115728]
(163) Wei Y; Gao ZQ; Otsuka Y; Naka K; Yonesaki T; Zhang H; Dong YH (2013) Structure-function studies of Escherichia coli RnlA reveal a novel toxin structure involved in bacteriophage resistance Mol Microbiol 90(5):956-65. [PudMed:24112600]
(164) Germain E; Castro-Roa D; Zenkin N; Gerdes K (2013) Molecular mechanism of bacterial persistence by HipA Mol Cell 52(2):248-54. [PudMed:24095282]
(165) Bjorkeng EK; Hjerde E; Pedersen T; Sundsfjord A; Hegstad K (2013) ICESluvan, a 94-kilobase mosaic integrative conjugative element conferring interspecies transfer of VanB-type glycopeptide resistance, a novel bacitracin resistance locus, and a toxin-antitoxin stabilization system J Bacteriol 195(23):5381-90. [PudMed:24078615]
(166) Loh JM; Proft T (2013) Toxin-antitoxin-stabilized reporter plasmids for biophotonic imaging of Group A streptococcus Appl Microbiol Biotechnol 97(22):9737-45. [PudMed:24061415]
(167) Mernik A; Andjelkovic U; Drobnak I; Lah J (2012) Differences in Unfolding Energetics of CcdB Toxins From V. fischeri and E. coli Acta Chim Slov 59(3):548-53. [PudMed:24061309]
(168) Pathak C; Im H; Yang YJ; Yoon HJ; Kim HM; Kwon AR; Lee BJ (2013) Crystal structure of apo and copper bound HP0894 toxin from Helicobacter pylori 26695 and insight into mRNase activity Biochim Biophys Acta 1834(12):2579-90. [PudMed:24060809]
(169) Polom D; Boss L; Wegrzyn G; Hayes F; Kedzierska B (2013) Amino acid residues crucial for specificity of toxin-antitoxin interactions in the homologous Axe-Txe and YefM-YoeB complexes FEBS J 280(22):5906-18. [PudMed:24028219]
(170) Boss L; Labudda L; Wegrzyn G; Hayes F; Kedzierska B (2013) The axe-txe complex of Enterococcus faecium presents a multilayered mode of toxin-antitoxin gene expression regulation PLoS One 8(9):e73569. [PudMed:24019928]
(171) Gelens L; Hill L; Vandervelde A; Danckaert J; Loris R (2013) A general model for toxin-antitoxin module dynamics can explain persister cell formation in E. coli PLoS Comput Biol 9(8):e1003190. [PudMed:24009490]
(172) Cataudella I; Sneppen K; Gerdes K; Mitarai N (2013) Conditional cooperativity of toxin - antitoxin regulation can mediate bistability between growth and dormancy PLoS Comput Biol 9(8):e1003174. [PudMed:24009488]
(173) van Rensburg JJ; Hergenrother PJ (2013) Detection of endogenous MazF enzymatic activity in Staphylococcus aureus Anal Biochem 443(1):81-7. [PudMed:23994560]
(174) Maisonneuve E; Castro-Camargo M; Gerdes K (2013) (p)ppGpp controls bacterial persistence by stochastic induction of toxin-antitoxin activity Cell 154(5):1140-50. [PudMed:23993101]
(175) Hadzi S; Garcia-Pino A; Martinez-Rodriguez S; Verschueren K; Christensen-Dalsgaard M; Gerdes K; Lah J; Loris R (2013) Crystallization of the HigBA2 toxin-antitoxin complex from Vibrio cholerae Acta Crystallogr Sect F Struct Biol Cryst Commun 69(Pt 9):1052-9. [PudMed:23989162]
(176) Frock AD; Montero CI; Blumer-Schuette SE; Kelly RM (2013) Stationary phase and nutrient levels trigger transcription of a genomic locus containing a novel peptide (TM1316) in the hyperthermophilic bacterium Thermotoga maritima Appl Environ Microbiol 79(21):6637-46. [PudMed:23974142]
(177) Jahn N; Brantl S (2013) One antitoxin--two functions: SR4 controls toxin mRNA decay and translation Nucleic Acids Res 41(21):9870-80. [PudMed:23969414]
(178) Mruk I; Kobayashi I (2014) To be or not to be: regulation of restriction-modification systems and other toxin-antitoxin systems Nucleic Acids Res 42(1):70-86. [PudMed:23945938]
(179) Xie Z; Qi F; Merritt J (2013) Development of a tunable wide-range gene induction system useful for the study of streptococcal toxin-antitoxin systems Appl Environ Microbiol 79(20):6375-84. [PudMed:23934493]
(180) Schuessler DL; Cortes T; Fivian-Hughes AS; Lougheed KE; Harvey E; Buxton RS; Davis EO; Young DB (2013) Induced ectopic expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA Mol Microbiol 90(1):195-207. [PudMed:23927792]
(181) Vercammen K; Garcia-Armisen T; Goeders N; Van Melderen L; Bodilis J; Cornelis P (2013) Identification of a metagenomic gene cluster containing a new class A beta-lactamase and toxin-antitoxin systems Microbiologyopen 2(4):674-83. [PudMed:23873667]
(182) Gao Y; Feng X; Xian M; Wang Q; Zhao G (2013) Inducible cell lysis systems in microbial production of bio-based chemicals Appl Microbiol Biotechnol 97(16):7121-9. [PudMed:23872961]
(183) Xu K; Dedic E; Cob-Cantal P; Dienemann C; Boggild A; Winther KS; Gerdes K; Brodersen DE (2013) Protein expression, crystallization and preliminary X-ray crystallographic analysis of the isolated Shigella flexneri VapC toxin Acta Crystallogr Sect F Struct Biol Cryst Commun 69(Pt 7):762-5. [PudMed:23832203]
(184) Nolle N; Schuster CF; Bertram R (2013) Two paralogous yefM-yoeB loci from Staphylococcus equorum encode functional toxin-antitoxin systems Microbiology 159(Pt 8):1575-85. [PudMed:23832005]
(185) Merhej V; Georgiades K; Raoult D (2013) Postgenomic analysis of bacterial pathogens repertoire reveals genome reduction rather than virulence factors Brief Funct Genomics 12(4):291-304. [PudMed:23814139]
(186) Samson JE; Belanger M; Moineau S (2013) Effect of the abortive infection mechanism and type III toxin/antitoxin system AbiQ on the lytic cycle of Lactococcus lactis phages J Bacteriol 195(17):3947-56. [PudMed:23813728]
(187) Ramisetty BC; Natarajan B; Santhosh RS (2013) mazEF-mediated programmed cell death in bacteria: "What is this? Crit Rev Microbiol 41(1):89-100. [PudMed:23799870]
(188) Fasani RA; Savageau MA (2013) Molecular mechanisms of multiple toxin-antitoxin systems are coordinated to govern the persister phenotype Proc Natl Acad Sci U S A 110(27):E2528-37. [PudMed:23781105]
(189) Bukowski M; Lyzen R; Helbin WM; Bonar E; Szalewska-Palasz A; Wegrzyn G; Dubin G; Dubin A; Wladyka B (2013) A regulatory role for Staphylococcus aureus toxin-antitoxin system PemIKSa Nat Commun 4:2012. [PudMed:23774061]
(190) Anantharaman V; Makarova KS; Burroughs AM; Koonin EV; Aravind L (2013) Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing Biol Direct 8:15. [PudMed:23768067]
(191) Averina OV; Alekseeva MG; Abilev SK; Il'in VK; Danilenko VN (2013) [Distribution of genes of toxin-antitoxin systems of mazEF and relBE families in bifidobacteria from human intestinal microbiota] Genetika 49(3):315-27. [PudMed:23755531]
(192) Ma Z; Geng J; Yi L; Xu B; Jia R; Li Y; Meng Q; Fan H; Hu S (2013) Insight into the specific virulence related genes and toxin-antitoxin virulent pathogenicity islands in swine streptococcosis pathogen Streptococcus equi ssp. zooepidemicus strain ATCC35246 BMC Genomics 14:377. [PudMed:23742619]
(193) Kumar S; Kolodkin-Gal I; Engelberg-Kulka H (2013) Novel quorum-sensing peptides mediating interspecies bacterial cell death MBio 4(3):e00314-13. [PudMed:23736285]
(194) Klimina KM; Kjasova DK; Poluektova EU; Krugel H; Leuschner Y; Saluz HP; Danilenko VN (2013) Identification and characterization of toxin-antitoxin systems in strains of Lactobacillus rhamnosus isolated from humans Anaerobe 22:82-9. [PudMed:23727113]
(195) Quax TE; Voet M; Sismeiro O; Dillies MA; Jagla B; Coppee JY; Sezonov G; Forterre P; van der Oost J; Lavigne R; Prangishvili D (2013) Massive activation of archaeal defense genes during viral infection J Virol 87(15):8419-28. [PudMed:23698312]
(196) Jurenaite M; Markuckas A; Suziedeliene E (2013) Identification and characterization of type II toxin-antitoxin systems in the opportunistic pathogen Acinetobacter baumannii J Bacteriol 195(14):3165-72. [PudMed:23667234]
(197) Amato SM; Orman MA; Brynildsen MP (2013) Metabolic control of persister formation in Escherichia coli Mol Cell 50(4):475-87. [PudMed:23665232]
(198) McNeil MB; Iglesias-Cans MC; Clulow JS; Fineran PC (2013) YgfX (CptA) is a multimeric membrane protein that interacts with the succinate dehydrogenase assembly factor SdhE (YgfY) Microbiology 159(Pt 7):1352-65. [PudMed:23657679]
(199) Ghafourian S; Raftari M; Sadeghifard N; Sekawi Z (2013) Toxin-antitoxin Systems: Classification, Biological Function and Application in Biotechnology Curr Issues Mol Biol 16(1):9-14. [PudMed:23652423]
(200) Schifano JM; Edifor R; Sharp JD; Ouyang M; Konkimalla A; Husson RN; Woychik NA (2013) Mycobacterial toxin MazF-mt6 inhibits translation through cleavage of 23S rRNA at the ribosomal A site Proc Natl Acad Sci U S A 110(21):8501-6. [PudMed:23650345]
(201) Unterholzner SJ; Hailer B; Poppenberger B; Rozhon W (2013) Characterisation of the stbD/E toxin-antitoxin system of pEP36, a plasmid of the plant pathogen Erwinia pyrifoliae Plasmid 70(2):216-25. [PudMed:23632277]
(202) Sevillano L; Diaz M; Santamaria RI (2013) Stable expression plasmids for Streptomyces based on a toxin-antitoxin system Microb Cell Fact 12:39. [PudMed:23617558]
(203) Inglis RF; Bayramoglu B; Gillor O; Ackermann M (2013) The role of bacteriocins as selfish genetic elements Biol Lett 9(3):20121173. [PudMed:23616642]
(204) Jaubert C; Danioux C; Oberto J; Cortez D; Bize A; Krupovic M; She Q; Forterre P; Prangishvili D; Sezonov G (2013) Genomics and genetics of Sulfolobus islandicus LAL14/1, a model hyperthermophilic archaeon Open Biol 3(4):130010. [PudMed:23594878]
(205) Tang F; Bossers A; Harders F; Lu C; Smith H (2013) Comparative genomic analysis of twelve Streptococcus suis (pro)phages Genomics 101(6):336-44. [PudMed:23587535]
(206) Freitas AR; Novais C; Tedim AP; Francia MV; Baquero F; Peixe L; Coque TM (2013) Microevolutionary events involving narrow host plasmids influences local fixation of vancomycin-resistance in Enterococcus populations PLoS One 8(3):e60589. [PudMed:23555993]
(207) Goeders N; Dreze PL; Van Melderen L (2013) Relaxed cleavage specificity within the RelE toxin family J Bacteriol 195(11):2541-9. [PudMed:23543711]
(208) Cheng G; Hao H; Dai M; Liu Z; Yuan Z (2013) Antibacterial action of quinolones: from target to network Eur J Med Chem 66:555-62. [PudMed:23528390]
(209) Anukam KC; Macklaim JM; Gloor GB; Reid G; Boekhorst J; Renckens B; van Hijum SA; Siezen RJ (2013) Genome sequence of Lactobacillus pentosus KCA1: vaginal isolate from a healthy premenopausal woman PLoS One 8(3):e59239. [PudMed:23527145]
(210) Miallau L; Jain P; Arbing MA; Cascio D; Phan T; Ahn CJ; Chan S; Chernishof I; Maxson M; Chiang J; Jacobs WR Jr; Eisenberg DS (2013) Comparative proteomics identifies the cell-associated lethality of M. tuberculosis RelBE-like toxin-antitoxin complexes Structure 21(4):627-37. [PudMed:23523424]
(211) Wright O; Stan GB; Ellis T (2013) Building-in biosafety for synthetic biology Microbiology 159(Pt 7):1221-35. [PudMed:23519158]
(212) Helaine S; Holden DW (2013) Heterogeneity of intracellular replication of bacterial pathogens Curr Opin Microbiol 16(2):184-91. [PudMed:23485258]
(213) Sberro H; Leavitt A; Kiro R; Koh E; Peleg Y; Qimron U; Sorek R (2013) Discovery of functional toxin/antitoxin systems in bacteria by shotgun cloning Mol Cell 50(1):136-48. [PudMed:23478446]
(214) Guerout AM; Iqbal N; Mine N; Ducos-Galand M; Van Melderen L; Mazel D (2013) Characterization of the phd-doc and ccd toxin-antitoxin cassettes from Vibrio superintegrons J Bacteriol 195(10):2270-83. [PudMed:23475970]
(215) Balado M; Lemos ML; Osorio CR (2013) Genetic characterization of pPHDP60, a novel conjugative plasmid from the marine fish pathogen Photobacterium damselae subsp. piscicida Plasmid 70(1):154-9. [PudMed:23474463]
(216) Makarova KS; Wolf YI; Koonin EV (2013) Comparative genomics of defense systems in archaea and bacteria Nucleic Acids Res 41(8):4360-77. [PudMed:23470997]
(217) Park SJ; Son WS; Lee BJ (2013) Structural overview of toxin-antitoxin systems in infectious bacteria: a target for developing antimicrobial agents Biochim Biophys Acta 1834(6):1155-67. [PudMed:23459128]
(218) Cook GM; Robson JR; Frampton RA; McKenzie J; Przybilski R; Fineran PC; Arcus VL (2013) Ribonucleases in bacterial toxin-antitoxin systems Biochim Biophys Acta 1829(6-7):523-31. [PudMed:23454553]
(219) Ning D; Jiang Y; Liu Z; Xu Q (2013) Characterization of a chromosomal type II toxin-antitoxin system mazEaFa in the Cyanobacterium Anabaena sp. PCC 7120 PLoS One 8(2):e56035. [PudMed:23451033]
(220) Kasari V; Mets T; Tenson T; Kaldalu N (2013) Transcriptional cross-activation between toxin-antitoxin systems of Escherichia coli BMC Microbiol 13:45. [PudMed:23432955]
(221) Belda E; Sekowska A; Le Fevre F; Morgat A; Mornico D; Ouzounis C; Vallenet D; Medigue C; Danchin A (2013) An updated metabolic view of the Bacillus subtilis 168 genome Microbiology 159(Pt 4):757-70. [PudMed:23429746]
(222) De Gieter S; Loris R; van Nuland NA; Garcia-Pino A (2014) (1)H, (1)(3)C, and (1)(5)N backbone and side-chain chemical shift assignment of the toxin Doc in the unbound state Biomol NMR Assign 8(1):145-8. [PudMed:23420131]
(223) Diago-Navarro E; Hernandez-Arriaga AM; Kubik S; Konieczny I; Diaz-Orejas R (2013) Cleavage of the antitoxin of the parD toxin-antitoxin system is determined by the ClpAP protease and is modulated by the relative ratio of the toxin and the antitoxin Plasmid 70(1):78-85. [PudMed:23419648]
(224) Dorsey-Oresto A; Lu T; Mosel M; Wang X; Salz T; Drlica K; Zhao X (2013) YihE kinase is a central regulator of programmed cell death in bacteria Cell Rep 3(2):528-37. [PudMed:23416055]
(225) Socolovschi C; Audoly G; Raoult D (2013) Connection of toxin-antitoxin modules to inoculation eschar and arthropod vertical transmission in Rickettsiales Comp Immunol Microbiol Infect Dis 36(2):199-209. [PudMed:23414774]
(226) Weel-Sneve et al. (2013) Single transmembrane peptide DinQ modulates membrane-dependent activities PLoS Genet. 9(2):e1003260. [PudMed:23408903]
(227) Brzozowska I; Zielenkiewicz U (2013) Regulation of toxin-antitoxin systems by proteolysis Plasmid 70(1):33-41. [PudMed:23396045]
(228) Bonnin RA; Poirel L; Nordmann P; Eikmeyer FG; Wibberg D; Puhler A; Schluter A (2013) Complete sequence of broad-host-range plasmid pNOR-2000 harbouring the metallo-beta-lactamase gene blaVIM-2 from Pseudomonas aeruginosa J Antimicrob Chemother 68(5):1060-5. [PudMed:23354281]
(229) Albrethsen J; Agner J; Piersma SR; Hojrup P; Pham TV; Weldingh K; Jimenez CR; Andersen P; Rosenkrands I (2013) Proteomic profiling of Mycobacterium tuberculosis identifies nutrient-starvation-responsive toxin-antitoxin systems Mol Cell Proteomics 12(5):1180-91. [PudMed:23345537]
(230) Rheinberg A; Swierzy IJ; Nguyen TD; Horz HP; Conrads G (2013) Cryptic Streptococcus mutans 5.6-kb plasmids encode a toxin-antitoxin system for plasmid stabilization J Oral Microbiol 5. [PudMed:23330057]
(231) Zhao J; Wang Q; Li M; Heijstra BD; Wang S; Liang Q; Qi Q (2013) Escherichia coli toxin gene hipA affects biofilm formation and DNA release Microbiology 159(Pt 3):633-40. [PudMed:23329678]
(232) Koyanagi S; Levesque CM (2013) Characterization of a Streptococcus mutans intergenic region containing a small toxic peptide and its cis-encoded antisense small RNA antitoxin PLoS One 8(1):e54291. [PudMed:23326602]
(233) Krupovic M; Gonnet M; Hania WB; Forterre P; Erauso G (2013) Insights into dynamics of mobile genetic elements in hyperthermophilic environments from five new Thermococcus plasmids PLoS One 8(1):e49044. [PudMed:23326305]
(234) Steif A; Meyer IM (2012) The hok mRNA family RNA Biol 9(12):1399-404. [PudMed:23324554]
(235) Brantl S (2012) Bacterial type I toxin-antitoxin systems RNA Biol 9(12):1488-90. [PudMed:23324552]
(236) Kopfmann S; Hess WR (2013) Toxin-antitoxin systems on the large defense plasmid pSYSA of Synechocystis sp. PCC 6803 J Biol Chem 288(10):7399-409. [PudMed:23322786]
(237) Bernier SP; Lebeaux D; DeFrancesco AS; Valomon A; Soubigou G; Coppee JY; Ghigo JM; Beloin C (2013) Starvation, together with the SOS response, mediates high biofilm-specific tolerance to the fluoroquinolone ofloxacin PLoS Genet 9(1):e1003144. [PudMed:23300476]
(238) Durand S et al. (2012) The essential function of B. subtilis RNase III is to silence foreign toxin genes. PLoS Genet 8(12):e1003181. [PudMed:23300471]
(239) Averina OV; Nezametdinova VZ; Alekseeva MG; Danilenko VN (2012) [Genetic instability of probiotic characteristics in the Bifidobacterium longum subsp. longum B379M strain during cultivation and maintenance] Genetika 48(11):1287-96. [PudMed:23297484]
(240) Han KD; Ahn DH; Lee SA; Min YH; Kwon AR; Ahn HC; Lee BJ (2013) Identification of chromosomal HP0892-HP0893 toxin-antitoxin proteins in Helicobacter pylori and structural elucidation of their protein-protein interaction J Biol Chem 288(8):6004-13. [PudMed:23297406]
(241) Kwan BW; Valenta JA; Benedik MJ; Wood TK (2013) Arrested protein synthesis increases persister-like cell formation Antimicrob Agents Chemother 57(3):1468-73. [PudMed:23295927]
(242) Wang X; Lord DM; Hong SH; Peti W; Benedik MJ; Page R; Wood TK (2013) Type II toxin/antitoxin MqsR/MqsA controls type V toxin/antitoxin GhoT/GhoS Environ Microbiol 15(6):1734-44. [PudMed:23289863]
(243) Schuster CF; Bertram R (2013) Toxin-antitoxin systems are ubiquitous and versatile modulators of prokaryotic cell fate FEMS Microbiol Lett 340(2):73-85. [PudMed:23289536]
(244) Samson JE; Spinelli S; Cambillau C; Moineau S (2013) Structure and activity of AbiQ, a lactococcal endoribonuclease belonging to the type III toxin-antitoxin system Mol Microbiol 87(4):756-68. [PudMed:23279123]
(245) Short FL; Pei XY; Blower TR; Ong SL; Fineran PC; Luisi BF; Salmond GP (2013) Selectivity and self-assembly in the control of a bacterial toxin by an antitoxic noncoding RNA pseudoknot Proc Natl Acad Sci U S A 110(3):E241-9. [PudMed:23267117]
(246) Wong CM; Tam HK; Ng WM; Boo SY; Gonzalez M (2013) Characterisation of a cryptic plasmid from an Antarctic bacterium Pedobacter cryoconitis strain BG5 Plasmid 69(2):186-93. [PudMed:23266397]
(247) Sala A; Calderon V; Bordes P; Genevaux P (2013) TAC from Mycobacterium tuberculosis: a paradigm for stress-responsive toxin-antitoxin systems controlled by SecB-like chaperones Cell Stress Chaperones 18(2):129-35. [PudMed:23264229]
(248) Wibberg D; Szczepanowski R; Eikmeyer F; Puhler A; Schluter A (2013) The IncF plasmid pRSB225 isolated from a municipal wastewater treatment plant's on-site preflooder combining antibiotic resistance and putative virulence functions is highly related to virulence plasmids identified in pathogenic E. coli isolates Plasmid 69(2):127-37. [PudMed:23212116]
(249) Slattery A; Victorsen AH; Brown A; Hillman K; Phillips GJ (2013) Isolation of highly persistent mutants of Salmonella enterica serovar typhimurium reveals a new toxin-antitoxin module J Bacteriol 195(4):647-57. [PudMed:23204462]
(250) Chan WT; Moreno-Cordoba I; Yeo CC; Espinosa M (2012) Toxin-antitoxin genes of the Gram-positive pathogen Streptococcus pneumoniae: so few and yet so many Microbiol Mol Biol Rev 76(4):773-91. [PudMed:23204366]
(251) Shkoporov AN; Khokhlova EV; Kulagina EV; Smeianov VV; Kuchmiy AA; Kafarskaya LI; Efimov BA (2013) Analysis of a novel 8.9kb cryptic plasmid from Bacteroides uniformis, its long-term stability and spread within human microbiota Plasmid 69(2):146-59. [PudMed:23201047]
(252) Yan X; Gurtler JB; Fratamico PM; Hu J; Juneja VK (2012) Phylogenetic identification of bacterial MazF toxin protein motifs among probiotic strains and foodborne pathogens and potential implications of engineered probiotic intervention in food Cell Biosci 2(1):39. [PudMed:23186337]
(253) Fozo EM (2012) New type I toxin-antitoxin families from "wild" and laboratory strains of E. coli: Ibs-Sib, ShoB-OhsC and Zor-Orz RNA Biol 9(12):1504-12. [PudMed:23182878]
(254) Brown BL; Lord DM; Grigoriu S; Peti W; Page R (2013) The Escherichia coli toxin MqsR destabilizes the transcriptional repression complex formed between the antitoxin MqsA and the mqsRA operon promoter J Biol Chem 288(2):1286-94. [PudMed:23172222]
(255) Long QX; He Y; Xie JP (2012) [The molecular physiological and genetic mechanisms underlying the superb efficacy of quinolones] Yao Xue Xue Bao 47(8):969-77. [PudMed:23162891]
(256) Ren D; Walker AN; Daines DA (2012) Toxin-antitoxin loci vapBC-1 and vapXD contribute to survival and virulence in nontypeable Haemophilus influenzae BMC Microbiol 12:263. [PudMed:23157645]
(257) Makarova KS; Anantharaman V; Aravind L; Koonin EV (2012) Live virus-free or die: coupling of antivirus immunity and programmed suicide or dormancy in prokaryotes Biol Direct 7:40. [PudMed:23151069]
(258) Gorlas A; Gimenez G; Raoult D; Roux V (2012) Draft genome sequences of Actinomyces timonensis strain 7400942T and its prophage J Bacteriol 194(23):6613-4. [PudMed:23144376]
(259) Kawano M (2012) Divergently overlapping cis-encoded antisense RNA regulating toxin-antitoxin systems from E. coli: hok/sok, ldr/rdl, symE/symR RNA Biol 9(12):1520-7. [PudMed:23131729]
(260) Sayed N; Nonin-Lecomte S; Rety S; Felden B (2012) Functional and structural insights of a Staphylococcus aureus apoptotic-like membrane peptide from a toxin-antitoxin module J Biol Chem 287(52):43454-63. [PudMed:23129767]
(261) Blower TR; Evans TJ; Przybilski R; Fineran PC; Salmond GP (2012) Viral evasion of a bacterial suicide system by RNA-based molecular mimicry enables infectious altruism PLoS Genet 8(10):e1003023. [PudMed:23109916]
(262) Brinkman CL; Bumgarner R; Kittichotirat W; Dunman PM; Kuechenmeister LJ; Weaver KE (2013) Characterization of the effects of an rpoC mutation that confers resistance to the Fst peptide toxin-antitoxin system toxin J Bacteriol 195(1):156-66. [PudMed:23104812]
(263) Schuster CF; Park JH; Prax M; Herbig A; Nieselt K; Rosenstein R; Inouye M; Bertram R (2013) Characterization of a mazEF toxin-antitoxin homologue from Staphylococcus equorum J Bacteriol 195(1):115-25. [PudMed:23104807]
(264) Wagner EG; Unoson C (2012) The toxin-antitoxin system tisB-istR1: Expression, regulation, and biological role in persister phenotypes RNA Biol 9(12):1513-9. [PudMed:23093802]
(265) Lewis K (2012) Persister cells: molecular mechanisms related to antibiotic tolerance Handb Exp Pharmacol (211):121-33. [PudMed:23090599]
(266) Keren I; Mulcahy LR; Lewis K (2012) Persister eradication: lessons from the world of natural products Methods Enzymol 517:387-406. [PudMed:23084949]
(267) Butt A; Muller C; Harmer N; Titball RW (2013) Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei FEMS Microbiol Lett 338(1):86-94. [PudMed:23082999]
(268) Liu Y; Wang Y; Schwarz S; Li Y; Shen Z; Zhang Q; Wu C; Shen J (2013) Transferable multiresistance plasmids carrying cfr in Enterococcus spp. from swine and farm environment Antimicrob Agents Chemother 57(1):42-8. [PudMed:23070165]
(269) Weaver KE (2012) The par toxin-antitoxin system from Enterococcus faecalis plasmid pAD1 and its chromosomal homologs RNA Biol 9(12):1498-503. [PudMed:23059908]
(270) Durand S; Jahn N; Condon C; Brantl S (2012) Type I toxin-antitoxin systems in Bacillus subtilis RNA Biol 9(12):1491-7. [PudMed:23059907]
(271) Norton JP; Mulvey MA (2012) Toxin-antitoxin systems are important for niche-specific colonization and stress resistance of uropathogenic Escherichia coli PLoS Pathog 8(10):e1002954. [PudMed:23055930]
(272) Smith AB; Lopez-Villarejo J; Diago-Navarro E; Mitchenall LA; Barendregt A; Heck AJ; Lemonnier M; Maxwell A; Diaz-Orejas R (2012) A common origin for the bacterial toxin-antitoxin systems parD and ccd, suggested by analyses of toxin/target and toxin/antitoxin interactions PLoS One 7(9):e46499. [PudMed:23029540]
(273) Min AB; Miallau L; Sawaya MR; Habel J; Cascio D; Eisenberg D (2012) The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg(2)(+) ion in the active site and a putative RNA-binding site Protein Sci 21(11):1754-67. [PudMed:23011806]
(274) Gerdes K; Maisonneuve E (2012) Bacterial persistence and toxin-antitoxin loci Annu Rev Microbiol 66:103-23. [PudMed:22994490]
(275) Van Melderen L (2012) GhoSTly bacterial persisters Nat Chem Biol 8(10):812-3. [PudMed:22987009]
(276) Boggild A; Sofos N; Andersen KR; Feddersen A; Easter AD; Passmore LA; Brodersen DE (2012) The crystal structure of the intact E. coli RelBE toxin-antitoxin complex provides the structural basis for conditional cooperativity Structure 20(10):1641-8. [PudMed:22981948]
(277) Wang X; Lord DM; Cheng HY; Osbourne DO; Hong SH; Sanchez-Torres V; Quiroga C; Zheng K; Herrmann T; Peti W; Benedik MJ; Page R; Wood TK (2012) A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS Nat Chem Biol 8(10):855-61. [PudMed:22941047]
(278) Moll I; Engelberg-Kulka H (2012) Selective translation during stress in Escherichia coli Trends Biochem Sci 37(11):493-8. [PudMed:22939840]
(279) Roux V; Robert C; Gimenez G; Gharbi R; Raoult D (2012) Draft genome sequence of Actinomyces massiliensis strain 4401292T J Bacteriol 194(18):5121. [PudMed:22933754]
(280) McGavin MJ; Arsic B; Nickerson NN (2012) Evolutionary blueprint for host- and niche-adaptation in Staphylococcus aureus clonal complex CC30 Front Cell Infect Microbiol 2:48. [PudMed:22919639]
(281) Satwika D; Klassen R; Meinhardt F (2012) Anticodon nuclease encoding virus-like elements in yeast Appl Microbiol Biotechnol 96(2):345-56. [PudMed:22899498]
(282) Zhang F; Xing L; Teng M; Li X (2012) Crystallization and preliminary crystallographic studies of the YafN-YafO complex from Escherichia coli Acta Crystallogr Sect F Struct Biol Cryst Commun 68(Pt 8):894-7. [PudMed:22869116]
(283) Kint CI; Verstraeten N; Wens I; Liebens VR; Hofkens J; Versees W; Fauvart M; Michiels J (2012) The Escherichia coli GTPase ObgE modulates hydroxyl radical levels in response to DNA replication fork arrest FEBS J 279(19):3692-704. [PudMed:22863262]
(284) La Rosa SL; Diep DB; Nes IF; Brede DA (2012) Construction and application of a luxABCDE reporter system for real-time monitoring of Enterococcus faecalis gene expression and growth Appl Environ Microbiol 78(19):7003-11. [PudMed:22843522]
(285) Tripathi A; Dewan PC; Barua B; Varadarajan R (2012) Additional role for the ccd operon of F-plasmid as a transmissible persistence factor Proc Natl Acad Sci U S A 109(31):12497-502. [PudMed:22802647]
(286) Rankin DJ; Turner LA; Heinemann JA; Brown SP (2012) The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict Proc Biol Sci 279(1743):3706-15. [PudMed:22787022]
(287) Brouwer MS; Roberts AP; Mullany P; Allan E (2012) In silico analysis of sequenced strains of Clostridium difficile reveals a related set of conjugative transposons carrying a variety of accessory genes Mob Genet Elements 2(1):8-12. [PudMed:22754747]
(288) Barbosa LC; Garrido SS; Garcia A; Delfino DB; Santos Ldo N; Marchetto R (2012) Design and synthesis of peptides from bacterial ParE toxin as inhibitors of topoisomerases Eur J Med Chem 54:591-6. [PudMed:22749642]
(289) Muranaka LS; Takita MA; Olivato JC; Kishi LT; de Souza AA (2012) Global expression profile of biofilm resistance to antimicrobial compounds in the plant-pathogenic bacterium Xylella fastidiosa reveals evidence of persister cells J Bacteriol 194(17):4561-9. [PudMed:22730126]
(290) Hansen S; Vulic M; Min J; Yen TJ; Schumacher MA; Brennan RG; Lewis K (2012) Regulation of the Escherichia coli HipBA toxin-antitoxin system by proteolysis PLoS One 7(6):e39185. [PudMed:22720069]
(291) Sterckx YG; Garcia-Pino A; Haesaerts S; Jove T; Geerts L; Sakellaris V; Van Melderen L; Loris R (2012) The ParE2-PaaA2 toxin-antitoxin complex from Escherichia coli O157 forms a heterodocecamer in solution and in the crystal Acta Crystallogr Sect F Struct Biol Cryst Commun 68(Pt 6):724-9. [PudMed:22684081]
(292) Rosvoll TC; Lindstad BL; Lunde TM; Hegstad K; Aasnaes B; Hammerum AM; Lester CH; Simonsen GS; Sundsfjord A; Pedersen T (2012) Increased high-level gentamicin resistance in invasive Enterococcus faecium is associated with aac(6')Ie-aph(2'')Ia-encoding transferable megaplasmids hosted by major hospital-adapted lineages FEMS Immunol Med Microbiol 66(2):166-76. [PudMed:22672387]
(293) Koh RS; Dunlop MJ (2012) Modeling suggests that gene circuit architecture controls phenotypic variability in a bacterial persistence network BMC Syst Biol 6:47. [PudMed:22607777]
(294) De Jonge N; Simic M; Buts L; Haesaerts S; Roelants K; Garcia-Pino A; Sterckx Y; De Greve H; Lah J; Loris R (2012) Alternative interactions define gyrase specificity in the CcdB family Mol Microbiol 84(5):965-78. [PudMed:22582791]
(295) Rothenbacher FP; Suzuki M; Hurley JM; Montville TJ; Kirn TJ; Ouyang M; Woychik NA (2012) Clostridium difficile MazF toxin exhibits selective, not global, mRNA cleavage J Bacteriol 194(13):3464-74. [PudMed:22544268]
(296) McKenzie JL; Duyvestyn JM; Smith T; Bendak K; Mackay J; Cursons R; Cook GM; Arcus VL (2012) Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry RNA 18(6):1267-78. [PudMed:22539524]
(297) Dawes FE; Bulach DM; Kuzevski A; Bettelheim KA; Venturini C; Djordjevic SP; Walker MJ (2012) Molecular characterization of a 21.4 kilobase antibiotic resistance plasmid from an alpha-hemolytic Escherichia coli O108:H- human clinical isolate PLoS One 7(4):e34718. [PudMed:22532831]
(298) Masuda H; Tan Q; Awano N; Wu KP; Inouye M (2012) YeeU enhances the bundling of cytoskeletal polymers of MreB and FtsZ, antagonizing the CbtA (YeeV) toxicity in Escherichia coli Mol Microbiol 84(5):979-89. [PudMed:22515815]
(299) Syed MA; Levesque CM (2012) Chromosomal bacterial type II toxin-antitoxin systems Can J Microbiol 58(5):553-62. [PudMed:22506850]
(300) Cataudella I; Trusina A; Sneppen K; Gerdes K; Mitarai N (2012) Conditional cooperativity in toxin-antitoxin regulation prevents random toxin activation and promotes fast translational recovery Nucleic Acids Res 40(14):6424-34. [PudMed:22495927]
(301) Lee B; Holkenbrink C; Treuner-Lange A; Higgs PI (2012) Myxococcus xanthus developmental cell fate production: heterogeneous accumulation of developmental regulatory proteins and reexamination of the role of MazF in developmental lysis J Bacteriol 194(12):3058-68. [PudMed:22493014]
(302) Moreno-Cordoba I; Diago-Navarro E; Barendregt A; Heck AJ; Alfonso C; Diaz-Orejas R; Nieto C; Espinosa M (2012) The toxin-antitoxin proteins relBE2Spn of Streptococcus pneumoniae: characterization and association to their DNA target Proteins 80(7):1834-46. [PudMed:22488579]
(303) Park JH; Yamaguchi Y; Inouye M (2012) Intramolecular regulation of the sequence-specific mRNA interferase activity of MazF fused to a MazE fragment with a linker cleavable by specific proteases Appl Environ Microbiol 78(11):3794-9. [PudMed:22447587]
(304) Williams JJ; Hergenrother PJ (2012) Artificial activation of toxin-antitoxin systems as an antibacterial strategy Trends Microbiol 20(6):291-8. [PudMed:22445361]
(305) Blower TR; Short FL; Rao F; Mizuguchi K; Pei XY; Fineran PC; Luisi BF; Salmond GP (2012) Identification and classification of bacterial Type III toxin-antitoxin systems encoded in chromosomal and plasmid genomes Nucleic Acids Res 40(13):6158-73. [PudMed:22434880]
(306) Sevillano L; Diaz M; Yamaguchi Y; Inouye M; Santamaria RI (2012) Identification of the first functional toxin-antitoxin system in Streptomyces PLoS One 7(3):e32977. [PudMed:22431991]
(307) Cline SD; Saleem S; Daines DA (2012) Regulation of the vapBC-1 toxin-antitoxin locus in nontypeable Haemophilus influenzae PLoS One 7(3):e32199. [PudMed:22427824]
(308) Erental A; Sharon I; Engelberg-Kulka H (2012) Two programmed cell death systems in Escherichia coli: an apoptotic-like death is inhibited by the mazEF-mediated death pathway PLoS Biol 10(3):e1001281. [PudMed:22412352]
(309) Otsuka Y; Yonesaki T (2012) Dmd of bacteriophage T4 functions as an antitoxin against Escherichia coli LsoA and RnlA toxins Mol Microbiol 83(4):669-81. [PudMed:22403819]
(310) Zhang Y; Yew WW; Barer MR (2012) Targeting persisters for tuberculosis control Antimicrob Agents Chemother 56(5):2223-30. [PudMed:22391538]
(311) Georgiades K (2012) Genomics of epidemic pathogens Clin Microbiol Infect 18(3):213-7. [PudMed:22369153]
(312) McKenzie JL; Robson J; Berney M; Smith TC; Ruthe A; Gardner PP; Arcus VL; Cook GM (2012) A VapBC toxin-antitoxin module is a posttranscriptional regulator of metabolic flux in mycobacteria J Bacteriol 194(9):2189-204. [PudMed:22366418]
(313) Leung V; Levesque CM (2012) A stress-inducible quorum-sensing peptide mediates the formation of persister cells with noninherited multidrug tolerance J Bacteriol 194(9):2265-74. [PudMed:22366415]
(314) Shapira A; Shapira S; Gal-Tanamy M; Zemel R; Tur-Kaspa R; Benhar I (2012) Removal of hepatitis C virus-infected cells by a zymogenized bacterial toxin PLoS One 7(2):e32320. [PudMed:22359682]
(315) Sharp JD; Cruz JW; Raman S; Inouye M; Husson RN; Woychik NA (2012) Growth and translation inhibition through sequence-specific RNA binding by Mycobacterium tuberculosis VapC toxin J Biol Chem 287(16):12835-47. [PudMed:22354968]
(316) Lang KS; Danzeisen JL; Xu W; Johnson TJ (2012) Transcriptome mapping of pAR060302, a blaCMY-2-positive broad-host-range IncA/C plasmid Appl Environ Microbiol 78(9):3379-86. [PudMed:22344651]
(317) Heaton BE; Herrou J; Blackwell AE; Wysocki VH; Crosson S (2012) Molecular structure and function of the novel BrnT/BrnA toxin-antitoxin system of Brucella abortus J Biol Chem 287(15):12098-110. [PudMed:22334680]
(318) Beckmann BM et al. (2012) A pRNA-induced structural rearrangement triggers 6S-1 RNA release from RNA polymerase in Bacillus subtilis. EMBO J 31(7):1727-38. [PudMed:22333917]
(319) Brzozowska I; Brzozowska K; Zielenkiewicz U (2012) Functioning of the TA cassette of streptococcal plasmid pSM19035 in various Gram-positive bacteria Plasmid 68(1):51-60. [PudMed:22309878]
(320) Winther KS; Gerdes K (2012) Regulation of enteric vapBC transcription: induction by VapC toxin dimer-breaking Nucleic Acids Res 40(10):4347-57. [PudMed:22287572]
(321) Short FL; Blower TR; Salmond GP (2012) A promiscuous antitoxin of bacteriophage T4 ensures successful viral replication Mol Microbiol 83(4):665-8. [PudMed:22283468]
(322) Armalyte J; Jurenaite M; Beinoraviciute G; Teiserskas J; Suziedeliene E (2012) Characterization of Escherichia coli dinJ-yafQ toxin-antitoxin system using insights from mutagenesis data J Bacteriol 194(6):1523-32. [PudMed:22247505]
(323) Kwon AR; Kim JH; Park SJ; Lee KY; Min YH; Im H; Lee I; Lee KY; Lee BJ (2012) Structural and biochemical characterization of HP0315 from Helicobacter pylori as a VapD protein with an endoribonuclease activity Nucleic Acids Res 40(9):4216-28. [PudMed:22241770]
(324) Masuda H; Tan Q; Awano N; Yamaguchi Y; Inouye M (2012) A novel membrane-bound toxin for cell division, CptA (YgfX), inhibits polymerization of cytoskeleton proteins, FtsZ and MreB, in Escherichia coli FEMS Microbiol Lett 328(2):174-81. [PudMed:22239607]
(325) Jahn N; Preis H; Wiedemann C; Brantl S (2012) BsrG/SR4 from Bacillus subtilis--the first temperature-dependent type I toxin-antitoxin system Mol Microbiol 83(3):579-98. [PudMed:22229825]
(326) Ohtani N; Tomita M; Itaya M (2012) The third plasmid pVV8 from Thermus thermophilus HB8: isolation, characterization, and sequence determination Extremophiles 16(2):237-44. [PudMed:22212656]
(327) Tashiro Y; Kawata K; Taniuchi A; Kakinuma K; May T; Okabe S (2012) RelE-mediated dormancy is enhanced at high cell density in Escherichia coli J Bacteriol 194(5):1169-76. [PudMed:22210768]
(328) Holberger LE; Garza-Sanchez F; Lamoureux J; Low DA; Hayes CS (2012) A novel family of toxin/antitoxin proteins in Bacillus species FEBS Lett 586(2):132-6. [PudMed:22200572]
(329) Frampton R; Aggio RB; Villas-Boas SG; Arcus VL; Cook GM (2012) Toxin-antitoxin systems of Mycobacterium smegmatis are essential for cell survival J Biol Chem 287(8):5340-56. [PudMed:22199354]
(330) Mate MJ; Vincentelli R; Foos N; Raoult D; Cambillau C; Ortiz-Lombardia M (2012) Crystal structure of the DNA-bound VapBC2 antitoxin/toxin pair from Rickettsia felis Nucleic Acids Res 40(7):3245-58. [PudMed:22140099]
(331) Dziewit L et al. (2011) Functional characterization of the type II PamI restriction-modification system derived from plasmid pAMI7 of Paracoccus aminophilus JCM 7686. FEMS Microbiol Lett 324(1):56-63. [PudMed:22092764]
(332) Hu Y; Benedik MJ; Wood TK (2012) Antitoxin DinJ influences the general stress response through transcript stabilizer CspE Environ Microbiol 14(3):669-79. [PudMed:22026739]
(333) Locke JB; Rahawi S; Lamarre J; Mankin AS; Shaw KJ (2012) Genetic environment and stability of cfr in methicillin-resistant Staphylococcus aureus CM05 Antimicrob Agents Chemother 56(1):332-40. [PudMed:22024827]
(334) Ning D et al. (2011) The proteolytic activation of the relNEs (ssr1114/slr0664) toxin-antitoxin system by both proteases Lons and ClpP2s/Xs of Synechocystis sp. PCC 6803. Curr Microbiol 63(5):496-502. [PudMed:21909782]
(335) Lee MW; Rogers EE; Stenger DC (2012) Xylella fastidiosa plasmid-encoded PemK toxin is an endoribonuclease Phytopathology 102(1):32-40. [PudMed:21864087]
(336) Hu MX et al. (2010) Recent advancements in toxin and antitoxin systems involved in bacterial programmed cell death. Int J Microbiol. 2010:781430. [PudMed:21253538]
(337) Blower TR et al. (2011) A processed noncoding RNA regulates an altruistic bacterial antiviral system. Nat Struct Mol Biol. 18(2):185-90.. [PudMed:21240270]
(338) Syed MA et al. (2011) The Chromosomal mazEF Locus of Streptococcus mutans Encodes a Functional Type II Toxin-Antitoxin Addiction System. J Bacteriol. 193(5):1122-30. [PudMed:21183668]
(339) Han KD et al. (2011) Functional Identification of Toxin-Antitoxin Molecules from Helicobacter pylori 26695 and Structural Elucidation of the Molecular Interactions. J Biol Chem. 286(6):4842-53. [PudMed:21123184]
(340) Yuan J et al. (2011) The three vibrio cholerae chromosome II-encoded ParE toxins degrade chromosome I following loss of chromosome II. J Bacteriol. 193(3):611-9. [PudMed:21115657]
(341) Han X et al. (2011) The role of Escherichia coli YrbB in the lethal action of quinolones. J Antimicrob Chemother. 66(2):323-31. [PudMed:21098540]
(342) Arcus VL et al. (2011) The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array. Protein Eng Des Sel. 24(1-2):33-40. [PudMed:21036780]
(343) Halvorsen EM; Williams JJ; Bhimani AJ; Billings EA; Hergenrother PJ (2011) Txe, an endoribonuclease of the enterococcal Axe-Txe toxin-antitoxin system, cleaves mRNA and inhibits protein synthesis Microbiology 157(Pt 2):387-97. [PudMed:21030436]
(344) Koga M; Otsuka Y; Lemire S; Yonesaki T (2011) Escherichia coli rnlA and rnlB compose a novel toxin-antitoxin system Genetics 187(1):123-30. [PudMed:20980243]
(345) Barbosa LC et al. (2010) Function inferences from a molecular structural model of bacterial ParE toxin. Bioinformation. 4(10):438-40. [PudMed:20975905]
(346) Yuan J et al. (2010) Vibrio cholerae ParE2 poisons DNA gyrase via a mechanism distinct from other gyrase inhibitors. J Biol Chem. 285(51):40397-408. [PudMed:20952390]
(347) Rešetárová S et al. (2010) Expression and localization of SpoIISA toxin during the life cycle of Bacillus subtilis. Res Microbiol 161(9):750-6. [PudMed:20863891]
(348) Brown BL et al. (2010) Preliminary crystallographic analysis of the Escherichia coli antitoxin MqsA (YgiT/b3021) in complex with mqsRA promoter DNA. Acta Crystallogr Sect F Struct Biol Cryst Commun. 66(Pt 9):1060-3. [PudMed:20823526]
(349) Cambray G et al. (2010) Integrons. Annu Rev Genet 44:141-66. [PudMed:20707672]
(350) Han JS et al. (2010) Characterization of a chromosomal toxin-antitoxin, Rv1102c-Rv1103c system in Mycobacterium tuberculosis. Biochem Biophys Res Commun 400(3):293-8. [PudMed:20705052]
(351) Arbing MA et al. (2010) Crystal structures of Phd-Doc, HigA, and YeeU establish multiple evolutionary links between microbial growth-regulating toxin-antitoxin systems. Structure 18(8):996-1010. [PudMed:20696400]
(352) Ye S et al. (2010) The interaction between chromosome-encoded toxin Slr0664 and antitoxin Slr1114 of cyanobacteria Synechocystis sp. PCC6803 Wei Sheng Wu Xue Bao. 50(6):743-8. [PudMed:20687338]
(353) Rotem E et al. (2010) Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence Proc Natl Acad Sci U S A. 107(28):12541-6. [PudMed:20616060]
(354) Nieto C et al. (2010) The relBE2Spn toxin-antitoxin system of Streptococcus pneumoniae: role in antibiotic tolerance and functional conservation in clinical isolates. PLoS One. 5(6):e11289. [PudMed:20585658]
(355) Fivian-Hughes AS et al. (2010) Analyzing the regulatory role of the HigA antitoxin within Mycobacterium tuberculosis. J Bacteriol. 192(17):4348-56.. [PudMed:20585061]
(356) Diago-Navarro E et al. (2010) parD toxin-antitoxin system of plasmid R1 - basic contributions,biotechnological applications and relationships with closely-relatedtoxin-antitoxin systems. FEBS J 277(15):3097-117. [PudMed:20569269]
(357) Lewis K. (2010) Persister Cells. Annu Rev Microbiol 64:357-72. [PudMed:20528688]
(358) Cooper TF et al. (2010) Within-host competition selects for plasmid-encoded toxin-antitoxin systems. Proc Biol Sci. 277(1697):3149-55. [PudMed:20504809]
(359) Yang M et al. (2010) Characterization of the interaction and cross-regulation of three Mycobacteriumtuberculosis RelBE modules. PLoS One 5(5):e10672. [PudMed:20498855]
(360) Gargis AS et al. (2010) Complete nucleotide sequences of plasmids pACK1 and pACK3 from Staphylococcus simulans biovar staphylolyticus. Plasmid. 64(2):104-9.. [PudMed:20493903]
(361) Fiebig A et al. (2010) Interaction specificity, toxicity and regulation of a paralogous set ofParE/RelE-family toxin-antitoxin systems. Mol Microbiol 77(1):236-51. [PudMed:20487277]
(362) Goulard C et al. (2010) The Yersinia pestis chromosome encodes active addiction toxins. J Bacteriol 192(14):3669-77. [PudMed:20472800]
(363) Mutschler H et al. (2010) Assembly dynamics and stability of the Pneumococcal epsilon zeta Antitoxin Toxin(PezAT) system from Streptococcus pneumoniae. J Biol Chem 285(28):21797-806. [PudMed:20442221]
(364) Lioy VS et al. (2010) Plasmid pSM19035, a model to study stable maintenance in Firmicutes. Plasmid. 64(1):1-17. [PudMed:20403380]
(365) Miclea PS et al. (2010) Atypical transcriptional regulation and role of a new toxin-antitoxin-likemodule and its effect on the lipid composition of Bradyrhizobium japonicum. Mol Plant Microbe Interact 23(5):638-50. [PudMed:20367472]
(366) Hallez R et al. (2010) New toxins homologous to ParE belonging to three-component toxin-antitoxinsystems in Escherichia coli O157:H7. Mol Microbiol 76(3):719-32. [PudMed:20345661]
(367) Kasari V et al. (2010) The Escherichia coli mqsR and ygiT genes encode a new toxin-antitoxin pair. J Bacteriol 192(11):2908-19. [PudMed:20233923]
(368) Hu LL et al. (2010) The use of the ccdB lethal gene for constructing a zero background vector inorder to clone blunt-end PCR products. Mol Biol (Mosk) 44(1):174-6. [PudMed:20198872]
(369) Ruiz-Echevarria MJ et al. (1991) Structural and functional comparison between the stability systems ParD ofplasmid R1 and Ccd of plasmid F. Mol Gen Genet 225(3):355-62. [PudMed:2017133]
(370) Fozo EM et al. (2010) Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families. Nucleic Acids Res. 38(11):3743-59. [PudMed:20156992]
(371) Dalton KM et al. (2010) A conserved mode of protein recognition and binding in a ParD-ParE toxin-antitoxin complex. Biochemistry 49(10):2205-15. [PudMed:20143871]
(372) Garcia-Pino A et al. (2010) Purification and crystallization of Phd, the antitoxin of the phd/doc operon. Acta Crystallogr Sect F Struct Biol Cryst Commun 66(Pt 2):167-71 . [PudMed:20124714]
(373) Kim Y et al. (2010) Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD. Environ Microbiol 12(5):1105-21. [PudMed:20105222]
(374) Jones BV et al. (2010) Comparative metagenomic analysis of plasmid encoded functions in the human gutmicrobiome. BMC Genomics 11:46. [PudMed:20085629]
(375) Gallo M et al. (2010) A new member of the ribbon-helix-helix transcription factor superfamily from theplant pathogen Xanthomonas axonopodis pv.citri. J Struct Biol 170(1):21-31. [PudMed:20060909]
(376) Brown BL et al. (2009) Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprisedof a toxin homologous to RelE and an antitoxin with unique properties. PLoS Pathog. 5(12):e1000706. . [PudMed:20041169]
(377) Donegan NP et al. (2010) Proteolytic regulation of toxin-antitoxin systems by ClpPC in Staphylococcusaureus. J Bacteriol 192(5):1416-22. [PudMed:20038589]
(378) Rosvoll TC et al. (2010) PCR-based plasmid typing in Enterococcus faecium strains reveals widelydistributed pRE25-, pRUM-, pIP501- and pHTbeta-related replicons associated withglycopeptide resistance and stabilizing toxin-antitoxin systems. FEMS Immunol Med Microbiol 58(2):254-68. [PudMed:20015231]
(379) Ramage HR et al. (2009) Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxinsystems: implications for pathogenesis, stress responses, and evolution. PLoS Genet 5(12):e1000767. [PudMed:20011113]
(380) Neubauer C et al. (2009) The structural basis for mRNA recognition and cleavage by the ribosome-dependent endonuclease RelE. Cell. 139(6):1084-95.. [PudMed:20005802]
(381) De Jonge N et al. (2010) Structural and thermodynamic characterization of Vibrio fischeri CcdB. J Biol Chem 285(8):5606-13. [PudMed:19959472]
(382) Christensen-Dalsgaard M et al. (2010) Three new RelE-homologous mRNA interferases of Escherichia coli differentiallyinduced by environmental stresses. Mol Microbiol 75(2):333-48. [PudMed:19943910]
(383) Singletary LA et al. (2009) An SOS-regulated type 2 toxin-antitoxin system. J Bacteriol 191(24):7456-65. [PudMed:19837801]
(384) Lepka D et al. (2009) Adding to Yersinia enterocolitica gene pool diversity: two cryptic plasmids froma biotype 1A isolate. J Biomed Biotechnol 2009:398434. [PudMed:19834620]
(385) Nogueira T et al. (2009) Horizontal gene transfer of the secretome drives the evolution of bacterial cooperation and virulence. Curr Biol. 19(20):1683-91. [PudMed:19800234]
(386) Overgaard M et al. (2009) RelB and RelE of Escherichia coli form a tight complex that repressestranscription via the ribbon-helix-helix motif in RelB. J Mol Biol 394(2):183-96. [PudMed:19747491]
(387) Francuski D et al. (2009) Crystal structure of the antitoxin-toxin protein complex RelB-RelE fromMethanococcus jannaschii. J Mol Biol 393(4):898-908. [PudMed:19712680]
(388) Kolodkin-Gal I et al. (2009) A differential effect of E. coli toxin-antitoxin systems on cell death in liquidmedia and biofilm formation. PLoS One 4(8):e6785. [PudMed:19707553]
(389) De Jonge N et al. (2009) Rejuvenation of CcdB-poisoned gyrase by an intrinsically disordered proteindomain. Mol Cell 35(2):154-63. [PudMed:19647513]
(390) Engelberg-Kulka H et al. (2009) Activation of a built-in bacterial programmed cell death system as a novelmechanism of action of some antibiotics. Commun Integr Biol 2(3):211-2. [PudMed:19641731]
(391) Respondek M et al. (2009) Sequence-specific 1H, 15N and 13C resonance assignments of the 23.7-kDahomodimeric toxin CcdB from Vibrio fischeri. Biomol NMR Assign 3(1):145-7. [PudMed:19636967]
(392) Blower TR et al. (2009) Mutagenesis and functional characterization of the RNA and protein components ofthe toxIN abortive infection and toxin-antitoxin locus of Erwinia. J Bacteriol 191(19):6029-39. [PudMed:19633081]
(393) Yoshizumi S et al. (2009) Staphylococcus aureus YoeB homologues inhibit translation initiation. J Bacteriol 191(18):5868-72. [PudMed:19581360]
(394) Drobnak I et al. (2009) Energetics of MazG unfolding in correlation with its structural features. J Mol Biol 392(1):63-74. [PudMed:19523960]
(395) Romero P et al. (2009) Comparative genomic analysis of ten Streptococcus pneumoniae temperatebacteriophages. J Bacteriol 191(15):4854-62. [PudMed:19502408]
(396) Makarova KS et al. (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct 4:19. [PudMed:19493340]
(397) Fricke WF et al. (2009) Comparative genomics of the IncA/C multidrug resistance plasmid family. J Bacteriol 191(15):4750-7. [PudMed:19482926]
(398) Matcher GF et al. (2009) The effect of the location of the proteic post-segregational stability systemwithin the replicon of plasmid pTF-FC2 on the fine regulation of plasmidreplication. Plasmid 62(2):98-107. [PudMed:19481568]
(399) Simic M et al. (2009) Driving forces of gyrase recognition by the addiction toxin CcdB. J Biol Chem 284(30):20002-10. [PudMed:19465484]
(400) Robson J et al. (2009) The vapBC operon from Mycobacterium smegmatis is an autoregulatedtoxin-antitoxin module that controls growth via inhibition of translation. J Mol Biol 390(3):353-67. [PudMed:19445953]
(401) Hurley JM et al. (2009) Bacterial toxin HigB associates with ribosomes and mediatestranslation-dependent mRNA cleavage at A-rich sites. J Biol Chem 284(28):18605-13. [PudMed:19423702]
(402) Winther KS et al. (2009) Ectopic production of VapCs from Enterobacteria inhibits translation andtrans-activates YoeB mRNA interferase. Mol Microbiol 72(4):918-30. [PudMed:19400780]
(403) Wozniak RA et al. (2009) A toxin-antitoxin system promotes the maintenance of an integrative conjugative element. PLoS Genet. 5(3):e1000439. [PudMed:19325886]
(404) Van Melderen L et al. (2009) Bacterial toxin-antitoxin systems: more than selfish entities? PLoS Genet. 5(3):e1000437. . [PudMed:19325885]
(405) Harrison JJ et al. (2009) The chromosomal toxin gene yafQ is a determinant of multidrug tolerance forEscherichia coli growing in a biofilm. Antimicrob Agents Chemother 53(6):2253-8. [PudMed:19307375]
(406) Amitai S et al. (2009) Escherichia coli MazF leads to the simultaneous selective synthesis of both"death proteins" and "survival proteins". PLoS Genet 5(3):e1000390. [PudMed:19282968]
(407) Zhu L et al. (2009) Staphylococcus aureus MazF specifically cleaves a pentad sequence, UACAU, whichis unusually abundant in the mRNA for pathogenic adhesive factor SraP. J Bacteriol 191(10):3248-55. [PudMed:19251861]
(408) Kolodkin-Gal I et al. (2009) The stationary-phase sigma factor sigma(S) is responsible for the resistance ofEscherichia coli stationary-phase cells to mazEF-mediated cell death. J Bacteriol 191(9):3177-82. [PudMed:19251848]
(409) Mine N et al. (2009) The decay of the chromosomally encoded ccdO157 toxin-antitoxin system in theEscherichia coli species. Genetics 181(4):1557-66. [PudMed:19189956]
(410) Donegan NP et al. (2009) Regulation of the mazEF toxin-antitoxin module in Staphylococcus aureus and itsimpact on sigB expression. J Bacteriol 191(8):2795-805. [PudMed:19181798]
(411) Jayaraman R. (2008) Bacterial persistence: some new insights into an old phenomenon. J Biosci 33(5):795-805. [PudMed:19179767]
(412) Fu Z et al. (2009) Overexpression of MazFsa in Staphylococcus aureus induces bacteriostasis by selectively targeting mRNAs for cleavage. J Bacteriol. 191(7):2051-9. [PudMed:19168622]
(413) Christensen-Dalsgaard M et al. (2008) RNA decay by messenger RNA interferases. Methods Enzymol 447:521-35. [PudMed:19161859]
(414) Schumacher MA et al. (2009) Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB Science. 323(5912):396-401. [PudMed:19150849]
(415) Cooper CR et al. (2009) Role of vapBC toxin-antitoxin loci in the thermal stress response of Sulfolobussolfataricus. Biochem Soc Trans 37(Pt 1):123-6. [PudMed:19143615]
(416) Kawano H et al. (2009) Long-term survival of Escherichia coli lacking the HipBA toxin-antitoxin systemduring prolonged cultivation. Biosci Biotechnol Biochem 73(1):117-23. [PudMed:19129642]
(417) Fineran et al. (2009) The phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair Proc Natl Acad Sci U S A 106(3):894-9. [PudMed:19124776]
(418) Zhang Y et al. (2009) The inhibitory mechanism of protein synthesis by YoeB, an Escherichia colitoxin. J Biol Chem 284(11):6627-38. [PudMed:19124462]
(419) Korch SB et al. (2009) Three Mycobacterium tuberculosis Rel toxin-antitoxin modules inhibitmycobacterial growth and are expressed in infected human macrophages. J Bacteriol 191(5):1618-30. [PudMed:19114484]
(420) Shokeen S et al. (2009) An intramolecular upstream helix ensures the stability of a toxin-encoding RNA in Enterococcus faecalis. J Bacteriol 191(5):1528-36. [PudMed:19103923]
(421) Kolodkin-Gal I et al. (2008) The communication factor EDF and the toxin-antitoxin module mazEF determine themode of action of antibiotics. PLoS Biol 6(12):e319. [PudMed:19090622]
(422) Ahmadi M et al. (2007) The effect of heat stress on the antibacterial resistance and plasmid profile inEscherichia coli isolates. Pak J Biol Sci 10(23):4261-5. [PudMed:19086582]
(423) Jorgensen MG et al. (2009) HicA of Escherichia coli defines a novel family of translation-independent mRNAinterferases in bacteria and archaea. J Bacteriol 191(4):1191-9. [PudMed:19060138]
(424) Fozo EM et al. (2008) Small toxic proteins and the antisense RNAs that repress them. Microbiol Mol Biol Rev. 72(4):579-89. [PudMed:19052321]
(425) Diago-Navarro E et al. (2009) Novel Escherichia coli RF1 mutants with decreased translation terminationactivity and increased sensitivity to the cytotoxic effect of the bacterialtoxins Kid and RelE. Mol Microbiol 71(1):66-78. [PudMed:19019162]
(426) Gupta A. (2009) Killing activity and rescue function of genome-wide toxin-antitoxin loci of Mycobacterium tuberculosis. FEMS Microbiol Lett. 290(1):45-53.. [PudMed:19016878]
(427) Bajaj K et al. (2008) Structural correlates of the temperature sensitive phenotype derived fromsaturation mutagenesis studies of CcdB. Biochemistry 47(49):12964-73. [PudMed:19006334]
(428) Garcia-Pino A et al. (2008) Crystallization of Doc and the Phd-Doc toxin-antitoxin complex. Acta Crystallogr Sect F Struct Biol Cryst Commun 64(Pt 11):1034-8. [PudMed:18997335]
(429) Liu X et al. (2008) Genetic characterization of two putative toxin-antitoxin systems on crypticplasmids from Bacillus thuringiensis strain YBT-1520. J Microbiol Biotechnol 18(10):1630-3. [PudMed:18955810]
(430) Miallau L et al. (2009) Structure and proposed activity of a member of the VapBC family oftoxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis. J Biol Chem 284(1):276-83. [PudMed:18952600]
(431) Trovatti E et al. (2008) Peptides based on CcdB protein as novel inhibitors of bacterial topoisomerases. Bioorg Med Chem Lett 18(23):6161-4. [PudMed:18938079]
(432) Christensen-Dalsgaard M et al. (2008) Translation affects YoeB and MazF messenger RNA interferase activities by different mechanisms. Nucleic Acids Res. 36(20):6472-81. [PudMed:18854355]
(433) Herrero A et al. (2008) Characterization of pUO-StVR2, a virulence-resistance plasmid evolved from thepSLT virulence plasmid of Salmonella enterica serovar Typhimurium. Antimicrob Agents Chemother 52(12):4514-7. [PudMed:18852276]
(434) Kumar P et al. (2008) Crystal structure of Mycobacterium tuberculosis YefM antitoxin reveals that itis not an intrinsically unstructured protein. J Mol Biol 383(3):482-93. [PudMed:18793646]
(435) Garcia-Pino A et al. (2008) Doc of prophage P1 is inhibited by its antitoxin partner Phd through foldcomplementation. J Biol Chem 283(45):30821-7. [PudMed:18757857]
(436) Cheng L et al. (2008) A novel toxin-antitoxin operon talA/B from the Gram-positive bacterium Leifsonia xyli subsp. cynodontis. FEBS Lett. 582(21-22):3211-6. . [PudMed:18722371]
(437) Fozo EM et al. (2008) Repression of small toxic protein synthesis by the Sib and OhsC small RNAs. Mol Microbiol 70(5):1076-93. [PudMed:18710431]
(438) Zhang W et al. (2008) Complete nucleotide sequence of plasmid plca36 isolated from Lactobacillus casei Zhang. Plasmid 60(2):131-5. [PudMed:18634821]
(439) Chan LL et al. (2008) A general method for discovering inhibitors of protein-DNA interactions usingphotonic crystal biosensors. ACS Chem Biol 3(7):437-48. [PudMed:18582039]
(440) Guglielmini J et al. (2008) Automated discovery and phylogenetic analysis of new toxin-antitoxin systems. BMC Microbiol 8:104. [PudMed:18578869]
(441) Shi YL et al. (2008) [RelE toxin protein of Mycobacterium tuberculosis induces growth inhibition oflung cancer A-549 cell] Sichuan Da Xue Xue Bao Yi Xue Ban 39(3):368-72. [PudMed:18575317]
(442) Overgaard M et al. (2008) Messenger RNA interferase RelE controls relBE transcription by conditionalcooperativity. Mol Microbiol 69(4):841-57. [PudMed:18532983]
(443) Sletvold H et al. (2008) Complete sequence of Enterococcus faecium pVEF3 and the detection of anomega-epsilon-zeta toxin-antitoxin module and an ABC transporter. Plasmid 60(1):75-85. [PudMed:18511120]
(444) Li GY et al. (2008) Structural mechanism of transcriptional autorepression of the Escherichia coliRelB/RelE antitoxin/toxin module. J Mol Biol 380(1):107-19. [PudMed:18501926]
(445) Perichon B et al. (2008) Sequence of conjugative plasmid pIP1206 mediating resistance to aminoglycosidesby 16S rRNA methylation and to hydrophilic fluoroquinolones by efflux. Antimicrob Agents Chemother 52(7):2581-92. [PudMed:18458128]
(446) Saavedra De Bast M et al. (2008) Chromosomal toxin-antitoxin systems may act as antiaddiction modules. J Bacteriol 190(13):4603-9. [PudMed:18441063]
(447) Liu M et al. (2008) Bacterial addiction module toxin Doc inhibits translation elongation through itsassociation with the 30S ribosomal subunit. Proc Natl Acad Sci U S A 105(15):5885-90. [PudMed:18398006]
(448) Fang F et al. (2008) Characterization of endogenous plasmids from Lactobacillus salivarius UCC118. Appl Environ Microbiol 74(10):3216-28. [PudMed:18390685]
(449) Lee S et al. (2008) Crystal structure of Escherichia coli MazG, the regulator of nutritional stressresponse. J Biol Chem 283(22):15232-40. [PudMed:18353782]
(450) Kolodkin-Gal I et al. (2008) The extracellular death factor: physiological and genetic factors influencingits production and response in Escherichia coli. J Bacteriol 190(9):3169-75. [PudMed:18310334]
(451) Li X et al. (2008) Cleavage of mRNAs and role of tmRNA system under amino acid starvation in Escherichia coli. Mol Microbiol. 68(2):462-73.. [PudMed:18284591]
(452) Zhao L et al. (2008) Biochemical characterization of a chromosomal toxin-antitoxin system inMycobacterium tuberculosis. FEBS Lett 582(5):710-4. [PudMed:18258191]
(453) Nariya H et al. (2008) MazF, an mRNA interferase, mediates programmed cell death during multicellularMyxococcus development. Cell 132(1):55-66. [PudMed:18191220]
(454) Florek P et al. (2008) Expression of functional Bacillus SpoIISAB toxin-antitoxin modules inEscherichia coli. FEMS Microbiol Lett 278(2):177-84. [PudMed:18096016]
(455) Bajaj K et al. (2007) Stereochemical criteria for prediction of the effects of proline mutations onprotein stability. PLoS Comput Biol 3(12):e241. [PudMed:18069886]
(456) Kolodkin-Gal I et al. (2007) A linear pentapeptide is a quorum-sensing factor required for mazEF-mediatedcell death in Escherichia coli. Science 318(5850):652-5. [PudMed:17962566]
(457) Fu Z et al. (2007) Characterization of MazFSa, an endoribonuclease from Staphylococcus aureus. J Bacteriol 189(24):8871-9. [PudMed:17933891]
(458) Cherny I et al. (2007) Structural and thermodynamic characterization of the Escherichia coli RelBEtoxin-antitoxin system: indication for a functional role of differentialstability. Biochemistry 46(43):12152-63. [PudMed:17924660]
(459) Schmidt O et al. (2007) prlF and yhaV encode a new toxin-antitoxin system in Escherichia coli. J Mol Biol 372(4):894-905. [PudMed:17706670]
(460) Wang NR et al. (2007) A continuous fluorometric assay for the assessment of MazF ribonucleaseactivity. Anal Biochem 371(2):173-83. [PudMed:17706586]
(461) Sevin EW et al. (2007) RASTA-Bacteria: a web-based tool for identifying toxin-antitoxin loci inprokaryotes. Genome Biol. 8(8):R155. . [PudMed:17678530]
(462) Oberer M et al. (2007) The solution structure of ParD, the antidote of the ParDE toxin antitoxinmodule, provides the structural basis for DNA and toxin binding. Protein Sci 16(8):1676-88. [PudMed:17656583]
(463) Carroll P et al. (2007) Expression of Mycobacterium tuberculosis Rv1991c using an arabinose-induciblepromoter demonstrates its role as a toxin. FEMS Microbiol Lett 274(1):73-82. [PudMed:17623030]
(464) Tsilibaris V et al. (2007) What is the benefit to Escherichia coli of having multiple toxin-antitoxinsystems in its genome? J Bacteriol 189(17):6101-8. [PudMed:17513477]
(465) Daines DA et al. (2007) VapC-1 of nontypeable Haemophilus influenzae is a ribonuclease. J Bacteriol 189(14):5041-8. [PudMed:17496075]
(466) Khoo SK et al. (2007) Molecular and structural characterization of the PezAT chromosomaltoxin-antitoxin system of the human pathogen Streptococcus pneumoniae. J Biol Chem 282(27):19606-18. [PudMed:17488720]
(467) Kawano M et al. (2007) An antisense RNA controls synthesis of an SOS-induced toxin evolved from an antitoxin. Mol Microbiol 64(3):738-54. [PudMed:17462020]
(468) Agarwal S et al. (2007) Identification and characterization of a novel toxin-antitoxin module from Bacillus anthracis. FEBS Lett. 581(9):1727-34. [PudMed:17416361]
(469) De Jonge N et al. (2007) Purification and crystallization of Vibrio fischeri CcdB and its complexes withfragments of gyrase and CcdA. Acta Crystallogr Sect F Struct Biol Cryst Commun 63(Pt 4):356-60. [PudMed:17401216]
(470) O'Connor EB et al. (2007) pEOC01: a plasmid from Pediococcus acidilactici which encodes an identicalstreptomycin resistance (aadE) gene to that found in Campylobacter jejuni. Plasmid 58(2):115-26. [PudMed:17395262]
(471) Gerdes K et al. (2007) RNA antitoxins. Curr Opin Microbiol. 10(2):117-24. [PudMed:17376733]
(472) Gvakharia BO et al. (2007) Global transcriptional response of Nitrosomonas europaea to chloroform and chloromethane. Appl Environ Microbiol. 73(10):3440-5. [PudMed:17369330]
(473) Monti MC et al. (2007) Interactions of Kid-Kis toxin-antitoxin complexes with the parDoperator-promoter region of plasmid R1 are piloted by the Kis antitoxin andtuned by the stoichiometry of Kid-Kis oligomers. Nucleic Acids Res 35(5):1737-49. [PudMed:17317682]
(474) Kamphuis MB et al. (2007) Structure and function of bacterial kid-kis and related toxin-antitoxin systems. Protein Pept Lett 14(2):113-24. [PudMed:17305597]
(475) Wilbaux M et al. (2007) Functional interactions between coexisting toxin-antitoxin systems of the ccdfamily in Escherichia coli O157:H7. J Bacteriol 189(7):2712-9. [PudMed:17259320]
(476) Shang ZL et al. (2007) [Molecular cloning and expression of hypothetical proteins Rv1494 and Rv1495 ofM.tuberculosis H37Rv strain.] Nan Fang Yi Ke Da Xue Xue Bao 27(1):15-9. [PudMed:17259135]
(477) Nielsen AK et al. (1991) The rifampicin-inducible genes srnB from F and pnd from R483 are regulated by antisense RNAs and mediate plasmid maintenance by killing of plasmid-free segregants. Mol Microbiol. 5(8):1961-73.. [PudMed:1722558]
(478) Kamphuis MB et al. (2007) Interactions between the toxin Kid of the bacterial parD system and theantitoxins Kis and MazE. Proteins 67(1):219-31. [PudMed:17206710]
(479) Moritz EM et al. (2007) Toxin-antitoxin systems are ubiquitous and plasmid-encoded invancomycin-resistant enterococci. Proc Natl Acad Sci U S A 104(1):311-6. [PudMed:17190821]
(480) Mondal K et al. (2007) Role of stimuli-sensitive polymers in protein refolding: alpha-amylase and CcdB(controller of cell division or death B) as model proteins. Langmuir 23(1):70-5. [PudMed:17190487]
(481) Dziewit L et al. (2007) The SXT conjugative element and linear prophage N15 encode toxin-antitoxin-stabilizing systems homologous to the tad-ata module of the Paracoccus aminophilus plasmid pAMI2. J Bacteriol 189(5):1983-97. [PudMed:17158670]
(482) Black DS et al. (1991) Structure and organization of hip, an operon that affects lethality due toinhibition of peptidoglycan or DNA synthesis. J Bacteriol 173(18):5732-9. [PudMed:1715862]
(483) Budde PP et al. (2007) Characterization of a higBA toxin-antitoxin locus in Vibrio cholerae. J Bacteriol 189(2):491-500. [PudMed:17085558]
(484) Gerdes K et al. (1990) Mechanism of post-segregational killing by the hok/sok system of plasmid R1: sok antisense RNA regulates formation of a hok mRNA species correlated with killing of plasmid-free cells. Mol Microbiol 4(11):1807-18. [PudMed:1707122]
(485) Engelberg-Kulka H et al. (2006) Bacterial programmed cell death and multicellular behavior in bacteria. PLoS Genet 2(10):e135. [PudMed:17069462]
(486) Fico S et al. (2006) TasA-tasB, a new putative toxin-antitoxin (TA) system from Bacillusthuringiensis pGI1 plasmid is a widely distributed composite mazE-doc TA system. BMC Genomics 7:259. [PudMed:17038198]
(487) Christensen-Dalsgaard M et al. (2006) Two higBA loci in the Vibrio cholerae superintegron encode mRNA cleaving enzymesand can stabilize plasmids. Mol Microbiol 62(2):397-411. [PudMed:17020579]
(488) Madl T et al. (2006) Structural basis for nucleic acid and toxin recognition of the bacterialantitoxin CcdA. J Mol Biol 364(2):170-85. [PudMed:17007877]
(489) Smith AB et al. (2006) A strand-passage conformation of DNA gyrase is required to allow the bacterialtoxin, CcdB, to access its binding site. Nucleic Acids Res 34(17):4667-76. [PudMed:16963775]
(490) Makarova KS et al. (2006) The HicAB cassette, a putative novel, RNA-targeting toxin-antitoxin system inarchaea and bacteria. Bioinformatics 22(21):2581-4. [PudMed:16895922]
(491) Bodogai M et al. (2006) The ntrPR operon of Sinorhizobium meliloti is organized and functions as atoxin-antitoxin module. Mol Plant Microbe Interact 19(7):811-22. [PudMed:16838793]
(492) Korch SB et al. (2006) Ectopic overexpression of wild-type and mutant hipA genes in Escherichia coli:effects on macromolecular synthesis and persister formation. J Bacteriol 188(11):3826-36. [PudMed:16707675]
(493) Cruzeiro-Silva C et al. (2006) In-Cell NMR spectroscopy: inhibition of autologous protein expression reducesEscherichia coli lysis. Cell Biochem Biophys 44(3):497-502. [PudMed:16679537]
(494) Umanskaya ON et al. (2006) Inhibition of DNA topoisomerase II may trigger illegitimate recombination inliving cells: experiments with a model system. J Cell Biochem 99(2):598-608. [PudMed:16676353]
(495) Vazquez-Laslop N et al. (2006) Increased persistence in Escherichia coli caused by controlled expression oftoxins or other unrelated proteins. J Bacteriol 188(10):3494-7. [PudMed:16672603]
(496) Kolodkin-Gal I et al. (2006) Induction of Escherichia coli chromosomal mazEF by stressful conditions causesan irreversible loss of viability. J Bacteriol 188(9):3420-3. [PudMed:16621839]
(497) Aguirre-Ramirez M et al. (2006) Expression of the F plasmid ccd toxin-antitoxin system in Escherichia coli cellsunder nutritional stress. Can J Microbiol 52(1):24-30. [PudMed:16541156]
(498) Buts L et al. (2005) Crystallization of the C-terminal domain of the addiction antidote CcdA incomplex with its toxin CcdB. Acta Crystallogr Sect F Struct Biol Cryst Commun 61(Pt 10):949-52. [PudMed:16511204]
(499) Godoy VG et al. (2006) Y-family DNA polymerases respond to DNA damage-independent inhibition of replication fork progression. EMBO J 25(4):868-79. [PudMed:16482223]
(500) Ogata H et al. (2005) Rickettsia felis, from culture to genome sequencing. Ann N Y Acad Sci 1063:26-34. [PudMed:16481487]
(501) Nieto C et al. (2006) The chromosomal relBE2 toxin-antitoxin locus of Streptococcus pneumoniae:characterization and use of a bioluminescence resonance energy transfer assay todetect toxin-antitoxin interaction. Mol Microbiol 59(4):1280-96. [PudMed:16430700]
(502) Kamphuis MB et al. (2006) Model for RNA binding and the catalytic site of the RNase Kid of the bacterialparD toxin-antitoxin system. J Mol Biol 357(1):115-26. [PudMed:16413033]
(503) Gross M et al. (2006) MazG -- a regulator of programmed cell death in Escherichia coli. Mol Microbiol 59(2):590-601. [PudMed:16390452]
(504) Bajaj K et al. (2005) Mutagenesis-based definitions and probes of residue burial in proteins. Proc Natl Acad Sci U S A 102(45):16221-6. [PudMed:16251276]
(505) Lemos JA et al. (2005) Characteristics of Streptococcus mutans strains lacking the MazEF and RelBEtoxin-antitoxin modules. FEMS Microbiol Lett 253(2):251-7. [PudMed:16243456]
(506) Engelberg-Kulka H et al. (2005) mazEF: a chromosomal toxin-antitoxin module that triggers programmed cell deathin bacteria. J Cell Sci 118(Pt 19):4327-32. [PudMed:16179604]
(507) Silvaggi JM et al. (2005) Small untranslated RNA antitoxin in Bacillus subtilis J Bacteriol. 187(19):6641-50.. [PudMed:16166525]
(508) Jiang Y et al. (2005) The complete sequence and analysis of the large virulence plasmid pSS ofShigella sonnei. Plasmid 54(2):149-59. [PudMed:16122562]
(509) Zielenkiewicz U et al. (2005) The toxin-antitoxin system of the streptococcal plasmid pSM19035. J Bacteriol 187(17):6094-105. [PudMed:16109951]
(510) Kamada K et al. (2005) Conformational change in the catalytic site of the ribonuclease YoeB toxin byYefM antitoxin. Mol Cell. 19(4):497-509. . [PudMed:16109374]
(511) Cherny I et al. (2005) The YoeB toxin is a folded protein that forms a physical complex with theunfolded YefM antitoxin. Implications for a structural-based differentialstability of toxin-antitoxin systems. J Biol Chem 280(34):30063-72. [PudMed:15980067]
(512) Szpirer CY et al. (2005) Separate-component-stabilization system for protein and DNA production withoutthe use of antibiotics. Biotechniques 38(5):775-81. [PudMed:15945374]
(513) Pellegrini O et al. (2005) The Bacillus subtilis ydcDE operon encodes an endoribonuclease of the MazF/PemKfamily and its inhibitor. Mol Microbiol 56(5):1139-48. [PudMed:15882409]
(514) Gerdes K et al. (2005) Prokaryotic toxin-antitoxin stress response loci. Nat Rev Microbiol 3(5):371-82. [PudMed:15864262]
(515) Dao-Thi MH et al. (2005) Molecular basis of gyrase poisoning by the addiction toxin CcdB. J Mol Biol 348(5):1091-102. [PudMed:15854646]
(516) Munoz-Gomez AJ et al. (2005) RNase/anti-RNase activities of the bacterial parD toxin-antitoxin system. J Bacteriol 187(9):3151-7. [PudMed:15838042]
(517) Wilson DN et al. (2005) RelBE or not to be. Nat Struct Mol Biol 12(4):282-4. [PudMed:15809644]
(518) Takagi H et al. (2005) Crystal structure of archaeal toxin-antitoxin RelE-RelB complex withimplications for toxin activity and antitoxin effects. Nat Struct Mol Biol. 12(4):327-31. [PudMed:15768033]
(519) Zhao X et al. (2005) Percolation of the phd repressor-operator interface. J Bacteriol 187(6):1901-12. [PudMed:15743936]
(520) Lah J et al. (2005) Energetics of structural transitions of the addiction antitoxin MazE: is aprogrammed bacterial cell death dependent on the intrinsically flexible natureof the antitoxins? J Biol Chem 280(17):17397-407. [PudMed:15735309]
(521) Pandey DP et al. (2005) Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes. Nucleic Acids Res. 33(3):966-76. [PudMed:15718296]
(522) Sorvig E et al. (2005) Plasmid p256 from Lactobacillus plantarum represents a new type of replicon inlactic acid bacteria, and contains a toxin-antitoxin-like plasmid maintenancesystem. Microbiology 151(Pt 2):421-31. [PudMed:15699191]
(523) McKinley JE et al. (2005) Characterization of the Phd repressor-antitoxin boundary. J Bacteriol 187(2):765-70. [PudMed:15629948]
(524) Vogel J et al. (2004) The small RNA IstR inhibits synthesis of an SOS-induced toxic peptide. Curr Biol 14(24):2271-6. [PudMed:15620655]
(525) Amitai S et al. (2004) MazF-mediated cell death in Escherichia coli: a point of no return. J Bacteriol 186(24):8295-300. [PudMed:15576778]
(526) Keren I et al. (2004) Specialized persister cells and the mechanism of multidrug tolerance inEscherichia coli. J Bacteriol 186(24):8172-80. [PudMed:15576765]
(527) Bachrach G et al. (2004) Characterization of the novel Fusobacterium nucleatum plasmid pKH9 and evidenceof an addiction system. Appl Environ Microbiol 70(12):6957-62. [PudMed:15574887]
(528) Bhinge A et al. (2004) Accurate detection of protein:ligand binding sites using molecular dynamicssimulations. Structure 12(11):1989-99. [PudMed:15530363]
(529) Hazan R et al. (2004) Escherichia coli mazEF-mediated cell death as a defense mechanism that inhibitsthe spread of phage P1. Mol Genet Genomics 272(2):227-34. [PudMed:15316771]
(530) Christensen SK et al. (2004) Delayed-relaxed response explained by hyperactivation of RelE. Mol Microbiol 53(2):587-97. [PudMed:15228536]
(531) Zhang YX et al. (2004) Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospirainterrogans chromosome. Cell Res 14(3):208-16. [PudMed:15225414]
(532) Munoz-Gomez AJ et al. (2004) Insights into the specificity of RNA cleavage by the Escherichia coli MazFtoxin. FEBS Lett 567(2-3):316-20. [PudMed:15178344]
(533) Dao-Thi MH et al. (2004) Crystallization of CcdB in complex with a GyrA fragment. Acta Crystallogr D Biol Crystallogr 60(Pt 6):1132-421. . [PudMed:15159578]
(534) Hazan R et al. (2004) Escherichia coli mazEF-mediated cell death is triggered by various stressfulconditions. J Bacteriol 186(11):3663-9. [PudMed:15150257]
(535) Chakshusmathi G et al. (2004) Design of temperature-sensitive mutants solely from amino acid sequence. Proc Natl Acad Sci U S A 101(21):7925-30. [PudMed:15148363]
(536) Smith JA et al. (2004) Modular organization of the Phd repressor/antitoxin protein. J Bacteriol 186(9):2692-8. [PudMed:15090510]
(537) Engelberg-Kulka H et al. (2004) Bacterial programmed cell death systems as targets for antibiotics. Trends Microbiol 12(2):66-71. [PudMed:15036322]
(538) Deane SM et al. (2004) Plasmid evolution and interaction between the plasmid addiction stabilitysystems of two related broad-host-range IncQ-like plasmids. J Bacteriol 186(7):2123-33. [PudMed:15028698]
(539) Zhang J et al. (2004) Interference of mRNA function by sequence-specific endoribonuclease PemK. J Biol Chem 279(20):20678-84. [PudMed:15024022]
(540) Christensen SK et al. (2004) Overproduction of the Lon protease triggers inhibition of translation inEscherichia coli: involvement of the yefM-yoeB toxin-antitoxin system. Mol Microbiol 51(6):1705-17. [PudMed:15009896]
(541) Pullinger GD et al. (1992) A Salmonella dublin virulence plasmid locus that affects bacterial growth undernutrient-limited conditions. Mol Microbiol 6(12):1631-43. [PudMed:1495391]
(542) Bajaj K et al. (2004) Thermodynamic characterization of monomeric and dimeric forms of CcdB(controller of cell division or death B protein). Biochem J 380(Pt 2):409-17. [PudMed:14763902]
(543) Cherny I et al. (2004) The YefM antitoxin defines a family of natively unfolded proteins: implicationsas a novel antibacterial target. J Biol Chem 279(9):8252-61. [PudMed:14672926]
(544) Anantharaman V et al. (2003) New connections in the prokaryotic toxin-antitoxin network: relationship withthe eukaryotic nonsense-mediated RNA decay system. Genome Biol 4(12):R81. [PudMed:14659018]
(545) Korch SB et al. (2003) Characterization of the hipA7 allele of Escherichia coli and evidence that highpersistence is governed by (p)ppGpp synthesis. Mol Microbiol 50(4):1199-213. [PudMed:14622409]
(546) Brown JM et al. (2003) A novel family of Escherichia coli toxin-antitoxin gene pairs. J Bacteriol. 185(22):6600-8.. [PudMed:14594833]
(547) Zhang Y et al. (2003) MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis inEscherichia coli. Mol Cell 12(4):913-23. [PudMed:14580342]
(548) Katz ME et al. (1992) Molecular characterization of a genomic region associated with virulence inDichelobacter nodosus. Infect Immun 60(11):4586-92. [PudMed:1398971]
(549) Christensen SK et al. (2003) Toxin-antitoxin loci as stress-response-elements: ChpAK/MazF and ChpBK cleavetranslated RNAs and are counteracted by tmRNA. J Mol Biol 332(4):809-19. [PudMed:12972253]
(550) Zhang J et al. (2003) Characterization of the interactions within the mazEF addiction module ofEscherichia coli. J Biol Chem 278(34):32300-6. [PudMed:12810711]
(551) Parr RD et al. (2003) New donor vector for generation of histidine-tagged fusion proteins using theGateway Cloning System. Plasmid 49(2):179-83. [PudMed:12726771]
(552) Kamada K et al. (2003) Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxinrecognition. Mol Cell 11(4):875-84. [PudMed:12718874]
(553) de la Cueva-Mendez G. (2003) Distressing bacteria: structure of a prokaryotic detox program. Mol Cell 11(4):848-50. [PudMed:12718870]
(554) Nyström T. (2003) Conditional senescence in bacteria: death of the immortals. Mol Microbiol. 48(1):17-23. [PudMed:12657042]
(555) Sat B et al. (2003) The Escherichia coli mazEF suicide module mediates thymineless death. J Bacteriol 185(6):1803-7. [PudMed:12618443]
(556) Grady R et al. (2003) Axe-Txe, a broad-spectrum proteic toxin-antitoxin system specified by amultidrug-resistant, clinical isolate of Enterococcus faecium. Mol Microbiol 47(5):1419-32. [PudMed:12603745]
(557) Barrett JF. (2001) Targeting DNA gyrase. Expert Opin Ther Targets 5(4):531-533. [PudMed:12540265]
(558) Lah J et al. (2003) Recognition of the intrinsically flexible addiction antidote MazE by a dromedarysingle domain antibody fragment. Structure, thermodynamics of binding,stability, and influence on interactions with DNA. J Biol Chem 278(16):14101-11. [PudMed:12533537]
(559) Camacho AG et al. (2002) In vitro and in vivo stability of the epsilon2zeta2 protein complex of the broadhost-range Streptococcus pyogenes pSM19035 addiction system. Biol Chem 383(11):1701-13. [PudMed:12530535]
(560) Pedersen K et al. (2003) The bacterial toxin RelE displays codon-specific cleavage of mRNAs in theribosomal A site. Cell 112(1):131-40. [PudMed:12526800]
(561) Hargreaves D et al. (2002) Structural and functional analysis of the kid toxin protein from E. coli plasmidR1. Structure 10(10):1425-33. [PudMed:12377128]
(562) Pedersen K et al. (2002) Rapid induction and reversal of a bacteriostatic condition by controlledexpression of toxins and antitoxins. Mol Microbiol 45(2):501-10. [PudMed:12123459]
(563) Kawano M et al. (2002) Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35-amino-acid cell-killing peptide and a cis-encoded small antisense RNA in Escherichia coli. Mol Microbiol 45(2):333-49. [PudMed:12123448]
(564) Allali N et al. (2002) The highly conserved TldD and TldE proteins of Escherichia coli are involved inmicrocin B17 processing and in CcdA degradation. J Bacteriol 184(12):3224-31. [PudMed:12029038]
(565) Jiang Y et al. (2002) ParE toxin encoded by the broad-host-range plasmid RK2 is an inhibitor of Escherichia coli gyrase. Mol Microbiol 44(4):971-9. [PudMed:12010492]
(566) Van Melderen L. (2002) Molecular interactions of the CcdB poison with its bacterial target, the DNAgyrase. Int J Med Microbiol 291(6-7):537-44. [PudMed:11890555]
(567) Lew BM et al. (2002) An in vivo screening system against protein splicing useful for the isolation ofnon-splicing mutants or inhibitors of the RecA intein of Mycobacteriumtuberculosis. Gene 282(1-2):169-77. [PudMed:11814689]
(568) Oberer M et al. (2002) The anti-toxin ParD of plasmid RK2 consists of two structurally distinctmoieties and belongs to the ribbon-helix-helix family of DNA-binding proteins. Biochem J 361(Pt 1):41-7. [PudMed:11743881]
(569) Dao-Thi MH et al. (2002) Intricate interactions within the ccd plasmid addiction system. J Biol Chem 277(5):3733-42. [PudMed:11741897]
(570) Pomerantsev AP et al. (2001) Genetic organization of the Francisella plasmid pFNL10. Plasmid 46(3):210-22. [PudMed:11735370]
(571) Christensen SK et al. (2001) RelE, a global inhibitor of translation, is activated during nutritional stress. Proc Natl Acad Sci U S A 98(25):14328-33. [PudMed:11717402]
(572) Greenfield TJ et al. (2001) Antisense RNA regulation of the par post-segregational killing system: structural analysis and mechanism of binding of the antisense RNA, RNAII and its target, RNAI. Mol Microbiol. 42(2):527-37.. [PudMed:11703673]
(573) Picardeau M et al. (2001) Killing effect and antitoxic activity of the Leptospira interroganstoxin-antitoxin system in Escherichia coli. J Bacteriol 183(21):6494-7. [PudMed:11591696]
(574) Chatterji M et al. (2001) Effect of different classes of inhibitors on DNA gyrase from Mycobacteriumsmegmatis. J Antimicrob Chemother 48(4):479-85. [PudMed:11581225]
(575) Afif H et al. (2001) The ratio between CcdA and CcdB modulates the transcriptional repression of theccd poison-antidote system. Mol Microbiol 41(1):73-82. [PudMed:11454201]
(576) Brown JS et al. (2001) A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence. Mol Microbiol 40(3):572-85. [PudMed:11359564]
(577) Tian QB et al. (2001) Specific protein-DNA and protein-protein interaction in the hig gene system, aplasmid-borne proteic killer gene system of plasmid Rts1. Plasmid 45(2):63-74. [PudMed:11322821]
(578) Meinhart A et al. (2001) Crystallization and preliminary X-ray diffraction studies of the epsilonzetaaddiction system encoded by Streptococcus pyogenes plasmid pSM19035. Acta Crystallogr D Biol Crystallogr 57(Pt 5):745-724. . [PudMed:11320325]
(579) Galvani C et al. (2001) Purification of the RelB and RelE proteins of Escherichia coli: RelE binds toRelB and to ribosomes. J Bacteriol 183(8):2700-3. [PudMed:11274135]
(580) Hazan R et al. (2001) Postsegregational killing mediated by the P1 phage "addiction module" phd-docrequires the Escherichia coli programmed cell death system mazEF. J Bacteriol 183(6):2046-50. [PudMed:11222604]
(581) Sat B et al. (2001) Programmed cell death in Escherichia coli: some antibiotics can trigger mazEFlethality. J Bacteriol 183(6):2041-5. [PudMed:11222603]
(582) Clissold PM et al. (2000) PIN domains in nonsense-mediated mRNA decay and RNAi. Curr Biol 10(24):R888-90. [PudMed:11137022]
(583) Marianovsky I et al. (2001) The regulation of the Escherichia coli mazEF promoter involves an unusualalternating palindrome. J Biol Chem 276(8):5975-84. [PudMed:11071896]
(584) Cooper TF et al. (2000) Postsegregational killing does not increase plasmid stability but acts tomediate the exclusion of competing plasmids. Proc Natl Acad Sci U S A 97(23):12643-8. [PudMed:11058151]
(585) Lewis K. (2000) Programmed death in bacteria. Microbiol Mol Biol Rev 64(3):503-14. [PudMed:10974124]
(586) Mittenhuber G. (1999) Occurrence of mazEF-like antitoxin/toxin systems in bacteria. J Mol Microbiol Biotechnol 1(2):295-302. [PudMed:10943559]
(587) Oberer M et al. (1999) Thermodynamic properties and DNA binding of the ParD protein from the broadhost-range plasmid RK2/RP4 killing system. Biol Chem 380(12):1413-20. [PudMed:10661868]
(588) Gerdes K. (2000) Toxin-antitoxin modules may regulate synthesis of macromolecules duringnutritional stress. J Bacteriol 182(3):561-72. [PudMed:10633087]
(589) Barer MR; Harwood CR (1999) Bacterial viability and culturability Adv Microb Physiol 41:93-137. [PudMed:10500845]
(590) Rawlings DE. (1999) Proteic toxin-antitoxin, bacterial plasmid addiction systems and their evolutionwith special reference to the pas system of pTF-FC2. FEMS Microbiol Lett 176(2):269-77. [PudMed:10427709]
(591) Gazit E et al. (1999) The Doc toxin and Phd antidote proteins of the bacteriophage P1 plasmidaddiction system form a heterotrimeric complex. J Biol Chem 274(24):16813-8. [PudMed:10358024]
(592) Falla TJ et al. (1999) Stabilization of Rhizobium symbiosis plasmids. Microbiology 145 ( Pt 3):515-6. [PudMed:10217483]